Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
Open accessAbstract
While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its efficacy is poorly understood. Here, we show that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis. EODF treatment results in a shift in the gut microbiota composition leading to elevation of the fermentation products acetate and lactate and to the selective upregulation of monocarboxylate transporter 1 expression in beige cells. Microbiota-depleted mice are resistance to EODF-induced beiging, while transplantation of the microbiota from EODF-treated mice to microbiota-depleted mice activates beiging and improves metabolic homeostasis. These findings provide a new gut-microbiota-driven mechanism for activating adipose tissue browning and treating metabolic diseases.
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Gut microbiota seems to play an important role as a regulator of WAT browning.
“In addition, gut microbiota also seems to play an important role as a regulator of WAT browning.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [248]
Intermittent fasting does not promote WAT browning in germ-free mice.
“Underlining once again the role of gut microbiota, intermittent fasting does not promote WAT browning in germ-free mice [248].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [248]
Intermittent fasting is associated with body weight decrease and WAT browning, also by increasing the Firmicutes level.
“Indeed, intermittent fasting is associated with body weight decrease and WAT browning, also by increasing the Firmicutes level [248].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [248]
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Oral L-Glutamine Pretreatment Attenuates Skeletal Muscle Atrophy Induced by 24-h Fasting in Mice
de Vasconcelos, D. A. A., Giesbertz, P., de Souza, D. R., Vitzel, K. F., Abreu, P., Marzuca-Nassr, G. N., Fortes, M. A. S., Murata, G. M., Hirabara, S. M., Curi, R., et al. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.05.010 · Cited by 33 · see citing works
Ma, Y., Nenkov, M., Chen, Y., & Gaßler, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158352 · Cited by 28 · see citing works
Self-citationThe Health-Promoting Effects and the Mechanism of Intermittent Fasting
Liu, S., Zeng, M., Wan, W., Huang, M., Li, X., Xie, Z., Wang, S., & Cai, Y. (2023) · Journal of Diabetes Research · doi:10.1155/2023/4038546 · Cited by 27 · see citing works
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- Authors
- Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., Patel, D., Ma, Y., Brocker, C. N., Yan, T., Krausz, K. W., Xiang, R., Gavrilova, O., Patterson, A. D., & Gonzalez, F. J.
- Affiliations
- National Institutes of Health (US)
- Hunan Normal University (CN)
- Pennsylvania State University (US)
- Central South University (CN)
- Corresponding author
- Li, Guolin
- Gonzalez, Frank J.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 26
- Issue
- 4
- Pages
- 672-685.e4
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5668683
- OpenAlex
- W2753963188
- Cited by
- 667
- References
- 66
- Citations by year
- 2026: 44 · 2025: 72 · 2024: 90 · 2023: 82 · 2022: 102 · 2021: 95 · 2020: 87 · 2019: 54 · 2018: 33 · 2017: 8
- FWCI
- 36.84
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-11-07)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute Intramural Research Program (ZIA BC005562)
- National Institutes of Environmental Health Sciences (ES022186)
- National Natural Science Funds of China (31271257, 9164910027, 81403007)
- Science and Technology Project of Hunan Province (2013FJ2001)
- Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (20134486)
- Chinese Scholarship Council (201406725005)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- intermittent fasting, white adipose tissue browning, beige adipocytes, thermogenesis, gut microbiota, obesity, insulin resistance, hepatic steatosis, acetate, lactate, MCT1, microbiota transplantation, metabolic homeostasis
- MeSH terms
- Gastrointestinal Microbiome, Adipose Tissue, Beige, Animals, Energy Metabolism, Fasting, Fatty Liver, Fibroblast Growth Factors, Insulin Resistance, Mice, Inbred C57BL, Obesity, Signal Transduction, Thermogenesis, Metabolic Syndrome, Adipose Tissue, White
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