CoChat
Sign Up
Cited by 122Gastrointestinal motility and disordersAdvanced Chemical Sensor TechnologiesGut microbiota and health

Volatile Organic Compounds in Feces Associate With Response to Dietary Intervention in Patients With Irritable Bowel Syndrome

Open access
Rossi, Megan, Aggio, Raphael, Staudacher, Heidi M., Lomer, Miranda C., Lindsay, James O., Irving, Peter, Probert, Chris, Whelan, Kevin·2018·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2017.09.055
Open this paper in CoChat — free accountOpen PDF

Abstract

Background & aims Dietary interventions are effective in management of patients with irritable bowel syndrome (IBS), although responses vary. We investigated whether fecal levels of volatile organic compounds (VOCs) associate with response to dietary interventions in patients with IBS.Methods Adults who fulfilled the Rome III criteria for IBS were recruited to a 2x2 factorial randomized controlled trial. Patients were randomly assigned to a group counselled to follow a diet low in fructans, galacto-oligosaccharides, lactose, fructose, and polyols (low-FODMAP diet, n = 46) or a group that received placebo dietary advice (sham diet, n = 47) for 4 weeks. Patients from each group were also given either a multi-strain probiotic or placebo supplement. Response was defined as a reduction of 50 points or more on the validated IBS symptom scoring system. Fecal samples were collected from participants at baseline and end of the 4-week study period; VOCs were analyzed by a gas-chromatography sensor device. VOC profiles were determined using a pipeline involving wavelet transformation followed by feature selection based on random forest. A partial least squares classifier was constructed to classify VOC profiles by response and accuracies were determined using 10-fold cross-validation.Results Data from 93 patients who completed the study (63 female) were used in the final analysis. More patients responded to the low-FODMAP diet (37/46, 80%) than the sham diet (21/47, 45%) (P < .001), but there was no difference in response between patients given the probiotic (31/49, 63%) vs the placebo (27/44, 61%) (P = .850), with no interaction between the diet and supplement interventions. At baseline, VOC profiles contained 15 features that classified response to the low-FODMAP diet with a mean accuracy of 97% (95% CI, 96%-99%) and 10 features that classified response to probiotic with a mean accuracy of 89% (95% CI, 86%-92%). End of treatment models achieved similar predictive powers and accuracies.Conclusion Fecal VOC profiling is a low cost, non-invasive tool that might be used to predict responses of patients with IBS to low-FODMAP diet and probiotics and identify their mechanisms of action. ISRCTN registry no: 02275221.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cgh.2017.09.055

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Preliminary data suggest that response to a low FODMAP diet may be predicted from baseline faecal bacterial profile and metabolomic activity, while a gluten-free diet may benefit those with serum antigliadin antibodies.

    “Preliminary data suggest that response to a low FODMAP diet may be predicted from baseline faecal bacterial profile and metabolomic activity, while a gluten-free diet may benefit those with serum antigliadin antibodies.[213][214][215]”

    From British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021) · cites this paper as [214]

  • Which microbial enzymatic repertoire is required for a dietary intervention to be successful depends on the nutrients present in the study diet.

    “Which microbial enzymatic repertoire is required for a dietary intervention to be successful depends on the nutrients present in the study diet (70,494,510).”

    From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [510]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 32 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Staudacher H, Whelan K. The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in irritable bowel syndrome. Gut 2017;66:1517-1527.
  2. Francis CY, Morris J, Whorwell PJ. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syn- drome and its progress. Aliment Pharmacol Ther 1997;11:395-402.
  3. Staudacher HM, Lomer MCE, Farquharson FM, et al. Diet low in FODMAPs reduces symptoms in patients with irritable bowel syndrome and probiotic restores Bifidobacterium species: a randomized controlled trial. Gastroenterology 2017;153:936-947.

Cited by

Sorted by citations

Related

Authors
Rossi, M., Aggio, R., Staudacher, H. M., Lomer, M. C., Lindsay, J. O., Irving, P., Probert, C., & Whelan, K.
Affiliations
  • King's College London (GB)
  • University of Liverpool (GB)
  • Queen Mary University of London (GB)
Corresponding author
Whelan, Kevin
ORCID
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2018-03
Volume
16
Issue
3
Pages
385-391.e1
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2017.09.055
OpenAlex
W2762056035
Cited by
122
References
32
Citations by year
2026: 9 · 2025: 8 · 2024: 14 · 2023: 13 · 2022: 21 · 2021: 13 · 2020: 17 · 2019: 17 · 2018: 10
FWCI
12.62
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by-nc-nd)
  • Own your potential (DEAKIN) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
National Institute for Health and Care Research
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
irritable bowel syndrome, volatile organic compounds, low FODMAP diet, probiotics, treatment response biomarkers, wavelet transform, feature selection, non-invasive biomarkers, nutrition counseling, lactose
MeSH terms
Adult, Diet Therapy, Feces, Female, Humans, Male, Middle Aged, Placebos, Treatment Outcome, Probiotics, Irritable Bowel Syndrome, Volatile Organic Compounds

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review