The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Open accessAbstract
The circadian clock programs daily rhythms and coordinates multiple behavioral and physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent studies indicate that genetic alteration in the core molecular clock machinery can have pronounced effects on both peripheral and central metabolic regulatory signals. Many metabolic systems also cycle and may in turn affect function of clock genes and circadian systems. However, little is known about how alterations in energy balance affect the clock. Here we show that a high-fat diet in mice leads to changes in the period of the locomotor activity rhythm and alterations in the expression and cycling of canonical circadian clock genes, nuclear receptors that regulate clock transcription factors, and clock-controlled genes involved in fuel utilization in the hypothalamus, liver, and adipose tissue. These results indicate that consumption of a high-calorie diet alters the function of the mammalian circadian clock.
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In the citing paper
“Circadian rhythms are endogenously generated in the suprachiasmatic nucleus of the hypothalamus by feedback loops of transcripts of a group of “core clock” genes, including the CLOCK gene.40,41”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [40]
In the citing paper
“Time-keeping signals are passed on from the suprachiasmatic nucleus to oscillators in peripheral tissues also containing core clock genes.”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [40]
In the citing paper
“Even a high-fat diet may alter the function of the circadian clock, with an altered period of the locomotor activity rhythm and changes in the rhythms of the core clock genes in adipose and liver tissue [35–40,49].”
From Circadian control of glucose metabolism (2014) · cites this paper as [35]
In the citing paper
“In concert with these findings, simply feeding mice a high fat diet alters the circadian period and attenuates the diurnal pattern of feeding behavior (Kohsaka et al., 2007).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Kohsaka et al., 2007
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Metadata
- Authors
- Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J.
- Affiliations
- Northwestern University (US)
- Evanston Hospital (US)
- Corresponding author
- Bass, Joseph
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 6
- Issue
- 5
- Pages
- 414-421
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1997151200
- Cited by
- 1,528
- References
- 29
- Citations by year
- 2026: 76 · 2025: 94 · 2024: 86 · 2023: 88 · 2022: 112 · 2021: 111 · 2020: 133 · 2019: 88 · 2018: 99 · 2017: 92 · 2016: 91 · 2015: 99 · 2014: 79 · 2013: 66 · 2012: 59
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Amylin Pharmaceuticals
- National Institutes of Health
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL075029)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- high-fat diet, circadian clock, circadian rhythm, clock genes, locomotor activity rhythm, nuclear receptors, clock-controlled genes, hypothalamus, liver, adipose tissue, energy balance, metabolic regulation
- MeSH terms
- Animals, Behavior, Animal, Central Nervous System, Circadian Rhythm, Dietary Fats, Feeding Behavior, Gene Expression Regulation, Male, Mice, Inbred C57BL, Motor Activity, Trans-Activators, Receptors, Cytoplasmic and Nuclear, Mice, CLOCK Proteins
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