Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114 · see citing works

Obesity Wars

Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,105 · see citing works

Hypothalamic insulin signaling is required for inhibition of glucose production

Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904 · see citing works

Diabetes, Obesity, and the Brain

Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841 · see citing works

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

Schwartz, M. W., Figlewicz, D. P., Baskin, D. G., Woods, S. C., & Porte, D. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-3-387 · Cited by 808 · see citing works

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., & Rossetti, L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-861 · Cited by 719 · see citing works

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.271 · Cited by 654 · see citing works

Hypothalamic KATP channels control hepatic glucose production

Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature · doi:10.1038/nature03439 · Cited by 645 · see citing works

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, S., Feng, Z., Karkanias, G. B., et al. (2002) · Nature Neuroscience · doi:10.1038/nn861 · Cited by 572 · see citing works

Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

Schwartz, M. W., Sipols, A. J., Marks, J. L., Sanacora, G., White, J. D., Scheurink, A., Kahn, S. E., Baskin, D. G., Woods, S. C., & Figlewicz, D. P. (1992) · Endocrinology · doi:10.1210/endo.130.6.1597158 · Cited by 555 · see citing works

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

Niswender, K. D., Morrison, C. D., Clegg, D. J., Olson, R., Baskin, D. G., Myers, M. G., Seeley, R. J., & Schwartz, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.2.227 · Cited by 476 · see citing works

A brain-liver circuit regulates glucose homeostasis

Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392 · see citing works

Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes

Lin, X., Taguchi, A., Park, S., Kushner, J. A., Li, F., Li, Y., & White, M. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22217 · Cited by 313 · see citing works

Leptin action in the forebrain regulates the hindbrain response to satiety signals

Morton, G. J., Blevins, J. E., Williams, D. L., Niswender, K. D., Gelling, R. W., Rhodes, C. J., Baskin, D. G., & Schwartz, M. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22081 · Cited by 253 · see citing works

Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

Kubota, N., Terauchi, Y., Tobe, K., Yano, W., Suzuki, R., Ueki, K., Takamoto, I., Satoh, H., Maki, T., Kubota, T., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21484 · Cited by 239 · see citing works

Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance

Obici, S., & Rossetti, L. (2003) · Endocrinology · doi:10.1210/en.2003-0999 · Cited by 218 · see citing works

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

Morton, G. J., Niswender, K. D., Rhodes, C. J., Myers, M. G., Blevins, J. E., Baskin, D. G., & Schwartz, M. W. (2003) · Endocrinology · doi:10.1210/en.2002-0115 · Cited by 158 · see citing works

Transgenic rescue of insulin receptor–deficient mice

Okamoto, H., Nakae, J., Kitamura, T., Park, B.-C., Dragatsis, I., & Accili, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421645 · Cited by 151 · see citing works

Activation of IRS-2—Mediated Signal Transduction by IGF-1, but not TGF-α or EGF, Augments Pancreatic β-Cell Proliferation

Lingohr, M. K., Dickson, L. M., McCuaig, J. F., Hügl, S., Twardzik, D. R., & Rhodes, C. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.966 · Cited by 147 · see citing works

Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats.

Havel, P. J., Hahn, T. M., Sindelar, D. K., Baskin, D. G., Dallman, M. F., Weigle, D. S., & Schwartz, M. W. (2000) · Diabetes · doi:10.2337/diabetes.49.2.244 · Cited by 133 · see citing works

Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin

van den Hoek, A. M., Voshol, P. J., Karnekamp, B. N., Buijs, R. M., Romijn, J. A., Havekes, L. M., & Pijl, H. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2529 · Cited by 109 · see citing works

Some characteristics of feeding during streptozotocin-induced diabetes in the rat.

Booth, D. (1972) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0032968 · Cited by 108 · see citing works

Intracerebroventricular Neuropeptide Y Acutely Influences Glucose Metabolism and Insulin Sensitivity in the Rat

Marks, J. L., & Waite, K. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00554.x · Cited by 80 · see citing works

Attenuation of Diabetic Hyperphagia in Neuropeptide Y–Deficient Mice

Sindelar, D. K., Mystkowski, P., Marsh, D. J., Palmiter, R. D., & Schwartz, M. W. (2002) · Diabetes · doi:10.2337/diabetes.51.3.778 · Cited by 76 · see citing works

Hepatic and peripheral insulin resistance following streptozotocin-induced insulin deficiency in the dog

Bevilacqua, S., Barrett, E. J., Smith, D. J., Simonson, D. C., Olsson, M., Bratusch-Marrain, P. R., Ferrannini, E., & DeFronzo, R. A. (1985) · Metabolism · doi:10.1016/0026-0495(85)90105-2 · Cited by 44 · see citing works

Agouti-related protein is a mediator of diabetic hyperphagia

Qu, S.-Y., Yang, Y.-K., Li, J.-Y., Zeng, Q., & Gantz, I. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00230-5 · Cited by 24 · see citing works

Effect of duration of diabetic state on insulin action in isolated rat soleus muscles

Maegawa, H., Kobayashi, M., Watanabe, N., Ishibashi, O., Takata, Y., Kitamura, E., & Shigeta, Y. (1986) · Metabolism · doi:10.1016/0026-0495(86)90005-3 · Cited by 17 · see citing works

The integrative biology of type 2 diabetes

Roden, M., & Shulman, G. I. (2019) · Nature · doi:10.1038/s41586-019-1797-8 · Cited by 1,167 · see citing works

Pancreatic regulation of glucose homeostasis.

Röder, P. V., Wu, B., Liu, Y., & Han, W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.6 · Cited by 985 · see citing works

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705 · see citing works

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.004 · Cited by 695 · see citing works

A Ceramide-Centric View of Insulin Resistance

Chavez, J. A., & Summers, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.002 · Cited by 620 · see citing works

Insulin regulation of gluconeogenesis

Hatting, M., Tavares, C. D. J., Sharabi, K., Rines, A. K., & Puigserver, P. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13435 · Cited by 589 · see citing works

Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis

Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523 · see citing works

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

Kleinridders, A., Cai, W., Cappellucci, L., Ghazarian, A., Collins, W. R., Vienberg, S. G., Pothos, E. N., & Kahn, C. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500877112 · Cited by 486 · see citing works

Central insulin action in energy and glucose homeostasis

Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29063 · Cited by 438 · see citing works

Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism

Roh, E., Song, D. K., & Kim, M.-S. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.4 · Cited by 391 · see citing works

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Lu, M., Wan, M., Leavens, K. F., Chu, Q., Monks, B. R., Fernandez, S., Ahima, R. S., Ueki, K., Kahn, C. R., & Birnbaum, M. J. (2012) · Nature Medicine · doi:10.1038/nm.2686 · Cited by 392 · see citing works

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.002 · Cited by 391 · see citing works

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

Benoit, S. C., Kemp, C. J., Elias, C. F., Abplanalp, W., Herman, J. P., Migrenne, S., Lefevre, A.-L., Cruciani-Guglielmacci, C., Magnan, C., Yu, F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36714 · Cited by 351 · see citing works

Leptin and the Central Nervous System Control of Glucose Metabolism

Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works

Molecular pathophysiology of hepatic glucose production

Sharabi, K., Tavares, C. D. J., Rines, A. K., & Puigserver, P. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.09.003 · Cited by 331 · see citing works

Insulin-Like Signaling, Nutrient Homeostasis, and Life Span

Taguchi, A., & White, M. F. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100533 · Cited by 309 · see citing works

Selective Insulin and Leptin Resistance in Metabolic Disorders

Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 304 · see citing works

Central insulin action regulates peripheral glucose and fat metabolism in mice

Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 270 · see citing works

Neuronal control of peripheral insulin sensitivity and glucose metabolism

Ruud, J., Steculorum, S. M., & Brüning, J. C. (2017) · Nature Communications · doi:10.1038/ncomms15259 · Cited by 245 · see citing works

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

Klöckener, T., Heß, S., Belgardt, B., Paeger, L., Verhagen, L. A. W., Husch, A., Sohn, J., Hampel, B., Dhillon, H., Zigman, J. M., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2847 · Cited by 239 · see citing works

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis

Ren, D., Zhou, Y., Morris, D. L., Li, M., Li, Z., & Rui, L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29417 · Cited by 205 · see citing works

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Zhang, Z., Dodd, G. T., & Tiganis, T. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.07.003 · Cited by 181 · see citing works

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

Purkayastha, S., Zhang, H., Zhang, G., Ahmed, Z., Wang, Y., & Cai, D. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1006875108 · Cited by 182 · see citing works

The FoxO transcription factors and metabolic regulation

Nakae, J., Oki, M., & Cao, Y. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.025 · Cited by 176 · see citing works

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats

Ono, H., Pocai, A., Wang, Y., Sakoda, H., Asano, T., Backer, J., Schwartz, G. J., & Rossetti, L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34277 · Cited by 175 · see citing works

Insulin controls food intake and energy balance via NPY neurons

Loh, K., Zhang, L., Brandon, A. E., Wang, Q., Begg, D. P., Qi, Y., Fu, M., Kulkarni, R. N., Teo, J. D., Baldock, P. A. J., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.03.013 · Cited by 173 · see citing works

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

Titchenell, P. M., Chu, Q., Monks, B. R., & Birnbaum, M. J. (2015) · Nature Communications · doi:10.1038/ncomms8078 · Cited by 169 · see citing works

Hypothalamic Leptin Signaling Regulates Hepatic Insulin Sensitivity via a Neurocircuit Involving the Vagus Nerve

German, J., Kim, F., Schwartz, G. J., Havel, P. J., Rhodes, C. J., Schwartz, M. W., & Morton, G. J. (2009) · Endocrinology · doi:10.1210/en.2009-0445 · Cited by 164 · see citing works

Direct innervation of GnRH neurons by metabolic- & sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus

Leshan, R., Louis, G. W., Jo, Y., Rhodes, C., Münzberg, H., & Myers, M. G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0155-09.2009 · Cited by 154 · see citing works

Hormone Interactions Regulating Energy Balance During Pregnancy

Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02017.x · Cited by 161 · see citing works

Early Life Origins of Obesity: Role of Hypothalamic Programming

Bouret, S. G. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181977375 · Cited by 160 · see citing works

Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes

German, J. P., Wisse, B. E., Thaler, J. P., Oh-I, S., Sarruf, D. A., Ogimoto, K., Kaiyala, K. J., Fischer, J. D., Matsen, M. E., Taborsky, G. J., et al. (2010) · Diabetes · doi:10.2337/db09-1918 · Cited by 159 · see citing works

Insulin Resistance and Mitochondrial Dysfunction

González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 154 · see citing works

GluT4: A central player in hippocampal memory and brain insulin resistance

McNay, E. C., & Pearson-Leary, J. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113076 · Cited by 156 · see citing works

Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell

Ohta, Y., Kosaka, Y., Kishimoto, N. Y., Wang, J., Smith, S. B., Honig, G., Kim, H., Gasa, R., Neubauer, N., Liou, A., et al. (2011) · Diabetes · doi:10.2337/db10-1192 · Cited by 149 · see citing works

Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats

Zhang, W.-J., Tan, Y., Yue, J. T. Y., Vranić, M., & Wojtowicz, J. M. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00928.x · Cited by 150 · see citing works

Potential mechanisms of atypical antipsychotic-induced metabolic derangement: Clues for understanding obesity and novel drug design

Coccurello, R., & Moles, A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.008 · Cited by 146 · see citing works

Leptin Rapidly Improves Glucose Homeostasis in Obese Mice by Increasing Hypothalamic Insulin Sensitivity

Koch, C. E., Augustine, R. A., Steger, J., Ganjam, G. K., Benzler, J., Pracht, C., Lowe, C., Schwartz, M. W., Shepherd, P. R., Anderson, G. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3202-10.2010 · Cited by 136 · see citing works

Pancreatic Function, Type 2 Diabetes, and Metabolism in Aging

Gong, Z., & Muzumdar, R. H. (2012) · International Journal of Endocrinology · doi:10.1155/2012/320482 · Cited by 130 · see citing works

Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems

Gold, P. W., Licinio, J., & Pavlatou, M. G. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.167 · Cited by 132 · see citing works

Molecular pathophysiology of metabolic effects of antipsychotic medications

Ballon, J. S., Pajvani, U. B., Freyberg, Z., Leibel, R. L., & Lieberman, J. A. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.004 · Cited by 130 · see citing works

Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance

Benzler, J., Ganjam, G. K., Pretz, D., Oelkrug, R., Koch, C. E., Legler, K., Stöhr, S., Culmsee, C., Williams, L. M., & Tups, A. (2015) · Diabetes · doi:10.2337/db14-0093 · Cited by 129 · see citing works

Central insulin and leptin-mediated autonomic control of glucose homeostasis

Marino, J. S., Xu, Y., & Hill, J. W. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.03.001 · Cited by 123 · see citing works

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Dodd, G. T., Michael, N. J., Lee, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z., Cowley, M. A., et al. (2018) · eLife · doi:10.7554/elife.38704 · Cited by 114 · see citing works

CNS Regulation of Glucose Homeostasis

Lam, C., Chari, M., & Lam, T. K. T. (2009) · Physiology · doi:10.1152/physiol.00003.2009 · Cited by 110 · see citing works

Hypothalamic leptin regulation of energy homeostasis and glucose metabolism

Morton, G. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135590 · Cited by 112 · see citing works

Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding

Speed, N. K., Saunders, C., Davis, A. R., Owens, W. A., Matthies, H. J. G., Saadat, S., Kennedy, J. P., Vaughan, R. A., Neve, R. L., Lindsley, C. W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025169 · Cited by 107 · see citing works

Molecular Mechanisms of Hypothalamic Insulin Resistance

Ono, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061317 · Cited by 107 · see citing works

Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production

Filippi, B., Yang, C. S., Tang, C., & Lam, T. K. T. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.005 · Cited by 104 · see citing works

Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons

Mayer, C., & Belsham, D. D. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.02.031 · Cited by 98 · see citing works

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

Dodd, G. T., Xirouchaki, C. E., Eramo, M. J., Mitchell, C. A., Andrews, Z. B., Henry, B. A., Cowley, M. A., & Tiganis, T. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.019 · Cited by 94 · see citing works

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

Fukushima, A., Loh, K., Galić, S., Fam, B. C., Shields, B., Wiede, F., Tremblay, M. L., Watt, M. J., Andrikopoulos, S., & Tiganis, T. (2010) · Diabetes · doi:10.2337/db09-1365 · Cited by 91 · see citing works

Brain Signaling Systems in the Type 2 Diabetes and Metabolic Syndrome: Promising Target to Treat and Prevent These Diseases

Shpakov, A. O., Derkach, K. V., & Berstein, L. M. (2015) · Future Science OA · doi:10.4155/fso.15.23 · Cited by 92 · see citing works

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

Hill, J. W., Xu, Y., Preitner, F., Fukuda, M., Cho, Y.-R., Luo, J., Balthasar, N., Coppari, R., Cantley, L. C., Kahn, B. B., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0454 · Cited by 88 · see citing works

Minireview: The Brain as a Molecular Target for Diabetic Therapy

Prodi, E., & Obici, S. (2006) · Endocrinology · doi:10.1210/en.2006-0143 · Cited by 86 · see citing works

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes · doi:10.2337/db10-0221 · Cited by 86 · see citing works

Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation

Mayer, C., & Belsham, D. D. (2009) · Endocrinology · doi:10.1210/en.2009-0838 · Cited by 85 · see citing works

Activation of N-Methyl-d-aspartate (NMDA) Receptors in the Dorsal Vagal Complex Lowers Glucose Production

Lam, C., Chari, M., Su, B., Cheung, G. W. C., Kokorovic, A., Yang, C. S., Wang, P. Y. T., Lai, T. Y. Y., & Lam, T. K. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.087338 · Cited by 83 · see citing works

Lipid Sensing and Insulin Resistance in the Brain

Yue, J. T. Y., & Lam, T. K. T. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.013 · Cited by 82 · see citing works

Central lactate metabolism regulates food intake

Lam, C., Chari, M., Wang, P. Y. T., & Lam, T. K. T. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90481.2008 · Cited by 80 · see citing works

Neuronal Androgen Receptor Regulates Insulin Sensitivity via Suppression of Hypothalamic NF-κB–Mediated PTP1B Expression

Yu, I.-C. I., Lin, H., Liu, N.-C., Sparks, J. D., Yeh, S., Fang, L., Chen, L., & Chang, C. (2012) · Diabetes · doi:10.2337/db12-0135 · Cited by 78 · see citing works

Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis

Hu, F., Xu, Y., & Liu, F. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00121.2016 · Cited by 76 · see citing works

Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism

Benzler, J., Ganjam, G. K., Krüger, M., Pinkenburg, O., Kutschke, M., Stöhr, S., Steger, J., Koch, C. E., Oelkrug, R., Schwartz, M. W., et al. (2012) · Biochemical Journal · doi:10.1042/bj20120834 · Cited by 72 · see citing works

Androgen Receptor Roles in Insulin Resistance and Obesity in Males: The Linkage of Androgen-Deprivation Therapy to Metabolic Syndrome

Yu, I.-C. I., Lin, H., Sparks, J. D., Yeh, S., & Chang, C. (2014) · Diabetes · doi:10.2337/db13-1505 · Cited by 71 · see citing works

Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis

Caron, A., & Richard, D. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13263 · Cited by 68 · see citing works

The Inhibitory Effects of Insulin on Hepatic Glucose Production Are Both Direct and Indirect

Girard, J. R. (2006) · Diabetes · doi:10.2337/db06-s009 · Cited by 63 · see citing works

A Balance of Lipid-Sensing Mechanisms in the Brain and Liver

Caspi, L., Wang, P. Y. T., & Lam, T. K. T. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.07.005 · Cited by 58 · see citing works

Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies

Huang, Y., Lin, X., & Lin, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.695623 · Cited by 58 · see citing works

Evidence for Central Regulation of Glucose Metabolism

Carey, M., Kehlenbrink, S., & Hawkins, M. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.506782 · Cited by 57 · see citing works

Hypothalamic Protein Kinase C Regulates Glucose Production

Ross, R., Wang, P. Y. T., Chari, M., Lam, C., Caspi, L., Ono, H., Muse, E. D., Li, X., Juárez, R. G., Light, P. E., et al. (2008) · Diabetes · doi:10.2337/db08-0206 · Cited by 57 · see citing works

Hypothalamic WNT Signalling Is Impaired During Obesity and Reinstated by Leptin Treatment in Male Mice

Benzler, J., Andrews, Z. B., Pracht, C., Stöhr, S., Shepherd, P. R., Grattan, D. R., & Tups, A. (2013) · Endocrinology · doi:10.1210/en.2013-1746 · Cited by 55 · see citing works

Evidence against a Physiologic Role for Acute Changes in CNS Insulin Action in the Rapid Regulation of Hepatic Glucose Production

Ramnanan, C. J., Edgerton, D. S., & Cherrington, A. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.006 · Cited by 56 · see citing works

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria

Chhabra, K. H., Adams, J. M., Fagel, B., Lam, D. D., Qi, N., Rubinstein, M., & Low, M. J. (2015) · Diabetes · doi:10.2337/db15-0804 · Cited by 56 · see citing works

PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction

Acosta-Martínez, M. (2012) · Front. Endocrin. · doi:10.3389/fendo.2011.00110 · Cited by 56 · see citing works

Vitamins D and E Stimulate the PI3K-AKT Signalling Pathway in Insulin-Resistant SK-N-SH Neuronal Cells

Zaulkffali, A. S., Razip, N. N. M., Alwi, S. S. S., Jalil, A. A., Mutalib, M. S. A., Gopalsamy, B., Chang, S. K., Zainal, Z., Ibrahim, N. N., Zakaria, Z. A., et al. (2019) · Nutrients · doi:10.3390/nu11102525 · Cited by 54 · see citing works

Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance.

Chari, M., Lam, C. K. L., Wang, P. Y. T., & Lam, T. K. T. (2008) · Diabetes · doi:10.2337/db07-1464 · Cited by 53 · see citing works

Resistance to Diet-Induced Obesity and Improved Insulin Sensitivity in Mice With a Regulator of G Protein Signaling–Insensitive G184S Gnai2 Allele

Huang, X., Charbeneau, R. A., Fu, Y., Kaur, K., Gerin, I., MacDougald, O. A., & Neubig, R. R. (2007) · Diabetes · doi:10.2337/db07-0599 · Cited by 53 · see citing works

Control of hepatic glucose metabolism by islet and brain

Rojas, J. M., & Schwartz, M. W. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12332 · Cited by 52 · see citing works

Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain

Paranjape, S., Chan, O. T. M., Zhu, W., Horblitt, A. M., Grillo, C. A., Wilson, S. P., Reagan, L. P., & Sherwin, R. S. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00304.2011 · Cited by 52 · see citing works

Cellular Insulin Resistance Disrupts Leptin-Mediated Control of Neuronal Signaling and Transcription

Nazarians-Armavil, A., Menchella, J. A., & Belsham, D. D. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1338 · Cited by 47 · see citing works

Leptin, diabetes, and the brain

Morton, G. J., & Meek, T. H. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105568 · Cited by 45 · see citing works

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

Dodd, G. T., Lee, R. S., Brüning, J. C., & Tiganis, T. (2018) · Diabetes · doi:10.2337/db17-1485 · Cited by 46 · see citing works

Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon‐like peptide‐1 receptor agonists

Yassine, H. N., Solomon, V. A., Thakral, A., Sheikh‐Bahaei, N., Chui, H. C., Braskie, M. N., Schneider, L. S. S., & Talbot, K. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12474 · Cited by 42 · see citing works

Central insulin-mediated regulation of hepatic glucose production [Review]

Inoue, H. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej15-0540 · Cited by 43 · see citing works

Insulin reduces excitation in gastric-related neurons of the dorsal motor nucleus of the vagus

Blake, C. B., & Smith, B. N. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00276.2012 · Cited by 41 · see citing works

Insulin and glucagon signaling in the central nervous system

Filippi, B., Abraham, M. A., Yue, J. T. Y., & Lam, T. K. T. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9258-4 · Cited by 42 · see citing works

Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism

Rother, E., Könner, A. C., & Brüning, J. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00685.2007 · Cited by 38 · see citing works

Cortical thinning in type 2 diabetes mellitus and recovering effects of insulin therapy

Chen, Z., Sun, J., Yang, Y., Lou, X., Wang, Y., Wang, Y., & Ma, L. (2014) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2014.07.014 · Cited by 36 · see citing works

Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons

Huang, Y., He, Z., Gao, Y., Lieu, L., Yao, T. S., Sun, J. M., Liu, T., Javadi, C. S., Box, M., Afrin, S., et al. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00061 · Cited by 35 · see citing works

Hypothalamic sensing of circulating lactate regulates glucose production

Kokorovic, A., Cheung, G. W. C., Rossetti, L., & Lam, T. K. T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00596.x · Cited by 33 · see citing works

Central effects of humanin on hepatic triglyceride secretion

Gong, Z., Su, K., Cui, L., Tas, E., Zhang, T., Dong, H. H., Yakar, S., & Muzumdar, R. H. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2015 · Cited by 33 · see citing works

Insulin signalling in hypothalamic neurones

Belsham, D. D., & Dalvi, P. S. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12919 · Cited by 33 · see citing works

Chromium Picolinate Modulates Serotonergic Properties and Carbohydrate Metabolism in a Rat Model of Diabetes

Komorowski, J. R., Tuzcu, M., Şahin, N., Juturu, V., Orhan, C., Ulaş, M., & Şahin, K. (2012) · Biological Trace Element Research · doi:10.1007/s12011-012-9393-x · Cited by 32 · see citing works

Acute Inhibition of Central c‐Jun N‐terminal Kinase Restores Hypothalamic Insulin Signalling and Alleviates Glucose Intolerance in Diabetic Mice

Benzler, J., Ganjam, G. K., Legler, K., Stöhr, S., Krüger, M., Steger, J., & Tups, A. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12018 · Cited by 31 · see citing works

Hypothalamic Control of Hepatic Glucose Production and Its Potential Role in Insulin Resistance

Buettner, C., & Camacho, R. C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.09.001 · Cited by 31 · see citing works

Central administration of vaspin inhibits glucose production and augments hepatic insulin signaling in high-fat-diet-fed rat

Luo, X., Li, K., Zhang, C., Yang, G., Yang, M., Jia, Y., Zhang, L., Ma, Z. A., Boden, G., & Li, L. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.24 · Cited by 29 · see citing works

The Physiology of Insulin Clearance

Bergman, R. N., Kabir, M., & Ader, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031826 · Cited by 28 · see citing works

Hormonal Signaling Systems of the Brain in Diabetes Mellitus

Shpakov, A. O., Chistyakova, O. V., Derkach, K. V., & Bondarev, V. (2011) · InTech eBooks · doi:10.5772/28930 · Cited by 28 · see citing works

Prenatal High Estradiol Exposure Induces Sex-Specific and Dietarily Reversible Insulin Resistance Through Decreased Hypothalamic INSR

Wang, H., Zhou, C., Lv, M., Yang, Q., Li, J., Hou, M., Lin, J., Liu, X., Wu, Y., Sheng, J., et al. (2017) · Endocrinology · doi:10.1210/en.2017-03017 · Cited by 28 · see citing works

Was it something I ate? Understanding the bidirectional interaction of migraine and appetite neural circuits

Martins-Oliveira, M., Tavares, I., & Goadsby, P. J. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147629 · Cited by 30 · see citing works

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

Niswender, K. D., Morrison, C. D., Clegg, D. J., Olson, R., Baskin, D. G., Myers, M. G., Seeley, R. J., & Schwartz, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.2.227 · Cited by 476 · see citing works

Abstract 35: PI3K-mTOR Axis is a Critical Node for Hypothalamic Insulin Receptor Signaling and Sympathetic Activation Induced by Insulin

Muta, K., Morgan, D. A., & Rahmouni, K. (2013) · Hypertension · doi:10.1161/hyp.62.suppl_1.a35

Both p110α and p110β Isoforms of Phosphatidylinositol 3‐OH‐Kinase are Required for Insulin Signalling in the Hypothalamus

Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01975.x · Cited by 41 · see citing works

Short-term fasting differentially regulates PI3K/AkT/mTOR and ERK signalling in the rat hypothalamus

Dakic, T. B., Jevdjovic, T. V., Djordjevic, J. D., & Vujovic, P. Z. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111358 · Cited by 12 · see citing works

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia

Diggs‐Andrews, K. A., Zhang, X., Song, Z., Daphna-Iken, D., Routh, V. H., & Fisher, S. J. (2010) · Diabetes · doi:10.2337/db10-0401 · Cited by 99 · see citing works