The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus
Open accessAbstract
Summary Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and in vivo. We report that the kinase RIPK3 is essential for IAV-induced lysis of mammalian fibroblasts and lung epithelial cells. Replicating IAV drives assembly of a RIPK3-containing complex that includes the kinase RIPK1, the pseudokinase MLKL, and the adaptor protein FADD, and forms independently of signaling by RNA-sensing innate immune receptors (RLRs, TLRs, PKR), or the cytokines type I interferons and TNF-α. Downstream of RIPK3, IAV activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis, with the former reliant on RIPK3 kinase activity and neither on RIPK1 activity. Mice deficient in RIPK3 or doubly-deficient in MLKL and FADD, but not MLKL alone, are more susceptible to IAV than their wild-type counterparts, revealing an important role for RIPK3-mediated apoptosis in antiviral immunity. Collectively, these results outline RIPK3-activated cytolytic mechanisms essential for controlling respiratory IAV infection.
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Necroptosis and its role in inflammation
Pasparakis, M., & Vandenabeele, P. (2015) · Nature · doi:10.1038/nature14191 · Cited by 2,148
Identification of RIP1 kinase as a specific cellular target of necrostatins
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Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
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The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
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Self-citationKuriakose, T., Man, S. M., Subbarao Malireddi, R. K., Karki, R., Kesavardhana, S., Place, D. E., Neale, G., Vogel, P., & Kanneganti, T.-D. (2016) · Science Immunology · doi:10.1126/sciimmunol.aag2045 · Cited by 818
Christgen, S., Zheng, M., Kesavardhana, S., Karki, R., Malireddi, R. K. S., Banoth, B., Place, D. E., Briard, B., Sharma, B. R., Tuladhar, S., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00237 · Cited by 588
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Samson, A. L., Garnish, S. E., Hildebrand, J. M., & Murphy, J. M. (2021) · Science Signaling · doi:10.1126/scisignal.abc6178 · Cited by 82
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ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming
Place, D. E., Samir, P., Karki, R., Briard, B., Vogel, P., & Kanneganti, T.-D. (2018) · The American Journal of Pathology · doi:10.1016/j.ajpath.2017.12.006 · Cited by 22
Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy
Kimura-Ohba, S., Kitamura, M., Tsukamoto, Y., Kogaki, S., Sakai, S., Fushimi, H., Matsuoka, K., Takeuchi, M., Itoh, K., Ueda, K., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02723-z · Cited by 14
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Metadata
- Authors
- Nogusa, S., Thapa, R. J., Dillon, C. P., Liedmann, S., Oguin, T. H., Ingram, J. P., Rodriguez, D. A., Kosoff, R., Sharma, S., Sturm, O., Verbist, K., Gough, P. J., Bertin, J., Hartmann, B. M., Sealfon, S. C., Kaiser, W. J., Mocarski, E. S., López, C. B., Thomas, P. G., Oberst, A., Green, D. R., & Balachandran, S.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 20
- Issue
- 1
- Pages
- 13-24
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2429745182
- Cited by
- 364
- References
- 5
- FWCI
- 18.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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