Cited by 351Gut microbiota and healthGastrointestinal motility and disordersMicroscopic Colitis

A role for the gut microbiota in IBS

Collins, Stephen M.·2014·Nature Reviews Gastroenterology & Hepatology

Abstract

The past decade has witnessed an explosion of knowledge regarding the vast microbial community that resides within our intestine-the gut microbiota. The topic has generated great expectations in terms of gaining a better understanding of disorders ranging from IBD to metabolic disorders and obesity. IBS is a condition for which investigators have long been in search of plausible underlying pathogeneses and it is inevitable that altered composition or function of the gut microbiota will be considered as a potential aetiological factor in at least a subset of patients with IBS. This Review describes the evidence implicating the gut microbiota in not only the expression of the intestinal manifestations of IBS, but also the psychiatric morbidity that coexists in up to 80% of patients with IBS. The evidence described herein ranges from proof-of-concept studies in animals to observational studies and clinical trials in humans. The gut microbiota is subject to influences from a diverse range of factors including diet, antibiotic usage, infection and stress. These factors have previously been implicated in the pathophysiology of IBS and further prompt consideration of a role for the gut microbiota in IBS.

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Crossref · 10.1038/nrgastro.2014.40

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  • Changes in the F/B ratio are associated with various disorders, such as irritable bowel syndrome and inflammatory bowel disease, as well as with neurodegenerative diseases, such as PD, AD, and ALS.

    “Changes in the F/B ratio have been found to be associated with various disorders, such as irritable bowel syndrome and inflammatory bowel disease (97), as well as with neurodegenerative diseases, such as PD, AD, and ALS (98).”

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Authors
Collins, S. M.
Affiliations
McMaster University Medical Centre (CA)
Corresponding author
Collins, Stephen M.
Venue
Nature Reviews Gastroenterology & Hepatology
Published
2014-04-22
Volume
11
Issue
8
Pages
497-505
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
OpenAlex
W2059417056
Cited by
351
References
120
Citations by year
2026: 7 · 2025: 17 · 2024: 14 · 2023: 31 · 2022: 31 · 2021: 53 · 2020: 34 · 2019: 37 · 2018: 30 · 2017: 29 · 2016: 29 · 2015: 28 · 2014: 11
FWCI
3.04
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Epidemiology › Microscopic Colitis
Keywords
gut microbiota, irritable bowel syndrome, IBS pathogenesis, diet, antibiotic use, infection, stress
MeSH terms
Animals, Anti-Bacterial Agents, Behavior, Brain, Colon, Dietary Carbohydrates, Dietary Fats, Fermentation, Humans, Infections, Intestine, Small, Intestines, Stress, Psychological, Probiotics, Irritable Bowel Syndrome, Prebiotics

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