An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708

Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila

Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,551

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220

Human Genetics Shape the Gut Microbiome

Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476

A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Scher, J. U., Sczesnak, A., Longman, R. S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202 · Cited by 2,047

Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043

The epidemiology of global micronutrient deficiencies

Bailey, R. L., West Jr., K. P., & Black, R. E. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000371618 · Cited by 2,035

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Mayr, G., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,948

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904

Regional specialization within the intestinal immune system

Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,882

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature · doi:10.1038/nature13828 · Cited by 1,872

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., et al. (2008) · Nature · doi:10.1038/nature07416 · Cited by 1,542

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412

Sphingolipid metabolites in inflammatory disease

Maceyka, M. W., & Spiegel, S. (2014) · Nature · doi:10.1038/nature13475 · Cited by 1,308

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271

Measurement of gastrointestinal pH profiles in normal ambulant human subjects

Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D. (1988) · Gut · doi:10.1136/gut.29.8.1035 · Cited by 1,240

Viruses in the faecal microbiota of monozygotic twins and their mothers

Reyes, A., Haynes, M. R., Hanson, N., Angly, F. E., Heath, A. C., Rohwer, F. L., & Gordon, J. I. (2010) · Nature · doi:10.1038/nature09199 · Cited by 1,230

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

Kostic, A. D., Gevers, D., Siljander, H., Vatanen, T., Hyötyläinen, T., Hämäläinen, A., Peet, A., Tillmann, V., Pöhö, P., Mattila, I. M., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.001 · Cited by 1,198

Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science · doi:10.1126/science.1229000 · Cited by 1,173

Enteric defensins are essential regulators of intestinal microbial ecology

Salzman, N. H., Hung, K., Haribhai, D., Chu, H., Karlsson-Sjöberg, J., Amir, E., Teggatz, P., Barman, M., Hayward, M., Eastwood, D., et al. (2010) · Nature Immunology · doi:10.1038/ni.1825 · Cited by 1,156

γ-Aminobutyric acid production by culturable bacteria from the human intestine

Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156

The indigenous gastrointestinal microflora

Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153 · cited 1×

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples

Segata, N., Haake, S. K., Mannon, P., Lemon, K. P., Waldron, L., Gevers, D., Huttenhower, C., & Izard, J. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r42 · Cited by 1,076

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

Iliev, I. D., Funari, V. A., Taylor, K. D., Nguyen, Q., Reyes, C. N., Strom, S. P., Brown, J., Becker, C. A., Fleshner, P. R., Dubinsky, M., et al. (2012) · Science · doi:10.1126/science.1221789 · Cited by 1,073

Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry

Ejsing, C. S., Sampaio, J. L., Surendranath, V., Duchoslav, E., Ekroos, K., Klemm, R. W., Simons, K., & Shevchenko, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811700106 · Cited by 1,053

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

Ng, K. M., Ferreyra, J. A., Higginbottom, S. K., Lynch, J. B., Kashyap, P. C., Gopinath, S., Naidu, N., Choudhury, B., Weimer, B. C., Monack, D. M., et al. (2013) · Nature · doi:10.1038/nature12503 · Cited by 1,035

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 1,020

Malnutrition and Infection: Complex Mechanisms and Global Impacts

Schaible, U. E., & Kaufmann, S. H. E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040115 · Cited by 991

Bacteria, Colonic Fermentation, and Gastrointestinal Health

Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970

Bacteriophage adhering to mucus provide a non–host-derived immunity

Barr, J. J., Auro, R., Furlan, M., Whiteson, K., Erb, M. L., Pogliano, J., Stotland, A. B., Wolkowicz, R., Cutting, A. S., Doran, K. S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305923110 · Cited by 944

Gender Bias in Autoimmunity Is Influenced by Microbiota

Yurkovetskiy, L., Burrows, M. P., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D. A., Umesaki, Y., & Chervonsky, A. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.013 · Cited by 943

The human gut virome: inter-individual variation and dynamic response to diet

Minot, S., Sinha, R., Chen, J., Li, H., Keilbaugh, S. A., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2011) · Genome Research · doi:10.1101/gr.122705.111 · Cited by 935

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

Cadwell, K., Patel, K., Maloney, N. S., Liu, T., Ng, A., Storer, C. E., Head, R. D., Xavier, R. J., Stappenbeck, T. S., & Virgin, H. W. (2010) · Cell · doi:10.1016/j.cell.2010.05.009 · Cited by 927

The Interaction between Nutrition and Infection

Katona, P., & Katona‐Apte, J. (2008) · Clinical Infectious Diseases · doi:10.1086/587658 · Cited by 925

Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota

Albenberg, L., Esipova, T. V., Judge, C. P., Bittinger, K., Chen, J., Laughlin, A., Grunberg, S., Baldassano, R. N., Lewis, J. D., Li, H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.020 · Cited by 886

Microbes, Microbiota, and Colon Cancer

Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 853

Metagenomic Analyses of an Uncultured Viral Community from Human Feces

Breitbart, M., Hewson, I., Felts, B., Mahaffy, J. M., Nulton, J., Salamon, P., & Rohwer, F. L. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.20.6220-6223.2003 · Cited by 828

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis

Mortha, A., Chudnovskiy, A., Hashimoto, D., Bogunovic, M., Spencer, S. P., Belkaid, Y., & Merad, M. (2014) · Science · doi:10.1126/science.1249288 · Cited by 820

Xenobiotics shape the physiology and gene expression of the active human gut microbiome

Maurice, C. F., Haiser, H. J., & Turnbaugh, P. J. (2013) · Cell · doi:10.1016/j.cell.2012.10.052 · Cited by 811

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y. Y. W., & Bevins, C. L. (2003) · Nature · doi:10.1038/nature01520 · Cited by 765

Effects of short chain fatty acids on gut morphology and function

Scheppach, W. (1994) · Gut · doi:10.1136/gut.35.1_suppl.s35 · Cited by 756

Intestinal Alkaline Phosphatase Detoxifies Lipopolysaccharide and Prevents Inflammation in Zebrafish in Response to the Gut Microbiota

Bates, J. M., Akerlund, J., Mittge, E., & Guillemin, K. J. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.10.010 · Cited by 752

Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation

Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 751

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.001 · Cited by 732

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

Petrof, E. O., Gloor, G. B., Vanner, S. J., Weese, S. J., Carter, D., Daigneault, M. C., Brown, E. M., Schroeter, K., & Allen-Vercoe, E. (2013) · Microbiome · doi:10.1186/2049-2618-1-3 · Cited by 731

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K. D., Berres, M., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.050 · Cited by 727

The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates

Zoetendal, E. G., Raes, J., van den Bogert, B., Arumugam, M., Booijink, C. C. G. M., Troost, F. J., Bork, P., Wels, M., de Vos, W. M., & Kleerebezem, M. (2012) · The ISME Journal · doi:10.1038/ismej.2011.212 · Cited by 722

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.026 · Cited by 708

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta

Haiser, H. J., Gootenberg, D. B., Chatman, K., Sirasani, G., Balskus, E. P., & Turnbaugh, P. J. (2013) · Science · doi:10.1126/science.1235872 · Cited by 704 · cited 2×

New Insights on Classification, Identification, and Clinical Relevance ofBlastocystisspp

Tan, K. S. W. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00022-08 · Cited by 701

Metagenomics and future perspectives in virus discovery

Mokili, J. L., Rohwer, F. L., & Dutilh, B. E. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.12.004 · Cited by 686

Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.

Heller, F., Fuss, I., Nieuwenhuis, E., Blumberg, R., & Strober, W. (2002) · Immunity · doi:10.1016/s1074-7613(02)00453-3 · Cited by 648

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

An, D., Oh, S. F., Olszak, T., Neves, J. F., Avci, F. Y., Erturk-Hasdemir, D., Lu, X., Zeissig, S., Blumberg, R. S., & Kasper, D. L. (2014) · Cell · doi:10.1016/j.cell.2013.11.042 · Cited by 643

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642

Rapid evolution of the human gut virome

Minot, S. S., Bryson, A. L., Chehoud, C., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300833110 · Cited by 594

Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host

Strauss, J., Kaplan, G. G., Beck, P. L., Rioux, K. P., Panaccione, R., DeVinney, R., Lynch, T., & Allen‐Vercoe, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21606 · Cited by 578

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

Goto, Y., Obata, T., Kunisawa, J., Sato, S., Ivanov, I. I., Lamichhane, A., Takeyama, N., Kamioka, M., Sakamoto, M., Matsuki, T., et al. (2014) · Science · doi:10.1126/science.1254009 · Cited by 568

Towards the Human Colorectal Cancer Microbiome

Marchesi, J. R., Dutilh, B. E., Hall, N., Peters, W. H. M., Roelofs, R., Boleij, A., & Tjalsma, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020447 · Cited by 552

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

Pickard, J. M., Maurice, C. F., Kinnebrew, M. A., Abt, M. C., Schenten, D., Golovkina, T. V., Bogatyrev, S. R., Ismagilov, R. F., Pamer, E. G., Turnbaugh, P. J., et al. (2014) · Nature · doi:10.1038/nature13823 · Cited by 550

Water, sanitation, and hygiene (WASH), environmental enteropathy, nutrition, and early child development: making the links

Ngure, F. M., Reid, B. M., Humphrey, J. H., Mbuya, M. N. N., Pelto, G. H., & Stoltzfus, R. J. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12330 · Cited by 538

Fusobacterium Is Associated with Colorectal Adenomas

McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 533

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

Haberman, Y., Tickle, T. L., Dexheimer, P. J., Kim, M., Tang, D., Karns, R. A., Baldassano, R. N., Noe, J. D., Rosh, J. R., Markowitz, J. F., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75436 · Cited by 531

An enteric virus can replace the beneficial function of commensal bacteria

Kernbauer, E., Ding, Y., & Cadwell, K. (2014) · Nature · doi:10.1038/nature13960 · Cited by 527

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

Yang, Y., Torchinsky, M. B., Gobert, M., Xiong, H., Xu, M., Linehan, J. L., Alonzo, F., Ng, C., Chen, A., Lin, X., et al. (2014) · Nature · doi:10.1038/nature13279 · Cited by 520

Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni

Lecuit, M., Abachin, É., Martin, A., Poyart, C., Pochart, P., Suárez, F., Bengoufa, D., Feuillard, J., Lavergne‐Slove, A., Gordon, J. I., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031887 · Cited by 461

Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis

Rigottier‐Gois, L. (2013) · The ISME Journal · doi:10.1038/ismej.2013.80 · Cited by 451

Environmental enteropathy: critical implications of a poorly understood condition

Korpe, P. S., & Petri, W. A. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.04.007 · Cited by 449

Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-Nitrosoglutathione

Savidge, T., Newman, P., Pothoulakis, C., Rühl, A., Neunlist, M., Bourreille, A., Hurst, R. D., & Sofroniew, M. V. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.051 · Cited by 435

Immune Responses to the Microbiota at the Intestinal Mucosal Surface

Duerkop, B. A., Vaishnava, S., & Hooper, L. V. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.009 · Cited by 424

Complex host genetics influence the microbiome in inflammatory bowel disease

Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A. D., van Sommeren, S., Imhann, F., Stempak, J. M., et al. (2014) · Genome Medicine · doi:10.1186/s13073-014-0107-1 · Cited by 418

Intestinal absorption of water-soluble vitamins in health and disease

Said, H. M. (2011) · Biochemical Journal · doi:10.1042/bj20110326 · Cited by 416

Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid

Chyan, Y., Pöeggeler, B., Omar, R., Chain, D. G., Frangione, B., Ghiso, J. A., & Pappolla, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21937 · Cited by 409

Human interdigestive motility: variations in patterns from esophagus to colon.

Kellow, J., Borody, T., Phillips, S., Tucker, R., & Haddad, A. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90573-1 · Cited by 397

Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

Cullen, T. W., Schofield, W. B., Barry, N. A., Putnam, E. E., Rundell, E. A., Trent, M. S., Degnan, P. H., Booth, C. J., Yu, H., & Goodman, A. L. (2015) · Science · doi:10.1126/science.1260580 · Cited by 395

Variable geographic distribution of Blastocystis subtypes and its potential implications

Alfellani, M. A., Stensvold, C. R., Vidal-Lapiedra, A., Onuoha, E. S. U., Fagbenro-Beyioku, A. F., & Clark, C. G. (2013) · Acta Tropica · doi:10.1016/j.actatropica.2012.12.011 · Cited by 390

Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging

He, G., Shankar, R. A., Chzhan, M., Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4586 · Cited by 383

Immunoproliferative small intestinal disease associated with Campylobacter jejuni

Mesnard, B., Vroey, B. D., Maunoury, V., & Lecuit, M. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.03.020 · Cited by 382

Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition

Goldberg, R. F., Austen, W., Zhang, X.-B., Munene, G., Mostafa, G., Biswas, S., McCormack, M., Eberlin, K., Nguyen, J. T., Tatlıdede, H. S., et al. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0712140105 · Cited by 381

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

Kau, A. L., Planer, J. D., Liu, J., Rao, S. M., Yatsunenko, T., Trehan, I., MANARY, M. J., Liu, T., Stappenbeck, T. S., Maleta, K. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4877 · Cited by 376

The Multifaceted Role of the Intestinal Microbiota in Colon Cancer

Irrazábal, T., Belcheva, A., Girardin, S. E., Martín, A., & Philpott, D. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.039 · Cited by 361

Microbiota controls the homeostasis of glial cells in the gut lamina propria

Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S., & Pachnis, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.037 · Cited by 358

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

Larsson, J. M. H., Karlsson, H., Crespo, J. G., Johansson, M., Eklund, L., Sjövall, H., & Hansson, G. C. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21625 · Cited by 355

Household Environmental Conditions Are Associated with Enteropathy and Impaired Growth in Rural Bangladesh

Lin, A., Arnold, B. F., Afreen, S., Goto, R., Huda, T. M. N., Haque, R., Raqib, R., UNICOMB, L. E., Ahmed, T., Colford, J. M., et al. (2013) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.12-0629 · Cited by 347

Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?

Cornet, A. M., Savidge, T., Cabarrocas, J., Deng, W., Colombel, J., Lassmann, H., Desreumaux, P., & Liblau, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231474098 · Cited by 321

Dietary modulation of the microbiome affects autoinflammatory disease

Lukens, J. R., Gurung, P., Vogel, P., Johnson, G. R., Carter, R. A., McGoldrick, D. J., Bandi, S. R., Calabrese, C. R., Walle, L. V., Lamkanfi, M., et al. (2014) · Nature · doi:10.1038/nature13788 · Cited by 314

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

Brun, P., Giron, M. C., Qesari, M., Porzionato, A., Caputi, V., Zoppellaro, C., Banzato, S., Grillo, A. R., Spagnol, L., De Caro, R., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.047 · Cited by 300

Environmental Enteric Dysfunction: Pathogenesis, Diagnosis, and Clinical Consequences

Keusch, G. T., Denno, D. M., Black, R. E., Duggan, C., Guerrant, R. L., Lavery, J. V., Nataro, J. P., Rosenberg, I. H., Ryan, E. T., Tarr, P. I., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu485 · Cited by 294

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

Patel, K., Miyoshi, H., Beatty, W. L., Head, R. D., Malvin, N. P., Cadwell, K., Guan, J., Saitoh, T., Akira, S., Seglen, P. O., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.233 · Cited by 287

Contribution of Enteric Infection, Altered Intestinal Barrier Function, and Maternal Malnutrition to Infant Malnutrition in Bangladesh

Mondal, D., Minak, J., Alam, M., Liu, Y., Dai, J., Korpe, P. S., Liu, L., Haque, R., & Petri, W. A. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir807 · Cited by 277

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

Moon, C., Baldridge, M. T., Wallace, M. A., Burnham, C.-A. D., Virgin, H. W., & Stappenbeck, T. S. (2015) · Nature · doi:10.1038/nature14139 · Cited by 268

Immunoproliferative small intestinal disease associated with Campylobacter jejuni

Lecuit, M. (2009) · Hematology Meeting Reports · doi:10.4081/hmr.v1i5.265 · Cited by 264

Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells

Blumberg, R. S., Terhorst, C., Bleicher, P. A., McDermott, F. V., Allan, C. H., Landau, S. B., Trier, J. S., & Balk, S. P. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.8.2518 · Cited by 263

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

Brown, L. C. W., Peñaranda, C., Kashyap, P., Williams, B. B., Clardy, J., Kronenberg, M., Sonnenburg, J. L., Comstock, L. E., Bluestone, J. A., & Fischbach, M. A. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001610 · Cited by 262

The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota

Scanlan, P. D., Stensvold, C. R., Rajilić-Stojanović, M. D., Heilig, H. G. H. J., de Vos, W. M., O’Toole, P. W., & Cotter, P. D. (2014) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12396 · Cited by 261

On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae. 1929.

Fleming, A. (2001) · PubMed Central · Cited by 245

pH‐Profile and regional transit times of the normal gut measured by a radiotelemetry device

Fallingborg, J., Christensen, L. A., Ingeman‐Nielsen, M., Jacobsen, B. A., ABILDGAARD, K., & Rasmussen, H. H. (1989) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1989.tb00254.x · Cited by 243

Clinical features and diagnosis of celiac disease

Dewar, D. H., & Ciclitira, P. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.010 · Cited by 213

Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms

Al‐Saleem, T., & Al-Mondhiry, H. A. B. (2004) · Blood · doi:10.1182/blood-2004-07-2755 · Cited by 207

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

Schutte, A. H., Ermund, A., Becker‐Pauly, C., Johansson, M., Rodríguez-Piñeiro, A. M., Bäckhed, F., Müller, S., Lottaz, D., Bond, J. S., & Hansson, G. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407597111 · Cited by 198

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

Margolis, K. G., Stevanovic, K. D., Li, Z., Yang, Q., Oravecz, T., Zambrowicz, B., Jhaver, K. G., Diacou, A., & Gershon, M. D. (2013) · Gut · doi:10.1136/gutjnl-2013-304901 · Cited by 192

Communities of microbial eukaryotes in the mammalian gut within the context of environmental eukaryotic diversity

Parfrey, L. W., Walters, W. A., Lauber, C. L., Clemente, J. C., Berg-Lyons, D., Teiling, C., Kodira, C. D., Mohiuddin, M., Brunelle, J., Driscoll, M. D., et al. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00298 · Cited by 191

Sphingolipids in Bacteria and Fungi

Olsen, I., & Jantzen, E. (2001) · Anaerobe · doi:10.1006/anae.2001.0376 · Cited by 186

Abundant and Diverse Fungal Microbiota in the Murine Intestine

Scupham, A. J., Presley, L. L., Wei, B., Bent, E., Griffith, N., McPherson, M., Zhu, F., Oluwadara, O., Rao, N. P., Braun, J. G., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.1.793-801.2006 · Cited by 185

Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn's disease

Canani, R. B., Terrin, G., Borrelli, O., Romano, M. T., Manguso, F., Coruzzo, A., D’Armiento, F. P., Romeo, E. F., & Cucchiara, S. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.10.005 · Cited by 178

Growth and host interaction of mouse segmented filamentous bacteria in vitro

Schnupf, P., Gaboriau‐Routhiau, V., Gros, M., Friedman, R. C., Moya‐Nilges, M., Nigro, G., Cerf–Bensussan, N., & Sansonetti, P. J. (2015) · Nature · doi:10.1038/nature14027 · Cited by 175

RESPONSES OF SMALL INTESTINAL ARCHITECTURE AND FUNCTION OVER TIME TO ENVIRONMENTAL FACTORS IN A TROPICAL POPULATION

Kelly, P. M., Menzies, I. S., Crane, R., Zulu, I., Nickols, C. D., Feakins, R. M., Mwansa, J. C. L., Mudenda, V. C., Katubulushi, M., GREENWALD, S., et al. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.70.412 · Cited by 157

Influence of Milk-Feeding Type and Genetic Risk of Developing Coeliac Disease on Intestinal Microbiota of Infants: The PROFICEL Study

Palma, G. D., Capilla, A., Nova, E., Castillejo, G., Varea, V., Pozo, T., Garrote, J. A., Polanco, I., López, A., Ribes‐Koninckx, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030791 · Cited by 150

Mucosal bacterial microflora and mucus layer thickness inadolescents with inflammatory bowel disease

Fyderek, K., Strus, M., Kowalska‐Duplaga, K., Gosiewski, T., Wędrychowicz, A., Jedynak‐Wąsowicz, U., Sładek, M., Pieczarkowski, S., Adamski, P., Kochan, P., et al. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5287 · Cited by 149

Norovirus Triggered Microbiota-driven Mucosal Inflammation in Interleukin 10-deficient Mice

Basic, M., Keubler, L. M., Büettner, M., Achard, M., Breves, G., Schröder, B., Smoczek, A., Jörns, A., Wedekind, D., Zschemisch, N., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000441346.86827.ed · Cited by 143

Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase.

Henthorn, P. S., Raducha, M. G., Edwards, Y. H., Weiss, M. J., Slaughter, C. A., Lafferty, M. A., & Harris, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1234 · Cited by 137

Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate

Kajiya, M., Silva, M. J. B., Sato, K., Ouhara, K., & Kawai, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.117 · Cited by 127

GABA in the Mammalian Enteric Nervous System

Krantis, A. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.6.284 · Cited by 120

Commensal microbiota stimulate systemic neutrophil migration through induction of Serum amyloid A

Kanther, M., Tomkovich, S., Sun, X., Grosser, M. R., Koo, J. S., Flynn, E. J., Jobin, C., & Rawls, J. F. (2013) · Cellular Microbiology · doi:10.1111/cmi.12257 · Cited by 107

Abnormal Gut Integrity Is Associated With Reduced Linear Growth in Rural Malawian Children

Weisz, A. J., Manary, M. J., Stephenson, K. B., Agapova, S. E., Manary, F. G., Thakwalakwa, C. M., Shulman, R. J., & MANARY, M. J. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182650a4d · Cited by 105

A Multicenter, Randomized, Double-Blind Trial of Everolimus Versus Azathioprine and Placebo to Maintain Steroid-Induced Remission in Patients With Moderate-to-Severe Active Crohn's Disease

Reinisch, W., Panés, J., Lémann, M., Schreiber, S., Feagan, B. G., Schmidt, S. L., Sturniolo, G. C., Mikhailova, T. L., Alexeeva, O., Sanna, L., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.02024.x · Cited by 102

Fecal Microbiota Transplantation in Inflammatory Bowel Disease

Ianiro, G., Bibbò, S., Scaldaferri, F., Gasbarrini, A., & Cammarota, G. (2014) · Medicine · doi:10.1097/md.0000000000000097 · Cited by 100

Active ulcerative colitis associated with low prevalence of Blastocystis and Dientamoeba fragilis infection

Petersen, A. M., Stensvold, C. R., Mirsepasi‐Lauridsen, H. C., Engberg, J., Friis‐Møller, A., Porsbo, L. J., Hammerum, A. M., Nordgaard-Lassen, I., Nielsen, H. V., & Krogfelt, K. A. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.780094 · Cited by 98

Jejunal microflora in malnourished Gambian children.

Heyworth, B., & Brown, J. L. (1975) · Archives of Disease in Childhood · doi:10.1136/adc.50.1.27 · Cited by 93

Bacterial, archaeal, and eukaryal diversity in the intestines of Korean people

Nam, Y., Chang, H.-W., Kim, K., Roh, S. W., Kim, M., Jung, M., Lee, S., Kim, J.-Y., Yoon, J., & Bae, J. (2008) · The Journal of Microbiology · doi:10.1007/s12275-008-0199-7 · Cited by 93

Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse

Bröer, A., Juelich, T., Vanslambrouck, J. M., Tietze, N., Solomon, P. S., Holst, J., Bailey, C. G., Rasko, J. E. J., & Bröer, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.241323 · Cited by 86

The intestinal protozoa

Turkeltaub, J. A., McCarty, T. R., & Hotez, P. J. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000135 · Cited by 86

Crohn's disease: small bowel motility impairment correlates with inflammatory‐related markers C‐reactive protein and calprotectin

Bickelhaupt, S., Pazahr, S., Chuck, N. C., Blume, I. N., Froehlich, J. M., Cattin, R., Raible, S., Bouquet, H., Bill, U., Rogler, G., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12088 · Cited by 77

Changes of faecal microbiota in patients with Crohn's disease treated with an elemental diet and total parenteral nutrition

Shiga, H., Kajiura, T., Shinozaki, J., Takagi, S., Kinouchi, Y., Takahashi, S., Negoro, K., Endo, K., Kakuta, Y., Suzuki, M., et al. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.04.014 · Cited by 76

Microbes and Inflammation in Colorectal Cancer

Kostic, A. D., Chun, E., Meyerson, M. M., & Garrett, W. S. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0101 · Cited by 72

Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease.

Molnár, K., Vannay, Á., Szebeni, B., Bánki, N. F., Sziksz, E., Cseh, Á., Győrffy, H., Lakatos, P. L., Papp, M., Arató, A., et al. (2012) · Europe PMC (PubMed Central) · doi:10.3748/wjg.v18.i25.3254 · Cited by 64

Butyrate enemas enhance both cholinergic and nitrergic phenotype of myenteric neurons and neuromuscular transmission in newborn rat colon

Suply, E., de Vries, P., Soret, R., Cossais, F., & Neunlist, M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2011 · Cited by 62

Breath Hydrogen Test in the Diagnosis of Environmental Enteropathy in Children Living in an Urban Slum

dos Reis, J. C., de Morais, M. B., Oliva, C. A. G., & Fagundes‐Neto, U. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9288-9 · Cited by 60

Asymptomatic environmental enteropathy among slum-dwelling infants.

Neto, U. F., Martins, M. C., Lima, F. L., Patrı́cio, F. R. D. S., & Toledo, M. R. (1994) · Journal of the American College of Nutrition · doi:10.1080/07315724.1994.10718371 · Cited by 50

Serotonin receptor modulators in the treatment of irritable bowel syndrome

Lackner, J. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s140 · Cited by 47

Upper Small Intestinal Microflora in Diarrhea and Malnutrition in Nigerian Children

Omoike, I. U., & Abiodun, P. O. (1989) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-198910000-00009 · Cited by 44

Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis

Farkas, S. A., Hornung, M., Sattler, C., Guba, M. O., Steinbauer, M. G. M., Anthuber, M., Herfarth, H. H., Schlitt, H. J., & Geissler, E. K. (2005) · International Journal of Colorectal Disease · doi:10.1007/s00384-005-0793-7 · Cited by 43

Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine

Beuling, E., Kerkhof, I. M., Nicksa, G. A., Giuffrida, M. J., Haywood, J., de Kerk, D. J. A., Piaseckyj, C. M., Pu, W. T., Buchmiller, T. L., Dawson, P. A., et al. (2010) · Gut · doi:10.1136/gut.2009.204990 · Cited by 41

Conservation of Gene Cassettes among Diverse Viruses of the Human Gut

Minot, S. S., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042342 · Cited by 39

Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients

Ohama, T., Hori, M., Fujisawa, M., Kiyosue, M., Hashimoto, M., Ikenoue, Y., Jinno, Y., Miwa, H., Matsumoto, T., Murata, T., et al. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2241-2 · Cited by 37

Epidemiology of Small Bowel Bacterial Overgrowth and Rice Carbohydrate Malabsorption in Burmese (Myanmar) Village Children

Khin-Maung-U, K.-M.-U., Bolin, T. D., Duncombe, V. M., Myo-Khin, Nyunt‐Nyunt‐Wai, Pereira, S. P., & Linklater, J. (1992) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1992.47.298 · Cited by 34

Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors

Murakami, I., Wakasa, Y., Yamashita, S., Kurihara, T., Zama, K., Kobayashi, N., Mizutani, Y., Mitsutake, S., Shigyo, T., & Igarashi, Y. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-150 · Cited by 29

Gut microbiome structure and metabolic activity in inflammatory bowel disease

Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L. J., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0306-4 · Cited by 1,995

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Baruch, E. N., Youngster, I., Ben-Betzalel, G., Ortenberg, R., Lahat, A., Katz, L., Adler, K., Dick-Necula, D., Raskin, S., Bloch, N., et al. (2021) · Science · doi:10.1126/science.abb5920 · Cited by 1,757

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,357

The Human Gut Microbiome: From Association to Modulation

Schmidt, T. S. B., Raes, J., & Bork, P. (2018) · Cell · doi:10.1016/j.cell.2018.02.044 · Cited by 845

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808

Die Interaktion zwischen Darmbakterien und Mensch als zentraler Faktor für die Darmgesundheit

Haller, D., & Hörmannsperger, G. (2015) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-014-2095-0 · Cited by 7

Microbiome and Mucosal Immunity in the Intestinal Tract

Ahrend, H., Buchholtz, A., & Stope, M. B. (2024) · In Vivo · doi:10.21873/invivo.13801 · Cited by 15

Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease

Gruber, L., & Haller, D. (2014) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6539-2_13 · Cited by 1

Editorial: Host-microbiota interactions in IBD: immune modulation and barrier function

Li, H., Nag, S., Pîrcălăbioru, G. G., & Weiskirchen, R. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1869268 · Cited by 1

Crosstalk Between the Intestinal Microbiota and the Innate Immune System in Intestinal Homeostasis and Inflammatory Bowel Disease

Dupaul-Chicoine, J., Dagenais, M., & Saleh, M. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31828dcac7 · Cited by 68