The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy
Open accessAbstract
SUMMARY Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to optimize anti-tumor effects and lower toxicity. However, comprehensive characterization of clock genes and their clinical relevance in cancer is lacking. We systematically characterized the alterations of clock genes across 32 cancer types by analyzing data from TCGA, CTRP, and GDSC databases. Expression alterations of clock genes are associated with key oncogenic pathways, patient survival, tumor stage and subtype in multiple cancer types. Correlations between expression of clock genes and of other genes in the genome were altered in cancerous versus normal tissues. We identified interactions between clock genes and clinically actionable genes by analyzing co-expression, protein-protein interaction and ChIP-seq data, and also found that clock gene expression is correlated to anti-cancer drug sensitivity in cancer cell lines. Our study provides a comprehensive analysis of the circadian clock across different cancer types and highlights potential clinical utility of cancer chronotherapy.
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Pan-cancer analyses suggest kindlin-associated global mechanochemical alterations
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Metadata
- Authors
- Ye, Y., Xiang, Y., Ozguc, F. M., Kim, Y., Liu, C.-J., Park, P. K., Hu, Q., Diao, L., Lou, Y., Lin, C., Guo, A.-Y., Zhou, B., Wang, L., Chen, Z., Takahashi, J. S., Mills, G. B., Yoo, S.-H., & Han, L.
- Venue
- Cell Systems
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 6
- Issue
- 3
- Pages
- 314-328.e2
- ISSN
- 2405-4712 (ISSN-L)
- OpenAlex
- W2791222736
- Cited by
- 310
- References
- 11
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ye, Y., Xiang, Y., Ozguc, F. M., Kim, Y., Liu, C.-J., Park, P. K., Hu, Q., Diao, L., Lou, Y., Lin, C., Guo, A.-Y., Zhou, B., Wang, L., Chen, Z., Takahashi, J. S., Mills, G. B., Yoo, S.-H., & Han, L. (2018). The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy. Cell Systems. https://doi.org/10.1016/j.cels.2018.01.013
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