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Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons
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Axonal endo-/lysosomal organelles pathologically accumulate in axonal spheroids.
“The relevance of axonal endo-/lysosomal organelles is further highlighted by the fact that they pathologically accumulate in axonal spheroids.”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Lie et al., 2021
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MethodInfluentialTermination of autophagy and reformation of lysosomes regulated by mTOR
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Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
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“In neurons, axonal endosomes and autophagosomes acquire Rab7 and LAMP1 while maturing into LEs and amphisomes, which then undergo progressive acidification and further maturation toward lysosomal identity during their retrograde transport (Cheng et al., 2015; Deinhardt et al., 2006; Kuijpers et al., 2020; Lee et al.,…”
BackgroundResultThe position of lysosomes within the cell determines their luminal pH
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“, 2019), whether these are absolute requirements is still under debate (Ashrafi et al., 2014).”
BackgroundMotor coordination via a tug-of-war mechanism drives bidirectional vesicle transport
Hendricks, A. G., Perlson, E., Ross, J. L., Schroeder, H. W., Tokito, M., & Holzbaur, E. L. F. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.058 · Cited by 423
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Self-citationBordi, M., Berg, M. J., Mohan, P. S., Peterhoff, C. M., Alldred, M. J., Che, S., Ginsberg, S. D., & Nixon, R. A. (2016) · Autophagy · doi:10.1080/15548627.2016.1239003 · Cited by 353
Self-citationAutophagy and Its Normal and Pathogenic States in the Brain
Yamamoto, A., & Yue, Z. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014149 · Cited by 204
Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia
Suzuki, K., & Terry, R. D. (1967) · Acta Neuropathologica · doi:10.1007/bf00688828 · Cited by 169
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
Evans, C. S., & Holzbaur, E. L. (2020) · eLife · doi:10.7554/elife.50260 · Cited by 137 · cited 1×
“, 2010), and LAMP1 acquisition by autophagosomes is temporally separate from acidification (Evans and Holzbaur, 2020).”
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Metadata
- Authors
- Lie, P. P. Y., Yang, D.-S., Stavrides, P., Goulbourne, C. N., Zheng, P., Mohan, P. S., Cataldo, A. M., & Nixon, R. A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 35
- Issue
- 4
- Pages
- 109034
- ISSN
- 2211-1247
- PMC
- PMC8135226
- Cited by
- 97
- References
- 14
- Language
- en
- Licence
- Funders
- National Institutes of Health (P01AG017617, R01AG062376)
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