The DOI matches its Crossref record; 54 of the 57 references it cites were found in a registry or an index.
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Open accessAbstract
Skeletal muscles adapt to increasing workload by augmenting their fiber size, through mechanisms that are poorly understood. This study identifies the cytokine interleukin-6 (IL-6) as an essential regulator of satellite cell (muscle stem cell)-mediated hypertrophic muscle growth. IL-6 is locally and transiently produced by growing myofibers and associated satellite cells, and genetic loss of IL-6 blunted muscle hypertrophy in vivo. IL-6 deficiency abrogated satellite cell proliferation and myonuclear accretion in the preexisting myofiber by impairing STAT3 activation and expression of its target gene cyclin D1. The growth defect was indeed muscle cell intrinsic, since IL-6 loss also affected satellite cell behavior in vitro, in a STAT3-dependent manner. Myotube-produced IL-6 further stimulated cell proliferation in a paracrine fashion. These findings unveil a role for IL-6 in hypertrophic muscle growth and provide mechanistic evidence for the contribution of satellite cells to this process.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For instance, the pro-inflammatory cytokine IL-6 mediates lipid oxidation [7], induces the production of anti-inflammatory interleukins during exercise (e.g. IL-10 and IL-1ra) [8] and stimulates muscle growth [9].”
In the citing paper
“In vitro, IL-6 bears anabolic effects by regulating satellite cells’ function and enhancing glucose metabolism; furthermore, a loss of IL-6 signaling in myoblasts results in a reduced proliferation and migration [49,50].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [50]
In the citing paper
“Elimination of these cytokines in vivo has been shown to diminish muscle repair [118].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [118]
In the citing paper
“Briefly, a number of studies have shown that the chemokines and cytokines (TNF-α, IL-1β, IL-6) produced by initially infiltrating M1 macrophages are chemoattractant and mitogenic for muscle progenitor cells, including Pax7+ satellite cells [115–119].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [118]
In the citing paper
“Although the myokine IL-6 is mostly recognized for its regulatory effects in lipid and glucose metabolism, IL-6 also plays important roles in myogenesis.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [49]
In the citing paper
“Genetic loss of IL-6 impaired muscle hypertrophy in vivo, whereas myotube-produced IL-6 stimulated muscle cell proliferation in a paracrine fashion (49).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [49]
In the citing paper
“Although being considered pro-inflammatory, TNF-α and IL-6 also appear to play important role in the early stages of muscle regeneration following injury by enhancing myoblast proliferation and inhibiting differentiation [73,74,75].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [73]
In the citing paper
“This inhibition involves the down regulation of the MRFs, MyoD and Myogenin [73,74,75], with TNF-α receptor double knock out mice [74] and with IL-6 non-specific knock out mice [73] shown to present impaired myogenic differentiation and hypertrophy when compared to wild type mice during functional overloading.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [73]
Citations
Cites
1 retracted
Immunohistochemical detection of interleukin‐6 in human skeletal muscle fibers following exercise
Penkowa, M., Keller, C., Keller, P., Jauffred, S., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0311fje · Cited by 157
RetractedBodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 1×
“…3 C57BL/6 background (WT) and generated by heterozygous mating of mice carrying a targeted disruption in which the second exon in the IL-6 gene was replaced by a neo r cassette (Kopf et al., 1994), were generously provided by A. Bernad (Centro Nacional de Investiga-ciones Cardiovasculares, Madrid).”
MethodNF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
D, D. C. G., Albanese, C., Reuther, J. Y., Pestell, R. G., & Baldwin, A. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5785 · Cited by 1,304
Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD
Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., & Lassar, A. B. (1995) · Science · doi:10.1126/science.7863327 · Cited by 1,139
Skeletal muscle hypertrophy and atrophy signaling pathways
Glass, D. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.018 · Cited by 1,106
INTERLEUKIN-6: From Basic Science to Medicine—40 Years in Immunology
Kishimoto, T. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115806 · Cited by 1,040
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
Glass, D. J. (2003) · Nature Cell Biology · doi:10.1038/ncb0203-87 · Cited by 694
IL-6 signal transduction and its physiological roles: the signal orchestration model
Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673
IL-6-induced skeletal muscle atrophy
Haddad, F., Zaldivar, F., Cooper, D. M., & Adams, G. R. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01026.2004 · Cited by 612
Cited by
Sorted by citations
Items 701–800 of 868
Moderate Intensity Training By Listening To Music Decreases Interleukin-6 Levels In Rats
Purwoto, S. P., Pranoto, A., Hartono, H., & Sugiharto, S. (2020) · STRADA JURNAL ILMIAH KESEHATAN · doi:10.30994/sjik.v9i1.272 · Cited by 2
“According to Lutoslawska (2012) IL-6 also stimulates cell satellite and muscle hypertrophy and muscle repair, because it is an important molecule of muscle hypertrophy by controlling cell satellite proliferation and myonuclear accretion mediated by the activation of signal transducers and activators of transcription 3…”
BackgroundInfluentialCell senescence is a cause of frailty
Wan, T., Miwa, S., & von Zglinicki, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00013-4 · Cited by 1
The Potential Effect Of Leptin And Il-6 Levels On Covid-19 Severity In Obese Patients
Mousa, M. K., Ali, H. A., Kahlol, M. K., & Fatemi, F. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.s02.25 · Cited by 1
“Materials and Methods: This case-control study included 60 obese subjects, divided to 30 obese without any chronic disease and not infected with COVID-19, and 30 individuals were infected with COVID-19, with the age ranged between (25-60) years.”
MethodPietrzkowski, Z. J., Hunter, J., Evers, B., & Pond, H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396454-0.00050-3 · Cited by 1
[What if the origin of FAPs was contributing to their heterogeneity in muscle?]
Mathieu, M., Girousse, A., & Sengenès, C. (2023) · Medecine sciences : M/S · doi:10.1051/medsci/2023129 · Cited by 1
Pedersen, B. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_31-1 · Cited by 1
K, T. S. O. (2013) · Journal of Novel Physiotherapies · doi:10.4172/2165-7025.1000187 · Cited by 1
“Those growth factors and cytokines have been suggested to regulate muscle growth/hypertrophy [29,30].”
BackgroundThe effect of icing treatment on recovery process of damaged muscle in the rat
Ikezaki, K., Shibaguchi, T., Sugiura, T., & Miyata, H. (2017) · 体力科學 · doi:10.7600/jspfsm.66.345 · Cited by 1
Khairani, A. F., Nurhayati, T., Rahman, P., Nurhasanah, N., Khaerunnis, R., Jabbar, S. M. F. R., Mayasari, W. S., & Wahyudi, K. A. (2019) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2019.824.833 · Cited by 1
The effects of organophosphates in the early stages of human skeletal muscle regeneration
Marš, T., Miš, K., Katalinić, M., Pegan, K., Grubič, Z., & Pirkmajer, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819090-6.00049-0 · Cited by 1
Ohira, T., Kawano, F., Ozaki, Y., Fukuda, S., Goto, K., & Ohira, Y. (2020) · Biological Sciences in Space · doi:10.2187/bss.34.1 · Cited by 1
“…IL-6, which is one of the cytokines released from macrophages, plays the detrimental role in the regeneration of muscle, although some amount of IL-6 is also needed, as was reported that IL-6 facilitates muscle growth via the activation of satellite cells (McKay et al., 2009; Serrano et al., 2008).”
BackgroundMiedany, Y. M. E. (2022) · Springer eBooks · doi:10.1007/978-3-030-87950-1_3 · Cited by 1
Bone-Muscle Crosstalk in Advanced Cancer and Chemotherapy
Waning, D. L. (2022) · Springer eBooks · doi:10.1007/978-3-031-09518-4_9 · Cited by 1
DDIT3 Governs Milk Production Traits by Targeting IL-6 to Induce Apoptosis in Dairy Cattle
Cui, X., Li, C., Wei, Z., Meng, H., Zhang, F., Liu, Y., Wu, C., & Yang, S. (2022) · Agriculture · doi:10.3390/agriculture13010117 · Cited by 1
Nanosized Delivery Systems for Tissue Regeneration
Çınar, G., Mumcuoglu, D., Tekinay, A. B., & Guler, M. O. (2016) · Wiley eBooks · doi:10.1002/9781118987483.ch2 · Cited by 1
“Delivery of cytokines such as tumor necrosis factor‐α (TNF‐α) (Chen et al., 2007), interferon‐γ (Cheng et al., 2008), or interleukin‐6 (IL‐6) (Serrano et al., 2008) mediating inflammation in muscle regeneration processes can be an alternative approach for the treatments of acute or chronic muscle damages.”
BackgroundMaintaining the stemness of satellite cells during long-term culture
Ding (2019) · Research Publications (Maastricht University) · doi:10.26481/dis.20190327sd · Cited by 2
Acute Responses to Exercise with Blood Flow Restriction: A Systematic Review
Helzer, D. (2021) · Cited by 1
Stauber, T., Moschini, G., Hussien, A. A., Jaeger, P. K., Bock, K. D., & Snedeker, J. G. (2023) · eLife · doi:10.7554/elife.87092.1 · Cited by 1
Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in MicePreprint
Izumi-Mishima, Y., Tsutsumi, R., Shiuchi, T., Fujimoto, S., Taniguchi, M., Okamatsu‐Ogura, Y., Yoneshiro, T., Kuroda, M., Nomura, K., & Sakaue, H. (2024) · eLife · doi:10.7554/elife.99982.1 · Cited by 1
Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblastsPreprint
Stauber, T., Moschini, G., Hussien, A. A., Jaeger, P. K., Bock, K. D., & Snedeker, J. G. (2024) · eLife · doi:10.7554/elife.87092.2 · Cited by 1
Muscle Stem Cells: Their Discovery, Properties, andIn-VitroManipulation
McFarland, S., Pagani, I., & Conboy, I. M. (2013) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.201200001
Guimarães, D. E. D. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2012.tde-24072012-165034
Papel do adrenoceptor beta 2 na regeneração muscular esquelética.
da Silva, M. T. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2014.tde-14112014-154208
Montero, C. C. (2011) · Buleria (Universidad de León) · doi:10.18002/10612/1619
Readaptation of Atrophied Muscle – from Protein Degradation to Synthesis
Shenkman, E. A. (2014) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-014-9989-z
“Intensification of proliferative processes in the satellite cell pool is determined by a complex of growth factors, including NO-dependent hepatocyte growth factor (HGF), MGF, and interleukin-6 [32, 77, 82].”
BackgroundSignaling to muscle satellite cells
Borthwick, L. (2008) · Nature reports. Stem cells · doi:10.1038/stemcells.2008.29
PAPEL DO ADRENOCEPTOR BETA 2 NA REGENERAÇÃO MUSCULAR ESQUELÉTICA
Miyabara, E. H. (2014)
Organ-Specific Physiological Responses to Acute Physical Exercise and Long-Term Training
Garatachea, N., Berger, N. A., Lucía, A., Knuuti, J. M., HEINONEN, I. H. A., Kalliokoski, K. K., Hannukainen, J. C., Duncker, D. J., Nuutila, P., Bouchard, C., et al. (2015)
differentiationregulates skeletal myoblast Mechanical strain applied to human fibroblasts
Hicks, M. R., Cao, T. V., Campbell, D. H., & Standley, P. R. (2015)
Plasticity of skeletal muscle and variability of myonuclear domain
Kawai, M., & Miyata, H. (2013) · 体力科學 · doi:10.7600/jspfsm.62.189
The role of GSK-3 in myogenesis and recovery of atrophied muscle
Pansters, N. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20151008np
[Drug treatment of cholestatic liver diseases].
Reichen, J. (1992) · PubMed
Martins, M. S., Farinha, J. B., Benetti, C. B., Courtes, A. A., Duarte, T., da Silva, J. C. N., Medeiros, M. M. D. C., & Duarte, F. (2015)
McKay, B. R., & Parise, G. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_10
Hoene, M., Runge, H., Häring, H. U., Schleicher, E. D., & Weigert, C. (2016)
Worthey, C. (2016) · ISU Red - Research and eData (Illinois State University) · doi:10.30707/etd2016.worthey.c
Dependency on Non-myogenic Cells for Regeneration of Skeletal Muscle
Lynch, C. A., Andre, A. B., & Rawls, A. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-44996-8_3
The aging horse: Effects of inflammation on muscle satellite cells 1,2
Reed, S. A., LaVigne, E. K., Jones, A. K., Patterson, D. F., & Schauer, A. (2015)
Krakowski‐Roosen, H. (2017) · Der Onkologe · doi:10.1007/s00761-017-0202-1
Growth and differentiation factor-15 and microRNA in intensive care unit acquired paresis
Bloch, S. A. A. (2015) · Spiral (Imperial College London) · doi:10.25560/25739
“Interleukin-6 (IL-6) mRNA expression was used as a positive control to demonstrate that the stretch protocol was appropriately affecting the cells (as per (318, 325)).”
MethodMokarram, N. (2015) · SMARTech Repository (Georgia Institute of Technology)
Damas, F. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.39.2017.tde-11102017-092823
Satellite cell activity and self-renewal in patients with cerebral palsy
Yeager, S. K. (2025) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/0q5n-rn05
O’Leary, M. F. (2018) · University of Birmingham Institutional Research Archive (University of Birmingham)
Potential Regenerative Capacity of physiological serum, L-arginine and IGF-1 on Skeletal Muscle
Alkalamawy, N. (2018) · SVU- International Journal of Veterinary Sciences · doi:10.21608/svu.2018.17935
“IL-6 activate Stat3 signaling pathway that regulates satellite cell behavior, promoting myogenic lineage progression through regulatory effect on gene expression of myogenic differentiation 1 (Myod1) (Serrano et al., 2008 and Tierney et al., 2014).”
BackgroundMoss, A. D. (2015) · e-space (Manchester Metropolitan University) · doi:10.13140/rg.2.1.1730.6000
Unfolded protein response pathways in skeletal muscle homeostasis.
Bohnert, K. R. (2018) · doi:10.18297/etd/3033
Response of Interleukins to Resistance Exercise
Vasconcelos, E. D. S. (2018) · Virology & Immunology Journal · doi:10.23880/vij-16000141
Muscle-Derived Soluble Mediators Regulating Bone
Grano, M., & Colaianni, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11218-8
Papel da adiponectina no processo de regeneração muscular.
Mosele, F. C. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2019.tde-04092019-132713
Nutritional impact on molecular and physiological adaptations to exercise : nutrition matters
Knuiman, P. (2019) · doi:10.18174/479016
“Additionally, most literature assessing low-carbohydrate diets [14-18] or lowcarbohydrate availability with exercise [19-22] has focused on endurance exercise.”
BackgroundFausnacht, D. W. (2018) · VTechWorks (Virginia Tech)
Role of Fra-2/AP-1 in Myogenic Progenitor Cells
Sun, D. (2019) · YorkSpace (York University)
Lisano, J. K. (2019) · Scholarship & Creative Works - Digital UNC a service of University Libraries (University of Northern Colorado)
The role of platelets in skeletal muscle regeneration
Scully, D. (2019) · Repository@Hull (Worktribe) (University of Hull)
The Effects of Organophosphates in the Early Stages of Human Muscle Regeneration
Marš, T., Miš, K., Pirkmajer, S., & Grubič, Z. (2009) · Elsevier eBooks · doi:10.1016/b978-012374484-5.00045-6
From brain to muscle and back : novel approaches to harness the benefits of exercise
Kelahmetoglu, Y. (2020) · Figshare
Domingues-Faria, C., Rougé, S., Patrac, V., Salles, J., Walrand, S., Vasson, M., & Gonçalves-Mendes, N. (2021) · Research Square · doi:10.21203/rs.3.rs-156796/v1
“This follows with Serrano’s study showing that IL-6 promotes murine satellite cell proliferation via regulation of the cell‐cycle‐associated genes cyclin D1 and c‐myc (40).”
BackgroundKapoor, S., Subba, P., Sudheer Shenoy, P., & Bose, B. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10134-w
Polimorfismo e níveis solúveis de HLA-G em fisiculturistas
Fernandes, T. M. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.109.2020.tde-21072020-143210
Sugden, C. (2019) · SUNScholar (Stellenbosch University)
Acute Inflammatory Responses To Three Different Isokinetic Bench Press Loading Protocols
Koski, M. (2021) · Jyväskylä University Digital Archive (University of Jyväskylä)
Identificação de um perfil poligênico associado a respostas ao treinamento de força
Silva, S. B. D. C. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.39.2021.tde-18052021-164642
The Immediate Early Response of Proliferating Myoblasts to One Bout of Electrical Stimulation
Triolo, M. (2017) · YorkSpace (York University)
Atrophie, croissance et fonction musculaire : l'impact des leucocytes et de la triade RANK/RANKL/OPG
Dumont, N. A. (2013) · Corpus Université Laval (Université Laval)
(2009) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283328098
Perl, A. T. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718000272.793486332
Ilich, J. Z., Kelly, O. J., Gilman, J. C., Cvijetić, S., & Boschiero, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820088-9.00014-7
Crist, C. G., & Fujita, R. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733072374.793545521
Rodríguez, A. M., Bonet, M. L., & Ribot, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00026-2
Eckel, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809518-8.00004-0
Amphiregulin Mediates Non-Cell-Autonomous Effect of Senescence on ReprogrammingPreprint
von Joest, M., Chen, C., Douché, T., Chiche, A., Gianetto, Q. G., Matondo, M., & Li, H. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3936777
Agent Based Modeling of Skeletal Muscle Adaptation
Martin, K. (2015) · doi:10.18130/v31570
Exercício físico e sistema purinérgico
Falqueto, H., Júnior, J. L. R., Cardoso, A. M., & Manfredi, L. H. (2021) · Editora UFFS eBooks · doi:10.7476/9786586545494.0004
Potential Therapeutic Strategies for Muscular Dystrophy
Gaina, G. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102255
The Potential Benefits of Drug-Repositioning in Muscular Dystrophies
Lambrescu, I. M., Manole, E., Ceafalan, L. C., & Gaina, G. F. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110714
Journal, S. (2023) · Sciential - McMaster Undergraduate Science Journal · doi:10.15173/sciential.v1i10.3517
The Effect of Varying Eccentric Velocity on Muscle Hypertrophy
Amjad, M., & Dumont, R. (2023) · Sciential - McMaster Undergraduate Science Journal · doi:10.15173/sciential.v1i10.3339
Novel In Vitro Models for Healthy and Pathological Tissue Formation in Bone and Muscle
van Santen, V. J. B. (2023) · doi:10.5463/thesis.273
Obesity, Myokines, and Metabolic Health
Malandrino, N., & Ahima, R. S. (2023) · Springer eBooks · doi:10.1007/978-3-319-12125-3_56-1
Normal and Aberrant Muscle Tissue Healing, Learning from Health and Disease
Kostek, M. C., & Liu, S. (2023) · OBM Genetics · doi:10.21926/obm.genet.2303192
Kardiovaskuläre Prävention und Stoffwechselerkrankungen
Joisten, C. (2023) · Springer eBooks · doi:10.1007/978-3-662-62496-8_10
Muskulatur: „peripheres mechanisch- und Signalstoff-gestütztes Zentrum der Gesundheit“
Laube, W. (2023) · Springer eBooks · doi:10.1007/978-3-662-67753-7_8
O PAPEL DA INTERLEUCINA-6 FRENTE AO EXERCÍCIO FÍSICO RESISTIDO: UMA REVISÃO INTEGRATIVA
Romero, T. B., & Bomfim, I. D. S. (2023) · doi:10.22491/avanco_perspectivas_em_saude_b8
Effect of IL6 on the cancer-associated cachexia: a mini review
Taheri, Z. (2023) · Journal of Biological Studies · doi:10.62400/jbs.v6i1.7789
Acute responses of strength-related gene expressions to maximum strength and force sense acuity
Altun, M., Balcan, E., BATIR, S., Gökmen, M. H., Özgüneş, Ş., & Öztel, Z. (2024) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.55730/1300-0144.5775
“It has been reported that plasma IL-6 level was transiently increased in response to physical exercise conditions, suggesting that this increase is strongly associated with hypertrophic skeletal muscle growth [19].”
BackgroundImproving efficiency in the feedlot industry
Rients, E. L. (2022) · doi:10.31274/td-20240329-414
Martins, J. B., Dipp, T., Schaan, B. D., & Lehnen, A. M. (2024) · Research Square · doi:10.21203/rs.3.rs-4450743/v1
Izumi-Mishima, Y., Tsutsumi, R., Shiuchi, T., et al. (2024) · eLife · doi:10.7554/elife.99982.1.sa0
Izumi-Mishima, Y., Tsutsumi, R., Shiuchi, T., et al. (2024) · eLife · doi:10.7554/elife.99982.1.sa2
Metadata
- Authors
- Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 7
- Issue
- 1
- Pages
- 33-44
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1997149085
- Cited by
- 873
- References
- 57
- Citations by year
- 2026: 43 · 2025: 56 · 2024: 42 · 2023: 55 · 2022: 71 · 2021: 73 · 2020: 48 · 2019: 55 · 2018: 50 · 2017: 54 · 2016: 45 · 2015: 69 · 2014: 42 · 2013: 48 · 2012: 51
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2024 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association Française contre les Myopathies (Marató-TV3)
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Muscular Dystrophy Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- interleukin-6, satellite cells, skeletal muscle hypertrophy, muscle stem cells, STAT3 signaling, cyclin D1, myonuclear accretion, satellite cell proliferation, paracrine signaling, myofiber growth, cytokine deficiency
- MeSH terms
- Animals, Cell Line, Cell Movement, Enzyme-Linked Immunosorbent Assay, Hypertrophy, Immunohistochemistry, Muscular Diseases, Blotting, Western, Interleukin-6, Mice, Knockout, Muscle, Skeletal, Muscle Fibers, Skeletal, Cyclin D1, Reverse Transcriptase Polymerase Chain Reaction, Myoblasts, Satellite Cells, Skeletal Muscle, Cell Proliferation, STAT3 Transcription Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
