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Cited by 106Rheumatoid Arthritis Research and TherapiesNatural Compounds in Disease TreatmentAutoimmune and Inflammatory Disorders Research

Anti-inflammatory effect of all-trans-retinoic acid in inflammatory arthritis

Nozaki, Yuji, Yamagata, Toshiaki, Sugiyama, Masafumi, Ikoma, Shinya, Kinoshita, Koji, Funauchi, Masanori·2006·Clinical Immunology
DOI 10.1016/j.clim.2005.11.012
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Abstract

Objective To determine whether all-trans-retinoic acid (ATRA) improves the destruction of joints and the effect of cytokines on DBA/1J mice with collagen-induced arthritis (CIA).Methods Starting from the time of type II collagen injection, DBA/1J mice were injected intraperitoneally with PBS or 0.5 mg of ATRA 3 times per week for 35 days. The effects of treatment were monitored by determining arthritis and histological scores and measuring cellular proliferation, production of cytokines (IL-2, IL-10, IL-12, IL-6, IFN-gamma, and TNF-alpha) and IgG, and the expression of mRNAs for inducible nitric oxide synthase (iNOS), monocyte chemoattractant protein-1 (MCP-1), and CXCR3.Results The arthritis score and incidence of arthritis were lower in the mice treated with ATRA than in those treated with PBS. Histopathologic evidence of joint damage was 34% lower, and the infiltrations of macrophages were reduced in the mice treated with ATRA compared with those treated with PBS. Type II collagen- and ConA-stimulated proliferation of spleen cells, the production of cytokines (IL-6, IL-12, and TNF-alpha), the serum levels of total IgG and IgG1 anti-collagen antibodies, and the expression of mRNAs for MCP-1 were significantly reduced in the mice treated with ATRA than in those treated with PBS.Conclusion ATRA improved the clinical course and reduced the production of inflammatory cytokines, immunoglobulin, and chemokines in murine CIA. These data suggest that ATRA might be also effective for the treatment of inflammatory arthritis like human rheumatoid arthritis.

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  • Retinoids have been described as potent anti-inflammatory and protective in pathologies such as chronic obstructive pulmonary disease, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

    “retinoids have been described as potent anti-inflammatory and therefore protective in pathologies such as chronic obstructive pulmonary disease74, rheumatoid arthritis122, psoriasis123, and inflammatory bowel disease124.”

    From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [122]

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Authors
Nozaki, Y., Yamagata, T., Sugiyama, M., Ikoma, S., Kinoshita, K., & Funauchi, M.
Affiliations
Kindai University (JP)
Corresponding author
Kinoshita, Koji
ORCID
Venue
Clinical Immunology
Publisher
Elsevier BV
Published
2006-06
Volume
119
Issue
3
Pages
272-279
ISSN
1521-6616 (ISSN-L)
DOI
10.1016/j.clim.2005.11.012
OpenAlex
W1964207984
Cited by
106
References
37
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 12
FWCI
3.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
  • Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords
all-trans retinoic acid, inflammatory arthritis, collagen-induced arthritis, rheumatoid arthritis, anti-inflammatory activity, cytokines, type II collagen, anti-collagen antibodies, MCP-1, CXCR3, inducible nitric oxide synthase, macrophage infiltration, immunosuppression
MeSH terms
Animals, Anti-Inflammatory Agents, Arthritis, Experimental, Collagen, Gene Expression Regulation, Immunoglobulin G, Joints, Male, Mice, Inbred DBA, RNA, Messenger, Spleen, Tretinoin, Cytokines, Chemokine CCL2, Receptors, Chemokine, Cell Proliferation, Mice, Nitric Oxide Synthase Type II, Receptors, CXCR3

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