The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function
Open accessAbstract
SUMMARY Bactericidal antibiotics alter microbial metabolism as part of their lethality and can damage mitochondria in mammalian cells. In addition, antibiotic susceptibility is sensitive to extracellular metabolites, but it remains unknown if metabolites present at an infection site can affect either treatment efficacy or immune function. Here, we quantify local metabolic changes in the host microenvironment following antibiotic treatment for a peritoneal Escherichia coli infection. Antibiotic treatment elicits microbiome-independent changes in local metabolites but not those distal to the infection site by acting directly on host cells. The metabolites induced during treatment, such as AMP, reduce antibiotic efficacy and enhance phagocytic killing. Moreover, antibiotic treatment impairs immune function by inhibiting respiratory activity in immune cells. Collectively, these results highlight the immunomodulatory potential of antibiotics and reveal the local metabolic microenvironment to be an important determinant of infection resolution.
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Cited by
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Tyers, M., & Wright, G. D. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0141-x · Cited by 820
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Metadata
- Authors
- Yang, J. H., Bhargava, P., McCloskey, D., Mao, N., Palsson, B. O., & Collins, J. J.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 22
- Issue
- 6
- Pages
- 757-765.e3
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2774587815
- Cited by
- 267
- References
- 38
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yang, J. H., Bhargava, P., McCloskey, D., Mao, N., Palsson, B. O., & Collins, J. J. (2017). Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2017.10.020
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
