A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations
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The impact of high-protein diets on glycemic control might have been due to previous suggestions that protein affects appetite suppression and insulin sensitivity.
“This impact on glycemic control might have been due to previous suggestions that protein has effects on appetite suppression (63) and insulin sensitivity (64)(65)(66)(67)(68).”
From Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes (2013) · cites this paper as [63]
Increased gelatin-induced satiety and reduced energy intake may reflect hunger suppression rather than satiation or satiety.
“The observed increased gelatin-induced satiety and reduced energy intake thus may be a signal of hunger suppression rather than a satiation or satiety signal (39) .”
From Dietary protein: its role in satiety, energetics, weight loss and health. (2012) · cites this paper as [39]
Gelatin is considered an incomplete protein because it lacks tryptophan and contains relatively low amounts of other essential amino acids.
“Gelatin is considered as an incomplete protein because it is lacking tryptophan (TRP) and contains relatively low amounts of the other dietary essential amino acids (i.e.histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, and valine).”
From Dietary protein: its role in satiety, energetics, weight loss and health. (2012) · cites this paper as [39]
Both gelatin and gelatin with added tryptophan suppress hunger more than other proteins; subsequent energy intake was decreased after a breakfast with gelatin or gelatin plus tryptophan compared with casein, soya, whey, or whey without glycomacropeptide.
“Both gelatin and gelatin with added TRP suppress hunger more than other types of protein: subsequent energy intake was decreased after a breakfast with gelatin or gelatin with added TRP compared with casein, soya, whey, or whey without glycomacropeptide (GMP) (39) .”
From Dietary protein: its role in satiety, energetics, weight loss and health. (2012) · cites this paper as [39]
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- Authors
- Weigle, D. S., Breen, P. A., Matthys, C. C., Callahan, H. S., Meeuws, K. E., Burden, V. R., & Purnell, J. Q.
- Affiliations
- University of Washington (US)
- Oregon Health & Science University (US)
- Corresponding author
- Weigle, David S
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 82
- Issue
- 1
- Pages
- 41-48
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2128594304
- Cited by
- 774
- References
- 36
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 34 · 2023: 18 · 2022: 28 · 2021: 38 · 2020: 27 · 2019: 39 · 2018: 30 · 2017: 54 · 2016: 46 · 2015: 41 · 2014: 50 · 2013: 47 · 2012: 53
- FWCI
- 13.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK 17047, DK‐02860, DK02689, DK35816)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-35816, DK 55460, K24DK002860, R01DK055460, DK-17047, DK-02860, DK02689, K23DK002689, P30DK035816, P30DK017047)
- National Center for Research Resources (RR00037, M01RR000334, RR 000334)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- high-protein diet, dietary protein, appetite, energy intake, weight loss, leptin, ghrelin, satiety, low-carbohydrate diet, fat mass, leptin sensitivity, energy homeostasis
- MeSH terms
- Adult, Appetite, Body Composition, Body Weight, Energy Intake, Circadian Rhythm, Dietary Proteins, Humans, Insulin, Middle Aged, Satiation, Area Under Curve, Leptin, Peptide Hormones, Ghrelin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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