Cited by 392Pancreatic function and diabetesRegulation of Appetite and ObesityMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

A brain-liver circuit regulates glucose homeostasis

Open access

Pocai, Alessandro, Obici, Silvana, Schwartz, Gary J., Rossetti, Luciano·2005·Cell Metabolism

DOI 10.1016/j.cmet.2004.11.001

Open this paper in CoChat — free account Open PDF

Abstract

Increased glucose production (GP) is the major determinant of fasting hyperglycemia in diabetes mellitus. Previous studies suggested that lipid metabolism within specific hypothalamic nuclei is a biochemical sensor for nutrient availability that exerts negative feedback on GP. Here we show that central inhibition of fat oxidation leads to selective activation of brainstem neurons within the nucleus of the solitary tract and the dorsal motor nucleus of the vagus and markedly decreases liver gluconeogenesis, expression of gluconeogenic enzymes, and GP. These effects require central activation of ATP-dependent potassium channels (K(ATP)) and descending fibers within the hepatic branch of the vagus nerve. Thus, hypothalamic lipid sensing potently modulates glucose metabolism via neural circuitry that requires the activation of K(ATP) and selective brainstem neurons and intact vagal input to the liver. This crosstalk between brain and liver couples central nutrient sensing to peripheral nutrient production and its disruption may lead to hyperglycemia.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2004.11.001

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
Obesity as a medical problem
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
The inflammatory reflex
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345
Obesity Wars
Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,122
New drug targets for type 2 diabetes and the metabolic syndrome
Moller, D. E. (2001) · Nature · doi:10.1038/414821a · Cited by 1,012
Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors
Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
Self-citation
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736

Flagged first, then by citations

Show all 43 references

Sorted by citations

Items 101–200 of 392

The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis
Coll, A. P., & Yeo, G. S. H. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.010 · Cited by 85
Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis
Nishio, T., Taura, K., Iwaisako, K., Koyama, Y., Tanabe, K., Yamamoto, G., Okuda, Y., Ikeno, Y., Yoshino, K., Kasai, Y., et al. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-016-1304-z · Cited by 82
Lipid Sensing and Insulin Resistance in the Brain
Yue, J. T. Y., & Lam, T. K. T. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.013 · Cited by 83
Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity
Morrison, C. D., Huypens, P., Stewart, L. K., & Gettys, T. W. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.005 · Cited by 83
Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine
Cotero, V. E., Graf, J. F., Miwa, H., Hirschstein, Z., Qanud, K., Huerta, T. S., Tai, N., Ding, Y., Jimenez-Cowell, K., Tomaio, J. N., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00870-w · Cited by 82
Understanding Metabolic Homeostasis and Imbalance: What Is the Role of the Endocannabinoid System?
Kunos, G. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.06.007 · Cited by 79
Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism
Huang, Z., Liu, L., Zhang, J., Conde, K., Phansalkar, J., Li, Z., Yao, L., Xu, Z., Wang, W., Zhou, J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn5345 · Cited by 78
GABA dramatically improves glucose tolerance in streptozotocin-induced diabetic rats fed with high-fat diet
Sohrabipour, S., Sharifi, M., Talebi, A., Sharifi, M., & Soltani, N. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.01.047 · Cited by 79
Visceral nerves: vagal and sympathetic innervation.
Teff, K. L. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108321705 · Cited by 75
Brain glucose sensing: a subtle mechanism
Pénicaud, L., Leloup, C., Fioramonti, X., Lorsignol, A., & Bénani, A. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232908.84483.e0 · Cited by 81
Lower heart rate variability predicts increased level of C‐reactive protein 4 years later in healthy, nonsmoking adults
Jarczok, M. N., Koenig, J., Mauss, D., Fischer, J. E., & Thayer, J. F. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12295 · Cited by 75
Leptin Activates Hepatic 5′-AMP-activated Protein Kinase through Sympathetic Nervous System and α1-Adrenergic Receptor
Miyamoto, L., Ebihara, K., Kusakabe, T., Aotani, D., Yamamoto‐Kataoka, S., Sakai, T., Aizawa‐Abe, M., Yamamoto, Y., Fujikura, J., Hayashi, T., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.384545 · Cited by 74
Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action
Kimura, K., Nakamura, Y., Inaba, Y., Matsumoto, M., Kido, Y., Asahara, S., Matsuda, T., Watanabe, H., Maeda, A., Inagaki, F., et al. (2013) · Diabetes · doi:10.2337/db12-1701 · Cited by 74
Leptin receptor modulation of adiposity and fertility
Israel, D. D., & Chua, S. C. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.07.004 · Cited by 74
Hypothalamic Leucine Metabolism Regulates Liver Glucose Production
Su, Y., Lam, T. K. T., He, W., Pocai, A., Bryan, J., Aguilar‐Bryan, L., & Juárez, R. G. (2011) · Diabetes · doi:10.2337/db11-0857 · Cited by 75
Self-citation
Melanocortin‐4 receptor expression in a vago‐vagal circuitry involved in postprandial functions
Gautron, L., Lee, C., Funahashi, H., Friedman, J. M., Lee, S., & Elmquist, J. K. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22221 · Cited by 72
Hypothalamic lipotoxicity and the metabolic syndrome
de Morentin, P. B. M., Varela, L., Fernø, J., Nogueiras, R., Diéguez, C., & López, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.016 · Cited by 73
The central nervous system at the core of the regulation of energy homeostasis
Magnan, C. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s37 · Cited by 73
Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced obesity
Stewart, L. K., Wang, Z., Ribnicky, D., Soileau, J. L., Cefalu, W. T., & Gettys, T. W. (2009) · Diabetologia · doi:10.1007/s00125-008-1252-0 · Cited by 71
Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion
Osundiji, M. A., Lam, D. D., Shaw, J., Yueh, C.-Y., Markkula, S. P., Hurst, P., Colliva, C., Roda, A., Heisler, L. K., & Evans, M. L. (2011) · Diabetes · doi:10.2337/db11-1050 · Cited by 70
Central Nervous System Control of Glucose Homeostasis: A Therapeutic Target for Type 2 Diabetes?
Mirzadeh, Z., Faber, C. L., & Schwartz, M. W. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-010446 · Cited by 73
The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis
Guan, X. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00096.2014 · Cited by 70
Vagal Innervation of the Hepatic Portal Vein and Liver Is Not Necessary for Roux-En-Y Gastric Bypass Surgery-Induced Hypophagia, Weight Loss, and Hypermetabolism
Shin, A. C., Zheng, H., & Berthoud, H. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e31823e71b7 · Cited by 69
Atypical antipsychotics and the neural regulation of food intake and peripheral metabolism
Teff, K. L., & Kim, S. F. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.05.033 · Cited by 70
Metabolic Consequences of Solid Organ Transplantation
Bhat, M., Usmani, S. E., Azhie, A., & Woo, M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa030 · Cited by 71
Pinealectomy interferes with the circadian clock genes expression in white adipose tissue
de Farias, T. D. S. M., de Oliveira, A. C., Andreotti, S., do Amaral, F. G., Chimin, P., de Proença, A. R. A., Torres‐Leal, F. L., Sertié, R. A. L., Campaña, A. B., Lopes, A. B., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12211 · Cited by 64
The Hepatic Vagus Nerve Attenuates Fas-Induced Apoptosis in the Mouse Liver via α7 Nicotinic Acetylcholine Receptor
Hiramoto, T., Chida, Y., Sonoda, J., Yoshihara, K., Sudo, N., & Kubo, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.005 · Cited by 67
Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
Knight, C. M., Juárez, R. G., Lam, T. K. T., Arrieta‐Cruz, I., Huang, L., Schwartz, G. J., Barzilai, N., & Rossetti, L. (2011) · Diabetes · doi:10.2337/db10-0987 · Cited by 68
Self-citation
Functional Plasticity of Central TRPV1 Receptors in Brainstem Dorsal Vagal Complex Circuits of Streptozotocin-Treated Hyperglycemic Mice
Zsombok, A., Bhaskaran, M. D., Gao, H., Derbenev, A. V., & Smith, B. N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2081-11.2011 · Cited by 63
The Inhibitory Effects of Insulin on Hepatic Glucose Production Are Both Direct and Indirect
Girard, J. R. (2006) · Diabetes · doi:10.2337/db06-s009 · Cited by 65
Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo
Lam, C., Chari, M., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes · doi:10.2337/db10-0994 · Cited by 61
Lycopene ameliorates systemic inflammation-induced synaptic dysfunction via improving insulin resistance and mitochondrial dysfunction in the liver–brain axis
Wang, J., Zou, Q., Suo, Y., Tan, X., Yuan, T., Liu, Z., & Liu, X. (2019) · Food & Function · doi:10.1039/c8fo02460j · Cited by 62
Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome
Metz, C. N., & Pavlov, V. A. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00195.2018 · Cited by 61
Insights into the role of neuronal glucokinase
Backer, I. D., Hussain, S., Bloom, S. R., & Gardiner, J. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00034.2016 · Cited by 61
Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure
Deng, J., Yuan, F., Guo, Y., Xiao, Y., Niu, Y., Deng, Y., Han, X., Guan, Y., Chen, S., & Guo, F. (2016) · Diabetes · doi:10.2337/db16-0954 · Cited by 61
Ventromedial hypothalamus glucose‐inhibited neurones: A role in glucose and energy homeostasis?
Hirschberg, P. R., Sarkar, P., Teegala, S. B., & Routh, V. H. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12773 · Cited by 63
A Balance of Lipid-Sensing Mechanisms in the Brain and Liver
Caspi, L., Wang, P. Y. T., & Lam, T. K. T. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.07.005 · Cited by 58
Autonomic Regulation of Glucose Homeostasis: a Specific Role for Sympathetic Nervous System Activation
Carnagarin, R., Matthews, V. B., Herat, L. Y., Ho, J. K., & Schlaich, M. P. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1069-2 · Cited by 60
Evidence for Central Regulation of Glucose Metabolism
Carey, M., Kehlenbrink, S., & Hawkins, M. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.506782 · Cited by 65
Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production
Kwon, E., Joung, H.-Y., Liu, S.-M., Chua, S. C., Schwartz, G. J., & Jo, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-20160-w · Cited by 64
Self-citation
Minireview: Circadian Control of Metabolism by the Suprachiasmatic Nuclei
Kalsbeek, A., Kreier, F., Fliers, E., Sauerwein, H. P., Romijn, J. A., & Buijs, R. M. (2007) · Endocrinology · doi:10.1210/en.2007-0776 · Cited by 58
Untangling the effect of insulin action on brain mitochondria and metabolism
Schell, M., Wardelmann, K., & Kleinridders, A. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12932 · Cited by 58
The autonomic nervous system
Buijs, R. M. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53491-0.00001-8 · Cited by 57
Hypothalamic integration of portal glucose signals and control of food intake and insulin sensitivity
Delaere, F., Magnan, C., & Mithieux, G. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.05.001 · Cited by 64
Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology
Duca, F. A., Bauer, P. V., Hamr, S. C., & Lam, T. K. T. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.003 · Cited by 62
New aspects of melanocortin signaling: A role for PRCP in α-MSH degradation
Diano, S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.09.001 · Cited by 61
Avenues of Communication between the Brain and Tissues/Organs Involved in Energy Homeostasis
Yamada, T., & Katagiri, H. (2007) · Endocrine Journal · doi:10.1507/endocrj.kr-106 · Cited by 55
Brain-liver connections: role of the preautonomic PVN neurons
O’Hare, J., & Zsombok, A. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00302.2015 · Cited by 54
Enhanced NMDA Receptor-Mediated Modulation of Excitatory Neurotransmission in the Dorsal Vagal Complex of Streptozotocin-Treated, Chronically Hyperglycemic Mice
Bach, E. C., Halmos, K. C., & Smith, B. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121022 · Cited by 63
Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons
Cady, G., Landeryou, T., Garratt, M., Kopchick, J. J., Qi, N., García-Galiano, D., Elias, C. F., Myers, M. G., Miller, R. A., Sandoval, D. A., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.03.001 · Cited by 52
Brain insulin resistance and cognitive function: influence of exercise
Malin, S. K., Stewart, N. R., Ude, A. A., & Alderman, B. L. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00375.2022 · Cited by 53
Hepatic Muscarinic Acetylcholine Receptors Are Not Critically Involved in Maintaining Glucose Homeostasis in Mice
Li, J. H., Gautam, D., Han, S., Guettier, J., Cui, Y., Lü, H., Deng, C., O’Hare, J., Jou, W., Gavrilova, O., et al. (2009) · Diabetes · doi:10.2337/db09-0522 · Cited by 52
Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α
Mann, S. N., Hadad, N., Holte, M. N., Rothman, A. R., Sathiaseelan, R., Mondal, S. A., Agbaga, M., Unnikrishnan, A., Subramaniam, M., Hawse, J. R., et al. (2020) · eLife · doi:10.7554/elife.59616 · Cited by 52
Central nervous system melanocortin‐3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle
Sutton, G. M., Begriche, K., Kumar, K. G., Gimble, J. M., Pérez–Tilve, D., Nogueiras, R., McMillan, R. P., Hulver, M. W., Tschöp, M. H., & Butler, A. A. (2009) · The FASEB Journal · doi:10.1096/fj.09-142000 · Cited by 50
Plasticity of central autonomic neural circuits in diabetes
Zsombok, A., & Smith, B. N. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.12.001 · Cited by 48
Communication between the gut microbiota and peripheral nervous system in health and chronic disease
Cook, T. M., & Mansuy‐Aubert, V. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2068365 · Cited by 47
Transient Receptor Potential Vanilloid Type 1–Dependent Regulation of Liver-Related Neurons in the Paraventricular Nucleus of the Hypothalamus Diminished in the Type 1 Diabetic Mouse
Gao, H., Miyata, K., Bhaskaran, M. D., Derbenev, A. V., & Zsombok, A. (2012) · Diabetes · doi:10.2337/db11-0820 · Cited by 47
Glucose sensing by GABAergic neurons in the mouse nucleus tractus solitarii
Boychuk, C. R., Gyarmati, P., Xu, H., & Smith, B. N. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00310.2015 · Cited by 47
Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve
Zhang, Q., Yu, J., Liu, B., Lv, Z., Xia, T., Xiao, F., Chen, S., & Guo, F. (2013) · Diabetes · doi:10.2337/db12-1050 · Cited by 47
Leptin, diabetes, and the brain
Morton, G. J., & Meek, T. H. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105568 · Cited by 47
Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
Heni, M., Kullmann, S., Ahlqvist, E., Wagner, R. J., Machicao, F. E., Staiger, H., Häring, H.-U., Almgren, P., Groop, L., Small, D. M., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4095-0 · Cited by 47
Pro-Opiomelanocortin Modulates the Thermogenic and Physical Activity Responses to High-Fat Feeding and Markedly Influences Dietary Fat Preference
Tung, Y. C. L., Rimmington, D., O’Rahilly, S., & Coll, A. P. (2007) · Endocrinology · doi:10.1210/en.2007-0797 · Cited by 46
Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet
Lee, M., Kim, A. D., Chua, S. C., Obici, S., & Wardlaw, S. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00555.2006 · Cited by 47
Self-citation
Inter-organ metabolic communication involved in energy homeostasis: Potential therapeutic targets for obesity and metabolic syndrome
Yamada, T., Oka, Y., & Katagiri, H. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.006 · Cited by 46
Functional Heterogeneity of Arcuate Nucleus Pro-Opiomelanocortin Neurons: Implications for Diverging Melanocortin Pathways
Sohn, J., & Williams, K. W. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8240-6 · Cited by 46
Insulin's effect on the liver: "Direct or indirect?" continues to be the question
Girard, J. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27743 · Cited by 45
Effect of magnesium sulfate administration to improve insulin resistance in type 2 diabetes animal model: using the hyperinsulinemic‐euglycemic clamp technique
Sohrabipour, S., Sharifi, M., Sharifi, M., Talebi, A., & Soltani, N. (2018) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12387 · Cited by 44
A hindbrain inhibitory microcircuit mediates vagally-coordinated glucose regulation
Boychuk, C. R., Smith, K. C., Peterson, L. E., Boychuk, J. A., Butler, C. R., Derera, I. D., McCarthy, J. J., & Smith, B. N. (2019) · Scientific Reports · doi:10.1038/s41598-019-39490-x · Cited by 45
Tissue-Specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation
Patel, S., MacAulay, K., & Woodgett, J. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015845 · Cited by 43
Race and Resting-State Heart Rate Variability in Brazilian Civil Servants and the Mediating Effects of Discrimination: An ELSA-Brasil Cohort Study
Kemp, A. H., Koenig, J., Thayer, J. F., Bittencourt, M. S., Pereira, A. C., Santos, I. S., Dantas, E. M., Mill, J. G., Chor, D., Ribeiro, A. L. P., et al. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000359 · Cited by 41
Growth hormone enhances the recovery of hypoglycemia via ventromedial hypothalamic neurons
Furigo, I. C., de Souza, G. O., Teixeira, P. D. S., Guadagnini, D., Frazão, R., List, E. O., Kopchick, J. J., Prada, P. O., & Donato, J. (2019) · The FASEB Journal · doi:10.1096/fj.201901315r · Cited by 41
CNS Control of Glucose Metabolism: Response to Environmental Challenges
Arble, D. M., & Sandoval, D. A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00020 · Cited by 44
How Should We Think About the Role of the Brain in Glucose Homeostasis and Diabetes?
Deem, J. D., Muta, K., Scarlett, J. M., Morton, G. J., & Schwartz, M. W. (2017) · Diabetes · doi:10.2337/dbi16-0067 · Cited by 42
Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone
Niedringhaus, M. S., Jackson, P. G., Evans, S. R. T., Verbalis, J. G., Gillis, R. A., & Sahibzada, N. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00391.2007 · Cited by 40
Peripheral Focused Ultrasound Neuromodulation (pFUS)
Cotero, V. E., Miwa, H., Graf, J. F., Ashe, J. M., Loghin, E., Carlo, D. D., & Puleo, C. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108721 · Cited by 39
Hepatic nervous system and neurobiology of the liver
Jensen, K. J., Alpini, G., & Glaser, S. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00506.x · Cited by 38
Implementation of environmental enrichment after middle age promotes healthy aging
McMurphy, T. B., Huang, W., Queen, N. J., Ali, S., Widstrom, K. J., Liu, X., Xiao, R., Siu, J. J., & Cao, L. (2018) · Aging · doi:10.18632/aging.101502 · Cited by 38
Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling
Sadagurski, M., & White, M. F. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.008 · Cited by 39
Biosynthesis and Metabolism of ApoB-Containing Lipoproteins
Borén, J., Taskinen, M., & Packard, C. J. (2024) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062222-020716 · Cited by 46
Endogenous Glucose Production in Critical Illness
Al‐Yousif, N., Rawal, S., Jurczak, M. J., Mahmud, H., & Shah, F. A. (2021) · Nutrition in Clinical Practice · doi:10.1002/ncp.10646 · Cited by 40
Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats
Warne, J. P., Foster, M. T., Horneman, H. F., Pecoraro, N. C., Ginsberg, A. B., Akana, S. F., & Dallman, M. F. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135996 · Cited by 35
Restoration of Euglycemia After Duodenal Bypass Surgery Is Reliant on Central and Peripheral Inputs in Zucker fa/fa Rats
Jiao, J., Bae, E. J., Bandyopadhyay, G. K., Oliver, J., Marathe, C., Chen, M. J., Hsu, J.-Y., Chen, Y., Tian, H., Olefsky, J. M., et al. (2012) · Diabetes · doi:10.2337/db12-0681 · Cited by 35
Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
Lee, M., Matsunaga, H., Sugiura, Y., Hayasaka, T., Yamamoto, I., Ishimoto, T., Imoto, D., Suematsu, M., Iijima, N., Kimura, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22431-6 · Cited by 33
Perturbation of glucose flux in the liver by decreasing F26P2levels causes hepatic insulin resistance and hyperglycemia
Wu, C., Khan, S. A., Peng, L.-J., Li, H., Carmella, S. G., & Lange, A. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00126.2006 · Cited by 33
The vagus neurometabolic interface and clinical disease
Battinelli, E., Valdés‐Ferrer, S. I., & Steinberg, B. E. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0086-1 · Cited by 34
Identification of hypoglycemia-specific neural signals by decoding murine vagus nerve activity
Battinelli, E., Levy, T. J., Tsaava, T., Bouton, C. E., Tracey, K. J., Chavan, S. S., & Zanos, T. P. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0025-z · Cited by 34
Advances in the mechanism of high copper diets in restraining pigs growth
Gao, Y., Yang, W., Che, D., Adams, S., & Yang, L. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13213 · Cited by 33
Interaction of glucose sensing and leptin action in the brain
Li, R. J. W., Zhang, S., & Lam, T. K. T. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101011 · Cited by 36
Diabetes induces GABA receptor plasticity in murine vagal motor neurons
Boychuk, C. R., Halmos, K. C., & Smith, B. N. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00209.2015 · Cited by 33
Biodistribution of the fatty acid analogue 18F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia.
Guiducci, L., Grönroos, T. J., Järvisalo, M. J., Kišš, J., Viljanen, A. P. M., Naum, A. S., Viljanen, T., Savunen, T., Knuuti, J. M., Ferrannini, E., et al. (2007) · PubMed · Cited by 32
Immunohistochemical localization of transient receptor potential vanilloid type 1 and insulin receptor substrate 2 and their co-localization with liver-related neurons in the hypothalamus and brainstem
Zsombok, A., Gao, H., Miyata, K., Issa, A. T., & Derbenev, A. V. (2011) · Brain Research · doi:10.1016/j.brainres.2011.04.048 · Cited by 31
Hypothalamic Control of Hepatic Glucose Production and Its Potential Role in Insulin Resistance
Buettner, C., & Camacho, R. C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.09.001 · Cited by 31
Long-chain acyl-CoA hydrolase in the brain
Yamada, J. (2005) · Amino Acids · doi:10.1007/s00726-005-0181-1 · Cited by 32
The Brain-Gut-Islet Connection
Woods, S. C., Benoit, S. C., & Clegg, D. J. (2006) · Diabetes · doi:10.2337/db06-s015 · Cited by 30
Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway
Zhou, M., Xu, X., Wang, H., Yang, G., Yang, M., Zhao, X., Guo, H., Song, J., Zheng, H., Zhu, Z., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901836rr · Cited by 33
Fasting plasma triglycerides predict the glycaemic response to treatment of Type 2 diabetes by gastric electrical stimulation. A novel lipotoxicity paradigm
Lebovitz, H. E., Ludvik, B. H., Yaniv, I., Haddad, W., Schwartz, T. P., & Aviv, R. (2013) · Diabetic Medicine · doi:10.1111/dme.12132 · Cited by 31
Central administration of vaspin inhibits glucose production and augments hepatic insulin signaling in high-fat-diet-fed rat
Luo, X., Li, K., Zhang, C., Yang, G., Yang, M., Jia, Y., Zhang, L., Ma, Z. A., Boden, G., & Li, L. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.24 · Cited by 29
Overactivity of Liver-Related Neurons in the Paraventricular Nucleus of the Hypothalamus: Electrophysiological Findings indb/dbMice
Gao, H., Molinas, A., Miyata, K., Qiao, X., & Zsombok, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1706-17.2017 · Cited by 30
Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism
Haigh, J., New, L. E., & Filippi, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.580879 · Cited by 30
Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration
Mehan, S., Bhalla, S., Siddiqui, E. M., Sharma, N., Shandilya, A., & Khan, A. (2022) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s247153 · Cited by 29

Authors: Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Rossetti, Luciano
ORCID: Pocai, Alessandro
Schwartz, Gary J.
Rossetti, Luciano
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2005-01
Volume: 1
Issue: 1
Pages: 53-61
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2004.11.001
OpenAlex: W2054716401
Cited by: 392
References: 43
Citations by year: 2026: 5 · 2025: 10 · 2024: 20 · 2023: 9 · 2022: 15 · 2021: 14 · 2020: 19 · 2019: 16 · 2018: 10 · 2017: 22 · 2016: 19 · 2015: 17 · 2014: 15 · 2013: 21 · 2012: 26
FWCI: 27.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3119 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-48321, DK-47208, R01DK047208, DK20541, DK-45024)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: glucose homeostasis, fasting hyperglycemia, liver gluconeogenesis, glucose production, nucleus tractus solitarius, dorsal motor nucleus of the vagus, brainstem neurons, ATP-sensitive potassium channels, fat oxidation, diabetes mellitus
MeSH terms: Adenosine Triphosphate, Animals, Brain, Central Nervous System, Glucose, Homeostasis, Hyperglycemia, Kinetics, Liver, Male, Models, Biological, Neurons, Oxygen, Pancreas, Phosphoric Monoester Hydrolases, Potassium, Vagus Nerve, Potassium Channels, Glucose Clamp Technique, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Lipid Metabolism, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A brain-liver circuit regulates glucose homeostasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks