Cited by 60Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

The microbiome and disorders of the central nervous system

Felice, Valeria D., O'Mahony, Siobhain M.·2017·Pharmacology Biochemistry and Behavior

Abstract

Alterations of the gut microbiota have been associated with stress-related disorders including depression and anxiety and irritable bowel syndrome (IBS). More recently, researchers have started investigating the implication of perturbation of the microbiota composition in neurodevelopmental disorders including autism spectrum disorders and Attention-Deficit Hypersensitivity Disorder (ADHD). In this review we will discuss how the microbiota is established and its functions in maintaining health. We also summarize both pre and post-natal factors that shape the developing neonatal microbiota and how they may impact on health outcomes with relevance to disorders of the central nervous system. Finally, we discuss potential therapeutic approaches based on the manipulation of the gut bacterial composition.

Integrity signals

Registry

Crossref · 10.1016/j.pbb.2017.06.016

Cites

189 of 189 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • This is the first meta-analysis that systematically reviewed published data and examined microbiota alterations in patients with ASD.

    “Although several reviews suggested a microbiota alteration in patients with ASD (28, 30, 55–60), this is the first meta-analysis that systematically reviewed published data and examined microbiota alterations in patients with ASD.”

Cites

Flagged first, then by citations

1 of the 190 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Felice, V. D., & O'Mahony, S. M.
Affiliations
University College Cork (IE)
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2017-09
Volume
160
Pages
1-13
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2724933633
Cited by
60
References
190
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 2
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Science Foundation Ireland (SFI/12/RC/2273)
  • Irish Research Council Enterprise Partnership Scheme Postdoctoral Fellowship (EPSPD/2015/52)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota, central nervous system disorders, depression, anxiety, irritable bowel syndrome, autism spectrum disorder, attention deficit hyperactivity disorder, neurodevelopmental disorders, stress-related disorders, prenatal factors, postnatal factors
MeSH terms
Gastrointestinal Microbiome, Animals, Central Nervous System Diseases, Feces, Humans, Infant, Newborn, Intestines, Stress, Physiological, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review