A role for the gut microbiota in IBS
Abstract
The past decade has witnessed an explosion of knowledge regarding the vast microbial community that resides within our intestine-the gut microbiota. The topic has generated great expectations in terms of gaining a better understanding of disorders ranging from IBD to metabolic disorders and obesity. IBS is a condition for which investigators have long been in search of plausible underlying pathogeneses and it is inevitable that altered composition or function of the gut microbiota will be considered as a potential aetiological factor in at least a subset of patients with IBS. This Review describes the evidence implicating the gut microbiota in not only the expression of the intestinal manifestations of IBS, but also the psychiatric morbidity that coexists in up to 80% of patients with IBS. The evidence described herein ranges from proof-of-concept studies in animals to observational studies and clinical trials in humans. The gut microbiota is subject to influences from a diverse range of factors including diet, antibiotic usage, infection and stress. These factors have previously been implicated in the pathophysiology of IBS and further prompt consideration of a role for the gut microbiota in IBS.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Changes in the F/B ratio are associated with various disorders, such as irritable bowel syndrome and inflammatory bowel disease, as well as with neurodegenerative diseases, such as PD, AD, and ALS.
“Changes in the F/B ratio have been found to be associated with various disorders, such as irritable bowel syndrome and inflammatory bowel disease (97), as well as with neurodegenerative diseases, such as PD, AD, and ALS (98).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [97]
Cites
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works
Dethlefsen, L., & Relman, D. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000087107 · Cited by 2,421 · see citing works
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works
Prebiotic effects: metabolic and health benefits
Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,098 · see citing works
The Long-Term Stability of the Human Gut Microbiota
Faith, J. J., Guruge, J. L., Charbonneau, M., Subramanian, S., Seedorf, H., Goodman, A. L., Clemente, J. C., Knight, R., Heath, A. C., Leibel, R. L., et al. (2013) · Science · doi:10.1126/science.1237439 · Cited by 2,058 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Self-citationThe interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · see citing works
Self-citationBarbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475 · see citing works
Self-citationO’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392 · see citing works
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310 · see citing works
A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome
Halmos, E. P., Power, V. A., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.09.046 · Cited by 1,249 · see citing works
γ-Aminobutyric acid production by culturable bacteria from the human intestine
Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156 · see citing works
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155 · see citing works
Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123 · see citing works
Long-term impacts of antibiotic exposure on the human intestinal microbiota
Jernberg, C., Löfmark, S., Edlund, C., & Jansson, J. K. (2010) · Microbiology · doi:10.1099/mic.0.040618-0 · Cited by 1,067 · see citing works
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041 · see citing works
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024 · see citing works
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works
Dewulf, E. M., Cani, P. D., Claus, S. P., Fuentes, S., Puylaert, P. G., Neyrinck, A. M., Bindels, L. B., de Vos, W. M., Gibson, G. R., Thissen, J.-P., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303304 · Cited by 825 · see citing works
Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome
Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780 · see citing works
Shifting the balance: antibiotic effects on host–microbiota mutualism
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747 · see citing works
The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review
Moayyedi, P., Ford, A. C., Talley, N. J., Cremonini, F., Foxx-Orenstein, A. E., Brandt, L. J., & Quigley, E. M. M. (2010) · Gut · doi:10.1136/gut.2008.167270 · Cited by 728 · see citing works
Böhn, L., Störsrud, S., Törnblom, H., Bengtsson, U., & Simrén, M. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.105 · Cited by 655 · see citing works
Innate immune recognition of the microbiota promotes host-microbial symbiosis
Chu, H., & Mazmanian, S. K. (2013) · Nature Immunology · doi:10.1038/ni.2635 · Cited by 630 · see citing works
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions
Öhman, L., & Simrén, M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.4 · Cited by 617 · see citing works
Visceral pain: a review of experimental studies
Ness, T. J., & Gebhart, G. F. (1990) · Pain · doi:10.1016/0304-3959(90)90021-5 · Cited by 605 · see citing works
Ong, D. K., Mitchell, S. B., Barrett, J. S., Shepherd, S. J., Irving, P. M., Biesiekierski, J. R., Smith, S., Gibson, P. R., & Muir, J. G. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06370.x · Cited by 583 · see citing works
SILK, D. B. A., DAVIS, A., VULEVIC, J., TZORTZIS, G., & GIBSON, G. R. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03911.x · Cited by 551 · see citing works
Collins, S. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70034-3 · Cited by 511 · see citing works
Self-citationPimentel, M., Lin, H. C., Enayati, P., van den Burg, B., Lee, H.-R., Chen, J. H., Park, S., Kong, Y., & Conklin, J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00574.2004 · Cited by 508 · see citing works
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.08.002 · Cited by 501 · see citing works
Small intestinal bacterial overgrowth in patients with irritable bowel syndrome
Posserud, I., Stotzer, P.-O., Björnsson, E. S., Abrahamsson, H., & Simrén, M. (2007) · Gut · doi:10.1136/gut.2006.108712 · Cited by 499 · see citing works
tana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01427.x · Cited by 474 · see citing works
Psychometric scores and persistence of irritable bowel after infectious diarrhoea
Gwee, K., Read, N. W., Graham, J. C., McKendrick, M. W., Collins, S. M., Marshall, J. S., & Walters, S. J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90341-4 · Cited by 466 · see citing works
Self-citationComplex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
Kashyap, P. C., Marcobal, A., Ursell, L. K., Larauche, M., Duboc, H., Earle, K. A., Sonnenburg, E. D., Ferreyra, J. A., Higginbottom, S. K., Million, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.047 · Cited by 451 · see citing works
Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M. (2006) · Gut · doi:10.1136/gut.2005.066100 · Cited by 448 · see citing works
Self-citationPsychometric scores and persistence of irritable bowel after infectious diarrhoea
Ka, G., Graham, J. C., McKendrick, M. W., Collins, S. M., Marshall, J. S., Walters, S., & Read, N. W. (1996) · African journal of medical practice · Cited by 429 · see citing works
Self-citationMicrobes and the gut‐brain axis
Bercik, P., Collins, S. M., & Verdu, E. F. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01906.x · Cited by 417 · see citing works
Self-citationGwee, K.-A. (2003) · Gut · doi:10.1136/gut.52.4.523 · Cited by 415 · see citing works
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling
Anitha, M., Vijay–Kumar, M., Sitaraman, S. V., Gewirtz, A. T., & Srinivasan, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.034 · Cited by 397 · see citing works
Marshall, J. K., Thabane, M. E., Garg, A. X., Clark, W. F., Salvadori, M. I., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.053 · Cited by 370 · see citing works
Self-citationFunctional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome
Chassard, C., Dapoigny, M. C., Scott, K. P., Crouzet, L., Del’Homme, C., Marquet, P., Martin, J. C., Pickering, G. P., Ardid, D., Eschalier, A., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05007.x · Cited by 366 · see citing works
Buhner, S., Li, Q., Vignali, S., Barbara, G., De Giorgio, R., Stanghellini, V., Cremon, C., Zeller, F., Langer, R., Daniel, H., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.005 · Cited by 351 · see citing works
Meta-analysis of probiotics for the treatment of irritable bowel syndrome
McFarland, L. V., & Dublin, S. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2650 · Cited by 341 · see citing works
The microbiome and regulation of mucosal immunity
McDermott, A. J., & Huffnagle, G. B. (2013) · Immunology · doi:10.1111/imm.12231 · Cited by 335 · see citing works
Husebye, E., Hellström, P. M., Sundler, F., Chen, J., & Midtvedt, T. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.3.g368 · Cited by 319 · see citing works
Mättö, J., Maunuksela, L., Kajander, K., Palva, A., Korpela, R., Kassinen, A., & Saarela, M. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.08.009 · Cited by 301 · see citing works
Production, metabolism, and excretion of hydrogen in the large intestine
Christl, S. U., Murgatroyd, P. R., Gibson, G. R., & Cummings, J. H. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90765-q · Cited by 300 · see citing works
Microbial endocrinology: how stress influences susceptibility to infection
Freestone, P. P. E., Sandrini, S. M., Haigh, R. D., & Lyte, M. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2007.11.005 · Cited by 299 · see citing works
A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome
Hoveyda, N., Heneghan, C., Mahtani, K. R., Perera, R., Roberts, N., & Glasziou, P. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-15 · Cited by 297 · see citing works
Marshall, J. K., Thabane, M., Garg, A. X., Clark, W., Meddings, J., Collins, S. M., & for the WEL Investigators (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02284.x · Cited by 292 · see citing works
Self-citationAltered colonic function and microbiota profile in a mouse model of chronic depression
Park, A. J., Collins, J., Blennerhassett, P. A., Ghia, J., Verdu, E. F., Berčík, P., & Collins, S. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12153 · Cited by 291 · see citing works
Self-citationMenees, S. B., Maneerattannaporn, M., Kim, H. M., & Chey, W. D. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.355 · Cited by 283 · see citing works
Stress at the intestinal surface: catecholamines and mucosa–bacteria interactions
Lyte, M., Vulchanova, L., & Brown, D. R. (2011) · Cell and Tissue Research · doi:10.1007/s00441-010-1050-0 · Cited by 281 · see citing works
Probiotics and health: An evidence-based review
Aureli, P., Capurso, L., Castellazzi, A. M., Clerici, M., Giovannini, M., Morelli, L., Poli, A., Pregliasco, F. E., Salvini, F. M., & Zuccotti, G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.02.006 · Cited by 281 · see citing works
Crouzet, L., Gaultier, E., Del'Homme, C., Cartier, C., Delmas, E., Dapoigny, M., Fioramonti, J., & Bernalier‐Donadille, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12103 · Cited by 280 · see citing works
Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma
Russell, S., Gold, M. J., Willing, B. P., Thorson, L., McNagny, K. M., & Finlay, B. B. (2013) · Gut Microbes · doi:10.4161/gmic.23567 · Cited by 279 · see citing works
Prognosis in post-infective irritable bowel syndrome: a six year follow up study
Neal, K. R., Barker, L., & Spiller, R. E. (2002) · Gut · doi:10.1136/gut.51.3.410 · Cited by 274 · see citing works
Gonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V. (2003) · Gut · doi:10.1136/gut.52.1.91 · Cited by 273 · see citing works
Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
Salonen, A., de Vos, W. M., & Palva, A. (2010) · Microbiology · doi:10.1099/mic.0.043257-0 · Cited by 264 · see citing works
Pimentel, M., Mayer, A. G., Park, S., Chow, E. J., Hasan, A. G., & Kong, Y. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1021738515885 · Cited by 260 · see citing works
Li, W., Dowd, S. E., Scurlock, B., Acosta-Martinez, V., & Lyte, M. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.12.004 · Cited by 246 · see citing works
Villani, A., Lemire, M., Thabane, M., Belisle, A., Geneau, G., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., Franchimont, D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.049 · Cited by 244 · see citing works
Self-citationGlycobiome: Bacteria and mucus at the epithelial interface
Ouwerkerk, J. P., de Vos, W. M., & Belzer, C. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.001 · Cited by 228 · see citing works
van der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217 · see citing works
Ki Cha, B., Mun Jung, S., Hwan Choi, C., Song, I.-D., Woong Lee, H., Joon Kim, H., Hyuk, J., Kyung Chang, S., Kim, K., Chung, W.-S., et al. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31823712b1 · Cited by 216 · see citing works
Cremonini, F., & Talley, N. J. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.008 · Cited by 215 · see citing works
Simrén, M., Abrahamsson, H., & Björnsson, E. S. (2001) · Gut · doi:10.1136/gut.48.1.20 · Cited by 209 · see citing works
Collins, S. M., Kassam, Z., & Berčík, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.004 · Cited by 206 · see citing works
Self-citationDifferential Expression of Toll-Like Receptors in Patients With Irritable Bowel Syndrome
Brint, E. K., MacSharry, J., Fanning, A., Shanahan, F., & Quigley, E. M. M. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.438 · Cited by 205 · see citing works
Ford, A. C., & Talley, N. J. (2011) · Journal of Gastroenterology · doi:10.1007/s00535-011-0379-9 · Cited by 200 · see citing works
Knowles, S. R., Nelson, E. A., & Palombo, E. A. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.010 · Cited by 192 · see citing works
Archaea as emerging organisms in complex human microbiomes
Dridi, B., Raoult, D., & Drancourt, M. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.03.001 · Cited by 190 · see citing works
Pyleris, E., Giamarellos‐Bourboulis, E. J., Tzivras, D. M., Koussoulas, V., Barbatzas, C., & Pimentel, M. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2033-7 · Cited by 189 · see citing works
Bourdu, S., Dapoigny, M., Chapuy, E., Artigue, F., Vasson, M.-P., Dechelotte, P., Bommelaer, G., Eschalier, A., & Ardid, D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.082 · Cited by 176 · see citing works
Mucosal cytokine imbalance in irritable bowel syndrome
Macsharry, J., O'Mahony, L., Fanning, A., Bairead, E., Sherlock, G., Tiesman, J., Fulmer, A., Kiely, B., Dinan, T. G., Shanahan, F., et al. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802276127 · Cited by 174 · see citing works
Kim, G., Deepinder, F., Morales, W., Hwang, L. J., Weitsman, S. R., Chang, C., Gunsalus, R. P., & Pimentel, M. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2197-1 · Cited by 169 · see citing works
Langhorst, J., Junge, A., Rueffer, A., Wehkamp, J., Foell, D., Michalsen, A., Musial, F., & Dobos, G. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.86 · Cited by 167 · see citing works
Pimentel, M., Soffer, E., Chow, E. J., Kong, Y., & Lin, H. C. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1021039032413 · Cited by 165 · see citing works
Lyra, A., Rinttilä, T., Nikkilä, J., Krogius-Kurikka, L., Kajander, K., Malinen, E., Mättö, J., Mäkelä, L., & Palva, A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5936 · Cited by 160 · see citing works
Altered peripheral toll-like receptor responses in the irritable bowel syndrome
McKernan, D. P., Gaszner, G., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04624.x · Cited by 160 · see citing works
Maukonen, J., Satokari, R., Mättö, J., Söderlund, H., Mattila-Sandholm, T., & Saarela, M. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46134-0 · Cited by 156 · see citing works
Antibiotic use, childhood affluence and irritable bowel syndrome (IBS)
Mendall, M. A., & Kumar, D. (1998) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199801000-00011 · Cited by 155 · see citing works
Short-Chain Fatty Acids Stimulate Ileal Motility in Humans
Kamath, P. S., Phillips, S. F., & Zinsmeister, A. R. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80068-4 · Cited by 153 · see citing works
Hoffmann, C., Hill, D. A., Minkah, N., Kirn, T., Troy, A., Artis, D., & Bushman, F. (2009) · Infection and Immunity · doi:10.1128/iai.00493-09 · Cited by 142 · see citing works
Increased urine catecholamines and cortisol in women with irritable bowel syndrome.
Heitkemper, M. M., Jarrett, M. E., Cain, K. C., Shaver, J. L. F., Bond, E. F., Woods, N. F., & Walker, E. F. (1996) · PubMed · Cited by 127 · see citing works
Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome
Cox, M. J., Huang, Y. J., Fujimura, K. E., Liu, J. T., McKean, M., Boushey, H. A., Segal, M. R., Brodie, E., Cabana, M. D., & Lynch, S. V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008745 · Cited by 126 · see citing works
Belmonte, L., Beutheu Youmba, S., Bertiaux-Vandaële, N., Antonietti, M., Lecleire, S., Zalar, A., Gourcerol, G., Leroi, A.-M., Déchelotte, P., Coëffier, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042777 · Cited by 126 · see citing works
Review of rifaximin as treatment for SIBO and IBS
Pimentel, M. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780902780175 · Cited by 122 · see citing works
Whelan, K. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32834b8082 · Cited by 120 · see citing works
Corridoni, D., Pastorelli, L., Mattioli, B., Locovei, S., Ishikawa, D., Arseneau, K. O., Chieppa, M., Cominelli, F., & Pizarro, T. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042067 · Cited by 118 · see citing works
The microbiota link to irritable bowel syndrome
Jeffery, I. B., Quigley, E. M. M., Öhman, L., Simrén, M., & O’Toole, P. W. (2012) · Gut Microbes · doi:10.4161/gmic.21772 · Cited by 111 · see citing works
Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis
Ortiz-Lucas, M., Aurelio, T., Saz, P., & Sebastián, J. J. (2013) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082013000100005 · Cited by 103 · see citing works
Rajilić-Stojanović, M. D. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.006 · Cited by 103 · see citing works
The colonic microbiota in health and disease
Shanahan, F. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835a3493 · Cited by 103 · see citing works
Bile Acids Improve the Antimicrobial Effect of Rifaximin
Darkoh, C., Lichtenberger, L. M., Ajami, N. J., Dial, E. J., Jiang, Z., & DuPont, H. L. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00161-10 · Cited by 102 · see citing works
Öhman, L., Isaksson, S., Lundgren, A., Simrén, M., & Sjövall, H. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00410-6 · Cited by 98 · see citing works
Inflammation as a basis for functional GI disorders
Spiller, R. E. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2004.04.002 · Cited by 93 · see citing works
Is the Irritable Gut an Inflamed Gut?
Collins, S. M. (1992) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529209095988 · Cited by 91 · see citing works
Self-citationInstability of the faecal microbiota in diarrhoea-predominant irritable bowel syndrome
Durbán, A., Abellán, J. J., Jiménez-Hernández, N., Artacho, A., Garrigues, V., Ortiz, V., Ponce, J., Latorre, A., & Moya, A. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12184 · Cited by 83 · see citing works
Use of broad-spectrum antibiotics and the development of irritable bowel syndrome.
Villarreal, A. A., Aberger, F. J., Benrud, R., & Gundrum, J. D. (2012) · PubMed · Cited by 79 · see citing works
Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome
Barkhordari, E., Rezaei, N., Ansaripour, B., Larki, P., Alighardashi, M., Ahmadi-Ashtiani, H. R., Mahmoudi, M., Keramati, M.-R., Habibollahi, P., Bashashati, M., et al. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9342-4 · Cited by 78 · see citing works
Vitali, B., Ndagijimana, M., Maccaferri, S., Biagi, E., Guerzoni, M. E., & Brigidi, P. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.04.014 · Cited by 71 · see citing works
Spiegel, B. M. R. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.02.030 · Cited by 67 · see citing works
Furnari, M., Savarino, E. V., Bruzzone, L., Moscatelli, A., Gemignani, L., Giannini, E. G., Zentilin, P., Dulbecco, P., & Savarino (2012) · PubMed · Cited by 63 · see citing works
Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome
Berman, S. M., Suyenobu, B. Y., Naliboff, B. D., Bueller, J. A., Stains, J., Wong, H. Y., Mandelkern, M. A., FitzGerald, L., Ohning, G., Gupta, A., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.08.028 · Cited by 60 · see citing works
Bashashati, M., Rezaei, N., Bashashati, H., Shafieyoun, A., Daryani, N. E., Sharkey, K. A., & Storr, M. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01990.x · Cited by 60 · see citing works
Gastrointestinal motility in patients with the irritable bowel syndrome.
Abrahamsson, H. (1987) · Scandinavian Journal of Gastroenterology, Supplement · doi:10.3109/00365528709090996 · Cited by 35 · see citing works
Brasili, E., Mengheri, E., Tomassini, A., Capuani, G., Roselli, M., Finamore, A., Sciubba, F., Marini, F., & Miccheli, A. (2013) · Journal of Nutrition · doi:10.3945/jn.113.177105 · Cited by 35 · see citing works
Nutten, S., Schumann, A., Donnicola, D., Mercenier, A., Rami, S., & García‐Ródenas, C. L. (2006) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00055-06 · Cited by 20 · see citing works
Rodríguez, Ó., Hernández-Ruiz, J., López‐Vidal, Y., Charúa-Guindic, L., Bandeh-Moghaddam, H., Minzoni, A., Guzmán, C., & Schmulson, M. J. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12204 · Cited by 20 · see citing works
Jørgensen, J. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200750023651 · Cited by 12 · see citing works
Bailey (1999) · doi:10.1002/(sici)1098-2302(199909)35:2
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Gut microbiota are related to Parkinson's disease and clinical phenotype
Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968 · see citing works
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503 · see citing works
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works
De Vadder, F., Grasset, E., Mannerås Holm, L., Karsenty, G., Macpherson, A. J., Olofsson, L. E., & Bäckhed, F. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720017115 · Cited by 566 · see citing works
Tryptophan metabolism and gut-brain homeostasis
Roth, W., Zadeh, K., Vekariya, R., Ge, Y., & Mohamadzadeh, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062973 · Cited by 519 · see citing works
Gut Bacteria and Neurotransmitters
Dicks, L. M. T. (2022) · Microorganisms · doi:10.3390/microorganisms10091838 · Cited by 482 · see citing works
Gut-brain Axis and migraine headache: a comprehensive review
On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS), Arzani, M., Jahromi, S. R., Ghorbani, Z., Vahabizad, F., Martelletti, P., Ghaemi, A., Sacco, S., & Togha, M. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-1078-9 · Cited by 366 · see citing works
Pokusaeva, K., Johnson, C., Luk, B., Uribe, G., Fu, Y., Oezguen, N., Matsunami, R. K., Lugo, M., Major, A., Mori‐Akiyama, Y., et al. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.12904 · Cited by 337 · see citing works
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works
O’Mahony, S. M., Felice, V. D., Nally, K., Savignac, H. M., Claesson, M. J., Scully, P., Woznicki, J., Hyland, N. P., Shanahan, F., Quigley, E. M., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.054 · Cited by 272 · see citing works
Gut inflammation and dysbiosis in human motor neuron disease
Rowin, J., Xia, Y., Jung, B., & Sun, J. (2017) · Physiological Reports · doi:10.14814/phy2.13443 · Cited by 224 · see citing works
“Changes in the ratio of F/B ratio correlate with various human gut disorders, like irritable bowel syndrome (Collins 2014) and inflammatory bowel diseases (Tamboli et al. 2004) and with certain central nervous system disorders like Parkinson’s disease (Sampson et al. 2016).”
BackgroundMethodInfluentialThe influence of the gut microbiome on obesity, metabolic syndrome and gastrointestinal disease
Parekh, P. J., Balart, L. A., & Johnson, D. A. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.16 · Cited by 219 · see citing works
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203 · see citing works
Schepper, J. D., Collins, F. L., Rios-Arce, N. D., Raehtz, S., Schaefer, L., Gardinier, J. D., Britton, R. A., Parameswaran, N., & McCabe, L. R. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3635 · Cited by 182 · see citing works
The role of gut microbiota in bone homeostasis
Behera, J., Ison, J., Tyagi, S. C., & Tyagi, N. (2020) · Bone · doi:10.1016/j.bone.2020.115317 · Cited by 162 · see citing works
Association between gut microbiota and bone health: Potential mechanisms and prospective
Chen, Y.-C., Greenbaum, J., Shen, H., & Deng, H.-W. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00513 · Cited by 165 · see citing works
Flygare, S., Simmon, K., Miller, C., Qiao, Y., Kennedy, B., Di Sera, T., Graf, E. H., Tardif, K. D., Kapusta, A., Rynearson, S., et al. (2016) · Genome Biology · doi:10.1186/s13059-016-0969-1 · Cited by 164 · see citing works
Lenhart, A., & Chey, W. D. (2017) · Advances in Nutrition · doi:10.3945/an.117.015560 · Cited by 160 · see citing works
Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
Harvie, R. M., Chisholm, A. W., Bisanz, J. E., Burton, J. P., Herbison, P., Schultz, K., & Schultz, M. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4632 · Cited by 143 · see citing works
Adding fuel to the fire: the impact of stress on the ageing brain
Prenderville, J. A., Kennedy, P. J., Dinan, T. G., & Cryan, J. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.001 · Cited by 136 · see citing works
Rossi, M., Aggio, R., Staudacher, H. M., Lomer, M. C., Lindsay, J. O., Irving, P., Probert, C., & Whelan, K. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.09.055 · Cited by 122 · see citing works
Functional urological disorders: a sensitized defence response in the bladder–gut–brain axis
Leue, C., Kruimel, J., Vrijens, D., Masclee, A., van Os, J., & van Koeveringe, G. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2016.227 · Cited by 125 · see citing works
KUWAHARA, A., MATSUDA, K., KUWAHARA, Y., ASANO, S., INUI, T., & MARUNAKA, Y. (2020) · Biomedical Research · doi:10.2220/biomedres.41.199 · Cited by 112 · see citing works
Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders
Fila, M., Chojnacki, J., Pawlowska, E., Szczepanska, J., Chojnacki, C., & Blasiak, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810134 · Cited by 50 · see citing works
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works
Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing
Lawrence, K., & Hyde, J. (2017) · PLOS ONE · doi:10.1371/journal.pone.0179017 · Cited by 34 · see citing works
“Our findings are consistent with research suggesting that enhancing gut bacteria, through probiotic interventions, can alleviate some of the symptoms of IBS [17,18]; with the further suggestion that similar digestive improvements may be achieved through dietary therapy.”
BackgroundInfluentialRetractedAl Helo, A., & Department of family medicine, J. M. O. H. (2019) · Journal of Gastroenterology and Hepatology Research · doi:10.17554/j.issn.2224-3992.2019.08.818 · Cited by 3 · see citing works
- Authors
- Collins, S. M.
- Affiliations
- McMaster University Medical Centre (CA)
- Corresponding author
- Collins, Stephen M.
- ORCID
- Collins, Stephen M.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2014-04-22
- Volume
- 11
- Issue
- 8
- Pages
- 497-505
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2059417056
- Cited by
- 351
- References
- 120
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 14 · 2023: 31 · 2022: 31 · 2021: 53 · 2020: 34 · 2019: 37 · 2018: 30 · 2017: 29 · 2016: 29 · 2015: 28 · 2014: 11
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- gut microbiota, irritable bowel syndrome, IBS pathogenesis, diet, antibiotic use, infection, stress
- MeSH terms
- Animals, Anti-Bacterial Agents, Behavior, Brain, Colon, Dietary Carbohydrates, Dietary Fats, Fermentation, Humans, Infections, Intestine, Small, Intestines, Stress, Psychological, Probiotics, Irritable Bowel Syndrome, Prebiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review