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Cited by 17Diet and metabolism studiesDietary Effects on HealthBariatric Surgery and Outcomes

The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.

A protein-supplemented very-low-calorie diet does not mitigate reductions in lean mass and resting metabolic rate in subjects with overweight or obesity: A randomized controlled trial

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Magkos, Faidon, Hjorth, Mads F., Asping, Sarah, Rosenkrans, Maria I., Rasmussen, Sidse I., Ritz, Christian, Sjödin, Anders, Geiker, Nina R.W.·2021·Clinical Nutrition
DOI 10.1016/j.clnu.2021.10.006
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Abstract

BACKGROUND & AIMS: The European Food Safety Authority recently recommended an increase in the protein content of total diet replacement (TDR) products from 50 to 75 g/day. The rationale was to minimize reductions in lean mass (LM) and resting metabolic rate (RMR) that occur with weight loss, and thereby facilitate maintenance of lost weight. We sought to directly compare the efficacy of TDR regimens with the new vs the current protein requirement. METHODS: ) to very-low-calorie diets (VLCD) with either 52 or 77 g/day protein for 8 weeks (total energy intake of 600 or 700 kcal/day, respectively). LM was determined by dual energy X-ray absorptiometry and RMR by indirect calorimetry. RESULTS: Attrition rate was 22% in both groups. Both VLCDs decreased body weight, fat mass, LM, and RMR (all P < 0.05). Significant time-by-group interactions were detected for weight and fat mass (both P < 0.05), with corresponding reductions being smaller in the higher-protein than the standard-protein VLCD, likely because of the added calories. On the other hand, reductions in LM (6% from baseline) and RMR (9-10% from baseline) did not differ between groups (P = 0.155 and P = 0.389, respectively), and the contribution of LM to total weight loss was identical (27 ± 2% of lost weight, P = 0.973). CONCLUSIONS: Our results indicate that the proposed increase in the protein content of TDR products does not attenuate reductions in LM and RMR in individuals with overweight and obesity who are treated with <800 kcal/day VLCDs for 2 months. CLINICAL TRIAL REGISTRY: ClinicalTrials.gov # NCT04156165.

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Crossref · 10.1016/j.clnu.2021.10.006

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Metadata

Authors
Magkos, F., Hjorth, M. F., Asping, S., Rosenkrans, M. I., Rasmussen, S. I., Ritz, C., Sjödin, A., & Geiker, N. R. W.
Affiliations
University of Copenhagen (DK)
Corresponding author
Magkos, Faidon
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2021-12
Volume
40
Issue
12
Pages
5726-5733
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2021.10.006
OpenAlex
W3205024021
Cited by
17
References
40
Citations by year
2026: 4 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 2
FWCI
1.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Nutrition (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords
very low calorie diet, protein supplementation, total diet replacement, lean body mass, resting metabolic rate, weight loss, obesity, overweight, weight maintenance, fat mass, protein requirements
MeSH terms
Adult, Basal Metabolism, Dietary Proteins, Female, Humans, Male, Middle Aged, Obesity, Weight Loss, Body Mass Index, Dietary Supplements, Caloric Restriction, Overweight

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