The microbiome and disorders of the central nervous system
Abstract
Alterations of the gut microbiota have been associated with stress-related disorders including depression and anxiety and irritable bowel syndrome (IBS). More recently, researchers have started investigating the implication of perturbation of the microbiota composition in neurodevelopmental disorders including autism spectrum disorders and Attention-Deficit Hypersensitivity Disorder (ADHD). In this review we will discuss how the microbiota is established and its functions in maintaining health. We also summarize both pre and post-natal factors that shape the developing neonatal microbiota and how they may impact on health outcomes with relevance to disorders of the central nervous system. Finally, we discuss potential therapeutic approaches based on the manipulation of the gut bacterial composition.
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This is the first meta-analysis that systematically reviewed published data and examined microbiota alterations in patients with ASD.
“Although several reviews suggested a microbiota alteration in patients with ASD (28, 30, 55–60), this is the first meta-analysis that systematically reviewed published data and examined microbiota alterations in patients with ASD.”
From Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis (2019) · cites this paper as [56]
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- Authors
- Felice, V. D., & O'Mahony, S. M.
- Affiliations
- University College Cork (IE)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 160
- Pages
- 1-13
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2724933633
- Cited by
- 60
- References
- 190
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland (SFI/12/RC/2273)
- Irish Research Council Enterprise Partnership Scheme Postdoctoral Fellowship (EPSPD/2015/52)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, central nervous system disorders, depression, anxiety, irritable bowel syndrome, autism spectrum disorder, attention deficit hyperactivity disorder, neurodevelopmental disorders, stress-related disorders, prenatal factors, postnatal factors
- MeSH terms
- Gastrointestinal Microbiome, Animals, Central Nervous System Diseases, Feces, Humans, Infant, Newborn, Intestines, Stress, Physiological, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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