In vivo reprogramming drives Kras-induced cancer development
Open accessAbstract
The faithful shutdown of the somatic program occurs in the early stage of reprogramming. Here, we examined the effect of in vivo reprogramming on Kras-induced cancer development. We show that the transient expression of reprogramming factors (1–3 days) in pancreatic acinar cells results in the transient repression of acinar cell enhancers, which are similarly observed in pancreatitis. We next demonstrate that Kras and p53 mutations are insufficient to induce ERK signaling in the pancreas. Notably, the transient expression of reprogramming factors in Kras mutant mice is sufficient to induce the robust and persistent activation of ERK signaling in acinar cells and rapid formation of pancreatic ductal adenocarcinoma. In contrast, the forced expression of acinar cell-related transcription factors inhibits the pancreatitis-induced activation of ERK signaling and development of precancerous lesions in Kras-mutated acinar cells. These results underscore a crucial role of dedifferentiation-associated epigenetic regulations in the initiation of pancreatic cancers.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reprogramming in vivo induces tumor development.
“However, reprogramming in vivo induces tumor development5–7.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390 · see citing works
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184 · see citing works
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202 · see citing works
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471 · see citing works
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works
Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515 · see citing works
Generation of germline-competent induced pluripotent stem cells
Okita, K., Ichisaka, T., & Yamanaka, S. (2007) · Nature · doi:10.1038/nature05934 · Cited by 4,438 · see citing works
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.035 · Cited by 4,143 · see citing works
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442 · see citing works
Cancer epigenetics: from mechanism to therapy
Dawson, M. A., & Kouzarides, T. (2012) · Cell · doi:10.1016/j.cell.2012.06.013 · Cited by 3,203 · see citing works
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961 · see citing works
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
Wernig, M., Meissner, A., Foreman, R. K., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B., & Jaenisch, R. (2007) · Nature · doi:10.1038/nature05944 · Cited by 2,654 · see citing works
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609 · see citing works
Hidalgo, M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0901557 · Cited by 2,570 · see citing works
Ben‐Porath, I., Thomson, M., Carey, V. J., Ge, R., Bell, G. W., Regev, A., & Weinberg, R. A. (2008) · Nature Genetics · doi:10.1038/ng.127 · Cited by 2,523 · see citing works
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works
Self-citationRyan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348 · see citing works
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
Landt, S. G., Marinov, G. K., Kundaje, A., Kheradpour, P., Pauli, F., Batzoglou, S., Bernstein, B. E., Bickel, P., Brown, J. B., Cayting, P., et al. (2012) · Genome Research · doi:10.1101/gr.136184.111 · Cited by 2,033 · see citing works
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint
Jackson, E. L., Willis, N. A., Mercer, K. L., Bronson, R. T., Crowley, D. G., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,877 · see citing works
Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R., Lankisch, P. G., Andersen, J. R., DiMagno, E. P., Andrén‐Sandberg, Å., & Domellöf, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,753 · see citing works
Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.05.014 · Cited by 1,725 · see citing works
Genetics and biology of pancreatic ductal adenocarcinomaPreprint
Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N. M., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,570 · see citing works
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308 · see citing works
Guerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224 · see citing works
Pancreatic cancer biology and genetics
Bardeesy, N. M., & DePinho, R. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc949 · Cited by 1,144 · see citing works
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.
Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.052 · Cited by 988 · see citing works
A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C. M., Lim, S. M., Borkent, M., Apostolou, E., Alaei, S., Cloutier, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.039 · Cited by 861 · see citing works
Shen, L., Shao, N., Liu, X., & Nestler, E. J. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-284 · Cited by 852 · see citing works
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.722 · Cited by 830 · see citing works
Self-citationPresence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.042 · Cited by 741 · see citing works
Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697 · see citing works
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
Morton, J. P., Timpson, P., Karim, S. A., Ridgway, R. A., Athineos, D., Doyle, B., Jamieson, N. B., Oien, K. A., Lowy, A. M., Brunton, V. G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908428107 · Cited by 657 · see citing works
Clonal Analysis of Human Colorectal Tumors
Fearon, E. R., Hamilton, S. R., & Vogelstein, B. (1987) · Science · doi:10.1126/science.2889267 · Cited by 628 · see citing works
Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry
Berdasco, M., & Esteller, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.10.005 · Cited by 623 · see citing works
Visualization of omics data for systems biology
Gehlenborg, N., O’Donoghue, S. I., Baliga, N. S., Goesmann, A., Hibbs, M., Kitano, H., Kohlbacher, O., Neuweger, H., Schneider, R., Tenenbaum, D., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1436 · Cited by 622 · see citing works
Eggan, K. C., Akutsu, H., Loring, J. M., Jackson‐Grusby, L., Klemm, M., Rideout, W. M., Yanagimachi, R., & Jaenisch, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101118898 · Cited by 613 · see citing works
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R. M., Chondronasiou, D., Rovira, M., Fernandez-Marcos, P. J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., et al. (2016) · Science · doi:10.1126/science.aaf4445 · Cited by 589 · see citing works
Cooperative Binding of Transcription Factors Orchestrates Reprogramming
Chronis, C., Fiziev, P., Papp, B., Butz, S., Bonora, G., Sabri, S., Ernst, J., & Plath, K. (2017) · Cell · doi:10.1016/j.cell.2016.12.016 · Cited by 555 · see citing works
Genetics and biology of pancreatic ductal adenocarcinoma
Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527 · see citing works
EGF Receptor is Required for KRAS-induced Pancreatic Tumorigenesis
Ardito, C. M., Grüner, B., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P., DelGiorno, K. E., Carpenter, E. S., Halbrook, C., Hall, J. C., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.07.024 · Cited by 522 · see citing works
Guerra, C., Collado, M., Navas, C., Schuhmacher, A. J., Hernández-Porras, I., Cañamero, M., Rodriguez-Justo, M., Serrano, M., & Barbacid, M. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.011 · Cited by 516 · see citing works
Beard, C., Hochedlinger, K., Plath, K., Wutz, A., & Jaenisch, R. (2006) · genesis · doi:10.1002/gene.20180 · Cited by 482 · see citing works
Ohnishi, K., Semi, K., Yamamoto, T., Shimizu, M., Tanaka, A., Mitsunaga, K., Okita, K., Osafune, K., Arioka, Y., Maeda, T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.005 · Cited by 460 · see citing works
Self-citationRisk of pancreatic adenocarcinoma in chronic pancreatitis
Malka, D., Hammel, P. R., Maire, F., Rufat, P., Madeira, I., Pessione, F., Lévy, P., & Ruszniewski, P. B. (2002) · Gut · doi:10.1136/gut.51.6.849 · Cited by 456 · see citing works
Habbe, N., Shi, G., Meguid, R. A., Fendrich, V., Esni, F., Chen, H., Feldmann, G., Stoffers, D. A., Konieczny, S. F., Leach, S. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810097105 · Cited by 410 · see citing works
The power and the promise of oncogene-induced senescence markers
Collado, M., & Serrano, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1884 · Cited by 404 · see citing works
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
Jean–Paul De La, O., Emerson, L. L., Goodman, J. L., Froebe, S. C., Illum, B. E., Curtis, A. B., & Murtaugh, L. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810111105 · Cited by 396 · see citing works
Morris, J. P., Cano, D., Sekine, S., Wang, S. C., & Hebrok, M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40045 · Cited by 391 · see citing works
EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma
Navas, C., Hernández-Porras, I., Schuhmacher, A. J., Sibilia, M., Guerra, C., & Barbacid, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.001 · Cited by 391 · see citing works
Daniluk, J., Liu, Y., Deng, D., Chu, J., Huang, H., Gaiser, S., Cruz‐Monserrate, Z., Wang, H., Ji, B., & Logsdon, C. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59743 · Cited by 277 · see citing works
A single-gene transgenic mouse strain for reprogramming adult somatic cells
Carey, B. W., Markoulaki, S., Beard, C., Hanna, J., & Jaenisch, R. (2009) · Nature Methods · doi:10.1038/nmeth.1410 · Cited by 215 · see citing works
AFP-Producing Gastric Carcinoma: Multivariate Analysis of Prognostic Factors in 270 Patients
Adachi, Y., Tsuchihashi, J., Shiraishi, N., Yasuda, K., Etoh, T., & Kitano, S. (2003) · Oncology · doi:10.1159/000072332 · Cited by 180 · see citing works
Shi, G., Zhu, L., Sun, Y., Bettencourt, R., Damsz, B., Hruban, R. H., & Konieczny, S. F. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.12.066 · Cited by 168 · see citing works
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma
Krah, N. M., De La O, J.-P., Swift, G. H., Hoang, C. Q., Willet, S. G., Chen Pan, F., Cash, G. M., Bronner, M. P., Wright, C. V., MacDonald, R. J., et al. (2015) · eLife · doi:10.7554/elife.07125 · Cited by 166 · see citing works
The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection
Buganim, Y., Markoulaki, S., van Wietmarschen, N., Hoke, H., Wu, T., Ganz, K., Akhtar-Zaidi, B., He, Y., Abraham, B. J., Porubsky, D., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.003 · Cited by 163 · see citing works
Wei, D., Wang, L., Yan, Y., Jia, Z., Gagea, M., Li, Z., Zuo, X., Kong, X., Huang, S., & Xie, K. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.02.005 · Cited by 156 · see citing works
von Figura, G., Morris, J. P., Wright, C. V. E., & Hebrok, M. (2014) · Gut · doi:10.1136/gutjnl-2012-304287 · Cited by 143 · see citing works
Lüttges, J., Reinecke-Lüthge, A., Möllmann, B., Menke, M. A. O. H., Clemens, A., Klimpfinger, M., Sipos, B., & Klöppel, G. (1999) · Virchows Archiv · doi:10.1007/s004280050428 · Cited by 127 · see citing works
Murakami, T., Yao, T., Mitomi, H., Morimoto, T., Ueyama, H., Matsumoto, K., Saito, T., Osada, T., Nagahara, A., & Watanabe, S. (2015) · Gastric Cancer · doi:10.1007/s10120-015-0497-9 · Cited by 123 · see citing works
Increased Risk of Pancreatic Adenocarcinoma After Acute Pancreatitis
Munigala, S., Kanwal, F., Xian, H., Scherrer, J. F., & Agarwal, B. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.12.033 · Cited by 119 · see citing works
Koide, N., Nishio, A., Igarashi, J., Kajikawa, S., Adachi, W., & Amano, J. (1999) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00214-2 · Cited by 118 · see citing works
Koide, N., Nishio, A., Igarashi, J., et al. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01158.x · Cited by 92 · see citing works
Muratani, M., Deng, N., Ooi, W. F., Lin, S. J., Xing, M., Xu, C., Qamra, A., Tay, S. T., Malik, S., Wu, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms5361 · Cited by 81 · see citing works
Kinsey, C. G., Balakrishnan, V., O’Dell, M. R., Huang, J. L., Newman, L. A., Whitney‐Miller, C. L., Hezel, A. F., & Land, H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.061 · Cited by 80 · see citing works
Sone, M., Morone, N., Nakamura, T., Tanaka, A., Okita, K., Woltjen, K., Nakagawa, M., Heuser, J. E., Yamada, Y., Yamanaka, S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.017 · Cited by 77 · see citing works
Self-citationTrefoil Factor 1 Stimulates Both Pancreatic Cancer and Stellate Cells and Increases Metastasis
Arumugam, T., Brandt, W. D., Ramachandran, V., Moore, T. T., Wang, H., May, F. E. B., Westley, B. R., Hwang, R. F., & Logsdon, C. D. (2011) · Pancreas · doi:10.1097/mpa.0b013e31821f6927 · Cited by 72 · see citing works
Activation-Induced Cytidine Deaminase Alters the Subcellular Localization of Tet Family Proteins
Arioka, Y., Watanabe, A., Saito, K., & Yamada, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045031 · Cited by 47 · see citing works
Self-citationKomura, S., Semi, K., Itakura, F., Shibata, H., Ohno, T., Hotta, A., Woltjen, K., Yamamoto, T., Akiyama, H., & Yamada, Y. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.02.009 · Cited by 21 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Exploring the links between cancer and placenta development
Costanzo, V., Bardelli, A., Siena, S., & Abrignani, S. (2018) · Open Biology · doi:10.1098/rsob.180081 · Cited by 167 · see citing works
Patient-Derived Xenograft Models of Breast Cancer and Their Application
Murayama, T., & Gotoh, N. (2019) · Cells · doi:10.3390/cells8060621 · Cited by 138 · see citing works
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
Chondronasiou, D., Gill, D., Mosteiro, L., Urdinguio, R. G., Berenguer‐Llergo, A., Aguilera, M., Durand, S., Aprahamian, F., Nirmalathasan, N., Abad, M., et al. (2022) · Aging Cell · doi:10.1111/acel.13578 · Cited by 133 · see citing works
Wang, C., Rabadan Ros, R., Martinez-Redondo, P., Ma, Z., Shi, L., Xue, Y., Guillen-Guillen, I., Huang, L., Hishida, T., Liao, H.-K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23353-z · Cited by 119 · see citing works
In vivo partial cellular reprogramming enhances liver plasticity and regeneration
Hishida, T., Yamamoto, M., Hishida, Y., Shao, C., Huang, L., Wang, C., Shojima, K., Xue, Y., Hang, Y., Shokhirev, M. N., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110730 · Cited by 111 · see citing works
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
Kovatcheva, M., Melendez, E., Chondronasiou, D., Pietrocola, F., Bernad, R., Caballe, A., Junza, A., Capellades, J., Holguín-Horcajo, A., Prats, N., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00916-6 · Cited by 58 · see citing works
Uncertain Beginnings: Acinar and Ductal Cell Plasticity in the Development of Pancreatic Cancer
Grimont, A., Leach, S. D., & Chandwani, R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.07.014 · Cited by 58 · see citing works
Nakasuka, F., Tabata, S., Sakamoto, T., Hirayama, A., Ebi, H., Yamada, T., Umetsu, K., Ohishi, M., Ueno, A., Goto, H., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02323-7 · Cited by 54 · see citing works
Self-citationCellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Huyghe, A., Trajkova, A., & Lavial, F. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.07.013 · Cited by 55 · see citing works
3D chromatin architecture and epigenetic regulation in cancer stem cells
Feng, Y., Liu, X., & Pauklin, S. (2021) · Protein & Cell · doi:10.1007/s13238-020-00819-2 · Cited by 52 · see citing works
Man, C. H., Mercier, F., Liu, N., Dong, W., Stephanopoulos, G. N., Jiang, L., Jung, Y., Lin, C. P., Leung, A. Y. H., & Scadden, D. T. (2021) · Blood · doi:10.1182/blood.2021011563 · Cited by 47 · see citing works
Transcription Control of Liver Development
Tachmatzidi, E. C., Galanopoulou, O., & Talianidis, I. (2021) · Cells · doi:10.3390/cells10082026 · Cited by 45 · see citing works
Partial reprogramming strategy for intervertebral disc rejuvenation by activating energy switch
Cheng, F., Wang, C., Ji, Y., Yang, B., Shu, J., Shi, K., Wang, L., Wang, S., Zhang, Y., Huang, X., et al. (2022) · Aging Cell · doi:10.1111/acel.13577 · Cited by 42 · see citing works
Koujima, T., Tazawa, H., Ieda, T., Araki, H., Fushimi, T., Shoji, R., Kuroda, S., Kikuchi, S., Yoshida, R., Umeda, Y., et al. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.03.016 · Cited by 43 · see citing works
Terada, Y., Jo, N., Arakawa, Y., Sakakura, M., Yamada, Y., Ukai, T., Kabata, M., Mitsunaga, K., Mineharu, Y., Ohta, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.009 · Cited by 36 · see citing works
Self-citationDeciphering the roadmap of in vivo reprogramming toward pluripotency
Chondronasiou, D., de Villarreal, J. M., Melendez, E., Lynch, C. J., del Pozo, N., Kovatcheva, M., Aguilera, M., Prats, N., Real, F. X., & Serrano, M. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.09.009 · Cited by 36 · see citing works
Hashimoto, S., Tochio, T., Funasaka, K., Funahashi, K., Hartanto, T., Togashi, Y., Saito, M., Nishimoto, Y., Mizuguchi, Y., Nakaoka, K., et al. (2022) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2022.2114812 · Cited by 33 · see citing works
Huyghe, A., Furlan, G., Schröder, J., Bachelard-Cascales, É., Trajkova, A., Ruel, M., Stüder, F., Larcombe, M. R., Sun, Y., Mugnier, F., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00986-w · Cited by 33 · see citing works
A ride through the epigenetic landscape: aging reversal by reprogramming
Camillo, L. P. D. L., & Quinlan, R. B. A. (2021) · GeroScience · doi:10.1007/s11357-021-00358-6 · Cited by 30 · see citing works
The Evolving Landscape of Cancer Stem Cells and Ways to Overcome Cancer Heterogeneity
Taniguchi, H., Suzuki, Y., & Natori, Y. (2019) · Cancers · doi:10.3390/cancers11040532 · Cited by 30 · see citing works
Loo, T. M., Zhou, X., Tanaka, Y., Sugawara, S., Yamauchi, S., Kawasaki, H., Matsuoka, Y., Sugiura, Y., Sakuma, S., Yamanishi, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61894-9 · Cited by 31 · see citing works
Pioneer Factors and Architectural Proteins Mediating Embryonic Expression Signatures in Cancer
Dobersch, S., Rubio, K., & Barreto, G. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.01.008 · Cited by 26 · see citing works
Jin, R. U., & Mills, J. C. (2019) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000540 · Cited by 26 · see citing works
Natural killer cells act as an extrinsic barrier for in vivo reprogramming
Melendez, E., Chondronasiou, D., Mosteiro, L., de Villarreal, J. M., Fernández‐Alfara, M., Lynch, C. J., Grimm, D., Real, F. X., Alcamı́, J., Climent, N., et al. (2022) · Development · doi:10.1242/dev.200361 · Cited by 25 · see citing works
Loss of Pancreatic E-Cadherin Causes Pancreatitis-Like Changes and Contributes to Carcinogenesis
Kaneta, Y., Sato, T. A., Hikiba, Y., Sugimori, M., Sue, S., Kaneko, H., Irie, K., Sasaki, T., Kondo, M., Chuma, M., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.09.001 · Cited by 24 · see citing works
Wang, C., Hou, Y., Hong, Y., Tai, †. Y.-H., Shen, C., Hou, P., Fu, J.-L., Wu, C.-L., Cheng, S. M., Hwang, D., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02207-4 · Cited by 24 · see citing works
Cancer cells as a new source of induced pluripotent stem cells
Shamsian, A., Sahebnasagh, R., Norouzy, A., Hussein, S. H., Ghahremani, M. H., & Azizi, Z. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03145-y · Cited by 22 · see citing works
Lo, E. K. W., Mears, B. M., Maurer, H. C., Idrizi, A., Hansen, K. D., Thompson, E. D., Wood, L. D., Hruban, R. H., Olive, K. P., & Feinberg, A. P. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-4052 · Cited by 22 · see citing works
Changing Fate: Reprogramming Cells via Engineered Nanoscale Delivery Materials
Dehnavi, S. S., Zadeh, Z. E., Harvey, A. R., Voelcker, N. H., Parish, C. L., Williams, R. J., Elnathan, R., & Nisbet, D. R. (2022) · Advanced Materials · doi:10.1002/adma.202108757 · Cited by 22 · see citing works
Possible Strategies to Reduce the Tumorigenic Risk of Reprogrammed Normal and Cancer Cells
Lin, Y.-C., Ku, C.-C., Wuputra, K., Liu, C.-J., Wu, D.-C., Satou, M., Mitsui, Y., Saito, S., & Yokoyama, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105177 · Cited by 20 · see citing works
Signaling pathways and targeted interventions for precancers
Yang, J., Wang, S., Li, X., Xu, H. E., Sun, T., Hu, T., Luo, J., & Zhou, H. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02342-4 · Cited by 16 · see citing works
The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
Ito, K., Nagata, K., Ohta, S., Matsuda, Y., Ukai, T., Yasuda, I., Ota, A., Kobayashi, R., Kabata, M., Sankoda, N., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110721 · Cited by 15 · see citing works
Self-citationTranslational research in head and neck cancer: Molecular and immunological updates
Kumai, T., Shinomiya, H., Shibata, H., Takahashi, H., Kishikawa, T., Okada, R., Fujieda, S., & Sakashita, M. (2023) · Auris Nasus Larynx · doi:10.1016/j.anl.2023.08.006 · Cited by 14 · see citing works
Self-citationNakashiba, T., Ogoh, K., Iwano, S., Sugiyama, T., Mizuno‐Iijima, S., Nakashima, K., Mizuno, S., Sugiyama, F., Yoshiki, A., Miyawaki, A., et al. (2023) · Lab Animal · doi:10.1038/s41684-023-01238-6 · Cited by 13 · see citing works
Urrutia, G., de Assuncao, T. M., Mathison, A., Salmonson, A., Kerketta, R., Zeighami, A., Stodola, T. J., Adsay, V. N., Pehlivanoğlu, B., Dwinell, M. B., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.681153 · Cited by 11 · see citing works
Characterizing primary and secondary senescence in vivo
Sogabe, Y., Shibata, H., Kabata, M., Tanaka, A., Mitsunaga, K., Sunadome, K., Nakajima‐Koyama, M., Hirano, M., Nishida, E., Woltjen, K., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00917-y · Cited by 10 · see citing works
Self-citationMAF functions as a pioneer transcription factor that initiates and sustains myelomagenesis
Katsarou, A., Trasanidis, N., Ponnusamy, K., Kostopoulos, I. V., Alvarez-Benayas, J., Papaleonidopoulou, F., Keren, K., Sabbattini, P. M. R., Feldhahn, N., Papaioannou, M., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023009772 · Cited by 10 · see citing works
Induced Pluripotent Stem Cells from Cancer-Resistant Naked Mole-Rats
Miura, K., Oiwa, Y., & Kawamura, Y. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_13 · Cited by 10 · see citing works
Smarcb1 maintains the cellular identity and the chromatin landscapes of mouse embryonic stem cells
Sakakura, M., Ohta, S., Yagi, M., Tanaka, A., Jo, N., Woltjen, K., Yamamoto, T., & Yamada, Y. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.09.054 · Cited by 9 · see citing works
Self-citationCellular reprogramming to model and study epigenetic alterations in cancer
Kim, J. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.102062 · Cited by 9 · see citing works
Yan, Q., Zou, H., Zhao, X., Kapeleris, J., Monteiro, M. J., Li, F., Xu, Z. P., Deng, Y., Wu, Y., Tang, Y. F., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.996053 · Cited by 9 · see citing works
A versatile in vivo platform for reversible control of transgene expression in adult tissues
Taguchi, J., Yamada, Y., Ohta, S., Nakasuka, F., Yamamoto, T., Ozawa, M., & Yamada, Y. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.11.003 · Cited by 8 · see citing works
Self-citationOrgan‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
Jo, B., Lee, S., Eom, H., Kim, J., & Cha, H. (2025) · Aging Cell · doi:10.1111/acel.70268 · Cited by 8 · see citing works
Avelar, R. A., Palmer, D. H., Kulaga, A. Y., & Fuellen, G. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102737 · Cited by 8 · see citing works
Nakatsukasa, Y., Yamada, Y., & Yamada, Y. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.11.008 · Cited by 7 · see citing works
Self-citationInflammation and de-differentiation in pancreatic carcinogenesis
Seimiya, T., Otsuka, M., Iwata, T., Tanaka, E., Suzuki, T., Sekiba, K., Yamagami, M., Ishibashi, R., & Koike, K. (2018) · World Journal of Clinical Cases · doi:10.12998/wjcc.v6.i15.882 · Cited by 5 · see citing works
Pribluda, A., Daemen, A., Lima, A., Wang, X., Hafner, M. A., Poon, C., Modrusan, Z. D., Katakam, A. K., Foreman, O., Eastham, J., et al. (2022) · eLife · doi:10.7554/elife.57648 · Cited by 5 · see citing works
Szigeti, K. A., Baranyi, M., Surguta, S. E., Hegedűs, B., Piurkó, V., Tóvári, J., & Tı́már, J. (2026) · Scientific Reports · doi:10.1038/s41598-025-34204-y · Cited by 4 · see citing works
Nakashiba, T., Sugiyama, T., Iwano, S., Iwama, M., Yoshiki, A., Miyawaki, A., & Abe, K. (2026) · Cell Reports Methods · doi:10.1016/j.crmeth.2026.101369 · Cited by 4 · see citing works
Brunet, M., Vargas, C., Fanjul, M., Varry, D., Hanoun, N., Larrieu, D., Pieruccioni, L., Labrousse, G., Lulka, H., Capilla, F., et al. (2024) · Journal of Pathology · doi:10.1002/path.6298 · Cited by 4 · see citing works
Hu, X., Zhang, R., Yao, J., Mu, B., & Zhao, C. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12891 · Cited by 4 · see citing works
Azami, Y., Tsuyama, N., Abe, Y., Sugai, M. T., Kudo, K., Ota, A., Karnan, S., Muramatsu, M., Shigemura, T., Sasatani, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84628-5 · Cited by 4 · see citing works
Yamashita, S., Akada, K., Matsumoto, S., & Kinoshita, M. (2020) · doi:10.24465/msb.28.1_7 · Cited by 4 · see citing works
Ohta, S., & Yamada, Y. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102067 · Cited by 3 · see citing works
Self-citationMiyagi‐Shiohira, C., Saitoh, I., Watanabe, M., & Noguchi, H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030454 · Cited by 3 · see citing works
Lopez, K. M., Deng, J., Xu, Y., Sharkey, F. E., Wang, P., & Liu, J. (2024) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000170 · Cited by 2 · see citing works
In Vivo Reprogramming Highlights Epigenetic Regulation That Shapes Cancer Hallmarks
Yamada, Y., Sankoda, N., & Yamada, Y. (2025) · Cancer Science · doi:10.1111/cas.70067 · Cited by 2 · see citing works
Self-citationDeprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition
Zhang, Y., Kohno, S., Gao, K., Hasan, M., Baba, T., Zhang, Z., Sankoda, N., Yu, H., Pan, J., Gotoh, N., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01634-0 · Cited by 2 · see citing works
Self-citationZand, H., Hosseini, S. A., Cheraghpour, M., Alipour, M., & Sedaghat, F. (2024) · Advanced Biomedical Research · doi:10.4103/abr.abr_75_24 · Cited by 2 · see citing works
Cellular Reprogramming and Aging
Pereira, S. N., & de Jesus, B. B. (2020) · Learning materials in biosciences · doi:10.1007/978-3-030-43939-2_5 · Cited by 2 · see citing works
Availability of Pluripotent Stem Cells from Normal Cells in Cancer Science
Hassan, G., Afify, S. M., Du, J., Seno, A., & Seno, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-77052-5_15 · Cited by 2 · see citing works
In vivo targeted and deterministic single-cell malignant transformationPreprint
Scerbo, P., Tisserand, B., Delagrange, M., Debare, H., Bensimon, D., & Ducos, B. (2024) · eLife · doi:10.7554/elife.97650 · Cited by 2 · see citing works
Canonical and novel strategies to delay or reverse aging
Gilmour, B. C., Bergersen, L. H., & Fang, E. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91617-2.00005-5 · Cited by 1 · see citing works
Wild kras inhibit the migration and invasion of pancreatic cancer through Wnt /β-catenin pathwayPreprint
Hu, X., Zhao, C., Zhang, R., Yao, J., & Mu, B. (2022) · Research Square · doi:10.21203/rs.3.rs-1908047/v1 · Cited by 1 · see citing works
Familial Pancreatic Cancer at Elderly Siblings in Japan
Abe, M., Takeji, S., Kawasaki, K., Murakami, T., Kashimoto, Y., Yamamoto, S., Bando, K., Horiike, N., & Kumagi, T. (2019) · Euroasian Journal of Hepato-Gastroenterology · doi:10.5005/jp-journals-10018-1296
牛乳及びマイタケ（ Grifola frondosa ）の摂取は1,2-ジメチルヒドラジン処理マウス大腸において炎症関連サイトカインとアポトーシス関連タンパク質を調節する
Kmgrm, カ., 山下慎司, Fukuma, N. M., & 幹朗, 木. (2020) · ミルクサイエンス · doi:10.11465/milk.69.21
Huyghe, A., Furlan, G., Schröder, J., Stüder, J., Mugnier, F., Matteo, L., Wang, J., Yu, Y., Rama, N., Gibert, B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.28.424606
Brunet, M., Vargas, C., Fanjul, M., Pieruccioni, L., Varry, D., Labrousse, G., Lulka, H., Capilla, F., Couvelard, A., Gigoux, V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.08.531649
Verfügbarkeit von pluripotenten Stammzellen aus normalen Zellen in der Krebsforschung
Hassan, G., Afify, S. M., Du, J., Seno, A., & Seno, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-25378-2_15
In vivo targeted and deterministic single-cell malignant transformation
Scerbo, P., Tisserand, B., Delagrange, M., Debare, H., Bensimon, D., & Ducos, B. (2025) · eLife · doi:10.7554/elife.97650.3
In vivo targeted and deterministic single cell malignant transformationPreprint
Scerbo, P., Tisserand, B., Delagrange, M., Debare, H., Bensimon, D., & Ducos, B. (2024) · eLife · doi:10.7554/elife.97650.1
In vivo targeted and deterministic single cell malignant transformationPreprint
Scerbo, P., Tisserand, B., Delagrange, M., Debare, H., Bensimon, D., & Ducos, B. (2025) · eLife · doi:10.7554/elife.97650.2
Pioneer Transcription Factors Differentially Co-opt Bcl11a and Bcl11b to orchestrate ReprogrammingPreprint
Trajkova, A., Zakiev, E., Mendoza-Ferri, M. G., Messahli, I., Ruel, M., Krossa, I., Tapponnier, Y., Dejonckere, E., Hunter, E., Claret, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.19.694617
A cross-talk between p16High senescence and cellular reprogramming
Emelyanov, A., & Bulavin, D. V. (2026) · Clinical Science · doi:10.1042/cs20260240
Nakatsukasa, Y., Hirano, M., Yamada, Y., Ohta, S., Sankoda, N., Nakasuka, F., Nakayama, Y., Sakurai, S., Yamamoto, T., & Yamada, Y. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154488
Self-citationEmbryonic reprogramming drives anaplastic transformation in thyroid carcinoma
Kawaura, R., Unome, A., Tomita, H., Ishihara, H., Kuroki, M., Komura, S., Kato, K., Takashima, S., Nishio, N., Shigeyama, M., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.118195
Self-citation
- Authors
- Shibata, H., Komura, S., Yamada, Y., Sankoda, N., Tanaka, A., Ukai, T., Kabata, M., Sakurai, S., Kuze, B., Woltjen, K., Haga, H., Ito, Y., Kawaguchi, Y., Yamamoto, T., & Yamada, Y.
- Affiliations
- Kyoto University (JP)
- Gifu University (JP)
- Kyoto University Hospital (JP)
- Corresponding author
- Yamada, Yasuhiro
- ORCID
- Venue
- Nature Communications
- Published
- 2018-05-25
- Volume
- 9
- Issue
- 1
- Pages
- 2081-2081
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5970190
- OpenAlex
- W2803200695
- Cited by
- 76
- References
- 71
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 15 · 2021: 12 · 2020: 6 · 2019: 8 · 2018: 2
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by)
- Funders
- Naito Foundation
- Takeda Science Foundation
- Japan Agency for Medical Research and Development (CREST, JP18gm1110004, JP18cm0106203, 17jm0210039h0005)
- Research Center Network for Realization of Regenerative Medicine
- Princess Takamatsu Cancer Research Fund
- Japan Society for the Promotion of Science (15H04721, CREST, 19K21352, 16H06276, 18H04026)
- Core Research for Evolutional Science and Technology (JP18gm1110004)
- Strategic International Collaborative Research Program
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- in vivo reprogramming, pancreatic ductal adenocarcinoma, ERK signaling, pancreatic acinar cells, dedifferentiation, epigenetic regulation, p53, pancreatitis, precancerous lesions, transcription factors, tumor initiation
- MeSH terms
- Mouse Embryonic Stem Cells, alpha-Fetoproteins, Animals, Cell Transformation, Neoplastic, Female, Humans, Male, Mice, Inbred C57BL, Mice, Inbred ICR, Mice, Transgenic, Mutation, Pancreas, Pancreatic Neoplasms, Stomach, Stomach Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins p21(ras), MAP Kinase Signaling System, Carcinoma, Pancreatic Ductal, Epigenesis, Genetic, Mice, Acinar Cells, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
