Novel locus including FGF21 is associated with dietary macronutrient intake
Open accessAbstract
Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n = 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top associations (P < 10(-5)) for percentage of total caloric intake from protein and carbohydrate. rs838133 was replicated in silico in an independent sample from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) Nutrition Working Group (n = 38 360) and attained genome-wide significance in combined analysis (Pjoint = 7.9 × 10(-9)). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake.
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Genome-wide association studies have identified SNPs at the FGF21 locus that significantly correlate with changes in carbohydrate intake.
“Genome-wide association studies correlating changes in macronutrient intake with genetic variants have identified single-nucleotide polymorphisms at the FGF21 locus that significantly correlate with changes in carbohydrate intake117,118.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [117]
SNPs at the FGF21 locus are associated with changes in macronutrient intake.
“Two independent studies revealed that single nucleotide polymorphisms (SNPs) at the FGF21 locus are associated with changes in macronutrient intake (20, 127).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [20]
Variants rs838133 and rs838145 are associated with higher carbohydrate intake, and FGF21 is a candidate gene in the region.
“Specifically, these studies reported that variants rs838133 and rs838145 were associated with higher carbohydrate intake and that FGF21 was a candidate gene in the region (20, 127).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [20]
Human genetic linkage studies identified variants in the FGF21 locus associated with protein, carbohydrate, and fat intake.
“These 2 original studies identified variants in the FGF21 locus that were associated with protein, carbohydrate, and fat intake”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [173]
FGF21 sequence variants are linked with alterations in macronutrient preference and alcohol intake in humans.
“FGF21 sequence variants are linked with alterations in macronutrient preference and alcohol intake in humans”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [173]
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Cites
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279 · see citing works
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
Willett, W. C. (1998) · doi:10.1093/acprof:oso/9780195122978.001.0001 · Cited by 4,541 · see citing works
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438 · see citing works
Global nutrition transition and the pandemic of obesity in developing countries
Popkin, B. M., Adair, L. S., & Ng, S. W. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00456.x · Cited by 4,313 · see citing works
Reproducibility and validity of a semiquantitative food frequency questionnaire
WILLETT, W. C., SAMPSON, L., STAMPFER, M. J., ROSNER, B., BAIN, C., WITSCHI, J., HENNEKENS, C. H., & SPEIZER, F. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114086 · Cited by 4,274 · see citing works
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912 · see citing works
Self-citationRimm, E. B., Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Litin, L. B., & Willett, W. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116211 · Cited by 2,104 · see citing works
Self-citationthe DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segrè, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., et al. (2012) · Nature Genetics · doi:10.1038/ng.2383 · Cited by 1,912 · see citing works
Self-citationMaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
Li, Y., Willer, C. J., Ding, J., Scheet, P., & Abecasis, G. R. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20533 · Cited by 1,843 · see citing works
Hunter, D. J., Kraft, P., Jacobs, K. B., Cox, D. G., Yeager, M., Hankinson, S. E., Wacholder, S., Wang, Z., Welch, R. A., Hutchinson, A. A., et al. (2007) · Nature Genetics · doi:10.1038/ng2075 · Cited by 1,463 · see citing works
Self-citationProspective study of alcohol consumption and risk of coronary disease in men.
Rimm, E. B., Giovannucci, E. L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B., & Stampfer, M. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)90542-w · Cited by 1,239 · see citing works
Self-citationFibroblast Growth Factor 21 Corrects Obesity in Mice
Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works
Fruit and vegetable intake and risk of cardiovascular disease: The women’s health study
Liu, S., Manson, J. E., Lee, I.-M., Cole, S. R., Hennekens, C. H., Willett, W. C., & Buring, J. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.922 · Cited by 917 · see citing works
Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works
Mapping cis- and trans-regulatory effects across multiple tissues in twins
The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Grundberg, E., Small, K. S., Hedman, Å. K., Nica, A. C., Buil, A., Keildson, S., Bell, J. T., Yang, T.-P., Meduri, E., et al. (2012) · Nature Genetics · doi:10.1038/ng.2394 · Cited by 729 · see citing works
Psaty, B. M., O'Donnell, C. J., Gudnason, V., Lunetta, K. L., Folsom, A. R., Rotter, J. I., Uitterlinden, A. G., Harris, T. B., Witteman, J. C. M., & Boerwinkle, E. (2009) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.108.829747 · Cited by 599 · see citing works
The Nurses׳ Health Study: lifestyle and health among women
Colditz, G. A., & Hankinson, S. E. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1608 · Cited by 590 · see citing works
Validation of a semi-quantitative food frequency questionnaire: Comparison with a 1-year diet record
Willett, W. C., Reynolds, R. D., Cottrell-Hoehner, S., Sampson, L., & Browne, M. L. (1987) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)03057-1 · Cited by 545 · see citing works
Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works
ProbABEL package for genome-wide association analysis of imputed data
Aulchenko, Y. S., Struchalin, M. V., & van Duijn, C. M. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-134 · Cited by 396 · see citing works
Berglund, E. D., Li, C. Y., Bina, H. A., Lynes, S. E., Michael, M. D., Shanafelt, A. B., Kharitonenkov, A., & Wasserman, D. H. (2009) · Endocrinology · doi:10.1210/en.2009-0221 · Cited by 297 · see citing works
Yang, T.-P., Beazley, C., Montgomery, S. B., Dimas, A. S., Gutiérrez‐Arcelus, M., Stranger, B. E., Deloukas, P., & Dermitzakis, E. T. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq452 · Cited by 292 · see citing works
Sarruf, D. A., Thaler, J. P., Morton, G. J., German, J. P., Fischer, J. D., Ogimoto, K., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db09-1878 · Cited by 287 · see citing works
24-h uric acid excretion and the risk of kidney stones
Curhan, G. C., & Taylor, E. N. (2007) · Kidney International · doi:10.1038/sj.ki.5002708 · Cited by 279 · see citing works
Self-citationQi, L., Kraft, P. L., Hunter, D. J., & Hu, F. B. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn242 · Cited by 227 · see citing works
Self-citationTanaka, T., Ngwa, J. S., van Rooij, F. J., Zillikens, M. C., Wojczynski, M. K., Frazier-Wood, A. C., Houston, D. K., Kanoni, S., Lemaitre, R. N., Luan, J., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.052183 · Cited by 226 · see citing works
Self-citationVisscher, P. M., Yang, J., & Goddard, M. E. (2010) · Twin Research and Human Genetics · doi:10.1375/twin.13.6.517 · Cited by 203 · see citing works
Rouquier, S., Lowe, J. B., Kelly, R. J., Fertitta, A., Lennon, G. G., & Giorgi, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4632 · Cited by 196 · see citing works
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
Qi, L., Cornelis, M. C., Kraft, P. L., Stanya, K. J., Kao, W. H. L., Pankow, J. S., Dupuis, J., Florez, J. C., Fox, C. S., Paré, G., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq156 · Cited by 190 · see citing works
Self-citationHeritable Variation in Food Preferences and Their Contribution to Obesity
Reed, D. R., Bachmanov, A. A., Beauchamp, G. K., Tordoff, M. G., & Price, R. A. (1997) · Behavior Genetics · doi:10.1023/a:1025692031673 · Cited by 188 · see citing works
Chen, W.-W., Li, L., Yang, G.-Y., Li, K., Qi, X.-Y., Zhu, W., Tang, Y., Liu, H., & Boden, G. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-985148 · Cited by 186 · see citing works
Ridker, P. M., Chasman, D. I., Zee, R. Y. L., Parker, A. N., Rose, L. M., Cook, N. R., Buring, J. E., & for the Women’s Genome Health Study Working Group (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.099366 · Cited by 169 · see citing works
Self-citationCommon variants of FUT2 are associated with plasma vitamin B12 levels
Hazra, A., Kraft, P., Selhub, J., Giovannucci, E. L., Thomas, G. D., Hoover, R. N., Chanock, S. J., & Hunter, D. J. (2008) · Nature Genetics · doi:10.1038/ng.210 · Cited by 166 · see citing works
Self-citationGenetics of Food Intake and Eating Behavior Phenotypes in Humans
Rankinen, T., & Bouchard, C. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111218 · Cited by 137 · see citing works
Fibroblast Growth Factor 21 Predicts the Metabolic Syndrome and Type 2 Diabetes in Caucasians
Bobbert, T., Schwarz, F., Fischer‐Rosinsky, A., Pfeiffer, A. F. H., Möhlig, M., Mai, K., & Spranger, J. (2012) · Diabetes Care · doi:10.2337/dc12-0703 · Cited by 125 · see citing works
Uebanso, T., Taketani, Y., Yamamoto, H., Amo, K., Ominami, H., Arai, H., Takei, Y., Masuda, M., Tanimura, A., Harada, N., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022976 · Cited by 99 · see citing works
Protein Interaction-Based Genome-Wide Analysis of Incident Coronary Heart Disease
Jensen, M. K., Pers, T. H., Dworzyński, P., Girman, C. J., Brunak, S., & Rimm, E. B. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.960393 · Cited by 62 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050 · see citing works
Understanding the Physiology of FGF21
Fisher, F. M., & Maratos-Flier, E. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105339 · Cited by 912 · see citing works
FGF21 is an endocrine signal of protein restriction
Laeger, T., Henagan, T. M., Albarado, D. C., Redman, L. M., Bray, G. A., Noland, R. C., Münzberg, H., Hutson, S. M., Gettys, T. W., Schwartz, M. W., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74915 · Cited by 593 · see citing works
FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver
von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.003 · Cited by 347 · see citing works
FGF21 Regulates Sweet and Alcohol Preference
Talukdar, S., Owen, B. M., Song, P., Hernandez, G., Zhang, Y., Zhou, Y., Scott, W. T., Paratala, B., Turner, T., Smith, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.008 · Cited by 342 · see citing works
Flippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311 · see citing works
Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270 · see citing works
Schumann, G., Liu, C., O’Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611243113 · Cited by 241 · see citing works
Self-citationFructose ingestion acutely stimulates circulating FGF21 levels in humans
Dushay, J. R., Toschi, E., Mitten, E. K., Fisher, F. M., Herman, M. A., & Maratos-Flier, E. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2014.09.008 · Cited by 233 · see citing works
Sweet Sixteenth for ChREBP: Established Roles and Future Goals
Abdul-Wahed, A., Guilmeau, S., & Postic, C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.004 · Cited by 231 · see citing works
Tanaka, T., Ngwa, J. S., van Rooij, F. J., Zillikens, M. C., Wojczynski, M. K., Frazier-Wood, A. C., Houston, D. K., Kanoni, S., Lemaitre, R. N., Luan, J., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.052183 · Cited by 226 · see citing works
Self-citationFibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222 · see citing works
FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans
Søberg, S., Sandholt, C. H., Jespersen, N. Z., Toft, U., Madsen, A. L., von Holstein-Rathlou, S., Grevengoed, T. J., Christensen, K. B., Bredie, W. L. P., Potthoff, M. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.009 · Cited by 216 · see citing works
Jensen-Cody, S. O., Flippo, K. H., Claflin, K. E., Yavuz, Y., Sapouckey, S. A., Walters, G. C., Usachev, Y. M., Atasoy, D., Gillum, M. P., & Potthoff, M. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.008 · Cited by 166 · see citing works
A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism
Fisher, F. M., Kim, M., Doridot, L., Cunniff, J. C., Parker, T. S., Levine, D. M., Hellerstein, M. K., Hudgins, L. C., Maratos-Flier, E., & Herman, M. A. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2016.11.008 · Cited by 166 · see citing works
Bray, M. S., Loos, R. J. F., McCaffery, J. M., Ling, C., Franks, P. W., Weinstock, G. M., Snyder, M. P., Vassy, J. L., Agurs‐Collins, T., & The Conference Working Group (2016) · Obesity · doi:10.1002/oby.21381 · Cited by 138 · see citing works
Latest approaches for the treatment of obesity
Jackson, V. M., Breen, D. M., Fortin, J.-P., Liou, A., Kuzmiski, J. B., Loomis, A. K., Rives, M.-L., Shah, B., & Carpino, P. A. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1044966 · Cited by 132 · see citing works
Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
Lundsgaard, A.-M., Fritzen, A. M., Sjøberg, K. A., Myrmel, L. S., Madsen, L., Wojtaszewski, J. F. P., Richter, E. A., & Kiens, B. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2016.11.001 · Cited by 126 · see citing works
Fibroblast growth factor 21: a regulator of metabolic disease and health span
Xie, T., & Leung, P. S. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00101.2017 · Cited by 121 · see citing works
Frayling, T. M., Beaumont, R. N., Jones, S. E., Yaghootkar, H., Tuke, M. A., Ruth, K. S., Casanova, F., West, B., Locke, J., Sharp, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.070 · Cited by 101 · see citing works
FGF21 and the physiological regulation of macronutrient preference
Hill, C. M., Qualls-Creekmore, E., Berthoud, H.-R., Soto, P., Yu, S., McDougal, D. H., Münzberg, H., & Morrison, C. D. (2020) · Endocrinology · doi:10.1210/endocr/bqaa019 · Cited by 99 · see citing works
Baruch, A., Wong, C., Chinn, L. W., Vaze, A., Sonoda, J., Gelzleichter, T., Chen, S., Lewin-Koh, N., Morrow, L., Dheerendra, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012073117 · Cited by 95 · see citing works
Homeostatic sensing of dietary protein restriction: a case for FGF21
Hill, C. M., Berthoud, H.-R., Münzberg, H., & Morrison, C. D. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.002 · Cited by 68 · see citing works
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Larson, K. R., Chaffin, A. T.-B., Goodson, M. L., Fang, Y., & Ryan, K. K. (2019) · Endocrinology · doi:10.1210/en.2018-01056 · Cited by 68 · see citing works
Merino, J., Dashti, H. S., Li, S. X., Sarnowski, C., Justice, A. E., Graff, M., Papoutsakis, C., Smith, C. E., Dedoussis, G. V., Lemaitre, R. N., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0079-4 · Cited by 66 · see citing works
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Pérez‐Martí, A., Garcia‐Guasch, M., Tresserra‐Rimbau, A., Carrilho‐Do‐Rosário, A., Estruch, R., Salas‐Salvadó, J., Martínez‐González, M. Á., Lamuela‐Raventós, R., Marrero, P. F., Haro, D., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600725 · Cited by 56 · see citing works
Flippo, K. H., Jensen-Cody, S. O., Claflin, K. E., & Potthoff, M. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-76593-2 · Cited by 49 · see citing works
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Qi, L., Heianza, Y., Li, X., Sacks, F. M., & Bray, G. A. (2023) · Nutrients · doi:10.3390/nu15163665 · Cited by 17 · see citing works
Self-citation
- Authors
- Chu, A. Y., Workalemahu, T., Paynter, N. P., Rose, L. M., Giulianini, F., Tanaka, T., Ngwa, J. S., Qi, Q., Curhan, G. C., Rimm, E. B., Hunter, D. J., Pasquale, L. R., Ridker, P. M., Hu, F. B., Chasman, D. I., & Qi, L.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- National Institute on Aging (US)
- Boston University (US)
- Massachusetts Eye and Ear Infirmary (US)
- Corresponding author
- Qi, Lu
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-01-30
- Volume
- 22
- Issue
- 9
- Pages
- 1895-1902
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- PMC
- PMC3612009
- OpenAlex
- W2098667700
- Cited by
- 195
- References
- 38
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 10 · 2023: 18 · 2022: 16 · 2021: 16 · 2020: 22 · 2019: 17 · 2018: 21 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 8 · 2013: 4
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Human Molecular Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- American Heart Association
- Amgen
- National Institutes of Health (5r01ca049449-18, 5r01hl043851-10, 5r01ca058988-04)
- National Heart, Lung, and Blood Institute (R01HL080467, HL043851, HL 71981, R01HL071981, R01‐HL043851, R01HL073168, HL-073168, R01HL105756, HL080467, T32HL007575, HL34594, R01HL034594, R01HL088521)
- National Human Genome Research Institute (U01HG004399)
- National Cancer Institute (CA-49449, CA-87969, P01CA087969, R01‐CA049449, CA058988, U01CA049449, R01CA047988)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK091718, DK091718, R01DK058845, P30DK046200, K24DK080140, DK46200.)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- macronutrient intake, FGF21, tanks, FTO, protein intake, carbohydrate intake, energy intake, obesity, type 2 diabetes, genetic susceptibility
- MeSH terms
- Energy Intake, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Dietary Fats, Dietary Fiber, Dietary Proteins, Female, Fibroblast Growth Factors, Genotype, Humans, Male, Obesity, Cohort Studies, Body Mass Index, Linear Models, NF-kappa B, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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