The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia
Open accessAbstract
Secondary bacterial pneumonia frequently claimed the lives of victims during the devastating 1918 influenza A virus pandemic. Little is known about the viral factors contributing to the lethality of the 1918 pandemic. Here we show that expression of the viral accessory protein PB1-F2 enhances inflammation during primary viral infection of mice and increases both the frequency and severity of secondary bacterial pneumonia. The priming effect of PB1-F2 on bacterial pneumonia could be recapitulated in mice by intranasal delivery of a synthetic peptide derived from the C-terminal portion of the PB1-F2. Relative to its isogenic parent, an influenza virus engineered to express a PB1-F2 with coding changes matching the 1918 pandemic strain was more virulent in mice, induced more pulmonary immunopathology, and led to more severe secondary bacterial pneumonia. These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, in the staphylococcal superinfection model, lack of PB1-F2 significantly decreased mortality either using an isogenic virus (Figure 5A) or using the novel pandemic H1N1 strain that does not code for full-length PB1-F2 (Figure 5B) [34], whereas expression of the more inflammatory PB1-F2 [25] from the 1918 pandemic strain increased mortality.”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [25]
In the citing paper
“The viral cytotoxin PB1-F2 contributed to mortality in this model in a manner similar to that seen with pneumococcus [25], and expression of the pandemic 1918 PB1-F2 enhanced mortality.”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [25]
In the citing paper
“In both models, enhanced inflammatory responses seem to be important in potentiating disease when the virus and the superinfecting bacteria are present together [25].”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [25]
In the citing paper
“We had previously revealed, with use of the pneumococcal secondary infection model, that the increased inflammatory responses caused by expression of the influenza virus cytotoxin PB1-F2 contributed to morbidity and mortality [25].”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [25]
In the citing paper
“Roughly 3-10 days after viral infection, a proinflammatory state characterized by granulocyte and monocyte influx into the lungs amplifies host responses to bacteria, resulting in poor outcomes [23,25,43].”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [25]
In the citing paper
“There seems to be biphasic response to the virus that alters innate responses to the secondary bacterial pathogen.”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673
Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327
TOXIC-SHOCK SYNDROME NOT ASSOCIATED WITH MENSTRUATION
Reingold, A. L., Shands, K. N., Dan, B. B., & Broome, C. V. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92552-1 · Cited by 1,164
Characterization of the 1918 influenza virus polymerase genes
Taubenberger, J. K., Reid, A. H., Lourens, R. M., Wang, R., Jin, G., & Fanning, T. G. (2005) · Nature · doi:10.1038/nature04230 · Cited by 1,054
A novel influenza A virus mitochondrial protein that induces cell death
Chen, W., Calvo, P. A., Malide, D. A., Gibbs, J. S., Schubert, U., Bačík, I., Basta, S., O’Neill, R. E., Schickli, J. H., Palese, P., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1306 · Cited by 1,037
Insights into the Interaction between Influenza Virus and Pneumococcus
McCullers, J. A. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00058-05 · Cited by 846
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
Malley, R., Henneke, P., Morse, S. C., Cieslewicz, M. J., Lipsitch, M., Thompson, C. M., Kurt‐Jones, E. A., Paton, J. C., Wessels, M. R., & Golenbock, D. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0435928100 · Cited by 704
(2013) · Wiley eBooks · doi:10.1002/9781118636817 · Cited by 663
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 391
Hartshorn, K. L. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090880 · Cited by 27
Bui, V. N., Ogawa, H. K., Xininigen, Karibe, K., Matsuo, K., Awad, S. S. A., Minoungou, G. L., Yoden, S., Haneda, H., Ngo, L. H., et al. (2011) · Virology · doi:10.1016/j.virol.2011.11.019 · Cited by 27
Meunier, I., & von Messling, V. (2012) · Journal of Virology · doi:10.1128/jvi.07243-11 · Cited by 27
Host cellular signaling induced by influenza virus
Dai, X., Zhang, L.-S., & Hong, T. (2011) · Science China Life Sciences · doi:10.1007/s11427-010-4116-z · Cited by 27
Silic‐Benussi, M., Marin, O., Biasiotto, R., D’Agostino, D. M., & Ciminale, V. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.030 · Cited by 26
The Effects of Genetic Variation on H7N9 Avian Influenza Virus Pathogenicity
Huang, S., & Wang, S. (2020) · Viruses · doi:10.3390/v12111220 · Cited by 25
Pasricha, G., Mishra, A. C., & Chakrabarti, A. K. (2012) · Influenza and Other Respiratory Viruses · doi:10.1111/j.1750-2659.2012.00400.x · Cited by 25
Zaccara, G., Giovannelli, F., Giorgi, F. S., Franco, V., Gasparini, S., & Tacconi, F. M. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13296 · Cited by 26
Ventilator-Associated Pneumonia in Critically Ill Children
Mourani, P. M., & Sontag, M. K. (2017) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2017.06.005 · Cited by 26
Moatasim, Y., Kandeil, A., Aboulhoda, B. E., El‐Shesheny, R., AlKhazindar, M., AbdElSalam, E. T., Kutkat, O., Kamel, M. N., Taweel, A. N. E., Mostafa, A., et al. (2019) · Viruses · doi:10.3390/v11110990 · Cited by 25
Chronic helminth infections impair pneumococcal vaccine responses
Apiwattanakul, N., Thomas, P. G., Iverson, A., & McCullers, J. A. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.07.107 · Cited by 25
Unravelling the networks dictating host resistance versus tolerance during pulmonary infections
Meunier, I., Kaufmann, E., Downey, J., & Divangahi, M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2572-5 · Cited by 23
Influenza A (H10N7) Virus Causes Respiratory Tract Disease in Harbor Seals and Ferrets
van den Brand, J. M. A., Wohlsein, P., Herfst, S., Bodewes, R., Pfankuche, V. M., van de Bildt, M. W. G., Seehusen, F., Puff, C., Richard, M., Siebert, U., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159625 · Cited by 23
Ménage à trois: Virus, Host, and Microbiota in Experimental Infection Models
Mazel‐Sanchez, B., Yildiz, S., & Schmolke, M. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2018.12.004 · Cited by 25
Water-Borne Nanocoating for Rapid Inactivation of SARS-CoV-2 and Other Viruses
Bobrin, V. A., Chen, S. R., Reyes, C. F. G., Sun, B. F., Ng, C. K., Kim, Y., Purcell, D. F. J., Jia, Z., Gu, W., Armstrong, J. W., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c05075 · Cited by 24
Elderfield, R. A., & Barclay, W. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0204-6_8 · Cited by 27
Antibodies to PB1-F2 protein are induced in response to influenza A virus infection
Krejnusová, I., Gocníková, H., Bystrická, M., Blaškovičová, H., Poláková, K., Yewdell, J. W., Bennink, J. R., & Russ, G. (2009) · Archives of Virology · doi:10.1007/s00705-009-0479-5 · Cited by 24
Zavitz, C. C. J., Bauer, C. M. T., Gaschler, G. J., Fraser, K., Strieter, R. M., Hogaboam, C. M., & Stämpfli, M. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903304 · Cited by 24
Bid and Bim Collaborate during Induction of T Cell Death in Persistent Infection
Masson, F., Kupresanin, F., Mount, A. M., Strasser, A., & Belz, G. T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001918 · Cited by 23
Influenza Viruses: An Introduction
Kawaoka, Y., & Neumann, G. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-621-0_1 · Cited by 23
Demographic and Evolutionary Consequences of Pandemic Diseases
DeWitte, S. N., & Wissler, A. (2021) · Bioarchaeology International · doi:10.5744/bi.2020.0024 · Cited by 25
Tang, Y., Su, R., Gu, Q., Hu, Y., & Yang, H. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105502 · Cited by 22
Zaraket, H., Kondo, H., Hibino, A., Yagami, R., Odagiri, T., Takemae, N., Tsunekuni, R., Saito, T., Myint, Y. Y., Kyaw, Y., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00262 · Cited by 22
The Mouse as Model System to Study Host‐Pathogen Interactions in Influenza A Infections
Wilk, E., & Schughart, K. (2012) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo110173 · Cited by 22
New H6 influenza virus reassortment strains isolated from Anser fabalis in Anhui Province, China
Ge, Y., Chai, H., Fan, Z., Wang, X., Yao, Q., Ma, J., Chen, S., Hua, Y., Deng, G., & Chen, H. (2017) · Virology Journal · doi:10.1186/s12985-017-0680-1 · Cited by 21
Li, Z., Zhao, J., Zhou, H., Li, L., Ding, Y., Li, J., Zhou, B., Jiang, H., Zhong, N., Hu, W., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.03.033 · Cited by 21
Host Detection and the Stealthy Phenotype in Influenza Virus Infection
Dash, P., & Thomas, P. G. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_412 · Cited by 21
Influenza reverse genetics: dissecting immunity and pathogenesis
Ye, S., Evans, J. G., & Stambas, J. (2014) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2014.4 · Cited by 20
Buehler, J., Navi, D., Lorusso, A., Vincent, A. L., Lager, K. M., & Miller, C. L. (2013) · Journal of Virology · doi:10.1128/jvi.01520-13 · Cited by 20
Deventhiran, J., Kumar, S. R. P., Raghunath, S., LeRoith, T., & Elankumaran, S. (2015) · Journal of Virology · doi:10.1128/jvi.01551-15 · Cited by 20
Chen, S., Quan, K., Wang, D., Du, Y., Qin, T., Peng, D., & Liu, X. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.583588 · Cited by 20
Virus‐specific factors associated with zoonotic and pandemic potential
Tejeda, A. R., & Capua, I. (2013) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12075 · Cited by 22
Immunity to Influenza Infection in HumansPreprint
Topham, D. J., DeDiego, M. L., Nogales, A., Sangster, M. Y., & Sant, A. J. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a038729 · Cited by 20
Varghese, P. M., Kishore, U., & Rajkumari, R. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152279 · Cited by 19
Fiat Luc: Bioluminescence Imaging Reveals In Vivo Viral Replication Dynamics
Mehle, A. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005081 · Cited by 19
PB1-F2 expedition from the whole protein through the domain to aa residue function
Košík, I., Hollý, J., & Russ, G. (2013) · Acta Virologica · doi:10.4149/av_2013_02_138 · Cited by 18
The Contribution of Viral Proteins to the Synergy of Influenza and Bacterial Co-Infection
Mikušová, M., Tomčíková, K., Briestenská, K., Kostolanský, F., & Varečková, E. (2022) · Viruses · doi:10.3390/v14051064 · Cited by 19
Hrincius, E. R., Liedmann, S., Finkelstein, D., Vogel, P., Gansebom, S., Ehrhardt, C., Ludwig, S., Hains, D. S., Webby, R. J., & McCullers, J. A. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu609 · Cited by 17
Molecular signatures of virulence in the PB1-F2 proteins of H5N1 influenza viruses
Smith, A. M., & McCullers, J. A. (2013) · Virus Research · doi:10.1016/j.virusres.2013.02.012 · Cited by 17
Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China.
Duan, L., Zhu, H., Wang, J., Huang, K., Cheung, C.-L., Peiris, J. S. M., Chen, H., & Guan, Y. (2011) · PubMed · Cited by 17
Critical Role of HAX-1 in Promoting Avian Influenza Virus Replication in Lung Epithelial Cells
Li, X., Qu, B., He, G., Cardona, C. J., Song, Y., & Xing, Z. (2018) · Mediators of Inflammation · doi:10.1155/2018/3586132 · Cited by 17
Jeannoël, M., Casalegno, J., Ottmann, M., Badiou, C., Dumitrescu, O., Lina, B., & Lina, G. (2018) · Toxins · doi:10.3390/toxins10070286 · Cited by 17
First Season of 2009 H1N1 Influenza
Swedish, K. A., Conenello, G. M., & Factor, S. H. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20164 · Cited by 17
Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures
Solbak, S. M. Ø., Sharma, A. K., Bruns, K., Röder, R., Mitzner, D., Hahn, F., Niebert, R., Vedeler, A., Henklein, P., Henklein, P., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.11.009 · Cited by 16
Na, S., Kim, M., Kim, W., Kim, W. B., Hong, S., Lim, C., Koh, Y., Kwon, J., Hong, S., Lee, S., et al. (2010) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2010.524656 · Cited by 17
Viral PB1-F2 and host IFN-γ guide ILC2 and T cell activity during influenza virus infection
Barman, T. K., Huber, V. C., Bonin, J. L., Califano, D., Salmon, S. L., McKenzie, A. N. J., & Metzger, D. W. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118535119 · Cited by 16
Tang, X., Zhang, H., Song, Y., Zhou, D., & Wang, J. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.25 · Cited by 16
A 627K variant in the PB 2 protein of H9 subtype influenza virus in wild birds
Ge, Y., Yao, Q., Chai, H., Hua, Y., Deng, G., & Chen, H. (2018) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12592 · Cited by 16
Interaction between influenza virus andStreptococcus pneumoniaein severe pneumonia
Madhi, S. A., Schoub, B. D., & Klugman, K. P. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.5.663 · Cited by 16
Chevalier, C., Goffic, R. L., Jamme, F., Leymarie, O., Réfrégiers, M., & Delmas, B. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.710533 · Cited by 16
Pathogenic assessment of avian influenza viruses in migratory birds
Kim, E.-H., Kim, Y., Kim, S., Yu, K.-M., Casel, M. A. B., Jang, S., Pascua, P. N. Q., Webby, R. J., & Choi, Y. K. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.1899769 · Cited by 16
Klonoski, J. M., Watson, T., Bickett, T. E., Svendsen, J. M., Gau, T. J., Britt, A., Nelson, J. T., Schlenker, E. H., Chaussee, M. S., Rynda‐Apple, A., et al. (2018) · Viral Immunology · doi:10.1089/vim.2017.0193 · Cited by 15
Wang, B., Su, Q., Luo, J., Li, M., Wu, Q., Chang, H., Du, J., Huang, C., Ma, J., Han, S., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.593202 · Cited by 15
Palani, S., Bansal, S., Verma, A. K., Bauer, C. D., Shao, S., Uddin, M. B., & Sun, K. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2101135 · Cited by 14
Alymova, I. V., York, I. A., & McCullers, J. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111603 · Cited by 14
Weeks, J. N., Boyd, K. L., Rajam, G., Ades, E. W., & McCullers, J. A. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00057-11 · Cited by 14
Alymova, I. V., McCullers, J. A., Kamal, R. P., Vogel, P., Green, A. M., Gansebom, S., & York, I. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-25707-y · Cited by 15
Safaeyan, F., Nahaei, M. R., Seifi, S. J., Kafil, H. S., & Sadeghi, J. (2015) · German Medical Science GMS Publishing House · doi:10.3205/dgkh000249 · Cited by 13
Host-informed therapies for the treatment of pneumococcal pneumonia
Sundaresh, B., Xu, S., Noonan, B., Mansour, M. K., Leong, J. M., & van Opijnen, T. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.07.008 · Cited by 14
Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia
Qin, Z., Yang, Y., Wang, H., Luo, J., Huang, X., You, J., Wang, B., & Li, M. (2016) · BioMed Research International · doi:10.1155/2016/3801026 · Cited by 13
Impact of HIV on the severity of influenza
Álvarez, D. A. G., López-Cortés, L. F., & Cordero, E. (2016) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2016.1157474 · Cited by 14
Recent advances in nanomedicine therapy for bacterial pneumonia
Jin, W., Liao, L., Qin, T., Guan, X., Gao, H., Liang, P., Gao, M. L., & Lu, J. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.110920 · Cited by 12
The past, present and future of RNA respiratory viruses: influenza and coronaviruses
Makarov, V., Riabova, O., Ekins, S., Pluzhnikov, N., & Chepur, S. (2020) · Pathogens and Disease · doi:10.1093/femspd/ftaa046 · Cited by 13
Effects of PB1-F2 on the pathogenicity of H1N1 swine influenza virus in mice and pigs
Lee, J., Henningson, J. N., Ma, J., Duff, M., Lang, Y., Li, Y., Li, Y., Nagy, A., Sunwoo, S.-Y., Bawa, B., et al. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000695 · Cited by 12
Chevalier, C., Leymarie, O., Sedano, L., da Costa, B. R., Richard, C.-A., Maisonnasse, P., Réfrégiers, M., Jamme, F., & Goffic, R. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100885 · Cited by 11
Trifkovic, S., Gilbertson, B. P., Fairmaid, E. J., Cobbin, J. C. A., Rockman, S. P., & Brown, L. E. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.683152 · Cited by 11
Yadav, A., & Pandey, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1056036 · Cited by 11
What Have We Learned by Resurrecting the 1918 Influenza Virus?
Gilbertson, B. P., & Subbarao, K. (2023) · Annual Review of Virology · doi:10.1146/annurev-virology-111821-104408 · Cited by 13
Pasricha, G., Mukherjee, S., & Chakrabarti, A. K. (2018) · Advances in Virology · doi:10.1155/2018/5057184 · Cited by 11
The role of PB1-F2 in adaptation of high pathogenicity avian influenza virus H7N7 in chickens
Hohensee, L., Scheibner, D., Schäfer, A., Shelton, H. A., Mettenleiter, T. C., Breithaupt, A., Dorhoi, A., Abdelwhab, E. M., & Blohm, U. (2024) · Veterinary Research · doi:10.1186/s13567-023-01257-8 · Cited by 10
Munier, S., Moisy, D., Marc, D., & Naffakh, N. (2010) · Pathologie Biologie · doi:10.1016/j.patbio.2010.01.012 · Cited by 20
Hu, W. (2010) · Natural Science · doi:10.4236/ns.2010.211150 · Cited by 10
Surface glycoproteins determine the feature of the 2009 pandemic H1N1 virus
Kim, J. I., Lee, I., Park, S., & Park, M.-S. (2012) · BMB Reports · doi:10.5483/bmbrep.2012.45.11.137 · Cited by 10
The influenza virus PB1-F2 protein has interferon-antagonistic activity
Dudek, S. E., Wixler, L., Nordhoff, C., Nordmann, A., Anhlan, D., Wixler, V., & Ludwig, S. (2011) · Biological Chemistry · doi:10.1515/bc-2011-174 · Cited by 10
Huo, C., Li, Y., Tang, Y., Su, R., Xu, J., Dong, H. X., Hu, Y., & Yang, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094162 · Cited by 9
Influenza Virus: The Biology of a Changing Virus
Mubareka, S., & Palese, P. (2010) · Springer eBooks · doi:10.1007/978-3-0346-0279-2_1 · Cited by 10
Salzberger, B., Mohr, A., & Hitzenbichler, F. (2018) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-0666-1962 · Cited by 9
Synthesis of full length PB1‐F2 influenza A virus proteins from ‘Spanish flu’ and ‘bird flu’
Röder, R., Bruns, K., Sharma, A. K., Eissmann, A., Hahn, F., Studtrucker, N., Fossen, T., Wray, V., Henklein, P., & Schubert, U. (2008) · Journal of Peptide Science · doi:10.1002/psc.1031 · Cited by 9
Protective Capacity of Statins during Pneumonia Is Dependent on Etiological Agent and Obesity
Karlsson, E. A., Schultz‐Cherry, S., & Rosch, J. W. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00041 · Cited by 9
Evaluation of nasal levels of interferon and clinical severity of influenza in children
Scotta, M. C., Machado, D. G., Oliveira, S. G., de Moura, Â., Estorgato, G. R., de Souza, A. P. D., Porto, B. N., de Araújo, P. D., Sarria, E. E., Pitrez, P. M., et al. (2019) · Journal of Clinical Virology · doi:10.1016/j.jcv.2019.02.003 · Cited by 9
Song, Y., Wu, X., Wang, N., Ouyang, G., Qu, N., Cui, J., Qi, Y., Liao, M., & Jiao, P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01068 · Cited by 8
Vidić, J. (2013) · Journal of Analytical & Bioanalytical Techniques · doi:10.4172/2155-9872.s7-006 · Cited by 8
Ajjaji, D., Richard, C.-A., Mazérat, S., Chevalier, C., & Vidić, J. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.016 · Cited by 8
Low‐pathogenicity avian influenza
Perez, D. R., & de Wit, S. J. (2016) · doi:10.1002/9781118924341.ch11 · Cited by 8
Lee, P. (. Y., Bird, N., MacKenzie‐Kludas, C., Mansell, A., Kedzierska, K., Brown, L., & McAuley, J. (2016) · Immunology & Cell Biology · doi:10.1038/icb.2015.115 · Cited by 7
Wang, Y., Swayze, S., Brown, K. A., MacFadden, D. R., Lee, S. M., Schwartz, K. L., Daneman, N., & Langford, B. J. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae701 · Cited by 7
Wang, S., Zhang, H., Liu, R., Han, P., Yang, Q., Cheng, C., Chen, Y., Rong, Z., Su, C., Li, F., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04107-6 · Cited by 7
The epidemiology of pneumococcal infections—The Swedish experience
Darenberg, J., & Normark, B. H. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.10.088 · Cited by 7
The multifaceted effect of PB1-F2 specific antibodies on influenza A virus infection
Košík, I., Krejnusová, I., Práznovská, M., & Russ, G. (2013) · Virology · doi:10.1016/j.virol.2013.08.022 · Cited by 7
Importance of 1918 virus reconstruction to current assessments of pandemic risk
Belser, J. A., Maines, T. R., & Tumpey, T. M. (2018) · Virology · doi:10.1016/j.virol.2018.08.009 · Cited by 8
Detection of reassortant avian influenza A (H11N9) virus in wild birds in China
Ge, Y., Yao, Q., Wang, X., Chai, H., Deng, G., Chen, H., & Hua, Y. (2018) · Transboundary and Emerging Diseases · doi:10.1111/tbed.13044 · Cited by 7
Cheng, C., Yao, L., Chen, A., Jia, R., Huan, L., Guo, J., Bo, H., Shu, Y., & Zhang, Z. (2008) · Journal of drug targeting · doi:10.1080/10611860802473048 · Cited by 7
Virus sensing receptors in cellular infectivity of influenza A virus
Almatrrouk, S., Saba, I., Abozaid, S. M., Al-Qahtani, A. A., & Al‐Ahdal, M. N. (2021) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.13258 · Cited by 7
Prescott, M. A., & Pastey, M. K. (2010) · Biomarker Insights · doi:10.4137/bmi.s6257 · Cited by 7
Cheung, P. H., Yuen, T., Tang, T., Leung, H., Lee, T. T., Chan, P., Cheng, Y., Fung, S., Ye, Z., Chan, C., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.70062 · Cited by 6
The Role of Punctuated Evolution in the Pathogenicity of Influenza Viruses
McCullers, J. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.ei10-0001-2015 · Cited by 6
Mercan, Y., Atim, G., Kayed, A. E., Azbazdar, M. E., Kandeil, A., Ali, M. A., Rubrum, A. M., McKenzie, P., Webby, R. J., Erima, B., et al. (2021) · Viruses · doi:10.3390/v13040607 · Cited by 6
Monoclonal Antibodies Against the PB1-F2 Protein of H1N1 Influenza A Virus
Nordmann, A., Wixler, L., Ludwig, S., & Wixler, V. (2010) · Hybridoma · doi:10.1089/hyb.2010.0010 · Cited by 6
Structure and function of the influenza virus replication machinery and PB1‐F2
Mehle, A., & McCullers, J. A. (2013) · doi:10.1002/9781118636817.ch8 · Cited by 6
Leneva, I. A., Egorov, A., Falynskova, I. N., Makhmudova, N. R., Павловна, К. Н., Андреевна, Г. Е., Vartanova, N. O., & Поддубиков, А. В. (2019) · Journal of microbiology epidemiology immunobiology · doi:10.36233/0372-9311-2019-1-68-74 · Cited by 5
Metadata
- Authors
- McAuley, J. L., Hornung, F., Boyd, K. L., Smith, A. M., McKeon, R., Bennink, J., Yewdell, J. W., & McCullers, J. A.
- Affiliations
- St. Jude Children's Research Hospital (US)
- National Institute of Allergy and Infectious Diseases (US)
- University of Utah (US)
- Corresponding author
- McCullers, Jonathan A.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 2
- Issue
- 4
- Pages
- 240-249
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC2083255
- OpenAlex
- W1988457839
- Cited by
- 389
- References
- 39
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 18 · 2023: 8 · 2022: 11 · 2021: 17 · 2020: 10 · 2019: 13 · 2018: 22 · 2017: 18 · 2016: 22 · 2015: 22 · 2014: 23 · 2013: 33 · 2012: 31
- FWCI
- 21.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2116 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Lebanese Syrian Associated Charities
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI-54802, AI66349, R21AI054802, R01AI066349)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- PB1-F2, viral accessory proteins, secondary bacterial pneumonia, viral pathogenesis, lung inflammation, immunopathology, virulence, synthetic peptides, bacterial co-infection
- MeSH terms
- Animals, Female, Inflammation, Mice, Inbred BALB C, Orthomyxoviridae Infections, Peptides, Pneumonia, Pneumococcal, Recombinant Proteins, Streptococcus pneumoniae, Viral Proteins, Virulence, Mice, Influenza A Virus, H1N1 Subtype
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
