Cited by 780Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

Gut hormones and the regulation of energy homeostasis

Murphy, Kevin G., Bloom, Stephen R.·2006·Nature

Abstract

Food intake, energy expenditure and body adiposity are homeostatically regulated. Central and peripheral signals communicate information about the current state of energy balance to key brain regions, including the hypothalamus and brainstem. Hunger and satiety represent coordinated responses to these signals, which include neural and hormonal messages from the gut. In recent years our understanding of how neural and hormonal brain-gut signalling regulates energy homeostasis has advanced considerably. Gut hormones have various physiological functions that include specifically targeting the brain to regulate appetite. New research suggests that gut hormones can be used to specifically regulate energy homeostasis in humans, and offer a target for anti-obesity drugs.

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Crossref · 10.1038/nature05484

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Authors
Murphy, K. G., & Bloom, S. R.
Affiliations
Imperial College London (GB)
Venue
Nature
Published
2006-12
Volume
444
Issue
7121
Pages
854-859
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2078060668
Cited by
778
References
95
Citations by year
2026: 24 · 2025: 21 · 2024: 25 · 2023: 31 · 2022: 32 · 2021: 47 · 2020: 39 · 2019: 38 · 2018: 47 · 2017: 52 · 2016: 33 · 2015: 42 · 2014: 51 · 2013: 60 · 2012: 45
FWCI
3.60
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
gastrointestinal hormones, energy homeostasis, appetite regulation, hunger and satiety, hypothalamus, brainstem, dietary intake, energy expenditure, adiposity, anti-obesity drugs
MeSH terms
Animals, Appetite Regulation, Digestive System, Energy Metabolism, Homeostasis, Hormones, Humans

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