Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up
Abstract
It is hypothesized that CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) can prevent destruction of pancreatic islets protecting from type 1 diabetes (DM1). Here we present results of one year follow-up of 12 DM1 children treated with autologous expanded ex vivo Tregs. Patients received either a single or double Tregs infusion up to the total dose of 30×10(6)/kg. No severe adverse effects were observed. The treatment did not impair post-immunization antibody responses. Tregs infusion was followed by increase in Tregs number in peripheral blood. Most of the patients responded to the therapy with increase in C-peptide levels (8/12 and 4/6 after the first and the second dose, respectively). Tregs administration resulted also in lower requirement for exogenous insulin (8/12 treated patients versus 2/10 untreated controls in remission) with two children completely insulin independent at one year. Repetitive administration of Tregs is safe and can prolong survival of β-cells in DM1 (registration: ISRCTN06128462).
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Autologous haemopoietic stem-cell transplantation and autologous T-regulatory cell administration are other novel approaches.
“Other novel approaches include autologous haemopoietic stem-cell transplantation165,166 and autologous T-regulatory cell administration.167–169”
From Type 1 diabetes (2018) · cites this paper as [168]
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- Authors
- Marek-Trzonkowska, N., Myśliwiec, M., Dobyszuk, A., Grabowska, M., Derkowska, I., Juścińska, J., Owczuk, R., Szadkowska, A., Witkowski, P., Młynarski, W., Jarosz-Chobot, P., Bossowski, A., Siebert, J., & Trzonkowski, P.
- Affiliations
- Gdańsk Medical University (PL)
- Medical University of Lodz (PL)
- University of Chicago (US)
- Medical University of Silesia (PL)
- Medical University of Białystok (PL)
- Corresponding author
- Trzonkowski, Piotr
- ORCID
- Venue
- Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 153
- Issue
- 1
- Pages
- 23-30
- ISSN
- 1521-6616 (ISSN-L)
- OpenAlex
- W2054951100
- Cited by
- 384
- References
- 17
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 32 · 2023: 27 · 2022: 38 · 2021: 44 · 2020: 38 · 2019: 33 · 2018: 35 · 2017: 28 · 2016: 23 · 2015: 36 · 2014: 5
- FWCI
- 20.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Centre for Research and Development (NR13-0126-10)
- Polish Ministry of Science (IP2011 033771)
- National Centre of Science (DEC-2011/01/D/NZ3/00262)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- type 1 diabetes, regulatory T cells, ex vivo Treg expansion, islet survival, beta-cell protection, C-peptide, insulin independence, children, long-term follow-up, immunosuppression
- MeSH terms
- Adolescent, C-Peptide, Child, Child, Preschool, Diabetes Mellitus, Type 1, Follow-Up Studies, Humans, Risk Factors, Islets of Langerhans Transplantation, Treatment Outcome, T-Lymphocytes, Regulatory, Interleukin-2 Receptor alpha Subunit, Interleukin-7 Receptor alpha Subunit, Cell- and Tissue-Based Therapy
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