CoChat
Sign Up
Cited by 12Pleural and Pulmonary DiseasesEndometriosis Research and TreatmentExtracellular vesicles in disease

Circulating Endometrial Cells in Women with Spontaneous Pneumothorax

Kiss, Imrich, Pospisilova, Eliska, Kolostova, Katarina, Maly, Vilem, Stanek, Ivan, Lischke, Robert, Schutzner, Jan, Pawlak, Ireneusz +1 more·2020·Chest
DOI 10.1016/j.chest.2019.09.008
Open this paper in CoChat — free account

Abstract

Background The occurrence of catamenial pneumothorax (CP) is rare, and the awareness of this diagnosis among physicians is insufficient. CP is highly correlated with pelvic endometriosis and remains the most common form of thoracic endometriosis syndrome. Circulating endometrial cells (CECs) have been previously detected in patients with pelvic endometriosis. Could CECs bring new insights into pneumothorax management?Methods This study aims to describe the occurrence and molecular characteristics of CECs in women with spontaneous pneumothorax (SP) (N = 20) with high suspicion of its catamenial character. CECs were enriched from peripheral blood by size-based separation (MetaCell). In addition to cytomorphology, gene expression profiling of captured cells was performed for 24 endometriosis-associated genes.Results CECs were present in all 20 patients with SP. Enriched CECs exhibited four character features: epithelial, stem cell-like, stroma-like, and glandular. However, not all of them were present in every sampling. Gene expression profiling revealed two distinct phenotypes of CECs in SP and/or CP: one of them refers to the diaphragm openings syndrome and the other to endometrial tissue pleural implantations. Comparisons of the gene expression profiles of CECs in pneumothorax (CECs-SP group) with CECs in pelvic endometriosis (CECs-non-SP group) have revealed significantly higher expression of HER2 in the CECs-SP group compared with the CECs-non-SP group.Conclusions This proof-of-concept study demonstrates successful isolation and characterization of CECs in patients with SP. Identification of CECs in SP could alert endometriosis involvement and help early referral to gynecologic consultation for further examination and treatment.

Integrity signals

Registry

Crossref · 10.1016/j.chest.2019.09.008

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Circulating endometrial cells have been identified in the peripheral blood of patients with spontaneous pneumothorax that is suspicious for catamenial pneumothorax.

    “Kiss et al. have recently identified circulating endometrial cells in the peripheral blood of patients with spontaneous pneumothorax that is suspicious for catamenial pneumothorax.”

    From Thoracic Endometriosis Syndrome: A Comprehensive Review and Multidisciplinary Approach to Management (2024) · cites this paper as [78]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Kiss, I., Pospisilova, E., Kolostova, K., Maly, V., Stanek, I., Lischke, R., Schutzner, J., Pawlak, I., & Bobek, V.
Affiliations
  • Charles University (CZ)
  • Krajská Zdravotní (CZ)
ORCID
Venue
Chest
Publisher
Elsevier BV
Published
2020-02
Volume
157
Issue
2
Pages
342-355
ISSN
0012-3692 (ISSN-L)
DOI
10.1016/j.chest.2019.09.008
OpenAlex
W2974238747
Cited by
12
References
41
Citations by year
2025: 3 · 2024: 3 · 2022: 1 · 2021: 4 · 2020: 1
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • CHEST Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pleural and Pulmonary Diseases
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
spontaneous pneumothorax, catamenial pneumothorax, pelvic endometriosis, thoracic endometriosis, HER2 expression, pleural endometriosis
MeSH terms
Liquid Biopsy, Adult, Endometriosis, Endometrium, Female, Humans, Membrane Proteins, Middle Aged, Pleural Diseases, Pneumothorax, Vimentin, Case-Control Studies, CA-125 Antigen, Mucin-1, Erb-b2 Receptor Tyrosine Kinases, Receptor, ErbB-2, Keratin-18, Young Adult, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review