Cited by 145Seaweed-derived Bioactive CompoundsMarine Biology and Environmental ChemistryMarine and coastal plant biology

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Anti-proliferative activity and chemical characterization by comprehensive two-dimensional liquid chromatography coupled to mass spectrometry of phlorotannins from the brown macroalga Sargassum muticum collected on North-Atlantic coasts

Open access

Montero, Lidia, Sánchez-Camargo, Andrea P., García-Cañas, Virginia, Tanniou, Anaëlle, Stiger-Pouvreau, Valérie, Russo, Mariateresa, Rastrelli, Luca, Cifuentes, Alejandro, Herrero, Miguel, Ibáñez, Elena·2016·Journal of Chromatography A

DOI 10.1016/j.chroma.2015.07.053

Open this paper in CoChat — free account

Abstract

In the present work, the phlorotannin composition of different Sargassum muticum samples collected at different locations along the North Atlantic coasts as well as the bioactivities related to these components were investigated. After pressurized liquid extraction, the samples collected at the extreme locations of a latitudinal gradient from Portugal and Norway, were found to be the richest on total phenols and, particularly, on phlorotannins, containing up to 148.97 and 5.12mg phloroglucinol equivalents g(-1), respectively. The extracts obtained from these locations were further purified and chemically characterized using a modified HILIC×RP-DAD-MS/MS method. The application of this methodology allowed the tentative identification of a great variability of phlorotannins with different degrees of polymerization (from 3 to 11) and structures, determined for the first time in S. muticum. The most-abundant phlorotannins on these samples were fuhalols, hydroxyfuhalols and phlorethols, showing also particularities and important differences depending on the geographical location. Afterwards, the antiproliferative activity of these extracts against HT-29 adenocarcinoma colon cancer cells was studied. Results revealed that the richest S. muticum samples in terms of total phlorotannins, i.e., those from Norway, presented the highest activity, showing a good cytotoxic potential at concentrations in the medium micromolar range.

Integrity signals

Registry

Crossref · 10.1016/j.chroma.2015.07.053

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,986
Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
Monks, A. P., Scudiero, D. A., Skehan, P., Shoemaker, R. H., Paull, K. D., Vistica, D. T., Hose, C. D., Langley, J. W., Cronise, P., Vaigro-Wolff, A., et al. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.11.757 · Cited by 3,305
Phlorotannins, brown algal polyphenols
Ragan, M. A., & Glombitza, K. (1986) · Medical Entomology and Zoology · Cited by 503
Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds
Yuan, Y., & Walsh, N. A. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.02.002 · Cited by 421
Progress in Phycological Research
MOSS, B. L. (1985) · Phycologia · doi:10.2216/i0031-8884-24-3-374a.1 · Cited by 397
Plants, seaweeds, microalgae and food by-products as natural sources of functional ingredients obtained using pressurized liquid extraction and supercritical fluid extraction
Herrero, M., Sánchez‐Camargo, A. D. P., Cifuentes, A., & Ibáñez, E. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.01.018 · Cited by 344
Self-citation
Anti-proliferative and potential anti-diabetic effects of phenolic-rich extracts from edible marine algae
Nwosu, F., Morris, J., Lund, V. A., Stewart, D., Ross, H. A., & McDougall, G. J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2010.11.111 · Cited by 306
Antioxidant capacities of phlorotannins extracted from the brown algae Fucus vesiculosus
Wang, T., Jónsdóttir, R., Liu, H., Gu, L., Kristinsson, H. G., Raghavan, S., & Ólafsdóttir, G. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3003653 · Cited by 299
Effect of an acid treatment on the phytochemical and antioxidant characteristics of extracts from selected Lamiaceae species
Koşar, M., Dorman, H. J. D., & Hiltunen, R. (2004) · Food Chemistry · doi:10.1016/j.foodchem.2004.06.029 · Cited by 275
Anti-diabetic effects of brown algae derived phlorotannins, marine polyphenols through diverse mechanisms
Lee, S., & Jeon, Y. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.02.013 · Cited by 256

Show all 32 references

Sorted by citations

Recent Developments in Two-Dimensional Liquid Chromatography: Fundamental Improvements for Practical Applications
Pirok, B. W. J., Stoll, D. R., & Schoenmakers, P. J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04841 · Cited by 361
An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications
Lomartire, S., & Gonçalves, A. M. M. (2022) · Marine Drugs · doi:10.3390/md20020141 · Cited by 304
Extraction and Identification of Phlorotannins from the Brown Alga, Sargassum fusiforme (Harvey) Setchell
Li, Y., Fu, X., Duan, D., Liu, X., Xu, J., & Gao, X. (2017) · Marine Drugs · doi:10.3390/md15020049 · Cited by 272
Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on α-amylase, α-glucosidase, pancreatic lipase and tyrosinase
Yuan, Y., Zhang, J., Fan, J., Clark, J. H., Shen, P., Li, Y., & Zhang, C. (2018) · Food Research International · doi:10.1016/j.foodres.2018.07.021 · Cited by 227
Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae
Cikoš, A.-M., Jokić, S., Šubarić, D., & Jerković, I. (2018) · Marine Drugs · doi:10.3390/md16100348 · Cited by 225
Seaweed for climate mitigation, wastewater treatment, bioenergy, bioplastic, biochar, food, pharmaceuticals, and cosmetics: a review
Farghali, M., Mohamed, I. M. A., Osman, A. I., & Rooney, D. W. (2023) · Environmental Chemistry Letters · doi:10.1007/s10311-022-01520-y · Cited by 225
Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications
Silva, A., Silva, S. A., Carpena, M., Garcia‐Oliveira, P., Gullón, P., Barroso, M. F., Prieto, M. A., & Simal‐Gándara, J. (2020) · Antibiotics · doi:10.3390/antibiotics9100642 · Cited by 207
A Brief Review of Anaerobic Digestion of Algae for Bioenergy
Milledge, J. J., Nielsen, B. V., Maneein, S., & Harvey, P. J. (2019) · Energies · doi:10.3390/en12061166 · Cited by 191
Optimization of Phlorotannins Extraction from Fucus vesiculosus and Evaluation of Their Potential to Prevent Metabolic Disorders
Catarino, M. D., Silva, A. M. S., Mateus, N. F. D. C. B., & Cardoso, S. M. (2019) · Marine Drugs · doi:10.3390/md17030162 · Cited by 162
The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies
Santos, S. A. O., Félix, R., Pais, A. C. S., Rocha, S. M., & Silvestre, A. J. D. (2019) · Biomolecules · doi:10.3390/biom9120847 · Cited by 168
Prebiotics from Seaweeds: An Ocean of Opportunity?
Cherry, P., Yadav, S., Strain, C., Allsopp, P. J., McSorley, E. M., Ross, R. P., & Stanton, C. (2019) · Marine Drugs · doi:10.3390/md17060327 · Cited by 151
Bioactive Properties of Marine Phenolics
Mateos, R., Pérez‐Correa, J. R., & Domı́nguez, H. (2020) · Marine Drugs · doi:10.3390/md18100501 · Cited by 146
A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds
Ford, L., Theodoridou, K., Sheldrake, G. N., & Walsh, P. J. (2019) · Phytochemical Analysis · doi:10.1002/pca.2851 · Cited by 137
Phenolic compounds from three brown seaweed species using LC-DAD–ESI-MS/MS
Agregán, R., Munekata, P. E. S., Franco, D., Domínguez, R., Carballo, J., & Lorenzo, J. M. (2017) · Food Research International · doi:10.1016/j.foodres.2017.03.043 · Cited by 133
Natural Phenol Polymers: Recent Advances in Food and Health Applications
Panzella, L., & Napolitano, A. (2017) · Antioxidants · doi:10.3390/antiox6020030 · Cited by 123
Metabolite profiling of licorice (Glycyrrhiza glabra) from different locations using comprehensive two-dimensional liquid chromatography coupled to diode array and tandem mass spectrometry detection
Montero, L., Ibáñez, E., Russo, M., Sanzo, R. D., Rastrelli, L., Piccinelli, A. L., Celano, R., Cifuentes, A., & Herrero, M. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.01.040 · Cited by 121
Self-citation
Optimization of Extraction of Phlorotannins from the Arctic Fucus vesiculosus Using Natural Deep Eutectic Solvents and Their HPLC Profiling with Tandem High-Resolution Mass Spectrometry
Obluchinskaya, E. D., Pozharitskaya, O. N., Shevyrin, V. A., Kovaleva, E. G., Флисюк, Е. В., & Shikov, A. N. (2023) · Marine Drugs · doi:10.3390/md21050263 · Cited by 107
Algae Polyphenolic Compounds and Modern Antibacterial Strategies: Current Achievements and Immediate Prospects
Besednova, N. N., Andryukov, B. G., Zaporozhets, T. S., Kryzhanovsky, S. P., Kuznetsova, T. A., Fedyanina, L. N., Макаренкова, И. Д., & Николаевна, З. Т. (2020) · Biomedicines · doi:10.3390/biomedicines8090342 · Cited by 104
Phlorotannins: A review of extraction methods, structural characteristics, bioactivities, bioavailability, and future trends
Meng, W., Mu, T., Sun, H., & García‐Vaquero, M. (2021) · Algal Research · doi:10.1016/j.algal.2021.102484 · Cited by 103
Sunscreen, antioxidant, and bactericide capacities of phlorotannins from the brown macroalga Halidrys siliquosa
Lann, K. L., Surget, G., Couteau, C., Coiffard, L. J. M., Cérantola, S., Gaillard, F., Larnicol, M., Zubia, M., Guérard, F., Poupart, N., et al. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0853-0 · Cited by 100
Self-citation
Phlorotannins–bioactivity and extraction perspectives
Kumar, L. R. G., Paul, P. T., Anas, K. K., Tejpal, C. S., Chatterjee, N. S., Anupama, T. K., Mathew, S., & Ravishankar, C. N. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02749-4 · Cited by 100
Seaweed-derived phenolic compounds as diverse bioactive molecules: A review on identification, application, extraction and purification strategies
Sadeghi, A., Rajabiyan, A., Nabizade, N., Nezhad, N. M., & Ahmady, A. Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131147 · Cited by 111
Phytochemical Analysis and Evaluation of the Antioxidant, Anti-Inflammatory, and Antinociceptive Potential of Phlorotannin-Rich Fractions from Three Mediterranean Brown Seaweeds
Abdelhamid, A., Jouini, M., Amor, H. B. H., Mzoughi, Z., Dridi, M., Said, R. B., & Bouraoui, A. (2018) · Marine Biotechnology · doi:10.1007/s10126-017-9787-z · Cited by 93
Brown algae and their multiple applications as functional ingredient in food production
Tagliapietra, B. L., & Clerici, M. T. P. S. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112655 · Cited by 103
A comparative assessment of the activity and structure of phlorotannins from the brown seaweed Carpophyllum flexuosum
Zhang, R., Yuen, A. K. L., Magnusson, M., Wright, J. T., de Nys, R., Masters, A. F., & Maschmeyer, T. (2018) · Algal Research · doi:10.1016/j.algal.2017.11.027 · Cited by 90
Evaluation of Ultrasound, Microwave, Ultrasound–Microwave, Hydrothermal and High Pressure Assisted Extraction Technologies for the Recovery of Phytochemicals and Antioxidants from Brown Macroalgae
García‐Vaquero, M., Ravindran, R., Walsh, O., O’Doherty, J. V., Jaiswal, A. K., Tiwari, B. K., & Rajauria, G. (2021) · Marine Drugs · doi:10.3390/md19060309 · Cited by 90
Phlorotannins: From isolation and structural characterization, to the evaluation of their antidiabetic and anticancer potential
Erpel, F., Mateos, R., Pérez‐Jiménez, J., & Pérez‐Correa, J. R. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109589 · Cited by 94
Marine invasive macroalgae: Turning a real threat into a major opportunity - the biotechnological potential of Sargassum muticum and Asparagopsis armata
Pintéus, S., Lemos, M. F. L., Alves, C., Neugebauer, A. Z., Silva, J., Thomas, O., Botana, L. M., Gaspar, H., & Pedrosa, R. (2018) · Algal Research · doi:10.1016/j.algal.2018.06.018 · Cited by 94
Antiviral Effects of Polyphenols from Marine Algae
Besednova, N. N., Andryukov, B. G., Zaporozhets, T. S., Kryzhanovsky, S. P., Fedyanina, L. N., Kuznetsova, T. A., Николаевна, З. Т., & Shchelkanov, M. Y. (2021) · Biomedicines · doi:10.3390/biomedicines9020200 · Cited by 88
Antidiabetic and antioxidant activity of phlorotannins extracted from the brown seaweed Cystoseira compressa in streptozotocin-induced diabetic rats
Gheda, S., Naby, M. A., Mohamed, T., Pereira, L., & Khamis, A. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12347-5 · Cited by 85
Profiling phlorotannins from Fucus spp. of the Northern Portuguese coastline: Chemical approach by HPLC-DAD-ESI/MS and UPLC-ESI-QTOF/MS
Lopes, G., Barbosa, M., Vallejo, F., Gil‐Izquierdo, Á., Andrade, P. B., Valentão, P., Pereira, D. M., & Ferreres, F. (2017) · Algal Research · doi:10.1016/j.algal.2017.11.025 · Cited by 84
Synthesis of silver and gold nanoparticles by Sargassum muticum biomolecules and evaluation of their antioxidant activity and antibacterial properties
González-Ballesteros, N., Rodríguez-Argüelles, M. C., Lastra, M., González-Mediero, G., Rey‐Cao, S., Grimaldi, M., Cavazza, A., & Bigi, F. (2020) · Journal of nanostructure in chemistry · doi:10.1007/s40097-020-00352-y · Cited by 86
Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network
Catarino, M. D., Amarante, S. J., Mateus, N. F. D. C. B., Silva, A. M. S., & Cardoso, S. M. (2021) · Foods · doi:10.3390/foods10071478 · Cited by 83
Marine algal flavonoids and phlorotannins; an intriguing frontier of biofunctional secondary metabolites
Fernando, I. P. S., Lee, W., & Ahn, G. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1922351 · Cited by 80
Seaweed Phenolics as Natural Antioxidants, Aquafeed Additives, Veterinary Treatments and Cross-Linkers for Microencapsulation
Gunathilake, T., Akanbi, T. O., Suleria, H. A. R., Nalder, T. D., Francis, D. S., & Barrow, C. J. (2022) · Marine Drugs · doi:10.3390/md20070445 · Cited by 87
Multidimensional liquid chromatography in food analysis
Cacciola, F., Dugo, P., & Mondello, L. (2017) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2017.06.009 · Cited by 72
Polyphenol-Rich Extracts from Brown Macroalgae Lessonia trabeculate Attenuate Hyperglycemia and Modulate Gut Microbiota in High-Fat Diet and Streptozotocin-Induced Diabetic Rats
Yuan, Y., Zheng, Y., Zhou, J., Geng, Y., Zou, P., Li, Y., & Zhang, C. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05118 · Cited by 80
Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway
Catarino, M. D., da Silva, A. B. G., Cruz, M. T., Mateus, N. F. D. C. B., Silva, A. M. S., & Cardoso, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186897 · Cited by 77
Comprehensive two-dimensional liquid chromatography as a powerful tool for the analysis of food and food products
Cacciola, F., Rigano, F., Dugo, P., & Mondello, L. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.115894 · Cited by 76
Phlorotannins from Undaria pinnatifida Sporophyll: Extraction, Antioxidant, and Anti-Inflammatory Activities
Dong, X., Bai, Y., Xu, Z., Shi, Y., Sun, Y., Janaswamy, S., Yu, C., & Qi, H. (2019) · Marine Drugs · doi:10.3390/md17080434 · Cited by 75
Seaweed-based natural ingredients: Stability of phlorotannins during extraction, storage, passage through the gastrointestinal tract and potential incorporation into functional foods
Cassani, L., Gómez‐Zavaglia, A., Jiménez-López, C., Lourenço‐Lopes, C., Prieto, M. A., & Simal‐Gándara, J. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109676 · Cited by 73
The Use of Invasive Algae Species as a Source of Secondary Metabolites and Biological Activities: Spain as Case-Study
Pereira, A. G., Fraga‐Corral, M., Garcia‐Oliveira, P., Lourenço‐Lopes, C., Carpena, M., Prieto, M. A., & Simal‐Gándara, J. (2021) · Marine Drugs · doi:10.3390/md19040178 · Cited by 77
Tannin polymerization: an overview
Vera, M., & Urbano, B. F. (2021) · Polymer Chemistry · doi:10.1039/d1py00542a · Cited by 71
Ultrasound-assisted extraction of phlorotannins and polysaccharides from Silvetia compressa (Phaeophyceae)
Vázquez-Rodríguez, B., Gutierrez-Uribe, J. A., Antunes‐Ricardo, M., Santos‐Zea, L., & Cruz‐Suárez, L. E. (2020) · Journal of Applied Phycology · doi:10.1007/s10811-019-02013-2 · Cited by 69
Applications of Antioxidant Secondary Metabolites of Sargassum spp.
Catarino, M. D., Silva‐Reis, R., Chouh, A., Silva, S., Braga, S. S., Silva, A. M. S., & Cardoso, S. M. (2023) · Marine Drugs · doi:10.3390/md21030172 · Cited by 68
Online comprehensive two-dimensional hydrophilic interaction chromatography × reversed-phase liquid chromatography coupled with hybrid linear ion trap Orbitrap mass spectrometry for the analysis of phenolic acids in Salvia miltiorrhiza
Cao, J., Wang, S., Hu, H., He, C., Wan, J., Su, H., Wang, Y., & Li, P. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.09.041 · Cited by 68
Foodomics for human health: current status and perspectives
Braconi, D., Bernardini, G., Millucci, L., & Santucci, A. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1421072 · Cited by 71
Identification of Polyphenols from Chilean Brown Seaweeds Extracts by LC-DAD-ESI-MS/MS
Olate-Gallegos, C., Barriga, A., Vergara, C., Fredes, C., García, P., Giménez, B., & Robert, P. S. (2019) · Journal of Aquatic Food Product Technology · doi:10.1080/10498850.2019.1594483 · Cited by 67
Marine green macroalgae: A source of natural compounds with mineralogenic and antioxidant activities
Surget, G., Roberto, V. P., Le Lann, K., Mira, S., Guérard, F., Laizé, V., Poupart, N., Cancela, M. L., & Stiger-Pouvreau, V. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-0968-3 · Cited by 63
Self-citation
Comprehensive two‐dimensional liquid chromatography for polyphenol analysis in foodstuffs
Cacciola, F., Farnetti, S., Dugo, P., Marriott, P. J., & Mondello, L. (2016) · Journal of Separation Science · doi:10.1002/jssc.201600704 · Cited by 62
Phlorotannins of the Brown Algae Sargassum vulgare from the Mediterranean Sea Coast
Chouh, A., Nouadri, T., Catarino, M. D., Silva, A. M. S., & Cardoso, S. M. (2022) · Antioxidants · doi:10.3390/antiox11061055 · Cited by 62
Overview of Phlorotannins’ Constituents in Fucales
Catarino, M. D., Pires, S. M. G., Silva, S., Costa, F. J., Braga, S. S., Pinto, D. C. G. A., Silva, A. M. S., & Cardoso, S. M. (2022) · Marine Drugs · doi:10.3390/md20120754 · Cited by 63
From Ocean to Medicine: Harnessing Seaweed’s Potential for Drug Development
Cotas, J., Lomartire, S., Gonçalves, A. M. M., & Pereira, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020797 · Cited by 69
The application of on-line two-dimensional liquid chromatography (2DLC) in the chemical analysis of herbal medicines
Ji, S., Wang, S., Xu, H., Su, Z.-Y., Tang, D., Qiao, X., & Ye, M. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.08.014 · Cited by 62
Comprehensive Liquid Chromatography and Other Liquid-Based Comprehensive Techniques Coupled to Mass Spectrometry in Food Analysis
Cacciola, F., Donato, P., Sciarrone, D., Dugo, P., & Mondello, L. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04370 · Cited by 60
Bioprospecting of brown seaweeds for biotechnological applications: Phlorotannin actions in inflammation and allergy network
Barbosa, M., Lopes, G., Andrade, P. B., & Valentão, P. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.02.037 · Cited by 58
Two-dimensional liquid chromatography approaches in Foodomics – A review
Montero, L., & Herrero, M. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.07.036 · Cited by 58
Self-citation
The Quest for Phenolic Compounds from Seaweed: Nutrition, Biological Activities and Applications
Subbiah, V., Xie, C., Dunshea, F. R., Barrow, C. J., & Suleria, H. A. R. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2094406 · Cited by 61
The inhibition of anaerobic digestion by model phenolic compounds representative of those from Sargassum muticum
Milledge, J. J., Nielsen, B. V., & Harvey, P. J. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-018-1512-4 · Cited by 55
Influence of molecular weight on the properties of Sargassum muticum fucoidan
Álvarez-Viñas, M., Flórez-Fernández, N., González‐Muñoz, M. J., & Domı́nguez, H. (2018) · Algal Research · doi:10.1016/j.algal.2018.101393 · Cited by 55
Phlorotannins
Venkatesan, J., Keekan, K. K., Anil, S., Bhatnagar, I., & Kim, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22360-3 · Cited by 52
Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds
Carpena, M., Pereira, C. S. G. P., Silva, A., Barciela, P., Jorge, A. O. S., Perez-Vazquez, A., Pereira, A. G., Barreira, J. C. M., Oliveira, M. B. P. P., & Prieto, M. A. (2024) · Marine Drugs · doi:10.3390/md22100478 · Cited by 52
Fraction transfer process in on‐line comprehensive two‐dimensional liquid‐phase separations
Česla, P., & Křenková, J. (2016) · Journal of Separation Science · doi:10.1002/jssc.201600921 · Cited by 50
Reversed phase versus hydrophilic interaction liquid chromatography as first dimension of comprehensive two-dimensional liquid chromatography systems for the elucidation of the polyphenolic content of food and natural products
Cacciola, F., Arena, K., Mandolfino, F., Donnarumma, D., Dugo, P., & Mondello, L. (2021) · Journal of Chromatography A · doi:10.1016/j.chroma.2021.462129 · Cited by 47
Strategies to circumvent the solvent strength mismatch problem in online comprehensive two‐dimensional liquid chromatography
Chapel, S., & Heinisch, S. (2021) · Journal of Separation Science · doi:10.1002/jssc.202100534 · Cited by 50
Application of Hansen solubility approach for the subcritical and supercritical selective extraction of phlorotannins from Cystoseira abies-marina
Sánchez‐Camargo, A. D. P., Montero, L., Cifuentes, A., Herrero, M., & Ibáñez, E. (2016) · RSC Advances · doi:10.1039/c6ra16862k · Cited by 45
Self-citation
A concise review of the highly diverse genus Sargassum C. Agardh with wide industrial potential
Stiger‐Pouvreau, V., Mattio, L., N’Yeurt, A. D. R., Uwai, S., Domínguez, H., Flórez-Fernández, N., Connan, S., & Critchley, A. T. (2023) · Journal of Applied Phycology · doi:10.1007/s10811-023-02959-4 · Cited by 56
Self-citation
Evaluation of bioactivity of phenolic compounds from the brown seaweed of Sargassum fusiforme and development of their stable emulsion
Liu, N., Fu, X., Duan, D., Xu, J., Gao, X., & Zhao, L. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-017-1383-0 · Cited by 42
Effects of phlorotannin and polysaccharide fractions of brown seaweed Silvetia compressa on human gut microbiota composition using an in vitro colonic model
Vázquez-Rodríguez, B., Santos‐Zea, L., Heredia‐Olea, E., Acevedo-Pacheco, L., Santacruz, A., Gutierrez-Uribe, J. A., & Cruz‐Suárez, L. E. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104596 · Cited by 41
Valorisation strategies for brown seaweed biomass production in a European context
Bennett, J. P., Robinson, L. F., & Gomez, L. D. (2023) · Algal Research · doi:10.1016/j.algal.2023.103248 · Cited by 41
Anti-oxidant and anti-inflammatory activities of ultrasonic-assistant extracted polyphenol-rich compounds from Sargassum muticum
Yu, Y., Wang, L., Fu, X., Wang, L., Fu, X., Yang, M., Han, Z., Mou, H., & Jeon, Y. (2019) · Journal of Oceanology and Limnology · doi:10.1007/s00343-019-8138-5 · Cited by 41
A macroporous resin purification process to obtain food-grade phlorotannin-rich extracts with α-glucosidase inhibitory activity from Chilean brown seaweeds: An UHPLC-MS profiling
Erpel, F., Camilo, C., Mateos, R., & Pérez‐Correa, J. R. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134472 · Cited by 39
Comprehensive multidimensional liquid chromatography for advancing environmental and natural products research
Brandão, P. F., Duarte, A. C., & Duarte, R. M. B. O. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.05.016 · Cited by 38
Determination of the Metabolite Content of Brassica juncea Cultivars Using Comprehensive Two-Dimensional Liquid Chromatography Coupled with a Photodiode Array and Mass Spectrometry Detection
Arena, K., Cacciola, F., Dugo, L., Dugo, P., & Mondello, L. (2020) · Molecules · doi:10.3390/molecules25051235 · Cited by 38
The biotechnological potential of Asparagopsis armata: What is known of its chemical composition, bioactivities and current market?
Félix, R., Dias, P. D. M., Félix, C., Cerqueira, T., Andrade, P. B., Valentão, P., & Lemos, M. F. L. (2021) · Algal Research · doi:10.1016/j.algal.2021.102534 · Cited by 42
Antitumor Activity of Fucus vesiculosus-Derived Phlorotannins through Activation of Apoptotic Signals in Gastric and Colorectal Tumor Cell Lines
Catarino, M. D., Fernandes, I., Oliveira, H., Carrascal, M. A., Ferreira, R. M., Silva, A. M. S., Cruz, M. T., Mateus, N. F. D. C. B., & Cardoso, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147604 · Cited by 38
In vitro bioactive properties of phlorotannins recovered from hydrothermal treatment of Sargassum muticum
Casas, M. P., Rodríguez-Hermida, V., Pérez-Larrán, P., Conde, E., Liveri, M. L. T., Ribeiro, D., Fernandes, E. G. R., & Domı́nguez, H. (2016) · Separation and Purification Technology · doi:10.1016/j.seppur.2016.05.003 · Cited by 37
Antioxidant and Tyrosinase Inhibitor Activities of Ethanol Extracts of Brown Seaweed (Turbinaria conoides) as Lightening Ingredient
Sari, D. M., Anwar, E., Nurjanah, N., & Arifianti, A. E. (2019) · Pharmacognosy Journal · doi:10.5530/pj.2019.11.58 · Cited by 34
Antioxidant and chemotherapeutic efficacies of seaweed‐derived phlorotannins in cancer treatment: A review regarding novel anticancer drugs
Pradhan, B., & Ki, J. (2023) · Phytotherapy Research · doi:10.1002/ptr.7809 · Cited by 34
Comprehensive two-dimensional liquid chromatography
Mondello, L., Dugo, P., Donato, P., Herrero, M., Montero, L., & Schmitz, O. J. (2023) · Nature Reviews Methods Primers · doi:10.1038/s43586-023-00269-0 · Cited by 32
Self-citation
Extraction of macroalgae phenolic compounds for cosmetic application using eutectic solvents
Santos, J. M., Jesus, B. C., Ribeiro, H. M., Martins, A., Marto, J. M., Fitas, M., Pinto, P. C., Alves, C., Silva, J., Pedrosa, R., et al. (2024) · Algal Research · doi:10.1016/j.algal.2024.103438 · Cited by 32
A Biorefinery Approach to the Biomass of the Seaweed Undaria pinnatifida (Harvey Suringar, 1873): Obtaining Phlorotannins-Enriched Extracts for Wound Healing
Ferreira, C. A. M., Félix, R., Félix, C., Januário, A. P., Alves, N. M., Novais, S. C., Dias, J. R., & Lemos, M. F. L. (2021) · Biomolecules · doi:10.3390/biom11030461 · Cited by 31
Valorisation of Sargassum muticum through the extraction of phenolic compounds using eutectic solvents and intensification techniques
Jesus, B. C., de Miera, B. S., Santiago, R., Martins, A., Pedrosa, R., González‐Miquel, M., & Marrucho, I. M. (2023) · RSC Sustainability · doi:10.1039/d3su00051f · Cited by 29
Advancing quantification methods for polyphenols in brown seaweeds—applying a selective qNMR method compared with the TPC assay
Wekre, M. E., Hellesen Brunvoll, S., & Jordheim, M. (2022) · Phytochemical Analysis · doi:10.1002/pca.3162 · Cited by 29
Green technologies for cascade extraction of Sargassum muticum bioactives
Pérez-Larrán, P., Torres, M. D., Flórez-Fernández, N., Balboa, E. M., Moure, A., & Domı́nguez, H. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-018-1725-6 · Cited by 28
Phlorotannins from Padina tetrastromatica: structural characterisation and functional studies
Nair, D., Vanuopadath, M., Balasubramanian, A., Iyer, A., Ganesh, S., Anil, A. N., Vikraman, V., Pillai, P., Bose, C., Nair, B. G., et al. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-01792-y · Cited by 26
Comparison of Extraction Techniques and Surfactants for the Isolation of Total Polyphenols and Phlorotannins from the Brown Algae Lobophora variegata
Yılmaz, G. G., Gómez‐Pinchetti, J. L., Cifuentes, A., Herrero, M., & Ibáñez, E. (2019) · Analytical Letters · doi:10.1080/00032719.2019.1597878 · Cited by 26
Self-citation
Aquatic Phlorotannins and Human Health: Bioavailability, Toxicity, and Future Prospects
Okeke, E. S., Nweze, E. J., Chibuogwu, C. C., Anaduaka, E. G., Chukwudozie, K. I., & Ezeorba, T. P. C. (2021) · Natural Product Communications · doi:10.1177/1934578x211056144 · Cited by 25
Pressurized Hot Liquid Extraction with 15% v/v Glycerol-Water as An Effective Environment-Friendly Process to Obtain Durvillaea incurvata and Lessonia spicata Phlorotannin Extracts with Antioxidant and Antihyperglycemic Potential
Erpel, F., Mariotti‐Celis, M. S., Parada, J., Pedreschi, F., & Pérez‐Correa, J. R. (2021) · Antioxidants · doi:10.3390/antiox10071105 · Cited by 24
Adding value to marine invaders by exploring the potential of Sargassum muticum (Yendo) Fensholt phlorotannin extract on targets underlying metabolic changes in diabetes
Barbosa, M., Fernandes, F., Carlos, M. J., Valentão, P., & Andrade, P. B. (2021) · Algal Research · doi:10.1016/j.algal.2021.102455 · Cited by 24
Extraction and characterization of phlorotannin-enriched fractions from the Atlantic seaweed Bifurcaria bifurcata and evaluation of their cytotoxic activity in murine cell line
Gonçalves-Fernández, C., Sineiro, J., Moreira, R., & Gualillo, O. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-018-1729-2 · Cited by 23
Sustainable approach in phlorotannin recovery from macroalgae
Chia, S. R., Show, P. L., Phang, S., Ling, T. C., & Ong, H. C. (2018) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2018.02.015 · Cited by 20
Molecular weight distribution and structure analysis of phlorotannins in Sanhai kelp (Saccharina japonica) and evaluation of their antioxidant activities
Zhang, J., Xing, L., Meng, W., Zhang, X., Li, J., & Dong, P. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142569 · Cited by 19
Investigation of the Potential Phlorotannins and Mechanism of Six Brown Algae in Treating Type II Diabetes Mellitus Based on Biological Activity, UPLC-QE-MS/MS, and Network Pharmacology
Chen, J., Zhou, Z., Li, P., Ye, S., Li, W., Li, M., Zhu, L., & Ding, Y. (2023) · Foods · doi:10.3390/foods12163000 · Cited by 19
An Eco-Friendly Extraction and Purification Approach for Obtaining Active Ingredients for Cosmetics from Two Marine Brown Seaweeds
Gager, L., Connan, S., Cérantola, S., Petek, S., Couteau, C., Coiffard, L. J. M., & Stiger‐Pouvreau, V. (2024) · Marine Drugs · doi:10.3390/md22030112 · Cited by 19
Self-citation
Pressurized Liquid Extraction of Bioactives
Ballesteros-Vivas, D., Ortega-Barbosa, J. P., Sánchez‐Camargo, A. D. P., Rodríguez-Varela, L. I., & Parada‐Alfonso, F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22817-5 · Cited by 21
Self-citation
Two‐dimensional chromatography in screening of bioactive components from natural products
Xiang, H., Xu, P., Qiu, H., Wen, W., Zhang, A., & Tong, S. (2022) · Phytochemical Analysis · doi:10.1002/pca.3168 · Cited by 18
Optimization of Microwave-Assisted Extraction of Phlorotannin From Sargassum swartzii (Turn.) C. Ag. With Ethanol/Water
Toàn, T. Q., Phong, T. D., Tiến, Đ. Đ., Nguyen, M.-L., Anh, N. T. M., Minh, P. T. H., Duy, L. X., Do, H. N., Thi, H. H. P., Nhut, P. T., et al. (2021) · Natural Product Communications · doi:10.1177/1934578x21996184 · Cited by 17
Evaluation of fractions extracted from Polycladia myrica: biological activities, UVR protective effect, and stability of cream formulation based on it
Soleimani, S., Yousefzadi, M., Nezhad, S. B. M., Pozharitskaya, O. N., & Shikov, A. N. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02705-2 · Cited by 16
Chemodiversity and bioactivity assessment of phlorotannins from some Phaeophyta species from the Red Sea
Ismail, M. M., Zokm, G. M. E., Sikaily, A. E., Selim, A., & Ismail, G. A. (2023) · Journal of Applied Phycology · doi:10.1007/s10811-023-03000-4 · Cited by 16

Authors: Montero, L., Sánchez-Camargo, A. P., García-Cañas, V., Tanniou, A., Stiger-Pouvreau, V., Russo, M., Rastrelli, L., Cifuentes, A., Herrero, M., & Ibáñez, E.
Affiliations: Centre National de la Recherche Scientifique (FR)
University of Reggio Calabria (IT)
University of Salerno (IT)
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: Herrero, Miguel
ORCID: Rastrelli, Luca
Cifuentes, Alejandro
Herrero, Miguel
Ibáñez, Elena
Venue: Journal of Chromatography A
Publisher: Elsevier BV
Published: 2016-01
Volume: 1428
Pages: 115-125
ISSN: 0021-9673 (ISSN-L)
DOI: 10.1016/j.chroma.2015.07.053
OpenAlex: W884376253
Cited by: 145
References: 32
Citations by year: 2026: 6 · 2025: 9 · 2024: 11 · 2023: 15 · 2022: 11 · 2021: 22 · 2020: 16 · 2019: 19 · 2018: 15 · 2017: 13 · 2016: 8
FWCI: 18.69
Type: journal article
Language: en
Open access: green
archimer.ifremer.fr
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Chromatography A (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Institutional Archive of Ifremer (French Research Institute for Exploitation of the Sea) (submittedVersion, other-oa)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Administrative Department of Science, Technology and Innovation COLCIENCIAS
MICINN
Interreg IVB Biotecmar
Era-net Seas-era INVASIVES
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords: phlorotannins, Sargassum muticum, brown macroalgae, antiproliferative activity, cytotoxicity, HT-29 cells, regional variation, North Atlantic coast, comprehensive two-dimensional liquid chromatography, phenolic compounds
MeSH terms: Antineoplastic Agents, Atlantic Ocean, Chromatography, Liquid, Humans, Phenols, Phloroglucinol, Tannins, HT29 Cells, Sargassum, Cell Proliferation, Tandem Mass Spectrometry

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Anti-proliferative activity and chemical characterization by comprehensive two-dimensional liquid chromatography coupled to mass spectrometry of phlorotannins from the brown macroalga Sargassum muticum collected on North-Atlantic coasts

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks