The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials
Abstract
Introduction So far, no study has summarized the findings on the effects of berberine intake on anthropometric parameters, C-reactive protein (CRP) and liver enzymes. This systematic review and meta-analysis were done based upon randomized controlled trials (RCTs) to analyze the effects of berberine on anthropometric parameters, CRP and liver enzymes.Method Following databases were searched for eligible studies published from inception to 30 July 2019: MEDLINE, EMBASE, Web of Science, Cochrane Library, PubMed and Google scholar. Necessary data were extracted. Data were pooled by the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI).Result 12 studies were included. Berberine treatment moderately but significantly decreased body weight (WMD = -2.07 kg, 95% CI -3.09, -1.05, P < 0.001), body mass index (BMI) (WMD = -0.47 kg/m 2, 95% CI -0.70, -0.23, P < 0.001), waist circumference (WC) (WMD = -1.08 cm, 95% CI -1.97, -0.19, P = 0.018) and C-reactive protein (CRP) concentrations (WMD = -0.42 mg/L, 95% CI -0.82, -0.03, P = 0.034). However, berberine intake did not affect liver enzymes, including alanine aminotransferase (ALT) (WMD = -1.66 I/U, 95% CI -3.98, 0.65, P = 0.160) and aspartate aminotransferase (AST) (WMD = -0.87 I/U, 95% CI -2.56, 0.82, P = 0.311).Conclusion This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake which may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders. Berberine administration had no significant effect on ALT and AST levels.
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Systematic reviews showed that berberine improved obesity parameters including BMI.
“Systematic reviews showed that berberine improved obesity parameters including BMI [68, 69].”
From The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (2021) · cites this paper as [68]
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- Authors
- Asbaghi, O., Ghanbari, N., shekari, M., Reiner, Ž., Amirani, E., Hallajzadeh, J., Mirsafaei, L., & Asemi, Z.
- Affiliations
- Lorestan University of Medical Sciences (IR)
- Qazvin University of Medical Sciences (IR)
- University Hospital Centre Zagreb (HR)
- Kashan University of Medical Sciences (IR)
- University of Maragheh (IR)
- Mazandaran University of Medical Sciences (IR)
- Corresponding author
- Hallajzadeh, Jamal
- Asemi, Zatollah
- Venue
- Clinical Nutrition ESPEN
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 38
- Pages
- 43-49
- ISSN
- 2405-4577 (ISSN-L)
- OpenAlex
- W3022904652
- Cited by
- 47
- References
- 62
- Citations by year
- 2026: 15 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 2
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition ESPEN (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- berberine, obesity, body weight, body mass index, waist circumference, C-reactive protein, inflammation, liver enzymes, alanine aminotransferase, aspartate aminotransferase, anthropometric parameters
- MeSH terms
- Berberine, Humans, Inflammation, Liver, Obesity, Randomized Controlled Trials as Topic, Dietary Supplements
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