Cited by 133Chemical Synthesis and AnalysisWnt/β-catenin signaling in development and cancerRNA Interference and Gene Delivery

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Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

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Dietrich, Laura, Rathmer, Bernd, Ewan, Kenneth, Bange, Tanja, Heinrichs, Stefan, Dale, Trevor C., Schade, Dennis, Grossmann, Tom N.·2017·Cell Chemical Biology

DOI 10.1016/j.chembiol.2017.06.013

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Abstract

The Wnt signaling pathway plays a critical role in cell proliferation and differentiation, thus it is often associated with diseases such as cancers. Unfortunately, although attractive, developing anti-cancer strategy targeting Wnt signaling has been challenging given that the most attractive targets are involved in protein-protein interactions (PPIs). Here, we develop a stapled peptide inhibitor that targets the interaction between β-catenin and T cell factor/lymphoid enhancer-binding factor transcription factors, which are crucially involved in Wnt signaling. Our integrative approach combines peptide stapling to optimize proteolytic stability, with lessons learned from cell-penetrating peptide (CPP) design to maximize cellular uptake resulting in NLS-StAx-h, a selective, cell permeable, stapled peptide inhibitor of oncogenic Wnt signaling that efficiently inhibits β-catenin-transcription factor interactions. We expect that this type of integrative strategy that endows stapled peptides with CPP features will be generally useful for developing inhibitors of intracellular PPIs.

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Authors: Dietrich, L., Rathmer, B., Ewan, K., Bange, T., Heinrichs, S., Dale, T. C., Schade, D., & Grossmann, T. N.
Affiliations: Max Planck Society (DE)
TU Dortmund University (DE)
Cardiff University (GB)
Max Planck Institute of Molecular Physiology (DE)
Essen University Hospital (DE)
Corresponding author: Grossmann, Tom N.
ORCID: Ewan, Kenneth
Bange, Tanja
Heinrichs, Stefan
Dale, Trevor C.
Schade, Dennis
Grossmann, Tom N.
Venue: Cell Chemical Biology
Publisher: Elsevier BV
Published: 2017-08
Volume: 24
Issue: 8
Pages: 958-968.e5
ISSN: 2451-9448 (ISSN-L)
2451-9456
DOI: 10.1016/j.chembiol.2017.06.013
OpenAlex: W2741166200
Cited by: 126
References: 98
Citations by year: 2026: 10 · 2025: 4 · 2024: 23 · 2023: 12 · 2022: 13 · 2021: 19 · 2020: 14 · 2019: 14 · 2018: 16 · 2017: 1
FWCI: 5.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 381 d)
Locations: Cell chemical biology (publishedVersion)
PubMed (publishedVersion)
ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
VU Research Portal (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Max-Planck-Gesellschaft
Cancer Research UK (C368/A4545, C368/A7990)
AstraZeneca
European Research Council (678623)
Boehringer Ingelheim
Bayer HealthCare
Bayer CropScience
Deutsche Forschungsgemeinschaft (GR3592/2-1)
Bundesministerium für Bildung und Forschung (131605)
Biotechnology and Biological Sciences Research Council (BB/D00117X/1)
Merck KGaA
Topics: Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: Wnt signaling, β-catenin, protein-protein interaction inhibitors, stapled peptides, cell-penetrating peptides, T-cell factor, nuclear localization signal, membrane permeability, cancer therapy
MeSH terms: Amino Acid Sequence, Cell Membrane Permeability, Cell Movement, HeLa Cells, Humans, Gene Expression, Genes, Reporter, Microscopy, Confocal, Cell Line, Tumor, Cell Proliferation, beta Catenin, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Protein Interaction Domains and Motifs, Cell-Penetrating Peptides, Wnt Signaling Pathway, Axin Protein

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Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

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