The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens
Open accessAbstract
Summary Inflammasome-mediated host defenses have been extensively studied in innate immune cells. Whether inflammasomes function for innate defense in intestinal epithelial cells, which represent the first line of defense against enteric pathogens, remains unknown. We observed enhanced Salmonella enterica serovar Typhimurium colonization in the intestinal epithelium of caspase-11 deficient mice, but not at systemic sites. In polarized epithelial monolayers, siRNA-mediated depletion of caspase-4, a human orthologue of caspase-11, also led to increased bacterial colonization. Decreased rates of pyroptotic cell death, a host defense mechanism that extrudes S. Typhimurium infected cells from the polarized epithelium, accounted for increased pathogen burdens. The caspase-4 inflammasome also governs activation of the proinflammatory cytokine, interleukin (IL)-18, in response to intracellular (S. Typhimurium) and extracellular (enteropathogenic Escherichia coli) enteric pathogens, via intracellular LPS sensing. Therefore an epithelial cell intrinsic non-canonical inflammasome plays a critical role in antimicrobial defense at the intestinal mucosal surface.
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Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Non-canonical inflammasome activation targets caspase-11
Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136 · cited 1×
“Historically, these IECs have been primarily regarded as a mechanical barrier against invading pathogens, whereas the underlying lamina propria and lymphoid tissues, rich in professional immune cells, are considered the main immunological responders in the gut to pathogenic challenge (Artis, 2008).”
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
Broz, P., Ruby, T., Belhocine, K., Bouley, D. M., Kayagaki, N., Dixit, V. M., & Monack, D. M. (2012) · Nature · doi:10.1038/nature11419 · Cited by 535
Revisiting Caspase-11 Function in Host Defense
Ng, T. M., & Monack, D. M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.009 · Cited by 32
Cited by
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
Shi, J., Gao, W., & Shao, F. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.10.004 · Cited by 3,088
Pyroptotic cell death defends against intracellular pathogens
Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021
The intestinal epithelium: central coordinator of mucosal immunity
Allaire, J. M., Crowley, S. M., Law, H. T., Chang, S.-Y., Ko, H.-J., & Vallance, B. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.04.002 · Cited by 933
Self-citationDiverging inflammasome signals in tumorigenesis and potential targeting
Karki, R., & Kanneganti, T.-D. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0123-y · Cited by 641
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
Birchenough, G. M. H., Nyström, E. E. L., Johansson, M. E. V., & Hansson, G. C. (2016) · Science · doi:10.1126/science.aaf7419 · Cited by 568
Metadata
- Authors
- Knodler, L. A., Crowley, S. M., Sham, H. P., Yang, H., Wrande, M., Ma, C., Ernst, R. K., Steele-Mortimer, O., Celli, J., & Vallance, B. A.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 16
- Issue
- 2
- Pages
- 249-256
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W1970837608
- Cited by
- 435
- References
- 5
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens. https://app.cochat.ai/papers/10.1016/j.chom.2014.07.002
- The paper
- Knodler, L. A., Crowley, S. M., Sham, H. P., Yang, H., Wrande, M., Ma, C., Ernst, R. K., Steele-Mortimer, O., Celli, J., & Vallance, B. A. (2014). Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2014.07.002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
