Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity
Open accessAbstract
Diabetes is a risk factor for periodontitis, an inflammatory bone disorder and the greatest cause of tooth loss in adults. Diabetes has a significant impact on the gut microbiota; however, studies in the oral cavity have been inconclusive. By 16S rRNA sequencing, we show here that diabetes causes a shift in oral bacterial composition and, by transfer to germ-free mice, that the oral microbiota of diabetic mice is more pathogenic. Furthermore, treatment with IL-17 antibody decreases the pathogenicity of the oral microbiota in diabetic mice; when transferred to recipient germ-free mice, oral microbiota from IL-17-treated donors induced reduced neutrophil recruitment, reduced IL-6 and RANKL, and less bone resorption. Thus, diabetes-enhanced IL-17 alters the oral microbiota and renders it more pathogenic. Our findings provide a mechanistic basis to better understand how diabetes can increase the risk and severity of tooth loss.
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Studies using germ-free mice have demonstrated the role of diabetes in disrupting the equilibrium of the oral microbiota and confirmed the role of the oral microbiota in periodontal disease pathogenesis.
“Studies using germ‐free mice have also been employed in the context of the oral microbiome, demonstrating the role of diabetes in disrupting the equilibrium of the oral microbiota50 and confirming the role of the oral microbiota in periodontal disease pathogenesis.51, 52”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [50]
Dysbiosis is prompted by various factors, including host diet, inflammatory responses, systemic disruptions, and habits such as alcohol intake, smoking tobacco and consuming alcohol.
“Such dysbiosis is prompted by various factors, including host diet, inflammatory responses, systemic disruptions, and habits such as alcohol intake, smoking tobacco and consuming alcohol.50, 180, 181, 182, 183, 184, 185, 186”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [50]
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- Authors
- Xiao, E., Mattos, M., Vieira, G. H. A., Chen, S., Corrêa, J. D., Wu, Y., Albiero, M. L., Bittinger, K., & Graves, D. T.
- Affiliations
- Peking University (CN)
- University of Pennsylvania (US)
- Universidade de São Paulo (BR)
- Sichuan University (CN)
- Universidade Federal de Minas Gerais (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Graves, Dana T.
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 22
- Issue
- 1
- Pages
- 120-128.e4
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC5701758
- OpenAlex
- W2734722878
- Cited by
- 396
- References
- 52
- Citations by year
- 2026: 31 · 2025: 58 · 2024: 52 · 2023: 71 · 2022: 40 · 2021: 56 · 2020: 39 · 2019: 27 · 2018: 18 · 2017: 3
- FWCI
- 32.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIDCR (R01DE017732, R01DE021921)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- diabetes mellitus, IL-17, oral microbiota, periodontitis, tooth loss, germ-free mice, bacterial transfer, bone resorption, neutrophil recruitment, interleukin-6, RANKL, host-microbe interactions
- MeSH terms
- Animals, Bacteria, Bone Resorption, Diabetes Mellitus, Experimental, DNA, Bacterial, Genes, Bacterial, Inflammation, Mice, Inbred C57BL, Mouth, Osteoclasts, Periodontitis, RNA, Ribosomal, 16S, Virulence, Colony Count, Microbial, Interleukin-6, Alveolar Bone Loss, Tooth Loss, Sequence Analysis, Interleukin-17, Neutrophil Infiltration, Mice, RANK Ligand, Microbiota
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