The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Functional Modularity of the Arginine Catabolic Mobile Element Contributes to the Success of USA300 Methicillin-Resistant Staphylococcus aureus
Open accessAbstract
Summary The successful USA300 Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) lineage predominantly causes skin and soft tissue infections (SSTIs) and is highly associated with carriage of the Arginine Catabolic Mobile Element (ACME). However, the contribution of ACME to USA300 fitness during SSTIs remains incompletely understood. We show that the constitutive ACME-encoded arginine-deiminase system (Arc) allows USA300 to thrive in acidic environments that mimic human skin. Consequently, ACME-Arc drives excessive production of host polyamines, compounds uniquely toxic to S. aureus. To mitigate this, ACME also encodes SpeG, a polyamine-resistance enzyme that is essential for combating excess host polyamines in a murine SSTI model. Inhibiting host polyamine production not only restored ΔspeG persistence within infected wounds but also severely altered the host healing process, implying that polyamines play integral roles in coordinating the wound-healing response. Together, these data underscore the functional modularity of ACME and its contribution to the success of USA300 CA-MRSA.
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Cites
Poring over pores: α-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
Bubeck Wardenburg, J., Bae, T., Otto, M., DeLeo, F. R., & Schneewind, O. (2007) · Nature Medicine · doi:10.1038/nm1207-1405 · Cited by 492
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus
Li, M., Diep, B. A., Villaruz, A. E., Braughton, K. R., Jiang, X., DeLeo, F. R., Chambers, H. F., Lu, Y., & Otto, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900743106 · Cited by 394 · cited 1×
“The increased prevalence of USA300 disease is partially explained by the overproduction of toxins resulting in hypervirulence in animal models (Bubeck Wardenburg et al., 2007; Li et al., 2009; Montgomery et al., 2008).”
BackgroundRichardson, A. R., Libby, S. J., & Fang, F. C. (2008) · Science · doi:10.1126/science.1155207 · Cited by 296
Self-citationWardenburg, J. B., Palazzolo‐Ballance, A. M., Otto, M., Schneewind, O., & DeLeo, F. R. (2008) · The Journal of Infectious Diseases · doi:10.1086/592053 · Cited by 236
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Lipinska, U., Hermans, K., Meulemans, L., Dumitrescu, O., Badiou, C., Duchateau, L., Haesebrouck, F., Etienne, J., & Lina, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022864 · Cited by 100
Cited by
Mobile Genetic Elements Associated with Antimicrobial Resistance
Partridge, S. R., Kwong, S. M., Firth, N., & Jensen, S. O. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00088-17 · Cited by 2,751
Skin microbiota–host interactions
Chen, Y. E., Fischbach, M. A., & Belkaid, Y. (2018) · Nature · doi:10.1038/nature25177 · Cited by 786
Are coagulase-negative staphylococci virulent?
Heilmann, C., Ziebuhr, W., & Becker, K. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.11.012 · Cited by 298
The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus
Alonzo, F., & Torres, V. J. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00055-13 · Cited by 276
Bosi, E., Monk, J. M., Aziz, R. K., Fondi, M., Nizet, V., & Palsson, B. Ø. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523199113 · Cited by 266
Metadata
- Authors
- Thurlow, L. R., Joshi, G. S., Clark, J. R., Spontak, J. S., Neely, C. J., Maile, R., & Richardson, A. R.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 13
- Issue
- 1
- Pages
- 100-107
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2040159335
- Cited by
- 201
- References
- 6
- FWCI
- 15.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thurlow, L. R., Joshi, G. S., Clark, J. R., Spontak, J. S., Neely, C. J., Maile, R., & Richardson, A. R. (2013). Functional Modularity of the Arginine Catabolic Mobile Element Contributes to the Success of USA300 Methicillin-Resistant Staphylococcus aureus. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2012.11.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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