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Cited by 133Transcranial Magnetic Stimulation StudiesNeuroscience and Neuropharmacology ResearchNeurological disorders and treatments

Demonstration of short-term plasticity in the dorsolateral prefrontal cortex with theta burst stimulation: A TMS-EEG study

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Chung, Sung Wook, Lewis, Benjamin P., Rogasch, Nigel C., Saeki, Takashi, Thomson, Richard H., Hoy, Kate E., Bailey, Neil W., Fitzgerald, Paul B.·2017·Clinical Neurophysiology
DOI 10.1016/j.clinph.2017.04.005

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Abstract

Objectives To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex. Methods 10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations. Results Significant increases in N120 amplitudes (p<0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r=-0.670, p=0.001). Conclusions This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials. Significance TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex.

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Authors
Chung, S. W., Lewis, B. P., Rogasch, N. C., Saeki, T., Thomson, R. H., Hoy, K. E., Bailey, N. W., & Fitzgerald, P. B.
Affiliations
  • The Alfred Hospital (AU)
  • Monash University (AU)
Corresponding author
Chung, Sung Wook
ORCID
Venue
Clinical Neurophysiology
Publisher
Elsevier BV
Published
2017-07
Volume
128
Issue
7
Pages
1117-1126
ISSN
1388-2457 (ISSN-L)
DOI
10.1016/j.clinph.2017.04.005
OpenAlex
W2588283669
Cited by
133
References
12
Citations by year
2026: 13 · 2025: 12 · 2024: 12 · 2023: 18 · 2022: 21 · 2021: 20 · 2020: 13 · 2019: 9 · 2018: 14 · 2017: 1
FWCI
5.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Neurophysiology (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders
  • BrainsWay
  • National Health and Medical Research Council (1078567, 1082894, 1072057)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
theta burst stimulation, intermittent theta burst stimulation, continuous theta burst stimulation, short-term plasticity, dorsolateral prefrontal cortex, cortical reactivity, long-interval intracortical inhibition, TMS-evoked potentials, TMS-EEG
MeSH terms
Adult, Electroencephalography, Evoked Potentials, Female, Humans, Male, Middle Aged, Neuronal Plasticity, Random Allocation, Theta Rhythm, Prefrontal Cortex, Transcranial Magnetic Stimulation, Young Adult

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