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Cited by 22Dietary Effects on HealthPancreatic function and diabetesDiabetes and associated disorders

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Chronic intermittent fasting impairs β cell maturation and function in adolescent mice

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Matta, Leonardo, Weber, Peter, Erener, Suheda, Walth-Hummel, Alina, Hass, Daniela, Bühler, Lea K., Klepac, Katarina, Szendroedi, Julia, Guerra, Joel, Rohm, Maria, Sterr, Michael, Lickert, Heiko, Bartelt, Alexander, Herzig, Stephan·2025·Cell Reports
DOI 10.1016/j.celrep.2024.115225

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Abstract

Intermittent fasting (IF) is a nutritional lifestyle intervention with broad metabolic benefits, but whether the impact of IF depends on the individual's age is unclear. Here, we investigated the effects of IF on systemic metabolism and pancreatic islet function in old, middle-aged, and young mice. Short-term IF improved glucose homeostasis across all age groups, without altering islet function and morphology. In contrast, while chronic IF was beneficial for adult mice, it resulted in impaired β-cell function in the young. Using scRNAseq, we delineated that the β-cell maturation and function score were reduced in young mice. In human islets, a similar pattern was observed in Type 1 (T1D), but not in Type 2 diabetes (T2D), suggesting that the impact of chronic IF in adolescence is linked to the development of β-cell dysfunction. Our study suggests considering the duration of IF in younger people, as it may enhance rather than reduce diabetes outcomes.

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Metadata

Authors
Matta, L., Weber, P., Erener, S., Walth-Hummel, A., Hass, D., Bühler, L. K., Klepac, K., Szendroedi, J., Guerra, J., Rohm, M., Sterr, M., Lickert, H., Bartelt, A., & Herzig, S.
Affiliations
  • Helmholtz Munich (DE)
  • University Hospital Heidelberg (DE)
  • Heidelberg University (DE)
Corresponding author
  • Bartelt, Alexander
  • Herzig, Stephan
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2025-02
Volume
44
Issue
2
Pages
115225
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2024.115225
OpenAlex
W4406573277
Cited by
22
References
4
Citations by year
2026: 9 · 2025: 12
FWCI
13.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • SSRN Electronic Journal (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • European Research Council
  • German Center for Cardiovascular Disease
  • Deutsche Forschungsgemeinschaft (SFB1123-B10, SPP2306 BA4925/2-1)
  • Deutsches Zentrum für Diabetesforschung
  • Horizon 2020 (949017)
  • Federal Ministry of Education and Research Bonn Office
Topics
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
intermittent fasting, beta cell maturation, beta-cell function, islet function, glucose homeostasis, age-dependent effects, adolescence, type 1 diabetes, type 2 diabetes, beta-cell dysfunction
MeSH terms
Intermittent Fasting, Animals, Cell Differentiation, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Fasting, Female, Glucose, Humans, Male, Mice, Inbred C57BL, Insulin-Secreting Cells, Mice

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