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The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

In vivo partial cellular reprogramming enhances liver plasticity and regeneration

Hishida, Tomoaki, Yamamoto, Mako, Hishida-Nozaki, Yuriko, Shao, Changwei, Huang, Ling, Wang, Chao, Shojima, Kensaku, Xue, Yuan, Hang, Yuqing, Shokhirev, Maxim, Memczak, Sebastian, Sahu, Sanjeeb Kumar, Hatanaka, Fumiyuki, Ros, Ruben Rabadan, Maxwell, Matthew B., Chavez, Jasmine, Shao, Yanjiao, Liao, Hsin-Kai, Martinez-Redondo, Paloma, Guillen-Guillen, Isabel, Hernandez-Benitez, Reyna, Esteban, Concepcion Rodriguez, Qu, Jing, Holmes, Michael C., Yi, Fei, Hickey, Raymond D., Garcia, Pedro Guillen, Delicado, Estrella Nuñez, Castells, Antoni, Campistol, Josep M., Yu, Yang, Hargreaves, Diana C., Asai, Akihiro, Reddy, Pradeep, Liu, Guang-Hui, Izpisua Belmonte, Juan Carlos·2022·Cell Reports
DOI 10.1016/j.celrep.2022.110730PMC PMC9807246
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  • Early transient events evoked by OSKM factors, such as somatic silencing and chromatin remodeling while reprogramming is initiated, seem to be required for both cellular rejuvenation and full reprogramming.

    “Despite these different contexts, 'early transient events' evoked by OSKM factors, such as somatic silencing and chromatin remodeling while reprogramming is initiated, seem to be required for both cellular rejuvenation and full reprogramming [74][75][76] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [76]

    The Results section (page unavailable) reports that short-term 4F expression transiently downregulated mature-hepatocyte markers and changed chromatin accessibility. The Introduction also reports that short-term 4F induction ameliorated aging processes in an earlier mouse study. This paper does not establish that those early changes are required for either cellular rejuvenation or full reprogramming. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • One day of DOX treatment in Hep-4F mice resulted in increased cell proliferation in the liver and loss of mature hepatocyte markers, indicating successful partial reprogramming to a progenitor state and enhanced liver regeneration capacity.

    “One day of DOX treatment resulted in increased cell proliferation in the liver and loss of mature hepatocyte markers, indicative of successful partial reprogramming to a progenitor state and enhanced liver regeneration capacity.”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [76]

    The Results sections on hepatocyte-specific 4F expression and regenerative capacity report that one-day Dox treatment reduced mature hepatocyte markers, increased proliferation, and improved outcomes after liver injury. The paper also reports increased liver-progenitor markers, but describes the resulting cells as being in an “undetermined plastic state”; it does not establish that they reached a progenitor state. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Increased repair capacity by transient reprogramming has been shown for models of tissue damage in the endocrine pancreas, skeletal muscle, nerve fibers, eye, skin, heart and liver.

    “This increased repair capacity has been shown for models of tissue damage in the endocrine pancreas 214 , skeletal muscle 214 , nerve fibers 215 , eye 215 , skin 216 , heart 218 and liver 219 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [219]

  • Cell proliferation is not the only driver of partial reprogramming.

    “This suggests that cell proliferation is not the only driver of partial reprogramming 76 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [76]

  • Expressing only MYC could not induce the loss of hepatocyte markers.

    “expressing only MYC, known as a hepatocyte proliferation accelerator, could not induce the loss of hepatocyte markers.”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [76]

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Research works printed but not linked: 34

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Metadata

Authors
Hishida, T., Yamamoto, M., Hishida-Nozaki, Y., Shao, C., Huang, L., Wang, C., Shojima, K., Xue, Y., Hang, Y., Shokhirev, M., Memczak, S., Sahu, S. K., Hatanaka, F., Ros, R. R., Maxwell, M. B., Chavez, J., Shao, Y., Liao, H.-K., Martinez-Redondo, P., Guillen-Guillen, I., Hernandez-Benitez, R., Esteban, C. R., Qu, J., Holmes, M. C., Yi, F., Hickey, R. D., Garcia, P. G., Delicado, E. N., Castells, A., Campistol, J. M., Yu, Y., Hargreaves, D. C., Asai, A., Reddy, P., Liu, G.-H., & Izpisua Belmonte, J. C.
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2022-04
Volume
39
Issue
4
Pages
110730
ISSN
2211-1247
DOI
10.1016/j.celrep.2022.110730
PMC
PMC9807246
Cited by
116
References
13
Language
en
Licence
Funders
  • Uehara Memorial Foundation
  • G Harold and Leila Y Mathers Foundation
  • Moxie Foundation
  • California Institute for Regenerative Medicine
  • Leona M. and Harry B. Helmsley Charitable Trust

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