The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome
Open accessAbstract
SUMMARY Human immunodeficiency virus (HIV) infection is associated with increased intestinal translocation of microbial products and enteropathy as well as alterations in gut bacterial communities. However, whether the enteric virome contributes to this infection and resulting immunodeficiency remains unknown. We characterized the enteric virome and bacterial microbiome in a cohort of Ugandan patients, including HIV-uninfected or HIV-infected subjects and those either treated with anti-retroviral therapy (ART) or untreated. Low peripheral CD4 T cell counts were associated with an expansion of enteric adenovirus sequences and this increase was independent of ART treatment. Additionally, the enteric bacterial microbiome of patients with lower CD4 T counts exhibited reduced phylogenetic diversity and richness with specific bacteria showing differential abundance, including increases in Enterobacteriaceae, which have been associated with inflammation. Thus, immunodeficiency in progressive HIV infection is associated with alterations in the enteric virome and bacterial microbiome, which may contribute to AIDS-associated enteropathy and disease progression.
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Diet rapidly and reproducibly alters the human gut microbiome
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Self-citationUniFrac: a New Phylogenetic Method for Comparing Microbial Communities
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection
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Self-citationWaste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible
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Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
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Self-citation. Plasma levels of soluble CD14 independently predict mortality in HIV infection.
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Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon
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Shkoporov, A. N., Clooney, A. G., Sutton, T. D. S., Ryan, F. J., Daly, K. M., Nolan, J. A., McDonnell, S. A., Khokhlova, E. V., Draper, L. A., Forde, A., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.09.009 · Cited by 737
Gosmann, C., Anahtar, M. N., Handley, S. A., Farcasanu, M., Abu-Ali, G., Bowman, B. A., Padavattan, N., Desai, C., Droit, L., Moodley, A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2016.12.013 · Cited by 696
Self-citationThe Gut Virome Database Reveals Age-Dependent Patterns of Virome Diversity in the Human Gut
Gregory, A. C., Zablocki, O., Zayed, A. A., Howell, A., Bolduc, B., & Sullivan, M. B. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.08.003 · Cited by 658
The human virome: assembly, composition and host interactions
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Metadata
- Authors
- Monaco, C. L., Gootenberg, D. B., Zhao, G., Handley, S. A., Ghebremichael, M. S., Lim, E. S., Lankowski, A., Baldridge, M. T., Wilen, C. B., Flagg, M., Norman, J. M., Keller, B. C., Luévano, J. M., Wang, D., Boum, Y., Martin, J. N., Hunt, P. W., Bangsberg, D. R., Siedner, M. J., Kwon, D. S., & Virgin, H. W.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 19
- Issue
- 3
- Pages
- 311-322
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2296527675
- Cited by
- 408
- References
- 52
- FWCI
- 20.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Monaco, C. L., Gootenberg, D. B., Zhao, G., Handley, S. A., Ghebremichael, M. S., Lim, E. S., Lankowski, A., Baldridge, M. T., Wilen, C. B., Flagg, M., Norman, J. M., Keller, B. C., Luévano, J. M., Wang, D., Boum, Y., Martin, J. N., Hunt, P. W., Bangsberg, D. R., Siedner, M. J., . . . Virgin, H. W. (2016). Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2016.02.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
