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The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins
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Abstract
Sphingolipid levels are crucial determinants of neurodegenerative disorders and therefore require tight regulation. The Orm protein family and ceramides inhibit the rate-limiting step of sphingolipid biosynthesis—the condensation of L-serine and palmitoyl-coenzyme A (CoA). The yeast isoforms Orm1 and Orm2 form a complex with the serine palmitoyltransferase (SPT). While Orm1 and Orm2 have highly similar sequences, they are differentially regulated, though the mechanistic details remain elusive. Here, we determine the cryoelectron microscopy structure of the SPT complex containing Orm2. Complementary in vitro activity assays and genetic experiments with targeted lipidomics demonstrate a lower activity of the SPT-Orm2 complex than the SPT-Orm1 complex. Our results suggest a higher inhibitory potential of Orm2, despite the similar structures of the Orm1- and Orm2-containing complexes. The high conservation of SPT from yeast to man implies different regulatory capacities for the three human ORMDL isoforms, which might be key for understanding their role in sphingolipid-mediated neurodegenerative disorders.
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Metadata
- Authors
- Körner, C., Schäfer, J.-H., Esch, B. M., Parey, K., Walter, S., Teis, D., Januliene, D., Schmidt, O., Moeller, A., & Fröhlich, F.
- Affiliations
- Osnabrück University (DE)
- Innsbruck Medical University (AT)
- Corresponding author
- Schmidt, Oliver
- Moeller, Arne
- Fröhlich, Florian
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2024-08
- Volume
- 43
- Issue
- 8
- Pages
- 114627
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W4401794228
- Cited by
- 10
- References
- 73
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 3
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- osnaDocs (Osnabrück University) (submittedVersion, cc-by-nc)
- osnaDocs (Osnabrück University)
- Funders
- BMBF Berlin (01ED2010)
- Deutsche Forschungsgemeinschaft (SFB1557 P11, INST 190/201-1, FR 3647/2-2, SFB1557 P6, INST.190/196-1 FUGG)
- Bundesministerium für Bildung und Frauen
- Friedrich-Ebert-Stiftung
- FWF
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- ORM2, ORM1, serine palmitoyltransferase, sphingolipid biosynthesis, ceramide, palmitoyl-CoA, cryo-EM structure, enzyme inhibition, yeast, neurodegenerative diseases, lipidomics
- MeSH terms
- Humans, Protein Binding, Saccharomyces cerevisiae, Sphingolipids, Saccharomyces cerevisiae Proteins, Serine C-Palmitoyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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