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Intestinal changes associated with fluoride exposure in rats: Integrative morphological, proteomic and microbiome analyses
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“exposure to fluoride resulted in a decrease in glutathione (GSH), follicle-stimulating hormone, and gastrotropin levels.34,40,46”
From Effect of Fluoride on Gut Microbiota: A Systematic Review (2025) · cites this paper as [34]
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“exposure to fluoride resulted in a decrease in glutathione (GSH), follicle-stimulating hormone, and gastrotropin levels.34,40,46”
From Effect of Fluoride on Gut Microbiota: A Systematic Review (2025) · cites this paper as [34]
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“exposure to fluoride resulted in a decrease in glutathione (GSH), follicle-stimulating hormone, and gastrotropin levels.34,40,46”
From Effect of Fluoride on Gut Microbiota: A Systematic Review (2025) · cites this paper as [34]
In the citing paper
“These changes resulted in increased expression of proinflammatory cytokines, such as IL-17A and IL-22,10,37 and mucosal sIgA antibody,34,36 that further led to the production of antimicrobial peptides such as CRAMP, β-defensin-1, and β-defensin-3, consequently leading to inflammatory diseases like IBD.10”
From Effect of Fluoride on Gut Microbiota: A Systematic Review (2025) · cites this paper as [34]
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Cites
Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications
Chelakkot, C., Ghim, J., & Ryu, S. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0126-x · Cited by 2,017
The microbiome and disorders of the central nervous system
Felice, V. D., & O'Mahony, S. M. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.016 · Cited by 60
Research works printed but not linked: 91
- Akiniwa, 1997, Re-examination of acute toxicity of fluoride, Fluoride, 30, 89
- Allin, 2015, Mechanisms in endocrinology: gut microbiota in patients with type 2 diabetes mellitus, Eur. J. Endocrinol., 172, R167, 10.1530/EJE-14-0874 · DOI
- Aniwan, 2017, Epidemiology, natural history, and risk stratification of Crohn’s disease, Gastroenterol. Clin. N. Am., 46, 463, 10.1016/j.gtc.2017.05.003 · DOI
- Araujo, 2019, Changes in energy metabolism induced by fluoride: insights from inside the mitochondria, Chemosphere, 236, 124357, 10.1016/j.chemosphere.2019.124357 · DOI
- Ardizzone, 2002, Inflammatory bowel disease: new insights into pathogenesis and treatment, J. Intern. Med., 252, 475, 10.1046/j.1365-2796.2002.01067.x · DOI
- Augenstein, 1991, Fluoride ingestion in children: a review of 87 cases, Pediatrics, 88, 907, 10.1542/peds.88.5.907 · DOI
- Baker, 2012, Widespread genetic switches and toxicity resistance proteins for fluoride, Science, 335, 233, 10.1126/science.1215063 · DOI · Paper page
- Balesaria, 2008, Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea, Eur. J. Gastroenterol. Hepatol., 20, 413, 10.1097/MEG.0b013e3282f41b82 · DOI
- Barbier, 2010, Molecular mechanisms of fluoride toxicity, Chem. Biol. Interact., 188, 319, 10.1016/j.cbi.2010.07.011 · DOI · Paper page
- Bell, 2019, Invited Review: from nose to gut - the role of the microbiome in neurological disease, Neuropathol. Appl. Neurobiol., 45, 195, 10.1111/nan.12520 · DOI
- Boyer, 2007, Differential responses of VIPergic and nitrergic neurons in paediatric patients with Crohn’s disease, Auton. Neurosci. : basic & clinical, 134, 106, 10.1016/j.autneu.2007.03.001 · DOI
- Chiorean, 2014, Transabdominal ultrasound for standardized measurement of bowel wall thickness in normal children and those with Crohn’s disease, Medical ultrasonography, 16, 319
- Chu, 2013, Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility, J. Biol. Chem., 288, 1200, 10.1074/jbc.M112.370718 · DOI
- Collins, 2009, The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease, Gastroenterology, 136, 2003, 10.1053/j.gastro.2009.01.075 · DOI · Paper page
- Csordas, 1996, Butyrate, aspirin and colorectal cancer, Eur. J. Canc. Prev., 5, 221, 10.1097/00008469-199608000-00002 · DOI
- Das, 1994, Toxic effects of chronic fluoride ingestion on the upper gastrointestinal tract, J. Clin. Gastroenterol., 18, 194, 10.1097/00004836-199404000-00004 · DOI
- Davis, 2008, Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool, Proc. Natl. Acad. Sci. U. S. A, 105, 4965, 10.1073/pnas.0801194105 · DOI
- Dionizio, 2018, Effect of duration of exposure to fluoride and type of diet on lipid parameters and de novo lipogenesis, Biol. Trace Elem. Res., 190, 157, 10.1007/s12011-018-1542-4 · DOI
- Dionizio, 2018, Chronic treatment with fluoride affects the jejunum: insights from proteomics and enteric innervation analysis, Sci. Rep., 8, 3180, 10.1038/s41598-018-21533-4 · DOI
- Dionizio, 2020, Effects of acute fluoride exposure on the jejunum and ileum of rats, Sci. Total Environ., 741, 10.1016/j.scitotenv.2020.140419 · DOI
- Dionizio, 2018, Chronic treatment with fluoride affects the jejunum: insights from proteomics and enteric innervation analysis, Sci. Rep., 8, 3180, 10.1038/s41598-018-21533-4 · DOI
- Duan, 2018, Association between water fluoride and the level of children’s intelligence: a dose-response meta-analysis, Publ. Health, 154, 87, 10.1016/j.puhe.2017.08.013 · DOI
- Dunipace, 1995, Effect of aging on animal response to chronic fluoride exposure, J. Dent. Res., 74, 358, 10.1177/00220345950740011201 · DOI
- Fond, 2015, The "psychomicrobiotic": targeting microbiota in major psychiatric disorders: a systematic review, Pathol. Biol., 63, 35, 10.1016/j.patbio.2014.10.003 · DOI · Paper page
- Gessner, 1994, Acute fluoride poisoning from a public water system, N. Engl. J. Med., 330, 95, 10.1056/NEJM199401133300203 · DOI
- Goschorska, 2018, Influence of acetylcholinesterase inhibitors used in alzheimer’s disease treatment on the activity of antioxidant enzymes and the concentration of glutathione in THP-1 macrophages under fluoride-induced oxidative stress, Int. J. Environ. Res. Publ. Health, 16, 10.3390/ijerph16010010 · DOI
- Goto, 2015, The gut microbiota and inflammatory bowel disease, Curr. Opin. Rheumatol., 27, 388, 10.1097/BOR.0000000000000192 · DOI
- Grober, 1999, Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer, J. Biol. Chem., 274, 29749, 10.1074/jbc.274.42.29749 · DOI
- Holzer, 1984, Substance P can contract the longitudinal muscle of the Guinea-pig small intestine by releasing intracellular calcium, Br. J. Pharmacol., 82, 259, 10.1111/j.1476-5381.1984.tb16466.x · DOI
- Houser, 2017, The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?, NPJ Parkinsons Dis, 3, 10.1038/s41531-016-0002-0 · DOI · Paper page
- Iiizumi, 2007, Proteomic characterization of the site-dependent functional difference in the rat small intestine, Biochim. Biophys. Acta, 1774, 1289, 10.1016/j.bbapap.2007.07.012 · DOI
- Johnson, 2015, Impact of dietary deviation on disease progression and gut microbiome composition in lupus-prone SNF1 mice, Clin. Exp. Immunol., 181, 323, 10.1111/cei.12609 · DOI
- Jung, 2004, Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor, Gut, 53, 78, 10.1136/gut.53.1.78 · DOI
- Kang, 2017, Baseline wall thickness is lower in mucosa-healed segments 1 Year after infliximab in pediatric Crohn disease patients, J. Pediatr. Gastroenterol. Nutr., 64, 279, 10.1097/MPG.0000000000001222 · DOI
- Kastl, 2020, The structure and function of the human small intestinal microbiota: current understanding and future directions, Cellular and molecular gastroenterology and hepatology, 9, 33, 10.1016/j.jcmgh.2019.07.006 · DOI
- Keely, 2016, The farnesoid X receptor: good for BAD, Cellular and molecular gastroenterology and hepatology, 2, 725, 10.1016/j.jcmgh.2016.08.004 · DOI
- Landrier, 2006, The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes, Am. J. Physiol. Gastrointest. Liver Physiol., 290, G476, 10.1152/ajpgi.00430.2005 · DOI
- Laserna-Mendieta, 2018, Determinants of reduced genetic capacity for butyrate synthesis by the gut microbiome in Crohn’s disease and ulcerative colitis, J Crohns Colitis, 12, 204, 10.1093/ecco-jcc/jjx137 · DOI
- Lee, 2015, Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases, Int. Res., 13, 11
- Lembeck, 1988, The 1988 ulf euler lecture. Substancce P: from extract to excitement, Acta Physiol. Scand., 133, 435, 10.1111/j.1748-1716.1988.tb08427.x · DOI
- Lerner, 2015, Rheumatoid arthritis-celiac disease relationship: joints get that gut feeling, Autoimmun. Rev., 14, 1038, 10.1016/j.autrev.2015.07.007 · DOI
- Lima Leite, 2014, Proteomic analysis of gastrocnemius muscle in rats with streptozotocin-induced diabetes and chronically exposed to fluoride, PLoS One, 9, 10.1371/journal.pone.0106646 · DOI
- Liu, 2017, NF-kappaB signaling in inflammation, Signal Transduct Target Ther, 2
- Llorente, 2015, The gut microbiota and liver disease, Cellular and molecular gastroenterology and hepatology, 1, 275, 10.1016/j.jcmgh.2015.04.003 · DOI
- Luhrs, 2001, Cytokine-activated degradation of inhibitory kappaB protein alpha is inhibited by the short-chain fatty acid butyrate, Int. J. Colorectal Dis., 16, 195, 10.1007/s003840100295 · DOI
- Luman, 1995, Idiopathic bile acid malabsorption: long-term outcome, Eur. J. Gastroenterol. Hepatol., 7, 641
- Makharia, 2011, Understanding and treating abdominal pain and spasms in organic gastrointestinal diseases: inflammatory bowel disease and biliary diseases, J. Clin. Gastroenterol., 45, S89, 10.1097/MCG.0b013e31821fbd82 · DOI
- Mantyh, 1995, Differential expression of substance P receptors in patients with Crohn’s disease and ulcerative colitis, Gastroenterology, 109, 850, 10.1016/0016-5085(95)90394-1 · DOI
- Mantyh, 1991, Substance P and the inflammatory and immune response, Ann. N. Y. Acad. Sci., 632, 263, 10.1111/j.1749-6632.1991.tb33114.x · DOI
- Marvin-Guy, 2005, Proteomics of the rat gut: analysis of the myenteric plexus-longitudinal muscle preparation, Proteomics, 5, 2561, 10.1002/pmic.200401265 · DOI
- Mazumdar, 1992, Immunocytochemical localization of vasoactive intestinal peptide and substance P in the colon from normal subjects and patients with inflammatory bowel disease, Am. J. Gastroenterol., 87, 176
- McCoy, 2015, New developments providing mechanistic insight into the impact of the microbiota on allergic disease, Clin. Immunol., 159, 170, 10.1016/j.clim.2015.05.007 · DOI
- Melo, 2017, Enteric innervation combined with proteomics for the evaluation of the effects of chronic fluoride exposure on the duodenum of rats, Sci. Rep., 7, 1070, 10.1038/s41598-017-01090-y · DOI
- Munster, 2015, Characterization of somatosensory profiles in patients with Crohn’s disease, Pain Pract., 15, 265, 10.1111/papr.12182 · DOI
- Nopakun, 1990, Mechanism of fluoride absorption from the rat small intestine, Nutr. Res., 10, 771, 10.1016/S0271-5317(05)80826-7 · DOI
- Nopakun, 1989, Fluoride absorption from the gastrointestinal tract of rats, J. Nutr., 119, 1411, 10.1093/jn/119.10.1411 · DOI
- Ooi, 2016, Asia-Pacific consensus statements on Crohn’s disease. Part 2: Management, J. Gastroenterol. Hepatol., 31, 56, 10.1111/jgh.12958 · DOI
- Pereira, 2018, Proposed mechanism for understanding the dose- and time-dependency of the effects of fluoride in the liver, Toxicol. Appl. Pharmacol., 358, 68, 10.1016/j.taap.2018.09.010 · DOI
- Pereira, 2013, Proteomic analysis of liver in rats chronically exposed to fluoride, PLoS One, 8, 10.1371/annotation/54b8fb45-bb22-469e-96b3-77e99ba62b77 · DOI
- Pryde, 2002, The microbiology of butyrate formation in the human colon, FEMS Microbiol. Lett., 217, 133, 10.1111/j.1574-6968.2002.tb11467.x · DOI · Paper page
- Racz, 2017, No change in bicarbonate transport but tight-junction formation is delayed by fluoride in a novel ameloblast model, Front. Physiol., 8, 940, 10.3389/fphys.2017.00940 · DOI
- Rosenbaum, 2017, Ultrasound and MRI predictors of surgical bowel resection in pediatric Crohn disease, Pediatr. Radiol., 47, 55, 10.1007/s00247-016-3704-x · DOI
- Rossel, 1999, Prognosis of adult-onset idiopathic bile acid malabsorption, Scand. J. Gastroenterol., 34, 587, 10.1080/003655299750026047 · DOI
- Sand, 2014, Structural and functional consequences of buserelin-induced enteric neuropathy in rat, BMC Gastroenterol., 14, 209, 10.1186/s12876-014-0209-7 · DOI
- Segain, 2000, Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn’s disease, Gut, 47, 397, 10.1136/gut.47.3.397 · DOI
- Sender, 2016, Revised estimates for the number of human and bacteria cells in the body, PLoS Biol., 14, 10.1371/journal.pbio.1002533 · DOI · Paper page
- Sharma, 2009, Gastric discomforts from fluoride in drinking water in sanganer tehsil, Rajasthan, India, Fluoride, 42, 286
- Shen, 2006, Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure, J. Cell Sci., 119, 2095, 10.1242/jcs.02915 · DOI · Paper page
- Soares, 2015, Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice, BMC Gastroenterol., 15, 3, 10.1186/s12876-015-0228-z · DOI
- Soderholm, 2002, Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn’s disease, Gut, 50, 307, 10.1136/gut.50.3.307 · DOI
- Spak, 1990, Studies of human gastric mucosa after application of 0.42% fluoride gel, J. Dent. Res., 69, 426, 10.1177/00220345900690020101 · DOI
- Strunecka, 2007, Fluoride interactions: from molecules to disease, Curr. Signal Transduct. Ther., 2, 190, 10.2174/157436207781745300 · DOI
- Strunecka, 2019, Chronic fluoride exposure and the risk of autism spectrum disorder, Int. J. Environ. Res. Publ. Health, 16, 10.3390/ijerph16183431 · DOI
- Susheela, 1993, Prevalence of endemic Fluorosis with gastrointestinal manifestations in People living in some North-Indian villages, Fluoride, 26, 97
- Susheela, 1992, vol. 25, 5
- Tai, 2015, The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity, Rev. Endocr. Metab. Disord., 16, 55, 10.1007/s11154-015-9309-0 · DOI
- Tavano, 2012, Neuroimmune interactions in patients with inflammatory bowel diseases: disease activity and clinical behavior based on Substance P serum levels, J Crohns Colitis, 6, 563, 10.1016/j.crohns.2011.11.004 · DOI
- ten Cate, 2019, Fluoride mode of action: once there was an observant dentist, J. Dent. Res., 98, 725, 10.1177/0022034519831604 · DOI
- Thompson, 2017, GATA4 is sufficient to establish jejunal versus ileal identity in the small intestine, Cellular and molecular gastroenterology and hepatology, 3, 422, 10.1016/j.jcmgh.2016.12.009 · DOI
- Trevizol, 2020, Effects of low-level fluoride exposure on glucose homeostasis in female NOD mice, Chemosphere, 254, 126602, 10.1016/j.chemosphere.2020.126602 · DOI
- Vogt, 1982, Acute fluoride poisoning associated with an on-site fluoridator in a Vermont elementary school, Am. J. Publ. Health, 72, 1168, 10.2105/AJPH.72.10.1168 · DOI
- Warburg, 1942, Insulation and crystalisation of the fermenting process of Enolase, Biochem. Z., 310, 384
- Waugh, 2019, The contribution of fluoride to the pathogenesis of eye diseases: molecular mechanisms and implications for Public Health, Int. J. Environ. Res. Publ. Health, 16, 10.3390/ijerph16050856 · DOI
- Wei, 2018, A mini review of fluoride-induced apoptotic pathways, Environ. Sci. Pollut. Res. Int., 25, 33926, 10.1007/s11356-018-3406-z · DOI
- Whitford, 1984, Fluoride absorption: the influence of gastric acidity, Calcif. Tissue Int., 36, 302, 10.1007/BF02405334 · DOI
- Worlicek, 1987, Ultrasound findings in Crohn’s disease and ulcerative colitis: a prospective study, J. Clin. Ultrasound : JCU (J. Clin. Ultrasound), 15, 153, 10.1002/jcu.1870150302 · DOI
- Wright, 2015, Recent advances in characterizing the gastrointestinal microbiome in Crohn’s disease: a systematic review, Inflamm. Bowel Dis., 21, 1219
- Yan, 2012, Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation, PLoS One, 7
- Yasuda, 2017, Fluoride depletes acidogenic taxa in oral but not gut microbial communities in mice, mSystems, 2, 10.1128/mSystems.00047-17 · DOI
- Zheng, 2002, The absorption and excretion of fluoride and arsenic in humans, Toxicol. Lett., 133, 77, 10.1016/S0378-4274(02)00082-6 · DOI
- Zuo, 2018, Toxic effects of fluoride on organisms, Life Sci., 198, 18, 10.1016/j.lfs.2018.02.001 · DOI
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Effect of Fluoride on Gut Microbiota: A Systematic Review
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Metadata
- Authors
- Dionizio, A., Uyghurturk, D. A., Melo, C. G. S., Sabino-Arias, I. T., Araujo, T. T., Ventura, T. M. S., Perles, J. V. C. M., Zanoni, J. N., Den Besten, P., & Buzalaf, M. A. R.
- ORCID
- Venue
- Chemosphere
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 273
- Pages
- 129607
- ISSN
- 0045-6535
- PMC
- PMC8076095
- Cited by
- 21
- References
- 2
- Language
- en
- Licence
- Funders
- University of California, San Francisco
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- National Institutes of Health
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- Dionizio, A., Uyghurturk, D. A., Melo, C. G. S., Sabino-Arias, I. T., Araujo, T. T., Ventura, T. M. S., Perles, J. V. C. M., Zanoni, J. N., Den Besten, P., & Buzalaf, M. A. R. (2021). Intestinal changes associated with fluoride exposure in rats: Integrative morphological, proteomic and microbiome analyses. Chemosphere. https://doi.org/10.1016/j.chemosphere.2021.129607