Cited by 391Influenza Virus Research StudiesRespiratory viral infections researchVirology and Viral Diseases

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia

Open access

McAuley, Julie L., Hornung, Felicita, Boyd, Kelli L., Smith, Amber M., McKeon, Raelene, Bennink, Jack, Yewdell, Jonathan W., McCullers, Jonathan A.·2007·Cell Host & Microbe

DOI 10.1016/j.chom.2007.09.001PMC PMC2083255

Open this paper in CoChat — free account Open PDF

Abstract

Secondary bacterial pneumonia frequently claimed the lives of victims during the devastating 1918 influenza A virus pandemic. Little is known about the viral factors contributing to the lethality of the 1918 pandemic. Here we show that expression of the viral accessory protein PB1-F2 enhances inflammation during primary viral infection of mice and increases both the frequency and severity of secondary bacterial pneumonia. The priming effect of PB1-F2 on bacterial pneumonia could be recapitulated in mice by intranasal delivery of a synthetic peptide derived from the C-terminal portion of the PB1-F2. Relative to its isogenic parent, an influenza virus engineered to express a PB1-F2 with coding changes matching the 1918 pandemic strain was more virulent in mice, induced more pulmonary immunopathology, and led to more severe secondary bacterial pneumonia. These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.chom.2007.09.001

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673
Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327
TOXIC-SHOCK SYNDROME NOT ASSOCIATED WITH MENSTRUATION
Reingold, A. L., Shands, K. N., Dan, B. B., & Broome, C. V. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92552-1 · Cited by 1,164
Characterization of the 1918 influenza virus polymerase genes
Taubenberger, J. K., Reid, A. H., Lourens, R. M., Wang, R., Jin, G., & Fanning, T. G. (2005) · Nature · doi:10.1038/nature04230 · Cited by 1,054
A novel influenza A virus mitochondrial protein that induces cell death
Chen, W., Calvo, P. A., Malide, D. A., Gibbs, J. S., Schubert, U., Bačík, I., Basta, S., O’Neill, R. E., Schickli, J. H., Palese, P., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1306 · Cited by 1,037
Insights into the Interaction between Influenza Virus and Pneumococcus
McCullers, J. A. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00058-05 · Cited by 846
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
Malley, R., Henneke, P., Morse, S. C., Cieslewicz, M. J., Lipsitch, M., Thompson, C. M., Kurt‐Jones, E. A., Paton, J. C., Wessels, M. R., & Golenbock, D. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0435928100 · Cited by 704
Textbook of Influenza
(2013) · Wiley eBooks · doi:10.1002/9781118636817 · Cited by 663

Flagged first, then by citations

Show all 39 references

Sorted by citations

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness
Morens, D. M., Taubenberger, J. K., & Fauci, A. S. (2008) · The Journal of Infectious Diseases · doi:10.1086/591708 · Cited by 1,625
“These include viral neuraminidase (NA)–induced exposure of bacterial adherence receptors; bacterial NA-induced upregulation of influenza infection; interleukin 10 –induced susceptibility to pneumococci and possibly staphylococci [76]; interferon type 1 effects [77]; viral PB1-F2 effects, the proaptotic and mitochondri…”
Background
Emergence and pandemic potential of swine-origin H1N1 influenza virus
Neumann, G., Noda, T., & Kawaoka, Y. (2009) · Nature · doi:10.1038/nature08157 · Cited by 1,590
The co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722
Influenza A viruses: new research developments
Medina, R., & García‐Sastre, A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2613 · Cited by 699
Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes
Gannagé, M., Dormann, D., Albrecht, R., Dengjel, J., Torossi, T., Rämer, P. C., Lee, M., Strowig, T., Arrey, F., Conenello, G., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.09.005 · Cited by 526
Bacterial Coinfection in Influenza: A Grand Rounds Review
Chertow, D. S., & Memoli, M. J. (2013) · JAMA · doi:10.1001/jama.2012.194139 · Cited by 390
A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA
Wise, H. M., Foeglein, Á., Sun, J., Dalton, R. M., Patel, S. N., Howard, W. A., Anderson, E. C., Barclay, W., & Digard, P. (2009) · Journal of Virology · doi:10.1128/jvi.00826-09 · Cited by 382
Back to Nature: Medicinal Plants as Promising Sources for Antibacterial Drugs in the Post-Antibiotic Era
Abdallah, E. M., Alhatlani, B. Y., Menezes, R. D. P., & Martins, C. H. G. (2023) · Plants · doi:10.3390/plants12173077 · Cited by 385
Cellular networks involved in the influenza virus life cycle
Watanabe, T., Watanabe, S., & Kawaoka, Y. (2010) · Cell Host and Microbe · doi:10.1016/j.chom.2010.05.008 · Cited by 355
Cellular MicroRNAs Inhibit Replication of the H1N1 Influenza A Virus in Infected Cells
Song, L., Liu, H., Gao, S., Jiang, W., & Huang, W. (2010) · Journal of Virology · doi:10.1128/jvi.00456-10 · Cited by 295
Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview
Mostafa, A., Abdelwhab, E. M., Mettenleiter, T. C., & Pleschka, S. (2018) · Viruses · doi:10.3390/v10090497 · Cited by 314
Back to the Future: Lessons Learned From the 1918 Influenza Pandemic
Short, K. R., Kedzierska, K., & van de Sandt, C. E. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00343 · Cited by 281
Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis
Yildiz, S., Mazel-Sanchez, B., Kandasamy, M., Manicassamy, B., & Schmolke, M. (2018) · Microbiome · doi:10.1186/s40168-017-0386-z · Cited by 264
Identification of Novel Influenza A Virus Proteins Translated from PA mRNA
Muramoto, Y., Noda, T., Kawakami, E., Akkina, R., & Kawaoka, Y. (2012) · Journal of Virology · doi:10.1128/jvi.02656-12 · Cited by 252
Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease
McAuley, J., Tate, M. D., Mackenzie-Kludas, C., Pinar, A. A., Zeng, W., Stutz, A., Latz, E., Brown, L. E., & Mansell, A. S. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003392 · Cited by 258
Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity
Yoshizumi, T., Ichinohe, T., Sasaki, O., Otera, H., Kawabata, S.-I., Mihara, K., & Koshiba, T. (2014) · Nature Communications · doi:10.1038/ncomms5713 · Cited by 245
The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein
Varga, Z. T., Ramos, I., Hai, R., Schmolke, M., García‐Sastre, A., Fernández-Sesma, A., & Palese, P. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002067 · Cited by 246
Induction and evasion of type I interferon responses by influenza viruses
García‐Sastre, A. (2011) · Virus Research · doi:10.1016/j.virusres.2011.10.017 · Cited by 235
Innate immune responses to influenza A H5N1: friend or foe?
Peiris, J. S. M., Cheung, C. Y., Leung, C. Y. H., & Nicholls, J. M. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.004 · Cited by 232
Norovirus Regulation of the Innate Immune Response and Apoptosis Occurs via the Product of the Alternative Open Reading Frame 4
McFadden, N., Bailey, D., Carrara, G., Benson, A., Chaudhry, Y., Shortland, A., Heeney, J. L., Yarovinsky, F., Peter Simmonds, K., Macdonald, A., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002413 · Cited by 228
Influenza Enhances Susceptibility to Natural Acquisition of and Disease due to Streptococcus pneumoniae in Ferrets
McCullers, J. A., McAuley, J. L., Browall, S., Iverson, A. R., Boyd, K. L., & Henriques Normark, B. (2010) · The Journal of Infectious Diseases · doi:10.1086/656333 · Cited by 218
Self-citation
Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition
Tate, M. D., Ong, J. D. H., Dowling, J. K., McAuley, J., Robertson, A. A. B., Latz, E., Drummond, G. R., Cooper, M. A., Hertzog, P. J., & Mansell, A. S. (2016) · Scientific Reports · doi:10.1038/srep27912 · Cited by 215
Virulence determinants of pandemic influenza viruses
Tscherne, D. M., & García‐Sastre, A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44947 · Cited by 207
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy
Wang, R., Zhu, Y., Ren, C., Yang, S., Tian, S., Chen, H., Jin, M., & Zhou, H. (2020) · Autophagy · doi:10.1080/15548627.2020.1725375 · Cited by 207
Emergence of Fatal Avian Influenza in New England Harbor Seals
Anthony, S. J., Leger, J. S., Pugliares, K. R., Ip, H. S., Chan, J. M., Carpenter, Z., Navarrete‐Macias, I., Sanchez-Leon, M., Saliki, J. T., Pedersen, J. C., et al. (2012) · mBio · doi:10.1128/mbio.00166-12 · Cited by 207
Immune Dysfunction and Bacterial Coinfections following Influenza
Metzger, D. W., & Sun, K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301152 · Cited by 203
Kinetics of Coinfection with Influenza A Virus and Streptococcus pneumoniae
Smith, A. M., Adler, F. R., Ribeiro, R. M., Gutenkunst, R. N., McAuley, J., McCullers, J. A., & Perelson, A. S. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003238 · Cited by 201
Host adaptation and transmission of influenza A viruses in mammals
Schrauwen, E. J. A., & Fouchier, R. A. M. (2014) · Emerging Microbes & Infections · doi:10.1038/emi.2014.9 · Cited by 204
Emerging Roles for the Influenza A Virus Nuclear Export Protein (NEP)
Paterson, D. J., & Fodor, E. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003019 · Cited by 207
Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential
Varga, Z. T., Grant, A., Manicassamy, B., & Palese, P. (2012) · Journal of Virology · doi:10.1128/jvi.01122-12 · Cited by 186
Innate Immune Evasion Strategies of Influenza Viruses
Hale, B. G., Albrecht, R. A., & García‐Sastre, A. (2009) · Future Microbiology · doi:10.2217/fmb.09.108 · Cited by 190
Novel Genotypes of H9N2 Influenza A Viruses Isolated from Poultry in Pakistan Containing NS Genes Similar to Highly Pathogenic H7N3 and H5N1 Viruses
Iqbal, M., Yaqub, T., Reddy, K., & McCauley, J. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005788 · Cited by 181
The Role of Viral, Host, and Secondary Bacterial Factors in Influenza Pathogenesis
Kash, J. C., & Taubenberger, J. K. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.08.030 · Cited by 178
Highly Sensitive Real-Time In Vivo Imaging of an Influenza Reporter Virus Reveals Dynamics of Replication and Spread
Tran, V., Moser, L. A., Poole, D. S., & Mehle, A. (2013) · Journal of Virology · doi:10.1128/jvi.02381-13 · Cited by 178
Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response
Maines, T. R., Szretter, K. J., Perrone, L. A., Belser, J. A., Bright, R. A., Zeng, H., Tumpey, T. M., & Katz, J. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00690.x · Cited by 172
Natural history of highly pathogenic avian influenza H5N1
Sonnberg, S., Webby, R. J., & Webster, R. G. (2013) · Virus Research · doi:10.1016/j.virusres.2013.05.009 · Cited by 171
Influenza virus primes mice for pneumonia from Staphylococcus aureus.
Iverson, A. R., Boyd, K. L., McAuley, J. L., Plano, L. R., Hart, M. E., & McCullers, J. A. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq113 · Cited by 168
PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology
McAuley, J., Chipuk, J. E., Boyd, K. L., Velde, N. V. D., Green, D. R., & McCullers, J. A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001014 · Cited by 164
Influenza A virus infection kinetics: quantitative data and models
Smith, A. M., & Perelson, A. S. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.129 · Cited by 164
Mouse Models of Acute Respiratory Distress Syndrome
Aeffner, F., Bolon, B. N., & Davis, I. C. (2015) · Toxicologic Pathology · doi:10.1177/0192623315598399 · Cited by 157
A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo
Conenello, G. M., Tisoncik-Go, J., Rosenzweig, E., Varga, Z. T., Palese, P., & Katze, M. G. (2010) · Journal of Virology · doi:10.1128/jvi.01987-10 · Cited by 162
The cell surface mucin MUC1 limits the severity of influenza A virus infection
McAuley, J., Corcilius, L., Tan, H.-X., Payne, R. J., McGuckin, M. A., & Brown, L. E. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.16 · Cited by 155
Pathogenesis of Respiratory Viral and Fungal Coinfections
Salazar, F., Bignell, E., Brown, G. D., Cook, P. C., & Warris, A. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00094-21 · Cited by 161
Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus
Pappas, C., Aguilar, P. V., Basler, C. F., Solórzano, A., Zeng, H., Perrone, L. A., Palese, P., García‐Sastre, A., Katz, J. M., & Tumpey, T. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711815105 · Cited by 153
Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species
Schmolke, M., Manicassamy, B., Pena, L., Sutton, T. C., Hai, R., Varga, Z. T., Hale, B. G., Steel, J., Perez, D. R., & García‐Sastre, A. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002186 · Cited by 153
The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein
Mazur, I., Anhlan, D., Mitzner, D., Wixler, L., Schubert, U., & Ludwig, S. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01116.x · Cited by 146
Viral bacterial co-infection of the respiratory tract during early childhood
Brealey, J. C., Sly, P. D., Young, P. R., & Chappell, K. J. (2015) · FEMS Microbiology Letters · doi:10.1093/femsle/fnv062 · Cited by 155
PB1-F2 Expression by the 2009 Pandemic H1N1 Influenza Virus Has Minimal Impact on Virulence in Animal Models
Hai, R., Schmolke, M., Varga, Z. T., Manicassamy, B., Wang, T. T., Belser, J. A., Pearce, M. B., García‐Sastre, A., Tumpey, T. M., & Palese, P. (2010) · Journal of Virology · doi:10.1128/jvi.02717-09 · Cited by 144
The inflammatory response triggered by Influenza virus: a two edged sword
Tavares, L. P., Teixeira, M. M., & Garcia, C. C. (2016) · Inflammation Research · doi:10.1007/s00011-016-0996-0 · Cited by 148
Pathogenesis of influenza virus infections: the good, the bad and the ugly
Kuiken, T., Riteau, B., Fouchier, R. A. M., & Rimmelzwaan, G. F. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.02.013 · Cited by 141
Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis
Smith, A. M., & McCullers, J. A. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_394 · Cited by 139
Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008
Lorusso, A., Vincent, A. L., Harland, M. L., Alt, D. P., Bayles, D. O., Swenson, S. L., Gramer, M. R., Russell, C. A., Smith, D. J., Lager, K. M., et al. (2010) · Journal of General Virology · doi:10.1099/vir.0.027557-0 · Cited by 136
A comprehensive map of the influenza A virus replication cycle
Matsuoka, Y., Matsumae, H., Katoh, M., Eisfeld, A. J., Neumann, G., Hase, T., Ghosh, S., Shoemaker, J. E., Lopes, T. J. S., Watanabe, T., et al. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-97 · Cited by 138
Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications
van der Sluijs, K. F., van der Poll, T., Lutter, R., Juffermans, N. P., & Schultz, M. J. (2010) · Critical Care · doi:10.1186/cc8893 · Cited by 136
Immunopathology in influenza virus infection: Uncoupling the friend from foe
Damjanovic, D., Small, C.-L. N., Jeyananthan, M., McCormick, S. M., & Xing, Z. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.05.005 · Cited by 134
The PA Protein Directly Contributes to the Virulence of H5N1 Avian Influenza Viruses in Domestic Ducks
Song, J., Feng, H., Xu, J., Zhao, D., Shi, J., Li, Y., Deng, G., Jiang, Y., Li, X., Zhu, P., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01975-10 · Cited by 129
Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus
Kim, Y., Pascua, P. N. Q., Kwon, H.-I., Lim, G., Kim, E.-H., Yoon, S., Park, S., Kim, S., Choi, E.-J., Si, Y., et al. (2014) · Emerging Microbes & Infections · doi:10.1038/emi.2014.75 · Cited by 127
Immunomodulatory therapy for severe influenza
Darwish, I., Mubareka, S., & Liles, W. C. (2011) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.11.56 · Cited by 129
Mechanisms of Severe Mortality-Associated Bacterial Co-infections Following Influenza Virus Infection
Jia, L., Xie, J., Zhao, J., Cao, D., Liang, Y., Hou, X., Wang, L., & Li, Z. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00338 · Cited by 128
Alveolar macrophages and type I IFN in airway homeostasis and immunity
Divangahi, M., King, I. L., & Pernet, E. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.03.005 · Cited by 127
Pathogenesis of Pandemic Influenza A (H1N1) and Triple-Reassortant Swine Influenza A (H1) Viruses in Mice
Belser, J. A., Wadford, D. A., Pappas, C., Gustin, K. M., Maines, T. R., Pearce, M. B., Zeng, H., Swayne, D. E., Pantin‐Jackwood, M. J., Katz, J. M., et al. (2010) · Journal of Virology · doi:10.1128/jvi.02742-09 · Cited by 122
Interplay between influenza A virus and the innate immune signaling
Ehrhardt, C., Seyer, R., Hrincius, E. R., Eierhoff, T., Wolff, T., & Ludwig, S. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.09.007 · Cited by 123
NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein
Jaworska, J., Coulombe, F., Downey, J., Tzelepis, F., Shalaby, K. H., Tattoli, I., Bérubé, J., Rousseau, S., Martin, J. G., Girardin, S. E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322118111 · Cited by 120
Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury
Herold, S., Ludwig, S., Pleschka, S., & Wolff, T. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1011530 · Cited by 114
The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis
McAuley, J. L., Zhang, K., & McCullers, J. A. (2010) · Journal of Virology · doi:10.1128/jvi.01785-09 · Cited by 110
Augmented Lung Inflammation Protects against Influenza A Pneumonia
Tuvim, M. J., Evans, S. E., Clement, C. G., Dickey, B. F., & Gilbert, B. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004176 · Cited by 109
Viral and Bacterial Co-Infections in the Lungs: Dangerous Liaisons
Oliva, J., & Terrier, O. (2021) · Viruses · doi:10.3390/v13091725 · Cited by 113
PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus Replication and Host Response
Hu, J., Mo, Y., Wang, X., Gu, M., Hu, Z., Zhong, L., Wu, Q., Hao, X., Hu, S., Liu, W., et al. (2015) · Journal of Virology · doi:10.1128/jvi.02132-14 · Cited by 107
Influenza A Virus Protein PB1-F2 Exacerbates IFN-β Expression of Human Respiratory Epithelial Cells
Goffic, R. L., Bouguyon, E., Chevalier, C., Vidić, J., da Costa, B. R., Leymarie, O., Bourdieu, C., Decamps, L., Dhorne‐Pollet, S., & Delmas, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903952 · Cited by 111
Influenza Circulation and the Burden of Invasive Pneumococcal Pneumonia during a Non‐pandemic Period in the United States
Walter, N. D., Taylor, T. H., Shay, D. K., Thompson, W., Brammer, L., Dowell, S. F., & Moore, M. R. (2009) · Clinical Infectious Diseases · doi:10.1086/649208 · Cited by 105
Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses
Basler, C. F., & Aguilar, P. V. (2008) · Antiviral Research · doi:10.1016/j.antiviral.2008.04.006 · Cited by 104
Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts
Fan, S., Hatta, M., Kim, J., Halfmann, P., Imai, M., Macken, C. A., Le, M. Q., Nguyen, T., Neumann, G., & Kawaoka, Y. (2014) · Nature Communications · doi:10.1038/ncomms6021 · Cited by 104
Treatment with Protein Synthesis Inhibitors Improves Outcomes of Secondary Bacterial Pneumonia after Influenza
Karlström, Å., Boyd, K. L., English, B. K., & McCullers, J. A. (2008) · The Journal of Infectious Diseases · doi:10.1086/596051 · Cited by 104
From where did the 2009 'swine-origin' influenza A virus (H1N1) emerge?
Gibbs, A. J., Armstrong, J. S., & Downie, J. C. (2009) · Virology Journal · doi:10.1186/1743-422x-6-207 · Cited by 103
TRAIL+ monocytes and monocyte‐related cells cause lung damage and thereby increase susceptibility to influenza–Streptococcus pneumoniae coinfection
Ellis, G. T., Davidson, S., Crotta, S., Branzk, N., Papayannopoulos, V., & Wack, A. (2015) · EMBO Reports · doi:10.15252/embr.201540473 · Cited by 102
PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome
Pinar, A. A., Dowling, J. K., Bitto, N. J., Robertson, A. A. B., Latz, E., Stewart, C. R., Drummond, G. R., Cooper, M. A., McAuley, J., Tate, M. D., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.756379 · Cited by 101
Influenza A Virus Infection of Human Primary Dendritic Cells Impairs Their Ability to Cross-Present Antigen to CD8 T Cells
Smed‐Sörensen, A., Chalouni, C. M., Chatterjee, B., Cohn, L. B., Blattmann, P., Nakamura, N., Delamarre, L., & Mellman, I. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002572 · Cited by 107
Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets
Watanabe, T., Watanabe, S., Shinya, K., Kim, J., Hatta, M., & Kawaoka, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806959106 · Cited by 100
Adaptive Mutations Resulting in Enhanced Polymerase Activity Contribute to High Virulence of Influenza A Virus in Mice
Rolling, T., Koerner, I., Zimmermann, P., Holz, K., Haller, O., Staeheli, P., & Kochs, G. (2009) · Journal of Virology · doi:10.1128/jvi.00212-09 · Cited by 97
Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan
Shi, W., Shi, Y., Wu, Y., Liu, D., & Gao, G. F. (2013) · Protein & Cell · doi:10.1007/s13238-013-3083-0 · Cited by 96
Determinants of virulence of influenza A virus
Schrauwen, E. J. A., de Graaf, M., Herfst, S., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2013) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-1984-8 · Cited by 94
Differential Localization and Function of PB1-F2 Derived from Different Strains of Influenza A Virus
Chen, C.-J., Chen, G., Wang, C., Huang, C.-H., Wang, Y.-C., & Shih, S. (2010) · Journal of Virology · doi:10.1128/jvi.00592-10 · Cited by 95
From virus to inflammation, how influenza promotes lung damage
Klomp, M., Ghosh, S., Mohammed, S., & Khan, M. N. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4ru0820-232r · Cited by 95
Current knowledge on PB1-F2 of influenza A viruses
Krumbholz, A., Philipps, A., Oehring, H., Schwarzer, K., Eitner, A., Wutzler, P., & Zell, R. (2010) · Medical Microbiology and Immunology · doi:10.1007/s00430-010-0176-8 · Cited by 95
Immune homeostasis in the respiratory tract and its impact on heterologous infection
Wissinger, E., Goulding, J., & Hussell, T. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.01.005 · Cited by 97
Confronting the next influenza pandemic with anti‐inflammatory and immunomodulatory agents: why they are needed and how they might work
Fedson, D. S. (2009) · Influenza and Other Respiratory Viruses · doi:10.1111/j.1750-2659.2009.00090.x · Cited by 92
Seasonal FluMist Vaccination Induces Cross-Reactive T Cell Immunity against H1N1 (2009) Influenza and Secondary Bacterial Infections
Sun, K., Ye, J., Perez, D. R., & Metzger, D. W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002664 · Cited by 91
Glycan Shielding of the Influenza Virus Hemagglutinin Contributes to Immunopathology in Mice
Wanzeck, K. C., Boyd, K. L., & McCullers, J. A. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201007-1184oc · Cited by 90
Chapter 2 Use of Animal Models to Understand the Pandemic Potential of Highly Pathogenic Avian Influenza Viruses
Belser, J. A., Szretter, K. J., Katz, J. M., & Tumpey, T. M. (2009) · Advances in virus research · doi:10.1016/s0065-3527(09)73002-7 · Cited by 88
The influenza virus PB1-F2 protein has interferon antagonistic activity
Dudek, S. E., Wixler, L., Nordhoff, C., Nordmann, A., Anhlan, D., Wixler, V., & Ludwig, S. (2011) · Biological Chemistry · doi:10.1515/bc.2011.174 · Cited by 89
Immunopathogenic and Antibacterial Effects of H3N2 Influenza A Virus PB1-F2 Map to Amino Acid Residues 62, 75, 79, and 82
Alymova, I. V., Green, A. M., van de Velde, N. C., McAuley, J., Boyd, K. L., Ghoneim, H. E., & McCullers, J. A. (2011) · Journal of Virology · doi:10.1128/jvi.05872-11 · Cited by 89
PB1-F2 Influenza A Virus Protein Adopts a β-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments
Chevalier, C., Bazzal, A. A., Vidić, J., Février, V., Bourdieu, C., Bouguyon, E., Goffic, R. L., Vautherot, J.-F., Bernard, J., Moudjou, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.067710 · Cited by 83
The amazing innate immune response to influenza A virus infection
Tripathi, S., White, M. R., & Hartshorn, K. L. (2013) · Innate Immunity · doi:10.1177/1753425913508992 · Cited by 88
Influenza epidemiology—past, present, and future
Lagacé-Wiens, P. R. S., Rubinstein, E., & Gumel, A. B. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181cbaf34 · Cited by 83
Toll-Like Receptor 2 Mediates Fatal Immunopathology in Mice During Treatment of Secondary Pneumococcal Pneumonia Following Influenza
Karlström, Å., Heston, S. M., Boyd, K. L., TUOMANEN, E. I., & McCullers, J. A. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir522 · Cited by 85
Combined Action of Influenza Virus and Staphylococcus aureus Panton–Valentine Leukocidin Provokes Severe Lung Epithelium Damage
Niemann, S., Ehrhardt, C., Medina, E., Warnking, K., Tuchscherr, L. P. N., Heitmann, V., Ludwig, S., Peters, G., & Löffler, B. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis468 · Cited by 83
The role of influenza in the severity and transmission of respiratory bacterial disease
Mina, M. J., & Klugman, K. P. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70131-6 · Cited by 84
Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice
Carey, M. A., Bradbury, J. A., Rebolloso, Y. D., Graves, J. P., Zeldin, D. C., & Germolec, D. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011610 · Cited by 77
Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein
Goffic, R. L., Leymarie, O., Chevalier, C., Rebours, E., da Costa, B. R., Vidić, J., Descamps, D., Sallenave, J., Rauch, M., Samson, M., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002202 · Cited by 72
Molecular studies of influenza B virus in the reverse genetics era
Jackson, D., Elderfield, R. A., & Barclay, W. (2010) · Journal of General Virology · doi:10.1099/vir.0.026187-0 · Cited by 75

Authors: McAuley, J. L., Hornung, F., Boyd, K. L., Smith, A. M., McKeon, R., Bennink, J., Yewdell, J. W., & McCullers, J. A.
Affiliations: St. Jude Children's Research Hospital (US)
National Institute of Allergy and Infectious Diseases (US)
University of Utah (US)
Corresponding author: McCullers, Jonathan A.
ORCID: McAuley, Julie L.
Boyd, Kelli L.
Smith, Amber M.
Yewdell, Jonathan W.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2007-10
Volume: 2
Issue: 4
Pages: 240-249
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2007.09.001
PMC: PMC2083255
OpenAlex: W1988457839
Cited by: 389
References: 39
Citations by year: 2026: 4 · 2025: 3 · 2024: 18 · 2023: 8 · 2022: 11 · 2021: 17 · 2020: 10 · 2019: 13 · 2018: 22 · 2017: 18 · 2016: 22 · 2015: 22 · 2014: 23 · 2013: 33 · 2012: 31
FWCI: 21.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2116 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Lebanese Syrian Associated Charities
National Institutes of Health
National Institute of Allergy and Infectious Diseases (AI-54802, AI66349, R21AI054802, R01AI066349)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: PB1-F2, viral accessory proteins, secondary bacterial pneumonia, viral pathogenesis, lung inflammation, immunopathology, virulence, synthetic peptides, bacterial co-infection
MeSH terms: Animals, Female, Inflammation, Mice, Inbred BALB C, Orthomyxoviridae Infections, Peptides, Pneumonia, Pneumococcal, Recombinant Proteins, Streptococcus pneumoniae, Viral Proteins, Virulence, Mice, Influenza A Virus, H1N1 Subtype

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks