Cited by 120Gut microbiota and healthInfant Nutrition and HealthProbiotics and Fermented Foods

Cross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health

Open access
Xiao, Meifang, Zhang, Chuan, Duan, Hui, Narbad, Arjan, Zhao, Jianxin, Chen, Wei, Zhai, Qixiao, Yu, Leilei +1 more·2024·npj Biofilms and Microbiomes

Abstract

Throughout the life span of a host, bifidobacteria have shown superior colonization and glycan abilities. Complex glycans, such as human milk oligosaccharides and plant glycans, that reach the colon are directly internalized by the transport system of bifidobacteria, cleaved into simple structures by extracellular glycosyl hydrolase, and transported to cells for fermentation. The glycan utilization of bifidobacteria introduces cross-feeding activities between bifidobacterial strains and other microbiota, which are influenced by host nutrition and regulate gut homeostasis. This review discusses bifidobacterial glycan utilization strategies, focusing on the cross-feeding involved in bifidobacteria and its potential health benefits. Furthermore, the impact of cross-feeding on the gut trophic niche of bifidobacteria and host health is also highlighted. This review provides novel insights into the interactions between microbe-microbe and host-microbe.

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Authors
Xiao, M., Zhang, C., Duan, H., Narbad, A., Zhao, J., Chen, W., Zhai, Q., Yu, L., & Tian, F.
Affiliations
  • Jiangnan University (CN)
  • Norwich Research Park (GB)
Corresponding author
  • Yu, Leilei
  • Tian, Fengwei
Venue
npj Biofilms and Microbiomes
Published
2024-06-19
Volume
10
Issue
1
Pages
47-47
ISSN
2055-5008 (ISSN-L)
OpenAlex
W4399796514
Cited by
120
References
166
Citations by year
2026: 70 · 2025: 44 · 2024: 6
FWCI
4.88
Type
journal article
Language
en
Open access
Locations
  • npj Biofilms and Microbiomes (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (BE2021623, 32372296)
  • Government of Jiangsu Province
  • Natural Science Foundation of Jiangsu Province ([BK20220155, BE2021623)
  • Xinjiang Production and Construction Corps (2018AB010)
  • Biotechnology and Biological Sciences Research Council (BBS/E/F/000PR10353, BBS/OS/NW/000006, BBS/E/F/000PR10356, BBS/E/QU/230001D)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
Bifidobacterium, cross-feeding, intestinal homeostasis, human milk oligosaccharides, gut microbiota, host-microbe interactions, microbial interactions, host nutrition, health benefits of probiotics
MeSH terms
Gastrointestinal Microbiome, Host Microbial Interactions, Animals, Bifidobacterium, Fermentation, Homeostasis, Humans, Polysaccharides

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