The Molecular Signatures Database Hallmark Gene Set Collection

Liberzon, Arthur, Birger, Chet, Thorvaldsdóttir, Helga, Ghandi, Mahmoud, Mesirov, Jill P., Tamayo, Pablo·2015·Cell Systems

DOI 10.1016/j.cels.2015.12.004

Cited by (1,112)

Items 901–1,000 of 1,112

Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease
Shixian Hu, Arno R. Bourgonje, Ranko Gaćeša, Bernadien H. Jansen, Johannes R. Björk, Amber Bangma, Iwan J. Hidding, Hendrik M. van Dullemen, Marijn Caroline Visschedijk, Klaas Nico Faber et al. · 2024 · Nature Communications
A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis
Max Cohen, Alexis N. Brumwell, Tsung Che Ho, Kiana Garakani, Genevieve Montas, Darren Leong, Vivianne W. Ding, Jeffrey Alan Golden, Binh N. Trinh, David M. Jablons et al. · 2024 · Journal of Clinical Investigation
Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis
Jiang Chang, Junting Lu, Qing Liu, Tao Xiang, Shaosen Zhang, Yonglin Yi, Dongxu Li, Tianyuan Liu, Zeyuan Liu, Xinjie Chen et al. · 2025 · Cancer Cell
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer
Mohanty, Atish, Nam, Arin, Srivastava, Saumya, Jones, Jeff, Lomenick, Brett, Singhal, Sharad S., Guo, Linlin, Cho, Hyejin, Li, Aimin, Behal, Amita et al. · 2023 · Science Advances
Compressing gene expression data using multiple latent space dimensionalities learns complementary biological representations
Gregory P. Way, Michael Zietz, Vincent Rubinetti, Daniel Scott Himmelstein, Casey S. Greene · 2020 · Genome biology
Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets
Robin J. G. Hartman, Daniek Kapteijn, Saskia Haitjema, Mireille N. Bekker, Michal Mokrý, Gerard Pasterkamp, Mete Civelek, Hester M. den Ruijter · 2020 · Scientific Reports
Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors
Zhao Zhang, Jing Ji, Youqiong Ye, Zhiao Chen, Ying Jing, Shengli Li, Hong Wei, Hang Ruan, Yaoming Liu, Qingsong Hu et al. · 2020 · Genome Medicine
Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer
Clinton Yam, Er-Yen Yen, Jeffrey T. Chang, Roland L. Bassett, Gheath Alatrash, Haven R. Garber, Lei Huo, Fei Yang, Anne V. Philips, Qingqing Ding et al. · 2021 · Clinical Cancer Research
Weighted Gene Co-expression Network Analysis Identifies a Cancer-Associated Fibroblast Signature for Predicting Prognosis and Therapeutic Responses in Gastric Cancer
Hang Zheng, Heshu Liu, Huayu Li, Weidong Dou, Xin Wang · 2021 · Frontiers in Molecular Biosciences
Transcriptomic Determinants of Response to Pembrolizumab Monotherapy across Solid Tumor Types
Răzvan Cristescu, Michael Nebozhyn, Chunsheng Zhang, Andrew V Albright, Julie Kobie, Lingkang Huang, Qing Zhao, Anran Wang, Hua Ma, Zhu Alexander Cao et al. · 2021 · Clinical Cancer Research
Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine
Victoria E. Cotero, John F. Graf, Hiromi Miwa, Zall Hirschstein, Khaled Qanud, Tomas S. Huerta, Ningwen Tai, Yuyan Ding, Kevin Jimenez-Cowell, Jacquelyn N. Tomaio et al. · 2022 · Nature Biomedical Engineering
Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis
Mengmeng Xu, Ying Kong, Nannan Chen, Wenlong Peng, Ruidong Zi, Manman Jiang, Jinfeng Zhu, Yuting Wang, Jicheng Yue, Jinrong Lv et al. · 2022 · Frontiers in Immunology
Tissue-specific impacts of aging and genetics on gene expression patterns in humans
Ryo Yamamoto, Ryan Chung, Juan Manuel Vázquez, Huanjie Sheng, Philippa L. Steinberg, Nilah M. Ioannidis, Peter H. Sudmant · 2022 · Nature Communications
Large-Scale Integration of Single-Cell RNA-Seq Data Reveals Astrocyte Diversity and Transcriptomic Modules across Six Central Nervous System Disorders
Zhenwei Qian, Jinglin Qin, Yi‐Wen Lai, Chen Zhang, Xiannian Zhang · 2023 · Biomolecules
TERT accelerates BRAF mutant–induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis
Pengcheng Yu, Ning Qu, Rui Zhu, Jia‐Qian Hu, Peizhen Han, Jiahao Wu, Licheng Tan, Hualei Gan, Cong He, Chuantao Fang et al. · 2023 · Science Advances
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
Damon A. Hofman, Jorge Ruiz‐Orera, Ian Yannuzzi, Rakesh A. Murugesan, Adam Brown, Karl R. Clauser, Alexandra Larisa Condurat, Jip T. van Dinter, Sem A.G. Engels, Amy B. Goodale et al. · 2024 · Molecular Cell
Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome
Gabriela Rapozo Guimarães, Giovanna Resk Maklouf, Cristiane Esteves Teixeira, Leandro de Oliveira Santos, Nayara Gusmão Tessarollo, Nayara Evelin de Toledo, Alessandra Freitas Serain, Cristóvão Antunes de Lanna, Marco Antônio M. Pretti, Jéssica Gonçalves Vieira da Cruz et al. · 2024 · Nature Communications
Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation
Alessio Ugolini, Alessandra De Leo, Xiaoqing Yu, Fabio Scirocchi, Xiaoxian Liu, Bárbara Peixoto, Delia Scocozza, Angelica Pace, Michela Perego, Alessandro Gardini et al. · 2025 · Cancer Discovery
Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation
Christian J. Berrios, Megha Padi, Mark A. Keibler, Donglim Esther Park, Molla Vadim, Jingwei Cheng, Soo Mi Lee, Gregory N Stephanopoulos, John F Quackenbush, James A. DeCaprio · 2016 · PLoS Pathogens
Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses
Pawan Poudel, Gift Nyamundanda, Yatish Patil, Maggie C.U. Cheang, Anguraj Sadanandam · 2019 · npj Breast Cancer
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Hillary, Robert F., McCartney, Daniel L., Harris, Sarah E., Stevenson, Anna J., Seeboth, Anne, Zhang, Qian, Liewald, David C., Evans, Kathryn L., Ritchie, Craig W., Tucker-Drob, Elliot M. et al. · 2019 · Nature Communications
Pan-cancer analysis on microRNA-associated gene activation
Hua Tan, SHAN HU HUANG, Zhigang Zhang, Xiaohua Qian, Peiqing Sun, Xiaobo Zhou · 2019 · EBioMedicine
Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution
Fabrizio Orsenigo, Lei Liu Conze, Suvi Jauhiainen, Monica Corada, Francesca Lazzaroni, Matteo Malinverno, Veronica Sundell, Sara Isabel Cunha, Johan Brännström, Maria Ascención Globisch et al. · 2020 · eLife
Translocated microbiome composition determines immunological outcome in treated HIV infection
Krystelle Nganou‐Makamdop, Aarthi Talla, Ashish Sharma, Samuel W. Darko, Amy Ransier, Farida Laboune, Jeffrey G. Chipman, Gregory J. Beilman, Torfi Hoskuldsson, Slim Fourati et al. · 2021 · Cell
Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2
Vijayashree Mysore, Suhail Tahir, Kazuhiro Furuhashi, Jatin Arora, Florencia Rosetti, Xavier Culleré, Pascal Yazbeck, Miroslav Sekulic, Madeleine E. Lemieux, Soumya Raychaudhuri et al. · 2022 · The Journal of Experimental Medicine
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer
Joyce V. Lee, Filomena Housley, Christina S. F. Yau, Rachel M. Nakagawa, Juliane Winkler, Johanna M. Anttila, Pauliina Munne, Mariel Savelius, Kathleen E. Houlahan, Daniel Van de Mark et al. · 2022 · Nature Communications
The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
Jens Bauer, Natalie Köhler, Yacine Maringer, Philip Bucher, Tatjana Bilich, Melissa Zwick, Severin Dicks, Annika Nelde, Marissa Lisa Dubbelaar, Jonas Scheid et al. · 2022 · Nature Communications
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas
Lisa D. Cervia, Tsukasa Shibue, Ashir A. Borah, Benjamin Gaeta, Linh He, Lisa Leung, Naomi Li, Sydney M. Moyer, Brian H. Shim, Nancy Dumont et al. · 2022 · Cancer Discovery
MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle
Gillian Fitzgerald, Guillermo Turiel, Tatiane Gorski, Inés Soro-Arnáiz, Jing Zhang, Nicola C. Casartelli, Evi Masschelein, Nicola A. Maffiuletti, Reto Sutter, Michael Leunig et al. · 2023 · Communications Biology
Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma
Lizhi Pang, Madeline Dunterman, Wenjing Xuan, Annette M. Gonzalez, Yiyun Lin, Wen-Hao Hsu, Fatima Khan, Robert S. Hagan, William A. Müller, Amy B. Heimberger et al. · 2023 · Cell Reports
A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study
Barbara Pardini, Giulio Ferrero, Sonia Tarallo, Gaetano Gallo, A. Francavilla, Nicola Licheri, Mario Trompetto, Giuseppe F. Clerico, Carlo Senore, Sergio Peyre et al. · 2023 · Gastroenterology
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Hui Li, Xiaofeng Jiang, Yongbing Xiao, Yuqing Zhang, Weiya Zhang, Michael Doherty, Jacquelyn Nestor, Changjun Li, Jing Ye, Tingting Sha et al. · 2023 · Bone Research
TGF-β and RAS jointly unmask primed enhancers to drive metastasis
Jun Ho Lee, Francisco J. Sánchez Rivera, Lan Ying He, Harihar Basnet, Fei Chen, Elena Spina, Liangji Li, Carles Torner, Jason Earl Chan, Dig Vijay Kumar Yarlagadda et al. · 2024 · Cell
Deep learning of pharmacogenomics resources: moving towards precision oncology
Yu‐Chiao Chiu, Hung-I Harry Chen, Aparna Gorthi, Milad Mostavi, Siyuan Zheng, Yufei Huang, Yidong Chen · 2019 · Briefings in Bioinformatics
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays
Ao Chen, Sha Liao, Mengnan Cheng, Kailong Ma, Liang Wu, Yiwei Lai, Xiaojie Qiu, Jin Yang, Wenjiao Li, Jiangshan Xu et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer
Kalisz, Mark, Bernardo, Edgar, Beucher, Anthony, Maestro, Miguel Angel, del Pozo, Natalia, Millán, Irene, Haeberle, Lena, Schlensog, Martin, Safi, Sami Alexander, Knoefel, Wolfram Trudo et al. · 2020 · The EMBO Journal
Cooperation Between MYC and β‐Catenin in Liver Tumorigenesis Requires Yap/Taz
Andrea Bisso, M. Filipuzzi, Gianni Paolo Gamarra Figueroa, Giulia Brumana, Francesca Biagioni, Mirko Doni, Giorgia Ceccotti, Nina Tanasković, Marco J. Morelli, Vera Pendino et al. · 2020 · Hepatology
High‐throughput, microscope‐based sorting to dissect cellular heterogeneity
Nicholas Hasle, Anthony Cooke, Sanjay R Srivatsan, Heather Z Huang, Jason J. Stephany, Zachary Krieger, Dana L. Jackson, Weiliang Tang, Sriram Pendyala, Raymond J. Monnat et al. · 2020 · Molecular Systems Biology
Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes
Marc Pfefferlé, Giada Ingoglia, Christian A. Schaer, Ayla Yalamanoglu, Raphael M. Buzzi, Irina L. Dubach, Ge Tan, Emilio Yangüez López-Cano, Nadja Schulthess, Kerstin Hansen et al. · 2020 · Journal of Clinical Investigation
Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas
Lijie Chen, Xing Niu, Xue Qiao, Sai Liu, Hongmei Ma, Xueqing Shi, Xuemei He, Ming Zhong · 2022 · Frontiers in Immunology
Identification of diagnostic genes for both Alzheimer’s disease and Metabolic syndrome by the machine learning algorithm
Jinwei Li, Yang Zhang, Tanli Lu, Rui Liang, Zhikang Wu, Meimei Liu, Linyao Qin, Hongmou Chen, Xianlei Yan, Shan Deng et al. · 2022 · Frontiers in Immunology
Proteogenomic analysis of lung adenocarcinoma reveals tumor heterogeneity, survival determinants, and therapeutically relevant pathways
Anthony R. Soltis, Nicholas W. Bateman, Jianfang Liu, Trinh Mai Nguyen, Teri J. Franks, Xijun Zhang, Clifton L. Dalgard, Coralie Viollet, Stella Somiari, Chunhua Yan et al. · 2022 · Cell Reports Medicine
A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
Amy J. Gleichman, Riki Kawaguchi, Michael V. Sofroniew, Stanley Thomas Carmichael · 2023 · Nature Communications
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity
Kay Hänggi, Jie Li, Achintyan Gangadharan, Xiaoxian Liu, Daiana Pamela Celias, Olabisi Osunmakinde, Aysenur Keske, Joshua Davis, Faiz F. Ahmad, Auriane Giron et al. · 2024 · Cancer Cell
CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety
Cynthia L. Palmer, Britton W. Boras, Bernadette Pascual, Na Li, Danan Li, Scott J. Garza, Nanni H. Huser, Jing Tang Yuan, Julie A. Cianfrogna, Tae Sung et al. · 2025 · Cancer Cell
Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma
Li, Zhuxuan, Zhuang, Xueqian, Pan, Chun-Hao, Yan, Yan, Thummalapalli, Rohit, Hallin, Jill, Torborg, Stefan, Singhal, Anupriya, Chang, Jason C., Manchado, Eusebio et al. · 2024 · Cancer Discovery
CircRNA-100338 Is Associated With mTOR Signaling Pathway and Poor Prognosis in Hepatocellular Carcinoma
Xiu−Yan Huang, Zi-Li Huang, Ping-Bao Zhang, Xinyu Huang, Jin Huang, Hongcheng Wang, Bin Xu, Jian Zhou, Zhao–You Tang · 2019 · Frontiers in Oncology
Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin Stuart Zand et al. · 2020 · eLife
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst, Samuel Corless, Tanja Musch, Anke S. Lonsdorf, Sylvia Erhardt, Frank Lyko, Manuel Rodríguez‐Paredes · 2020 · Genome Medicine
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
Minsoo Kim, Jillian R. Haney, Pan Zhang, Leanna M. Hernandez, Lee-kai Wang, Laura Pérez‐Cano, Loes M. Olde Loohuis, Luis de la Torre-Ubieta, Michael J. Gandal · 2021 · Nature Neuroscience
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease
Tatsuma Ban, Masako Kikuchi, Go R. Sato, Akio Manabe, Noriko Tagata, Kayo Harita, Akira Nishiyama, Kenichi Nishimura, Ryusuke Yoshimi, Yohei Kirino et al. · 2021 · Nature Communications
Extracellular Matrix in Synthetic Hydrogel‐Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors
Matthew J. Mosquera, Sungwoong Kim, Rohan Bareja, Zhou Fang, Shuangyi Cai, Heng Pan, Muhammad Imran Asad, M. Laura Martín, Michael Sigouros, Florencia P. Madorsky Rowdo et al. · 2021 · Advanced Materials
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression
Shaolong Cao, Jennifer Rui Wang, Shuangxi Ji, Yang Peng, Yaoyi Dai, Shuai Guo, Matthew D. Montierth, John Paul Shen, Xiao Hong Zhao, Jingxiao Chen et al. · 2022 · Nature Biotechnology
Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
Yu Gao, Curtis Cai, David Wullimann, Julia Niessl, Olga Rivera‐Ballesteros, Puran Chen, Joshua Lange, Angélica Cuapio, Ola Blennow, Lotta Hansson et al. · 2022 · Immunity
Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis
Rebecca Peyser Boiarsky, Nicholas J. Haradhvala, Jean-Baptiste Alberge, Romanos Sklavenitis‐Pistofidis, Tarek H. Mouhieddine, Oksana Zavidij, Ming‐Chieh Shih, Danielle T. Firer, Mendy L. Miller, Habib El‐Khoury et al. · 2022 · Nature Communications
standR: spatial transcriptomic analysis for GeoMx DSP data
Ning Liu, Dharmesh Dinesh Bhuva, Ahmed Mohamed, Micah Bokelund, Arutha Kulasinghe, Chin Wee Tan, Melissa J. Davis · 2023 · Nucleic Acids Research
A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism
Khaled Tighanimine, José Américo Nabuco Leva Ferreira de Freitas, Ivan Nemazanyy, Alexia Bankolé, Delphine Benarroch, Susanne Brodesser, Grégory R G Doré, Lucas J. Robinson, Paule Bénit, Sophia Ladraa et al. · 2024 · Nature Metabolism
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival
Michael Haley, Leoma D. Bere, James Minshull, Sokratia Georgaka, Natalia Garcia-Martin, Gareth J. Howell, David John Coope, Federico Roncaroli, Andrew Thomas King, David C. Wedge et al. · 2024 · Science Advances
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Lerma-Martin, Celia, Badia-i-Mompel, Pau, Ramirez Flores, Ricardo O., Sekol, Patricia, Schäfer, Philipp S. L., Riedl, Christian J., Hofmann, Annika, Thäwel, Thomas, Wünnemann, Florian, Ibarra-Arellano, Miguel A. et al. · 2024 · Nature Neuroscience
A functional genetic screen defines the AKT-induced senescence signaling network
Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D. et al. · 2020 · Cell Death & Differentiation
RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Qian Liang, Dan Ma, Xiaoqiang Zhu, Zhenhua Wang, Tiantian Sun, Chaoqin Shen, Tingting Yan, Xianglong Tian, TaChung Yu, Fangfang Guo et al. · 2017 · Clinical Cancer Research
De novo and inherited private variants in MAP1B in periventricular nodular heterotopia
Erin L. Heinzen, Adam C. O’Neill, Xiaolin Zhu, Andrew S. Allen, Melanie Bahlo, Jamel Chelly, Ming Hui Chen, William B. Dobyns, Saskia Freytag, Renzo Guerrini et al. · 2018 · PLoS Genetics
Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92
Eugenio Morelli, Lavinia Biamonte, Cinzia Federico, Nicola Amodio, Maria Teresa Di Martino, Maria Eugenia Gallo Cantafio, Martina Manzoni, Francesca Scionti, Mehmet Samur, Annamaria Gullà et al. · 2018 · Blood
Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma
Junling Zhuang, Fazal Shirazi, Ramesh Singh, Isere Kuiatse, Hua Wang, Hans Chulhee Lee, Zuzana Berkova, Allison Berger, Marc L. Hyer, Nibedita Chattopadhyay et al. · 2019 · Blood
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer
Derek J. Essegian, Rimpi Khurana, Vasileios Stathias, Stephan C. Schürer · 2020 · Cell Reports Medicine
Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis
Dipankar Bhattacharya, Brittany N. Basta, José María Mato, Amanda J. Craig, David Fernández‐Ramos, Fernando Lopitz‐Otsoa, Darya Tsvirkun, Liat Hayardeny, Vasuretha Chandar, Robert E. Schwartz et al. · 2021 · JHEP Reports
Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity
Ashraf Ul Kabir, Madhav Subramanian, Dong Hun Lee, Xiaoli Wang, Karen Krchma, Jun Wu, Teri Naismith, Carmen M. Halabi, Ju Young Kim, Fadi E. Pulous et al. · 2021 · Science Translational Medicine
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology
Gail Petuna Risbridger, Ashlee K. Clark, Laura H. Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L. Lister, David William Pook, Carmel Jo Pezaro, Shahneen Kaur Sandhu, Shivakumar Keerthikumar et al. · 2021 · Nature Communications
Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study
Weiwei Zhai, Hannah L. H. Lai, Neslihan Arife Kaya, Jianbin Chen, Hechuan Yang, Bingxin Lu, Jia Qi Lim, Siming Ma, Sin Chi Chew, Khi Pin Chua et al. · 2021 · National Science Review
Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis
Hyun Ho Han, Yan Wang, Josué Curto, Sreeharsha Gurrapu, Sara Laudato, Alekya Rumandla, Goutam Chakraborty, Xiaobo Wang, Hong Chen, Yan Jiang et al. · 2022 · Cell Reports
APOBEC-Mediated Mutagenesis is a Favorable Predictor of Prognosis and Immunotherapy for Bladder Cancer Patients: Evidence from Pan-Cancer Analysis and Multiple Databases
Run Shi, Xin Wang, Yang Feng Wu, Bin Xu, Tianyu Zhao, Christian Trapp, Xuanbin Wang, Kristian Unger, Cheng Zhou, Shun Lu et al. · 2022 · Theranostics
The meningeal transcriptional response to traumatic brain injury and aging
Ashley C. Bolte, Daniel A Shapiro, Arun B. Dutta, Wei Feng, Katherine R. Bruch, Michael A. Kovacs, Ana Royo Marco, Hannah E. Ennerfelt, John R. Lukens · 2022 · eLife
Identification of copper metabolism-related subtypes and establishment of the prognostic model in ovarian cancer
Songyun Zhao, Xin Zhang, Feng Gao, Hao Chi, Jinhao Zhang, Zhijia Xia, Chao Cheng, Jinhui Liu · 2023 · Frontiers in Endocrinology
The nuclear factor ID3 endows macrophages with a potent anti-tumour activity
Zihou Deng, Pierre-Louis Loyher, Tomi Lazarov, Li Li, Zeyang Shen, Bhavneet Bhinder, Hairu Yang, Yi Zhong, Araitz Alberdi, Joan Massagué et al. · 2024 · Nature
A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets
Ruchira Menka Jha, Dhivyaa Rajasundaram, Chaim T. Sneiderman, Brent Thomas Schlegel, Casey O’Brien, Zujian Xiong, Keri L. Janesko‐Feldman, Ria Trivedi, Vincent Vagni, Benjamin E. Zusman et al. · 2024 · Neuron
Genetic variation within endolysosomal system is associated with late-onset Alzheimer’s disease
Song Gao, Aaron Casey, Timothy J. Sargeant, Ville‐Petteri Mäkinen · 2018 · Brain
Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution
Jacob S. Heng, Amir Rattner, Genevieve Stein-O’Brien, Briana L. Winer, Bryan William Jones, Hilary J. Vernon, Loyal A. Goff, Jeremy Nathans · 2019 · Proceedings of the National Academy of Sciences
A precisely positioned MED12 activation helix stimulates CDK8 kinase activity
Felix Klatt, Alexander Leitner, Iana V. Kim, Hung Ho-Xuan, Elisabeth V. Schneider, Franziska Langhammer, Robin Weinmann, Melanie Müller, Robert Huber, Gunter Meister et al. · 2020 · Proceedings of the National Academy of Sciences
Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells
Lee, Mi-Ok, Jung, Kwang Bo, Jo, Seong-Jae, Hyun, Sung-Ae, Moon, Kyoung-Sik, Seo, Joung-Wook, Kim, Sang-Heon, Son, Mi-Young · 2019 · Journal of Biological Engineering
Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K BRAF -Mutant Melanoma
Inês Pires da Silva, Kevin Y. X. Wang, James S. Wilmott, Jeff Holst, Matteo Salvatore Carlino, John Park, Camelia Y. J. Quek, Matthew J. Wongchenko, Yibing Yan, Graham J. Mann et al. · 2019 · Clinical Cancer Research
Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration
Dongqing Li, Lara Kular, Manika Vij, Eva K. Herter, Xi Li, Aoxue Wang, Tongbin Chu, Maria A. Toma, Letian Zhang, Eleni Liapi et al. · 2019 · Proceedings of the National Academy of Sciences
Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling
Flavian D. Brown, Debattama R. Sen, Martin W. LaFleur, Jernej Godec, Veronika Lukacs‐Kornek, Frank Alexander Schildberg, Hye‐Jung Kim, Kathleen B. Yates, Stéphane J. H. Ricoult, Kevin Bi et al. · 2019 · Nature Immunology
Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing
Jacob S. Heng, Sean F. Hackett, Genevieve Stein-O’Brien, Briana L. Winer, John Williams, Loyal A. Goff, Jeremy Nathans · 2019 · Proceedings of the National Academy of Sciences
STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
Monika Oberhuber, Matteo Pecoraro, Mate Rusz, Georg Oberhuber, Maritta Wieselberg, Peter Haslinger, Elisabeth Gurnhofer, Michaela Schlederer, Tanja Limberger, Sabine Lagger et al. · 2020 · Molecular Systems Biology
Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua)
Karina Dale, Fekadu Yadetie, Mette Bjørge Müller, Daniela Maria Pampanin, Alejandra Gilabert, Xiaokang Zhang, Zhanna Tairova, Ane Haarr, Roger Lille‐Langøy, Jan Ludvig Lyche et al. · 2020 · Aquatic Toxicology
A pan-cancer transcriptome analysis of exitron splicing identifies novel cancer driver genes and neoepitopes
Ting-You Wang, Qi Liu, Yanan Ren, Sk. Kayum Alam, Li Wang, Zhu Zhu, Luke H. Hoeppner, Scott M. Dehm, Qi Cao, Rendong Yang · 2021 · Molecular Cell
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment
Guangxu Cao, Jiali Yue, Yetian Ruan, Ya Han, Yong Zhi, Jianqiao Lu, Min Liu, Xinxin Xu, Jin Wang, Quan Gu et al. · 2023 · The EMBO Journal
B cell lineage reconstitution underlies CAR-T cell therapeutic efficacy in patients with refractory myasthenia gravis
Dai‐Shi Tian, Chuan Qin, Ming‐Hao Dong, Michael Heming, Luo‐Qi Zhou, Wen Wang, Song-Bai Cai, Yun‐Fan You, Ke Shang, Jun Xiao et al. · 2024 · EMBO Molecular Medicine
The temporal progression of lung immune remodeling during breast cancer metastasis
Christopher S. McGinnis, Zhuang Miao, Daphne A. Superville, Winnie Yao, Andrei Goga, Nathan Edward Reticker-Flynn, Juliane Winkler, Ansuman T. Satpathy · 2024 · Cancer Cell
Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity
Luis Francisco Lorenzo‐Martín, Nicolas Broguière, Jakob Langer, Lucie Tillard, Mikhail Nikolaev, George Coukos, Krisztián Homicskó, Matthias P. Lütolf · 2024 · Nature Biotechnology
Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling
Lomeli Carpio Shull, Elizabeth W. Bradley, Meghan E. McGee‐Lawrence, Megan Moore Weivoda, Daniel Poston, Amel Dudakovic, Ming Xu, Tamar Tchkonia, James L. Kirkland, André J. van Wijnen et al. · 2016 · Science Signaling
The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer
Matthew R. Cooperberg, Nicholas Erho, June M. Chan, Felix Yi-Chung Feng, Nick Fishbane, Shuang George Zhao, Jeffry Simko, Janet E. Cowan, Jonathan M. Lehrer, Mohammed Alshalalfa et al. · 2018 · European Urology
Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
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