Cross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health
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Throughout the life span of a host, bifidobacteria have shown superior colonization and glycan abilities. Complex glycans, such as human milk oligosaccharides and plant glycans, that reach the colon are directly internalized by the transport system of bifidobacteria, cleaved into simple structures by extracellular glycosyl hydrolase, and transported to cells for fermentation. The glycan utilization of bifidobacteria introduces cross-feeding activities between bifidobacterial strains and other microbiota, which are influenced by host nutrition and regulate gut homeostasis. This review discusses bifidobacterial glycan utilization strategies, focusing on the cross-feeding involved in bifidobacteria and its potential health benefits. Furthermore, the impact of cross-feeding on the gut trophic niche of bifidobacteria and host health is also highlighted. This review provides novel insights into the interactions between microbe-microbe and host-microbe.
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The probiotic B. bifidum likely facilitated the establishment of these beneficial Bifidobacterium species through cross-feeding on HMOs, promoting a microbiome composition more similar to that of term infants.
“The probiotic B. bifidum likely facilitated the establishment of these beneficial species through cross-feeding on HMOs54,55, promoting a microbiome composition more similar to that of term infants.”
From Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants. (2025) · cites this paper as [55]
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Kiu, R., Darby, E. M., Alcon-Giner, C., Acuna-Gonzalez, A., Camargo, A., Lamberte, L. E., Phillips, S., Sim, K., Shaw, A. G., Clarke, P., et al. (2025) · Nature communications · doi:10.1038/s41467-025-62584-2 · Cited by 36 · see citing works
“The probiotic B. bi fi dum likely facilitated the establishment of these bene fi cial species through cross-feeding on HMOs 54,55 , promoting a microbiome composition more similar to that of term infants.”
Bacteriocin gene-mediated ecological adaptation of Bifidobacterium breve in the adult human gut
Wang, J., Qian, X., Li, Q., Jin, Z., Liu, N., Zhao, J., Chen, W., Wang, S., & Tian, P. (2026) · Cell Genomics · doi:10.1016/j.xgen.2025.101106 · Cited by 5 · see citing works
Self-citation
- Authors
- Xiao, M., Zhang, C., Duan, H., Narbad, A., Zhao, J., Chen, W., Zhai, Q., Yu, L., & Tian, F.
- Affiliations
- Jiangnan University (CN)
- Norwich Research Park (GB)
- Corresponding author
- Yu, Leilei
- Tian, Fengwei
- Venue
- npj Biofilms and Microbiomes
- Published
- 2024-06-19
- Volume
- 10
- Issue
- 1
- Pages
- 47-47
- ISSN
- 2055-5008 (ISSN-L)
- PMC
- PMC11186840
- OpenAlex
- W4399796514
- Cited by
- 120
- References
- 166
- Citations by year
- 2026: 70 · 2025: 44 · 2024: 6
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Biofilms and Microbiomes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (BE2021623, 32372296)
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province ([BK20220155, BE2021623)
- Xinjiang Production and Construction Corps (2018AB010)
- Biotechnology and Biological Sciences Research Council (BBS/E/F/000PR10353, BBS/OS/NW/000006, BBS/E/F/000PR10356, BBS/E/QU/230001D)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Bifidobacterium, cross-feeding, intestinal homeostasis, human milk oligosaccharides, gut microbiota, host-microbe interactions, microbial interactions, host nutrition, health benefits of probiotics
- MeSH terms
- Gastrointestinal Microbiome, Host Microbial Interactions, Animals, Bifidobacterium, Fermentation, Homeostasis, Humans, Polysaccharides
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