The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases
Open accessAbstract
The intestinal microbiota, which is composed of bacteria, viruses, and micro-eukaryotes, acts as an accessory organ system with distinct functions along the intestinal tract that are critical for health. This review focuses on how the microbiota drives intestinal disease through alterations in microbial community architecture, disruption of the mucosal barrier, modulation of innate and adaptive immunity, and dysfunction of the enteric nervous system. Inflammatory bowel disease is used as a model system to understand these microbial-driven pathologies, but the knowledge gained in this space is extended to less-well-studied intestinal diseases that may also have an important microbial component, including environmental enteropathy and chronic colitis-associated colorectal cancer.
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“In the gut, the GM and its metabolites have been shown to modulate gastrointestinal functions via their effects on intestinal permeability (32–35), mucosal immune function (36–38), intestinal motility and sensitivity (39, 40), and the enteric nervous system (ENS) (21, 24, 25, 41).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [38]
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Gut microbiome structure and metabolic activity in inflammatory bowel disease
Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L. J., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0306-4 · Cited by 1,995
Self-citationFecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
Baruch, E. N., Youngster, I., Ben-Betzalel, G., Ortenberg, R., Lahat, A., Katz, L., Adler, K., Dick-Necula, D., Raskin, S., Bloch, N., et al. (2021) · Science · doi:10.1126/science.abb5920 · Cited by 1,757
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,357
The Human Gut Microbiome: From Association to Modulation
Schmidt, T. S. B., Raes, J., & Bork, P. (2018) · Cell · doi:10.1016/j.cell.2018.02.044 · Cited by 845
Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808
Metadata
- Authors
- Wlodarska, M., Kostic, A. D., & Xavier, R. J.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Xavier, Ramnik J.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 17
- Issue
- 5
- Pages
- 577-591
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC4498258
- OpenAlex
- W2148770916
- Cited by
- 287
- References
- 166
- Citations by year
- 2026: 6 · 2025: 27 · 2024: 25 · 2023: 19 · 2022: 36 · 2021: 32 · 2020: 31 · 2019: 23 · 2018: 29 · 2017: 27 · 2016: 23 · 2015: 9
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Novartis Repository (Novartis) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092405, U54DK102557, P30DK043351)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- gut microbiota, microbiome-host interactions, inflammatory bowel disease, mucosal barrier disruption, innate immunity, adaptive immunity, enteric nervous system, environmental enteropathy, colitis-associated colorectal cancer
- MeSH terms
- Gastrointestinal Microbiome, Humans, Inflammatory Bowel Diseases, Gastrointestinal Tract, Host-Pathogen Interactions, Dysbiosis
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