The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Critical role for peptide YY in protein-mediated satiation and body-weight regulation
Open accessAbstract
Dietary protein enhances satiety and promotes weight loss, but the mechanisms by which appetite is affected remain unclear. We investigated the role of gut hormones, key regulators of ingestive behavior, in mediating the satiating effects of different macronutrients. In normal-weight and obese human subjects, high-protein intake induced the greatest release of the anorectic hormone peptide YY (PYY) and the most pronounced satiety. Long-term augmentation of dietary protein in mice increased plasma PYY levels, decreased food intake, and reduced adiposity. To directly determine the role of PYY in mediating the satiating effects of protein, we generated Pyy null mice, which were selectively resistant to the satiating and weight-reducing effects of protein and developed marked obesity that was reversed by exogenous PYY treatment. Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity.
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Cites
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Self-citationInhibition of Food Intake in Obese Subjects by Peptide YY 3–36
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604
Self-citationRoux, C. W. L., Aylwin, S. J. B., Batterham, R. L., Borg, C. M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M. A., Patel, A. G., & Bloom, S. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000183349.16877.84 · Cited by 985 · cited 3×
“Bariatric surgery, a highly effective but invasive means of inducing weight loss, is associated with elevated PYY levels, which may underlie the weight-reducing effects of this procedure (Korner et al., 2005; le Roux et al., 2006a; Morinigo et al., 2006).”
BackgroundResultSelf-citationSkov, A., Toubro, S., Rønn, B., Holm, L., & Astrup, A. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800867 · Cited by 743
The gut and energy balance: visceral allies in the obesity wars
Badman, M. K., & Flier, J. S. (2005) · Science · doi:10.1126/science.1109951 · Cited by 532
Pancreatic Polypeptide Reduces Appetite and Food Intake in Humans
Batterham, R. L., Le Roux, C. W., Cohen, M. A., Park, A. J., Ellis, S. M., Patterson, M., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030630 · Cited by 496
Self-citationA war on obesity, not the obese.
Friedman, J. M. (2003) · Science · doi:10.1126/science.1079856 · Cited by 375
High protein intake sustains weight maintenance after body weight loss in humans
Westerterp-Plantenga, M. S., Lejeune, M. P. G. M., Nijs, I., van Ooijen, M., & Kovacs, E. M. R. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802461 · Cited by 326
Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity
Boey, D., Lin, S., Karl, T., Baldock, P., Lee, N., Enriquez, R., Couzens, M., Slack, K., Dallmann, R., Sainsbury, A., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0237-0 · Cited by 186
Self-citationSchonhoff, S., Baggio, L., Ratineau, C., Ray, S. K., Lindner, J., Magnuson, M. A., Drucker, D. J., & Leiter, A. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.4189-4199.2005 · Cited by 53
Cited by
Gut hormones and the regulation of energy homeostasis
Murphy, K. G., & Bloom, S. R. (2006) · Nature · doi:10.1038/nature05484 · Cited by 778
Dietary protein, weight loss, and weight maintenance
Westerterp-Plantenga, M. S., Nieuwenhuizen, A., Tomé, D., Soenen, S., & Westerterp, K. R. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141056 · Cited by 570
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532
Self-citationAmino acid homeostasis and signalling in mammalian cells and organisms
Bröer, S., & Bröer, A. (2017) · Biochemical Journal · doi:10.1042/bcj20160822 · Cited by 502
Metadata
- Authors
- Batterham, R. L., Heffron, H., Kapoor, S., Chivers, J. E., Chandarana, K., Herzog, H., Le Roux, C. W., Thomas, E. L., Bell, J. D., & Withers, D. J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 4
- Issue
- 3
- Pages
- 223-233
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1989005361
- Cited by
- 626
- References
- 10
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Batterham, R. L., Heffron, H., Kapoor, S., Chivers, J. E., Chandarana, K., Herzog, H., Le Roux, C. W., Thomas, E. L., Bell, J. D., & Withers, D. J. (2006). Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metabolism. https://doi.org/10.1016/j.cmet.2006.08.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
