The Molecular Signatures Database Hallmark Gene Set Collection

Cited by (1,112)

Items 201–300 of 1,112

1. A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice
   Dahlin, Joakim S., Hamey, Fiona K., Pijuan-Sala, Blanca, Shepherd, Mairi, Lau, Winnie W. Y., Nestorowa, Sonia, Weinreb, Caleb, Wolock, Samuel, Hannah, Rebecca, Diamanti, Evangelia et al. · 2018 · Blood
2. Breast tumours maintain a reservoir of subclonal diversity during expansion
   Minussi, Darlan C., Nicholson, Michael D., Ye, Hanghui, Davis, Alexander, Wang, Kaile, Baker, Toby, Tarabichi, Maxime, Sei, Emi, Du, Haowei, Rabbani, Mashiat et al. · 2021 · Nature
3. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
   Georgilis, Athena, Klotz, Sabrina, Hanley, Christopher J., Herranz, Nicolas, Weirich, Benedikt, Morancho, Beatriz, Leote, Ana Carolina, D'Artista, Luana, Gallage, Suchira, Seehawer, Marco et al. · 2018 · Cancer Cell
4. Spatially aware dimension reduction for spatial transcriptomics
   Lulu Shang, Xiang Zhou · 2022 · Nature Communications
5. Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
   Hua‐Sheng Chiu, Sonal Somvanshi, Ektaben Patel, Ting-Wen Chen, Vivek Singh, Barry Zorman, Sagar L. Patil, Yinghong Pan, Sujash S. Chatterjee, Rory Johnson et al. · 2018 · Cell Reports
6. PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis
   Tim Wartewig, Zsuzsanna Kurgyis, Selina Jessica Keppler, Konstanze Pechloff, Erik Hameister, Rupert Öllinger, Roman Maresch, Thorsten Buch, Katja Steiger, Christof Winter et al. · 2017 · Nature
7. Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models
   Wang, Zebin, Sun, Kaiming, Xiao, Yonghong, Feng, Bin, Mikule, Keith, Ma, XiaoYan, Feng, Ningping, Vellano, Christopher P., Federico, Lorenzo, Marszalek, Joseph R. et al. · 2019 · Scientific Reports
8. Engineered immunogen binding to alum adjuvant enhances humoral immunity
   Tyson J. Moyer, Yu Kato, Wuhbet D. Abraham, Jason Y.H. Chang, Daniel W. Kulp, Nicki Watson, Hannah L. Turner, Sergey Menis, Robert K. Abbott, Jinal N. Bhiman et al. · 2020 · Nature Medicine
9. Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade
   Eduardo Bonavita, Christian P. Bromley, Gustav Jonsson, Victoria S. Pelly, Sudhakar Sahoo, Katherine Walwyn-Brown, Sofia Mensurado, Agrin Moeini, Eimear Flanagan, Charlotte R. Bell et al. · 2020 · Immunity
10. IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation
    Fan Zhang, Joseph Mears, Lorien Shakib, Jessica I. Beynor, Sara Shanaj, Ilya Korsunsky, Aparna Nathan, Laura T. Donlin, Soumya Raychaudhuri · 2021 · Genome Medicine
11. High-content CRISPR screening
    Christoph Bock, Paul Datlinger, Florence M. Chardon, Matthew A. Coelho, Matthew B. Dong, Keith A. Lawson, Tian Lu, Laetitia Maroc, Thomas M. Norman, Bicna Song et al. · 2022 · Nature Reviews Methods Primers
12. FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
    Jack D. Chan, Christina M. Scheffler, Isabelle Munoz, Kevin Sek, Joel N. Lee, Yukuan Huang, Kah Min Yap, Nicole Y. L. Saw, Jasmine Li, Amanda X.Y. Chen et al. · 2024 · Nature
13. DGCA: A comprehensive R package for Differential Gene Correlation Analysis
    Andrew Thomas McKenzie, Igor Katsyv, Won-Min Song, Minghui Wang, Bin Zhang · 2016 · BMC Systems Biology
14. The Proteogenomic Landscape of Curable Prostate Cancer
    Ankit Sinha, Vincent Huang, Julie M. Livingstone, Jenny Wang, Natalie S. Fox, Natalie Jayne Kurganovs, Vladimir Ignatchenko, Katharina Fritsch, Nilgun Donmez, Lawrence E. Heisler et al. · 2019 · Cancer Cell
15. Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma
    Philip Bischoff, Alexandra Trinks, Benedikt Obermayer, J. Patrick Pett, Jennifer Wiederspahn, Florian Uhlitz, Xizi Liang, Annika Lehmann, Philipp Sebastian Jurmeister, Aron Elsner et al. · 2021 · Oncogene
16. Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
    Lund, Harald, Pieber, Melanie, Parsa, Roham, Han, Jinming, Grommisch, David, Ewing, Ewoud, Kular, Lara, Needhamsen, Maria, Espinosa, Alexander, Nilsson, Emma et al. · 2018 · Nature Communications
17. HIF1α lactylation enhances KIAA1199 transcription to promote angiogenesis and vasculogenic mimicry in prostate cancer
    Yongwen Luo, Zhonghua Yang, Ying Yu, Peng Zhang · 2022 · International Journal of Biological Macromolecules
18. STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma
    Jing Ying Hu, Francisco J. Sánchez Rivera, Zhenghan Wang, Gabriela N. Johnson, Yu-Jui Ho, Karuna Ganesh, Shigeaki Umeda, Siting Gan, Adriana M. Mujal, Rebecca B. Delconte et al. · 2023 · Nature
19. Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
    Ana Uzquiano, Amanda J. Kedaigle, Martina Pigoni, Bruna da Silveira Paulsen, Xian Adiconis, Kwanho Kim, Tyler Faits, Surya Nagaraja, Noelia Antón-Bolaños, Chiara Gerhardinger et al. · 2022 · Cell
20. IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis
    Rasmus Siersbæk, Valentina Scabia, Sankari Nagarajan, Igor V. Chernukhin, Evangelia K. Papachristou, Rebecca Broome, Simon J. Johnston, Stacey E. P. Joosten, Andrew R. Green, Sanjeev Srinivas Kumar et al. · 2020 · Cancer Cell
21. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
    Wenjing Su, Hyun Ho Han, Yan Wang, Boyu Zhang, Bing Zhou, Yuanming Cheng, Alekya Rumandla, Sreeharsha Gurrapu, Goutam Chakraborty, Jie Su et al. · 2019 · Cancer Cell
22. Journal of Mammary Gland Biology and Neoplasia
    2013 · Journal of Mammary Gland Biology and Neoplasia
23. Unraveling tumor–immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy
    Alejandro Jiménez-Sánchez, Paulina Cybulska, Katherine LaVigne Mager, Simon Koplev, Oliver M. Cast, Dominique‐Laurent Couturier, Danish Memon, Pier Selenica, Ines Nikolovski, Yousef Mazaheri et al. · 2020 · Nature Genetics
24. Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
    Marion Claudia Salzer, Atefeh Lafzi, Antonio Berenguer, Catrin Youssif, Andrés Castellanos‐Martín, Guiomar Solanas, Francisca Oliveira Peixoto, Camille Stephan‐Otto Attolini, Neus Prats, Mònica Aguilera et al. · 2018 · Cell
25. Genome-wide association study of medication-use and associated disease in the UK Biobank
    Wu, Yeda, Byrne, Enda M., Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Mallett, Andrew J., Yang, Jian, Visscher, Peter M., Wray, Naomi R. · 2019 · Nature Communications
26. RASA2 ablation in T cells boosts antigen sensitivity and long-term function
    Julia C. Carnevale, Eric Shifrut, Nupura Kale, William A. Nyberg, Franziska Blaeschke, Yan Yi Chen, Zhongmei Li, Sagar P. Bapat, Morgan E. Diolaiti, Patrick C. O’Leary et al. · 2022 · Nature
27. GSEA-InContext: identifying novel and common patterns in expression experiments
    Rani K. Powers, Andrew Goodspeed, Harrison Pielke-Lombardo, Aik Choon Tan, James C. Costello · 2018 · Bioinformatics
28. Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
    Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon Jonas Rieke, Jenny Bischoff et al. · 2021 · Immunity
29. Improved reconstruction of single-cell developmental potential with CytoTRACE 2
    Minji Kang, José Juan Almagro Armenteros, Gunsagar Singh Gulati, Rachel Gleyzer, Susanna Avagyan, Erin L. Brown, Wubing Zhang, Abul Usmani, Noah J. Earland, Zhenqin Wu et al. · 2025 · Nature Methods
30. A plant-derived natural photosynthetic system for improving cell anabolism
    Pengfei Chen, Xin Liu, Chenhui Gu, Peiyu Zhong, Nan Song, Mobai Li, Zhanqiu Dai, Xiangqian Fang, Zhaoming Liu, Jianfeng Zhang et al. · 2022 · Nature
31. Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human
    Juanjuan Zhao, Shuye Zhang, Yang Liu, Xiaomeng He, Mengmeng Qu, Gang Xu, Hongbo Wang, Man Huang, Jing Pan, Zhenwen Liu et al. · 2020 · Cell Discovery
32. Context specificity of the EMT transcriptional response
    David P. Cook, Barbara C. Vanderhyden · 2020 · Nature Communications
33. Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report
    Muhammad M. Mohiuddin, Avneesh Kumar Singh, Linda Scobie, Corbin E. Goerlich, Alison Grazioli, Kapil Saharia, Claire Crossan, ALLEN P. BURKE, Cinthia Drachenberg, Cihan Oguz et al. · 2023 · The Lancet
34. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK
    Feng, Xiaodong, Arang, Nadia, Rigiracciolo, Damiano Cosimo, Lee, Joo Sang, Yeerna, Huwate, Wang, Zhiyong, Lubrano, Simone, Kishore, Ayush, Pachter, Jonathan A., König, Gabriele M. et al. · 2019 · Cancer Cell
35. Tumor microenvironment evaluation promotes precise checkpoint immunotherapy of advanced gastric cancer
    Dongqiang Zeng, Jiani Wu, Hui Luo, Yong Li, Jian Xiao, Jianjun Peng, Zilan Ye, Rui Zhou, Yunfang Yu, Gaofeng Wang et al. · 2021 · Journal for ImmunoTherapy of Cancer
36. Enrichr-KG: bridging enrichment analysis across multiple libraries
    John Erol Evangelista, Zhuorui Xie, Giacomo B. Marino, Nhi Le Uyen Nguyen, Daniel J. B. Clarke, Avi Ma’ayan · 2023 · Nucleic Acids Research
37. Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data
    Jean Fan, Hae‐Ock Lee, Soohyun Lee, Daeun Ryu, Semin Lee, Catherine Xue, Seok Jin Kim, Kihyun Kım, Nikolaos Barkas, Peter J. Park et al. · 2018 · Genome Research
38. A Review of Single-Cell RNA-Seq Annotation, Integration, and Cell–Cell Communication
    Changde Cheng, Wenan Chen, Hongjian Jin, Xiang 'Anthony' Chen · 2023 · Cells
39. Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients
    Charles Langelier, Matt S. Zinter, Katrina Kalantar, Gregory Anthony Yanik, Stephanie A. Christenson, Brian D. O’Donovan, Corin V. White, Michael R. Wilson, Anil Sapru, Christopher C. Dvorak et al. · 2017 · American Journal of Respiratory and Critical Care Medicine
40. Association of clonal hematopoiesis with chronic obstructive pulmonary disease
    Miller, Peter G., Qiao, Dandi, Rojas-Quintero, Joselyn, Honigberg, Michael C., Sperling, Adam S., Gibson, Christopher J., Bick, Alexander G., Niroula, Abhishek, McConkey, Marie E., Sandoval, Brittany et al. · 2022 · Blood
41. Predicting clinical outcomes from large scale cancer genomic profiles with deep survival models
    Safoora Yousefi, Fatemeh Amrollahi, Mohamed T. Amgad, Chengliang Dong, Joshua E. Lewis, Congzheng Song, David A. Gutman, Sameer H. Halani, Jose Enrique Velazquez Vega, Daniel Jay Brat et al. · 2017 · Scientific Reports
42. Deep learning-based multi-omics data integration reveals two prognostic subtypes in high-risk neuroblastoma
    Zhang, Li, Lv, Chenkai, Jin, Yaqiong, Cheng, Ganqi, Fu, Yibao, Yuan, Dongsheng, Tao, Yiran, Guo, Yongli, Ni, Xin, Shi, Tieliu · 2018 · Frontiers in Genetics
43. Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies
    Utthara Nayar, Ofir Cohen, Christian Kapstad, Michael S. Cuoco, Adrienne Gropper Waks, Seth Andrew Wander, Corrie Painter, Samuel S. Freeman, Nicole S. Persky, Lori Marini et al. · 2018 · Nature Genetics
44. Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma
    Zhang, Liang, Yao, Yixin, Zhang, Shaojun, Liu, Yang, Guo, Hui, Ahmed, Makhdum, Bell, Taylor, Zhang, Hui, Han, Guangchun, Lorence, Elizabeth et al. · 2019 · Science Translational Medicine
45. A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
    van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I., Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve et al. · 2023 · Nature Neuroscience
46. Benchmarking joint multi-omics dimensionality reduction approaches for the study of cancer
    Laura Cantini, Pooya Zakeri, Céline Hernandez, Aurélien Naldi, Denis Thieffry, Élisabeth Rémy, Anaı̈s Baudot · 2021 · Nature Communications
47. Recruited macrophages elicit atrial fibrillation
    Maarten Hulsmans, Maximilian J. Schloss, I‐Hsiu Lee, Aneesh C. Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel et al. · 2023 · Science
48. Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response
    Yan Mei, Xiumei Wang, Ji Zhang, Dan Liu, Junjie He, Chunliu Huang, Jing Liao, Yingzhao Wang, Yong-Yi Feng, Hongyu Li et al. · 2023 · Nature Cancer
49. CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy
    Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Junyun Lai, Amanda X.Y. Chen, Déborah Meyran, Kirsten L. Todd, Emma V. Petley, Sherly Mardiana, Christina Mølck et al. · 2021 · Nature Communications
50. Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression
    Ralph Francescone, Debora Barbosa Vendramini Costa, Janusz Franco‐Barraza, Jessica Wagner, Alexander Muir, Allison N. Lau, Linara Gabitova, Tatiana Pazina, Sapna Gupta, Tiffany Luong et al. · 2020 · Cancer Discovery
51. Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma
    Lindsay M. LaFave, Vinay K. Kartha, Sai Ma, Kevin Meli, Isabella S. Del Priore, Caleb A. Lareau, Santiago Naranjo, Peter M.K. Westcott, Fabiana M. Duarte, Venkat Sankar et al. · 2020 · Cancer Cell
52. Refining colorectal cancer classification and clinical stratification through a single-cell atlas
    Ateeq Muhammed Khaliq, Cihat Erdoğan, Zeyneb Kurt, Sultan Sevgi Turgut, Miles W. Grunvald, Tim Rand, Sonal Khare, Jeffrey Allen Borgia, Dana Michelle Hayden, Sam G. Pappas et al. · 2022 · Genome biology
53. Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission
    Shinya Tasaki, Katsuya Suzuki, Yoshiaki Kassai, Masaru Takeshita, Atsuko Murota, Yasushi Kondo, Tatsuya Ando, Yusuke Nakayama, Yuumi Okuzono, Maiko Takiguchi et al. · 2018 · Nature Communications
54. Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation
    Cuartero, Sergi, Weiss, Felix D., Dharmalingam, Gopuraja, Guo, Ya, Ing-Simmons, Elizabeth, Masella, Silvia, Robles-Rebollo, Irene, Xiao, Xiaolin, Wang, Yi-Fang, Barozzi, Iros et al. · 2018 · Nature Immunology
55. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer
    Di Zhao, Xin Lü, Guocan Wang, Zhengdao Lan, Wenting Liao, Jun Li, Xin Liang, Jasper Chen, Sagar R Shah, Xiaoying Shang et al. · 2017 · Nature
56. Dynamic genetic regulation of gene expression during cellular differentiation
    Strober, B. J., Elorbany, R., Rhodes, K., Krishnan, N., Tayeb, K., Battle, A., Gilad, Y. · 2019 · Science
57. lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer
    Mu Xu, Xiaoxiang Chen, Lin Kang, Kaixuan Zeng, Xiangxiang Liu, Xueni Xu, Bei Pan, Tao Xu, Li Sun, Bangshun He et al. · 2019 · Journal of Hematology & Oncology
58. Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures
    Arjun Baghela, Olga M. Pena, Amy H. Lee, Beverlie Baquir, Reza Falsafi, Andy An, Susan W. Farmer, Andrew Hurlburt, Alvaro Mondragon-Cardona, Juan Diego Rivera et al. · 2022 · EBioMedicine
59. In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
    Dubrot, Juan, Du, Peter P., Lane-Reticker, Sarah Kate, Kessler, Emily A., Muscato, Audrey J., Mehta, Arnav, Freeman, Samuel S., Allen, Peter M., Olander, Kira E., Ockerman, Kyle M. et al. · 2022 · Nature Immunology
60. Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation
    Kristina Koop, Christina Heichler, Anabel Schmied, Michael W. Vieth, Tatjana Primbs, Birgitta Carlé, Ferdinand Knieling, Jing Claussen, Alexander C. Klimowicz, Jie Zheng et al. · 2018 · Gastroenterology
61. Cellular adaptation to cancer therapy along a resistance continuum
    Gustavo S. França, Maayan Baron, Benjamin R. King, Jozef P. Bossowski, Alicia Bjornberg, Maayan Pour, Anjali N. Rao, Ayushi S. Patel, Seli̇m Misirlioğlu, Dalia Barkley et al. · 2024 · Nature
62. Immune gene signatures for predicting durable clinical benefit of anti-PD-1 immunotherapy in patients with non-small cell lung cancer
    Hwang, Sohyun, Kwon, Ah-Young, Jeong, Ju-Yeon, Kim, Sewha, Kang, Haeyoun, Park, Joonsuk, Kim, Joo-Hang, Han, Ok Jin, Lim, Sun Min, An, Hee Jung · 2020 · Scientific Reports
63. NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism
    Douglas B. Fox, Nina Marie G. Garcia, Brock J. McKinney, Ryan Lupo, Laura C. Noteware, Rachel Newcomb, Juan Liu, Jason W. Locasale, Matthew D. Hirschey, James V. Alvarez · 2020 · Nature Metabolism
64. Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
    Danish Memon, Adam Jacob Schoenfeld, Darwin Ye, George J. Fromm, Hira A. Rizvi, Xiang Zhang, Mohamed Reda Keddar, Divij Mathew, Kyung Jin Yoo, Jingya Qiu et al. · 2024 · Cancer Cell
65. CD8 T Cell Score as a Prognostic Biomarker for Triple Negative Breast Cancer
    Masanori Oshi, Mariko Asaoka, Yoshihisa Tokumaru, Li Yan, Ryusei Matsuyama, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe · 2020 · International Journal of Molecular Sciences
66. Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis
    Sarah Christina Sasson, Stephanie M. Slevin, Vincent Cheung, Isar Nassiri, Anna Claire Olsson-Brown, Eve Fryer, Ricardo C. Ferreira, Dominik Trzupek, Tarun Gupta, Lulia Al‐Hillawi et al. · 2021 · Gastroenterology
67. Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage
    Alessio David Nahmad, Eli Reuveni, Ella Goldschmidt, Tamar Tenne, Meytal Liberman, Miriam Horovitz‐Fried, Rami Khosravi, Hila Kobo, Eyal Reinstein, Asaf Madi et al. · 2022 · Nature Biotechnology
68. Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies
    Qian Liu, Jing Zhang, Chenchen Guo, Mengcheng Wang, Chenfei Wang, Yilv Yan, Liangdong Sun, Di Wang, Lele Zhang, Huansha Yu et al. · 2024 · Cell
69. Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans
    Martínez‐Zamudio, Ricardo I., Dewald, Hannah K., Vasilopoulos, Themistoklis, Gittens‐Williams, Lisa, Fitzgerald‐Bocarsly, Patricia, Herbig, Utz · 2021 · Aging Cell
70. Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment
    Rachael M. Zemek, Emma de Jong, Wee Loong Chin, Iona S. Schuster, Vanessa S. Fear, Thomas H. Casey, Cath Forbes, Sarah Dart, Connull Leslie, Ayham Zaitouny et al. · 2019 · Science Translational Medicine
71. Comprehensive Benchmarking and Integration of Tumor Microenvironment Cell Estimation Methods
    Alejandro Jiménez-Sánchez, Oliver M. Cast, Martin L. Miller · 2019 · Cancer Research
72. GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
    Yeda Wu, Graham K. Murray, Enda M. Byrne, Julia Sidorenko, Peter M. Visscher, Naomi R. Wray · 2021 · Nature Communications
73. Design and analysis of CRISPR–Cas experiments
    Ruth E. Hanna, John G. Doench · 2020 · Nature Biotechnology
74. Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
    Maria Hurskainen, Ivana Mižíková, David P. Cook, Noora Andersson, Chanèle Cyr-Depauw, Flore Lesage, Emmi Helle, Laurent Renesme, Robert P. Jankov, Markku Heikinheimo et al. · 2021 · Nature Communications
75. CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory
    Kidani, Yujiro, Nogami, Wataru, Yasumizu, Yoshiaki, Kawashima, Atsunari, Tanaka, Atsushi, Sonoda, Yudai, Tona, Yumi, Nashiki, Kunitaka, Matsumoto, Reimi, Hagiwara, Masaki et al. · 2022 · Proceedings of the National Academy of Sciences
76. Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
    Benjamin Jacob Drapkin, Julie George, Camilla Laulund Christensen, Mari A. Mino-Kenudson, Ruben Dries, Tilak Kumar Sundaresan, Sarah Phat, David T. Myers, Jun Zhong, Peter Igo et al. · 2018 · Cancer Discovery
77. Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing
    Li, Carman Man-Chung, Shapiro, Hana, Tsiobikas, Christina, Selfors, Laura M., Chen, Huidong, Rosenbluth, Jennifer, Moore, Kaitlin, Gupta, Kushali P., Gray, G. Kenneth, Oren, Yaara et al. · 2020 · Cell Reports
78. Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
    Daniel Chauss, Tilo Freiwald, Reuben McGregor, Bingyu Yan, Luopin Wang, Estefanía Nova‐Lamperti, Dhaneshwar Kumar, Zonghao Zhang, Heather Teague, Erin E. West et al. · 2021 · Nature Immunology
79. Epigenetic regulation during cancer transitions across 11 tumour types
    Nadezhda V. Terekhanova, Alla Y. Karpova, Wen-Wei Liang, Alexander J. Strzalkowski, Siqi Chen, Yize Li, Austin N. Southard-Smith, Michael D. Iglesia, Michael C. Wendl, Reyka G. Jayasinghe et al. · 2023 · Nature
80. Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging
    Kimmel, Jacob C., Penland, Lolita, Rubinstein, Nimrod D., Hendrickson, David G., Kelley, David R., Rosenthal, Adam Z. · 2019 · Genome Research
81. Harnessing genetic complexity to enhance translatability of Alzheimer’s disease mouse models: A path toward precision medicine
    Neuner, Sarah M., Heuer, Sarah E., Huentelman, Matthew J., O’Connell, Kristen M.S., Kaczorowski, Catherine C. · 2019 · Neuron
82. exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids
    Hongyan Lai, Yuchen Li, Hena Zhang, Jia Hu, Jiatao Liao, Ying Su, Qin Li, Bing Chen, Caiping Li, Zhen Wang et al. · 2021 · Nucleic Acids Research
83. High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
    Miyeko Mana, Amanda M. Hussey, Constantine N. Tzouanas, Shinya Imada, Yesenia Barrera Millan, Dorukhan H. Bahceci, Dominic R. Saiz, Anna Webb, Caroline A. Lewis, Peter Carmeliet et al. · 2021 · Cell Reports
84. Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk
    Xin Shao, Chengyu Li, Haihong Yang, Xiaoyan Lu, Jie Liao, Jingyang Qian, Kai Wang, Junyun Cheng, Penghui Yang, Huajun Chen et al. · 2022 · Nature Communications
85. Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin
    Eloïse M. Grasset, Matthew Dunworth, Gaurav Sharma, Melanie Loth, Joseph A. Tandurella, Ashley Cimino‐Mathews, Melissa Gentz, Sydney A. Bracht, Meagan Haynes, Elana Judith Fertig et al. · 2022 · Science Translational Medicine
86. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
    Caroline M. Nievergelt, Adam X. Maihofer, Elizabeth G. Atkinson, Chia‐Yen Chen, Karmel W. Choi, Jonathan R. I. Coleman, Nikolaos P. Daskalakis, Laramie E. Duncan, Renato A Polimanti, Cindy J. Aaronson et al. · 2024 · Nature Genetics
87. Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys
    Malika Aïd, Peter Abbink, Rafael A. Larocca, Michael B. Boyd, Ramya Nityanandam, Ovini Nanayakkara, Amanda Jezek Martinot, Edward T. Moseley, Eryn Blass, Erica N. Borducchi et al. · 2017 · Cell
88. Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery
    Natalie Boehnke, Joelle P. Straehla, Hannah C. Safford, Mustafa Kocak, Matthew G. Rees, Melissa M. Ronan, Danny Rosenberg, Charles H. Adelmann, Raghu R. Chivukula, Namita Nabar et al. · 2022 · Science
89. Genomic–transcriptomic evolution in lung cancer and metastasis
    Carlos Martínez‐Ruiz, James R. Black, Clare Puttick, Mark S. Hill, Jonas Demeulemeester, Elizabeth Larose Cadieux, Kerstin Thol, Thomas Patrick Jones, Selvaraju Veeriah, Cristina Naceur‐Lombardelli et al. · 2023 · Nature
90. Ageing-associated changes in transcriptional elongation influence longevity
    Debès, Cédric, Papadakis, Antonios, Grönke, Sebastian, Karalay, Özlem, Tain, Luke S., Mizi, Athanasia, Nakamura, Shuhei, Hahn, Oliver, Weigelt, Carina, Josipovic, Natasa et al. · 2023 · Nature
91. Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial
    Sandra P. D’Angelo, Shailender Bhatia, Andrew Scott Brohl, Omid Hamid, Janice M. Mehnert, Patrick Andres Maximilian Terheyden, Kent C. Shih, Isaac Brownell, Célèste Lebbé, Karl D. Lewis et al. · 2020 · Journal for ImmunoTherapy of Cancer
92. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
    Linara Gabitova-Cornell, Aizhan Surumbayeva, Suraj Peri, Janusz Franco‐Barraza, Diana Restifo, Nicole Weitz, Charline Ogier, Aaron R. Goldman, Tiffiney R. Hartman, Ralph Francescone et al. · 2020 · Cancer Cell
93. Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence
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94. Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
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