The DOI matches its Crossref record; 54 of the 57 references it cites were found in a registry or an index.
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Open accessAbstract
Skeletal muscles adapt to increasing workload by augmenting their fiber size, through mechanisms that are poorly understood. This study identifies the cytokine interleukin-6 (IL-6) as an essential regulator of satellite cell (muscle stem cell)-mediated hypertrophic muscle growth. IL-6 is locally and transiently produced by growing myofibers and associated satellite cells, and genetic loss of IL-6 blunted muscle hypertrophy in vivo. IL-6 deficiency abrogated satellite cell proliferation and myonuclear accretion in the preexisting myofiber by impairing STAT3 activation and expression of its target gene cyclin D1. The growth defect was indeed muscle cell intrinsic, since IL-6 loss also affected satellite cell behavior in vitro, in a STAT3-dependent manner. Myotube-produced IL-6 further stimulated cell proliferation in a paracrine fashion. These findings unveil a role for IL-6 in hypertrophic muscle growth and provide mechanistic evidence for the contribution of satellite cells to this process.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For instance, the pro-inflammatory cytokine IL-6 mediates lipid oxidation [7], induces the production of anti-inflammatory interleukins during exercise (e.g. IL-10 and IL-1ra) [8] and stimulates muscle growth [9].”
In the citing paper
“In vitro, IL-6 bears anabolic effects by regulating satellite cells’ function and enhancing glucose metabolism; furthermore, a loss of IL-6 signaling in myoblasts results in a reduced proliferation and migration [49,50].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [50]
In the citing paper
“Elimination of these cytokines in vivo has been shown to diminish muscle repair [118].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [118]
In the citing paper
“Briefly, a number of studies have shown that the chemokines and cytokines (TNF-α, IL-1β, IL-6) produced by initially infiltrating M1 macrophages are chemoattractant and mitogenic for muscle progenitor cells, including Pax7+ satellite cells [115–119].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [118]
In the citing paper
“Although the myokine IL-6 is mostly recognized for its regulatory effects in lipid and glucose metabolism, IL-6 also plays important roles in myogenesis.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [49]
In the citing paper
“Genetic loss of IL-6 impaired muscle hypertrophy in vivo, whereas myotube-produced IL-6 stimulated muscle cell proliferation in a paracrine fashion (49).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [49]
In the citing paper
“Although being considered pro-inflammatory, TNF-α and IL-6 also appear to play important role in the early stages of muscle regeneration following injury by enhancing myoblast proliferation and inhibiting differentiation [73,74,75].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [73]
In the citing paper
“This inhibition involves the down regulation of the MRFs, MyoD and Myogenin [73,74,75], with TNF-α receptor double knock out mice [74] and with IL-6 non-specific knock out mice [73] shown to present impaired myogenic differentiation and hypertrophy when compared to wild type mice during functional overloading.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [73]
Citations
Cites
1 retracted
Immunohistochemical detection of interleukin‐6 in human skeletal muscle fibers following exercise
Penkowa, M., Keller, C., Keller, P., Jauffred, S., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0311fje · Cited by 157
RetractedBodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 1×
“…3 C57BL/6 background (WT) and generated by heterozygous mating of mice carrying a targeted disruption in which the second exon in the IL-6 gene was replaced by a neo r cassette (Kopf et al., 1994), were generously provided by A. Bernad (Centro Nacional de Investiga-ciones Cardiovasculares, Madrid).”
MethodNF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
D, D. C. G., Albanese, C., Reuther, J. Y., Pestell, R. G., & Baldwin, A. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5785 · Cited by 1,304
Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD
Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., & Lassar, A. B. (1995) · Science · doi:10.1126/science.7863327 · Cited by 1,139
Skeletal muscle hypertrophy and atrophy signaling pathways
Glass, D. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.018 · Cited by 1,106
INTERLEUKIN-6: From Basic Science to Medicine—40 Years in Immunology
Kishimoto, T. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115806 · Cited by 1,040
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
Glass, D. J. (2003) · Nature Cell Biology · doi:10.1038/ncb0203-87 · Cited by 694
IL-6 signal transduction and its physiological roles: the signal orchestration model
Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673
IL-6-induced skeletal muscle atrophy
Haddad, F., Zaldivar, F., Cooper, D. M., & Adams, G. R. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01026.2004 · Cited by 612
Flagged first, then by citations
3 of the 57 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 868
Pten is necessary for the quiescence and maintenance of adult muscle stem cells
Yue, F., Bi, P., Wang, C., Shan, T., Nie, Y., Ratliff, T. L., Gavin, T. P., & Kuang, S. (2017) · Nature Communications · doi:10.1038/ncomms14328 · Cited by 125
Fusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation
Murach, K. A., Fry, C. S., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2021) · The FASEB Journal · doi:10.1096/fj.202101096r · Cited by 120
Stem cells for skeletal muscle repair
Shadrach, J., & Wagers, A. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0027 · Cited by 113
Resistance training, visceral obesity and inflammatory response: a review of the evidence
Strasser, B., Arvandi, M., & Siebert, U. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.00988.x · Cited by 120
“Additionally, muscle IL-6 has been identified as an essential regulator of satellite cell-mediated skeletal muscle hypertrophy both in vitro and in vivo studies (90).”
BackgroundProstaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation
Mo, C., Zhao, R., Vallejo, J. A., Igwe, O. J., Bonewald, L. F., Wetmore, L., & Brotto, M. A. P. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1026520 · Cited by 119
“For instance, interleukin-6 induces myoblast proliferation by activating Janus kinase/signal transducers and activators of the transcription 3 pathway.(4) Myostatin, a potent negative regulator of muscle mass, inhibits myoblast proliferation by inducing the degradation of cyclin D and p300.”
BackgroundArthur, S. T., & Cooley, I. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4262 · Cited by 131
“IL-6 has conflicting roles during muscle repair because it is known to be essential for satellite cell activation (192), but, when acting as a pro-inflammatory cytokine, IL-6 is also known to be associated with decreased satellite cell number and a loss of proliferative capacity (8).”
BackgroundBidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease
Chen, W., You, W., Valencak, T. G., & Shan, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101682 · Cited by 120
“Under homeostatic conditions, myofibers are the main source of IL-6, regulating both muscle hypertrophy and promoting myogenic lineage progression by activation of STAT3 in vivo in response to contraction (Serrano et al., 2008; Tierney et al., 2014).”
BackgroundMolecular mechanisms of skeletal muscle development, regeneration, and osteogenic conversion
Endo, T. (2015) · Bone · doi:10.1016/j.bone.2015.02.028 · Cited by 117
“IL-6 secreted from myofibers also stimulates satellite cell proliferation through STAT3 activation leading to Cyclin D1 andMyc expression [113].”
BackgroundImplications of exercise-induced adipo-myokines in bone metabolism
Lombardi, G., Sanchis‐Gomar, F., Perego, S., Sansoni, V., & Banfi, G. (2015) · Endocrine · doi:10.1007/s12020-015-0834-0 · Cited by 124
Satellite cells in ageing: use it or lose it
Chen, W., Datzkiw, D., & Rudnicki, M. A. (2020) · Open Biology · doi:10.1098/rsob.200048 · Cited by 122
Kwon, J. H., Moon, K. M., & Min, K.-W. (2020) · Healthcare · doi:10.3390/healthcare8040378 · Cited by 116
A Perspective on Immunomodulation and Tissue Repair
Mokarram, N., & Bellamkonda, R. V. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0941-0 · Cited by 115
Muñoz‐Cánoves, P., Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15182 · Cited by 117
Self-citationSkeletal muscle as an immunogenic organ
Nielsen, S. J., & Pedersen, B. K. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.02.005 · Cited by 115
Pro-Inflammatory Mediation of Myoblast Proliferation
Otis, J. S., Niccoli, S., Hawdon, N., Sarvas, J. L., Frye, M. A., Chicco, A. J., & Lees, S. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092363 · Cited by 120
“In particular, it is known that endogenous expression of IL-6 has mitogenic effects on MPCs [31,32].”
BackgroundCharacterization and Regulation of Mechanical Loading‐Induced Compensatory Muscle Hypertrophy
Adams, G. R., & Bamman, M. M. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110066 · Cited by 123
“In addition, a number of these putative agents would to influence the process of compensatory hypertrophy their effects on satellite cell activity.”
Role of metabolic stress for enhancing muscle adaptations: Practical applications
de Freitas, M. C., Gerosa-Neto, J., Zanchi, N. E., Lira, F. S., & Rossi, F. E. (2017) · World Journal of Methodology · doi:10.5662/wjm.v7.i2.46 · Cited by 124
Yang, Y. J., & Kim, D. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052604 · Cited by 119
Bartolomei, S., Sadres, E., Church, D. D., Arroyo, E., Gordon, J. A., Varanoske, A. N., Wang, R., Beyer, K. S., Oliveira, L., Stout, J. R., et al. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3598-9 · Cited by 111
“These results appear to support others studies (Febbraio and Pederson 2005; Serrano et al. 2008) suggesting that elevations in IL-6 concentrations may be related to an exercise-induced metabolic stress.”
ResultMechanisms of Blood Flow Restriction: The New Testament
Jessee, M. B., Mattocks, K. T., Buckner, S. L., Dankel, S. J., Mouser, J. G., Abe, T., & Loenneke, J. P. (2018) · Techniques in Orthopaedics · doi:10.1097/bto.0000000000000252 · Cited by 109
Macrophages Protect against Muscle Atrophy and Promote Muscle Recovery in Vivo and in Vitro
Dumont, N. A., & Frenette, J. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090884 · Cited by 113
In vitro response of macrophage polarization to a keratin biomaterial
Fearing, B. V., & Dyke, M. E. V. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.04.003 · Cited by 111
Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
Sampath, S. C., Sampath, S. C., Ho, A. T. V., Corbel, S. Y., Millstone, J. D., Lamb, J. R., Walker, J. R., Kinzel, B., Schmedt, C., & Blau, H. M. (2018) · Nature Communications · doi:10.1038/s41467-018-03876-8 · Cited by 111
“; https://doi.org/10.1101/303586 doi: bioRxiv preprint hypertrophy 18 .”
InfluentialPotential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration
Tachtsis, B., Camera, D., & Lacham-Kaplan, O. (2018) · Nutrients · doi:10.3390/nu10030309 · Cited by 104
“This inhibition involves the down regulation of the MRFs, MyoD and Myogenin [73–75], with TNF-α receptor double knock out mice [74] and with IL-6 non-specific knock out mice [73] shown to present impaired myogenic differentiation and hypertrophy when compared to wild type mice during functional overloading.”
BackgroundAlrasheed, N., Alrasheed, N., Hasan, I. H., Al-Amin, M., Al-Ajmi, H., & Mahmoud, A. (2016) · Drug Design, Development and Therapy · doi:10.2147/dddt.s109287 · Cited by 101
“IL-6 transduces hypertrophic signals via gp130 predominantly to STAT3(15) in cardiac myocytes and satellite cells.(61) Therefore, the IL-6-gp130-JAK/STAT signaling pathway has a key role in cardiac hypertrophy.”
BackgroundShabbir, A., Zisa, D. C., Lin, H., Mastri, M., Roloff, G. W., Suzuki, G., & Lee, T. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00488.2010 · Cited by 104
TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A
Trendelenburg, A. U., Meyer, A. S., Jacobi, C., Feige, J. N., & Glass, D. J. (2012) · Skeletal Muscle · doi:10.1186/2044-5040-2-3 · Cited by 106
Satellite cell proliferation and skeletal muscle hypertrophy
Adams, G. R. (2006) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-053 · Cited by 110
Enhancing the efficacy of mesenchymal stem cell therapy
Mastri, M. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i2.82 · Cited by 102
Hoene, M., Runge, H., Häring, H. U., Schleicher, E. D., & Weigert, C. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00025.2012 · Cited by 110
Skeletal muscle mass recovery from atrophy in IL‐6 knockout mice
Washington, T. A., White, J. P., Davis, J. M., Wilson, L. B., Lowe, L. L., Sato, S., & Carson, J. A. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02281.x · Cited by 106
“Serrano et al. (Serrano et al. 2008) reported that mice lacking IL-6 and subjected to functional overload had repressed muscle satellite cell activation which was associated with the repression of myogenin.”
BackgroundInfluentialHara, M., Yuasa, S., Shimoji, K., Onizuka, T., Hayashiji, N., Ohno, Y., Arai, T., Hattori, F., Kaneda, R., Kimura, K., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101059 · Cited by 98
“Of these factors, STAT3 has been reported to contribute to the proliferation of myocyte precursor cells (Megeney et al., 1996; Serrano et al., 2008).”
BackgroundOkiyama, N., Sugihara, T., Iwakura, Y., Yokozeki, H., Miyasaka, N., & Kohsaka, H. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24689 · Cited by 99
Philippou, Α., Maridaki, M. D., Theos, A., & Koutsilieris, M. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394383-5.00010-2 · Cited by 92
Modulating exercise-induced hormesis: Does less equal more?
Peake, J. M., Markworth, J. F., Nosaka, K., Raastad, T., Wadley, G. D., & Coffey, V. G. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01055.2014 · Cited by 98
“Through these signaling pathways, acute production of RONS and inflammatory mediators can ultimately promote adaptations in skeletal muscle such as mitochondrial biogenesis and remodeling/hypertrophy (53, 124, 125, 169, 197).”
BackgroundSteyn, P. J., Dzobo, K., Smith, R., & Myburgh, K. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215273 · Cited by 95
“IL-6 and phosphorylated STAT3-induced genes have been linked with cell cycle regulation and proliferation [48].”
BackgroundPatsalos, A., Halász, L., Medina-Serpas, M. A., Berger, W. K., Dániel, B., Tzerpos, P., Kiss, M., Nagy, G., Fischer, C., Simándi, Z., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210420 · Cited by 94
Lilja, M. R., Mandić, M., Apró, W., Melin, M., Olsson, K., Rosenborg, S., Gustafsson, T. P., & Lundberg, T. R. (2017) · Acta Physiologica · doi:10.1111/apha.12948 · Cited by 90
“Specifically, in the present cohort of young subjects, it is possible that blunting of important inflammatory processes, as reflected by the downregulated IL-6 gene expression, contributed to the attenuated hypertrophic response because previous studies have shown that induction of IL-6, and also other inflammatory an…”
Lee, J. O., Lee, H. J., Lee, Y. W., Han, J. A., Kang, M. J., Moon, J., Shin, M.-J., Lee, H. J., Chung, J. H., Lee, J., et al. (2020) · FEBS Journal · doi:10.1111/febs.15301 · Cited by 97
Regenerative inflammation: When immune cells help to re‐build tissues
Caballero‐Sánchez, N., Alonso‐Alonso, S., & Nagy, L. (2022) · FEBS Journal · doi:10.1111/febs.16693 · Cited by 100
“Its depletion suppresses inflammation and impairs MPC proliferation and muscle regeneration [127,128].”
BackgroundSkeletal muscle: molecular structure, myogenesis, biological functions, and diseases
Feng, L., Chen, Z., & Bian, H. (2024) · MedComm · doi:10.1002/mco2.649 · Cited by 100
“135,136 139 In addition to transmitting signals in a paracrine manner, physical cellular interactions between MuSCs and myofibers can promote direct communication through F-actin-based tunneling nanotubes.”
BackgroundLow-Frequency Electrical Stimulation Attenuates Muscle Atrophy in CKD—A Potential Treatment Strategy
Hu, L., Klein, J. D., Hassounah, F., Cai, H., Zhang, C., Xu, P., & Wang, X. H. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014020144 · Cited by 90
Searching for the link between inflammaging and sarcopenia
Wang, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101611 · Cited by 90
IL-6 release from muscles during exercise is stimulated by lactate-dependent protease activity
Højman, P., Brolin, C., Nørgaard-Christensen, N., Dethlefsen, C., Lauenborg, B. T., Olsen, C. K., Åbom, M. M., Krag, T. O. B., Gehl, J., & Pedersen, B. K. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00414.2018 · Cited by 96
“Il-6 has been shown to have numerous beneficial effects on whole body metabolism and energy homeostasis (14) as well as muscle-specific adaptation, including muscle hypertrophy and regeneration and glucose metabolism (23).”
BackgroundExercise as an anti-inflammatory therapy for cancer cachexia: a focus on interleukin-6 regulation
Daou, H. N. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00147.2019 · Cited by 93
Cuadrado, A., Corrado, N., Perdiguero, E., Lafarga, V., Muñoz‐Cánoves, P., & Nebreda, Á. R. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.85 · Cited by 91
Self-citationHenríquez‐Olguín, C., Altamirano, F. J., Valladares-Ide, D., Lopez, J. R., Allen, P. D., & Jaimovich, E. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.012 · Cited by 91
“Moreover, studies in rodents have shown that IL-6 contributes to muscle regeneration or hypertrophy after injury which may involve a similar stimulatory effect on satellite cell proliferation [55] and up-regulation of utrophin [56].”
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85
“In vitro, IL-6 bears anabolic effects by regulating satellite cells’ function and enhancing glucose metabolism; furthermore, a loss of IL-6 signaling in myoblasts results in a reduced proliferation and migration [49,50].”
BackgroundThe hormetic and hermetic role of IL-6
Forcina, L., Franceschi, C., & Musarò, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101697 · Cited by 85
“Indeed, chronic exposure to elevated levels of this cytokine leads to muscle atrophy, exacerbates muscle diseases (Haddad et al., 2005; Pelosi et al., 2015; Serrano et al., 2008) and interferes with myogenic differentiation in C2C12 myoblasts (M.”
BackgroundCurrent pharmacotherapies for sarcopenia
Hardee, J. P., & Lynch, G. S. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1622093 · Cited by 89
“muscle growth and remodelling [93], it is likely that long-term EXPERT OPINION ON PHARMACOTHERAPY 1649”
BackgroundMusculoskeletal senescence: a moving target ready to be eliminated
Baar, M. P., Perdiguero, E., Muñoz-Cánoves, P., & de Keizer, P. L. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.05.007 · Cited by 83
“IL6 is also a major component of the SASP [14], and has been shown to regulate the transition of satellite cells from a quiescent to an activated state [26].”
BackgroundSelf-citationSarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83
Loh, K. C., Leong, W.-I., Carlson, M. E., Oskouian, B., Kumar, A., Fyrst, H., Zhang, M., Proia, R. L., Hoffman, E. P., & Saba, J. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037218 · Cited by 87
“STAT3 plays a role in rodent and human SC proliferation, migration and differentiation [30,42–44,69].”
BackgroundAngiotensin II Inhibits Satellite Cell Proliferation and Prevents Skeletal Muscle Regeneration
Yoshida, T., Galvez, S., Tiwari, S., Rezk, B. M., Semprun‐Prieto, L., Higashi, Y., Sukhanov, S., Yablonka‐Reuveni, Z., & Delafontaine, P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.449074 · Cited by 85
McKay, B. R., Ogborn, D. I., Baker, J. M., Toth, K., Tarnopolsky, M. A., & Parise, G. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00305.2012 · Cited by 87
“Recently, IL-6 has been investigated as a positive regulator of SC proliferation in both animals and humans through its interactions with the Janus activated kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascade (35, 53, 56).”
BackgroundThe Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations
Leuchtmann, A. B., Adak, V., Dilbaz, S., & Handschin, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.709807 · Cited by 84
“In mice, a recent study reported that meteorin-like facilitates skeletal muscle repair by activating signal transducer and activator of transcription 3 (STAT3) signaling in macrophages to induce insulin-like growth factor 1 (IGF-1) production, which in turn had a direct effect on muscle SC proliferation (Baht et al.,…”
BackgroundInfluentialKaneshige, A., Kaji, T., Zhang, L., Saito, H., Nakamura, A., Kurosawa, T., Ikemoto‐Uezumi, M., Tsujikawa, K., Seno, S., Hori, M., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.11.003 · Cited by 88
Dantas, W. S., Zunica, E. R. M., Heintz, E. C., Vandanmagsar, B., Floyd, Z. E., Yu, Y., Fujioka, H., Hoppel, C. L., Belmont, K. P., Axelrod, C. L., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12982 · Cited by 84
“In muscle stem cells, IL-6 is produced by maturing myofibres and is required for hypertrophy.(28) In contrast, IL-6 production in terminally differentiated myofibres stimulates activation of the nuclear transcription factor STAT3 at”
BackgroundLukjanenko, L., Brachat, S., Pierrel, E., Lach‐Trifilieff, E., & Feige, J. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071084 · Cited by 84
Functional and Morphological Improvement of Dystrophic Muscle by Interleukin 6 Receptor Blockade
Pelosi, L., Berardinelli, M. G., Pasquale, L. D., Nicoletti, C., D’Amico, A., Carvello, F., Moneta, G. M., Catizone, A., Bertini, E., Benedetti, F. D., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.02.014 · Cited by 84
“IL6 is also locally and transiently produced in response to exercise and injury, and it plays an important role in satellite cell proliferation and muscle growth (Kurek et al., 1996; Serrano et al., 2008).”
BackgroundYue, F., Bi, P., Wang, C., Li, J., Liu, X., & Kuang, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.002 · Cited by 81
“Increased proliferation and fusion of satellite cells have been consistently shown to cause adult muscle hypertrophy by increasing the number ofmyonuclei (Serrano et al., 2008).”
Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions
Buvinic, S., Balanta‐Melo, J., Kupczik, K., Vásquez, W., Beato, C., & Toro‐Ibacache, V. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.606947 · Cited by 82
“In addition, IL-6 produced in response to strenuous and prolonged exercises increases satellite cells proliferation, leading to regeneration of damaged muscle myo fi bers and hypertrophy (142, 143).”
Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration
Xiao, F., Wang, H., Fu, X., Li, Y., Ma, K., Sun, L., Gao, X., & Wu, Z. (2010) · Cell Research · doi:10.1038/cr.2010.144 · Cited by 80
Ito, N., Rüegg, U. T., & Takeda, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092804 · Cited by 87
The immune system in Duchenne muscular dystrophy: Friend or foe
Villalta, S. A., Rosenberg, A. S., & Bluestone, J. A. (2015) · Rare Diseases · doi:10.1080/21675511.2015.1010966 · Cited by 83
Genes and the ageing muscle: a review on genetic association studies
Garatachea, N., & Lucía, A. (2011) · AGE · doi:10.1007/s11357-011-9327-0 · Cited by 79
“Recent data also indicate a pivotal role of this protein in the processes of muscle repair and hypertrophy following exercise-induced damage (Serrano et al. 2008).”
BackgroundForcina, L., Miano, C., Scicchitano, B. M., & Musarò, A. (2019) · Cells · doi:10.3390/cells8030232 · Cited by 82
The role of satellite cells in muscle hypertrophy
Blaauw, B., & Reggiani, C. (2014) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-014-9376-y · Cited by 90
“In addition, muscle hypertrophy is blunted in mice lacking IL6, and this reduced growth was linked to a compromised activation and fusion of satellite cells (Serrano et al. 2008).”
Exercise increases pancreatic β‐cell viability in a model of type 1 diabetes through IL‐6 signaling
de Paula, F. M. M., Leite, N. C., Vanzela, E. C., Kurauti, M. A., Dias, R. D. F., Carneiro, E. M., Boschero, A. C., & Zoppi, C. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-264820 · Cited by 78
“After anoverloading,muscles increase the production of IL-6, possibly via the p38 MAPK/NF-kB pathway (48), that critically regulates the function and differentiation of satellite cells into new myofibers, in a process mediated by the activation of STAT3, c-myc, and cyclin D1 (49).”
BackgroundFarup, J., Rahbek, S. K., Knudsen, I. S., de Paoli, F. V., Mackey, A. L., & Vissing, K. (2014) · Amino Acids · doi:10.1007/s00726-014-1810-3 · Cited by 88
Genes, physical fitness and ageing
Garatachea, N., & Lucía, A. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.09.003 · Cited by 84
Can muscle regeneration fail in chronic inflammation: a weakness in inflammatory myopathies?
Loell, I., & Lundberg, I. E. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02334.x · Cited by 81
Cell Types Used for Cultured Meat Production and the Importance of Myokines
Shaikh, S., Lee, E. J., Ahmad, K., Ahmad, S. S., Chun, H.-J., Lim, J. H., Lee, Y., & Choi, I. (2021) · Foods · doi:10.3390/foods10102318 · Cited by 81
“In addition, IL-6 deficiency inhibited MSC proliferation and myonuclear accretion in preexisting myofibers by impairing STAT3 activation [33].”
BackgroundStem Cell and Macrophage Roles in Skeletal Muscle Regenerative Medicine
Scala, P., Rehak, L., Giudice, V., Ciaglia, E., Puca, A. A., Selleri, C., Porta, G. D., & Maffulli, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910867 · Cited by 77
“IL-6 −/− mice, the regenerative rate is lower because proteins related to myogenesis are poorly expressed and newly formed myofibers are smaller with interstitial fibrosis, and also because satellite cells and myoblasts show a lower proliferation and migration rate [89,90].”
BackgroundEffects of Sleep Deprivation on Acute Skeletal Muscle Recovery after Exercise
DÁTTILO, M., ANTUNES, H. K. M., GALBES, N. M. N., MÔNICO-NETO, M., DE SÁ SOUZA, H., DOS SANTOS QUARESMA, M. V. L., LEE, K. S., UGRINOWITSCH, C., TUFIK, S., & DE MELLO, M. T. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002137 · Cited by 75
Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors
Aoki, Y., Miyatake, S., Shimizu‐Motohashi, Y., & Takeda, S. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s110163 · Cited by 77
“92 IL-6 contributes to satellite cell proliferation 93 and muscle growth, 94,95 in addition to its major role of inducing the transition from acute neutrophil infiltration to chronic mononuclear cell infiltration.”
Yakabe, M., Ogawa, S., Ota, H., Iijima, K., Eto, M., Ouchi, Y., & Akishita, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191318 · Cited by 74
Shefer, G., Rauner, G., Stuelsatz, P., Benayahu, D., & Yablonka‐Reuveni, Z. (2013) · The FEBS Journal · doi:10.1111/febs.12228 · Cited by 72
Exercise as an anti-inflammatory intervention to combat inflammatory diseases of muscle
Nader, G. A., & Lundberg, I. E. (2009) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283319d53 · Cited by 72
Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice
Pelosi, L., Berardinelli, M. G., Forcina, L., Spelta, E., Rizzuto, E., Nicoletti, C., Camilli, C., Testa, E., Catizone, A., Benedetti, F. D., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv323 · Cited by 72
Aoyama, S., Kim, H., Hirooka, R., Tanaka, M., Shimoda, T., Chijiki, H., Kojima, S., Sasaki, K., Takahashi, K., Makino, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2021.109336 · Cited by 77
Muscle cell‐derived cytokines in skeletal muscle regeneration
Waldemer, R. J., Kim, D., & Chen, J. (2022) · FEBS Journal · doi:10.1111/febs.16372 · Cited by 79
Acute myotube protein synthesis regulation by IL-6-related cytokines
Gao, S., Durstine, J. L., Koh, H.-J., Carver, W. E., Frizzell, N., & Carson, J. A. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00112.2017 · Cited by 69
“Mechanical stimuli from overload or resistance exercise results in increased muscle production of IL-6 and LIF, which can regulate the muscle hypertrophic process though autocrine/ paracrine manner (10, 58, 61).”
BackgroundInfluentialLkb1 Is Indispensable for Skeletal Muscle Development, Regeneration, and Satellite Cell Homeostasis
Shan, T., Zhang, P., Liang, X., Bi, P., Yue, F., & Kuang, S. (2014) · Stem Cells · doi:10.1002/stem.1788 · Cited by 74
Contraction and AICAR Stimulate IL-6 Vesicle Depletion From Skeletal Muscle Fibers In Vivo
Lauritzen, H. P. M. M., Brandauer, J., Schjerling, P., Koh, H., Treebak, J. T., Hirshman, M. F., Galbo, H., & Goodyear, L. J. (2013) · Diabetes · doi:10.2337/db12-1261 · Cited by 71
“In fact, previous studies have not clearly detected IL-6 protein within the muscle fibers from human biopsies (11) or mouse muscle sections (10) unless a state of inflammation (12,13) or injury (10) was present.”
BackgroundResultCX3CL1—a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle
Strömberg, A., Olsson, K., Dijksterhuis, J. P., Rullman, E., Schulte, G., & Gustafsson, T. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00236.2015 · Cited by 67
“Interestingly, both IL-6 and TNF- also are known to stimulate proliferation of satellite cells (21, 30); thus, this could be one indirect mechanism by which CX3CL1 acts as a mitogen for muscle cells.”
BackgroundHuman and mouse skeletal muscle stem and progenitor cells in health and disease
Mierzejewski, B., Archacka, K., Grabowska, I., Florkowska, A., Ciemerych, M. A., & Brzóska, E. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.01.004 · Cited by 70
Juffer, P., Bakker, A. D., Klein‐Nulend, J., & Jaspers, R. T. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9812-4 · Cited by 68
“cytokine, but it is also increased in skeletal muscle after exercise and induces muscle hypertrophy in vivo [27, 31].”
BackgroundBower, N. I., & Johnston, I. A. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00065.2010 · Cited by 70
“Several of the genetic pathways regulating muscle fiber hypertrophy and/or nuclear accretion have been identified including calcineurin signaling (54), interleukin 6 signaling (71), insulin-like growth factor signaling (63), and the myostatin (47) and PCG-1 pathways (68).”
BackgroundPelosi, M., Rossi, M. D., Barberi, L., & Musarò, A. (2014) · BioMed Research International · doi:10.1155/2014/206026 · Cited by 67
“It has been also shown that the autocrine production of IL-6 can promote myogenic differentiation [11, 12] and acts as a positive regulator of satellite cell-mediated hypertrophic muscle growth [13], suggesting that IL-6 plays an important role in myogenesis.”
BackgroundTidball, J. G., Flores, I., Welc, S. S., Wehling-Henricks, M., & Ochi, E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2020.111200 · Cited by 66
Davegårdh, C., Broholm, C., Perfilyev, A., Henriksen, T. I., García-Calzón, S., Peijs, L., Hansen, N. S., Volkov, P., Kjøbsted, R., Wojtaszewski, J. F. P., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0792-x · Cited by 66
“Background Human skeletal muscle stem cells, called satellite cells, are quiescent, but activated in response to muscle injury [1] and resistance exercise training [2].”
BackgroundVictor, E. G., Lock, P. C. S., Possato, J. C., da Rosa, G. L., Munari, U. B., de Souza, C. T., Pinho, R. A., da Silva, L. A., STRECK, E. L., & Paula, M. M. D. S. (2012) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-10-11 · Cited by 66
Fukada, S., Akimoto, T., & Sotiropoulos, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118742 · Cited by 71
Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients
Jiang, L. Q., Duque-Guimaraes, D. E., Machado, U. F., Zierath, J. R., & Krook, A. (2013) · Diabetes · doi:10.2337/db11-1790 · Cited by 65
“Furthermore, chronic IL-6 exposure induces proliferation of muscle satellite cells, thus promoting muscle regeneration and muscle hypertrophy (18).”
BackgroundSchéele, C., Nielsen, S. J., Kelly, M., Broholm, C., Nielsen, A. R., Taudorf, S., Pedersen, M., Fischer, C. P., & Pedersen, B. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039657 · Cited by 65
“IL-6 has been shown to promote myogenesis [29] and SOCS3 promotes myogenic differentiation by down regulating the STAT3 signaling pathway [32].”
BackgroundChen, B., Xu, J., He, X., Xu, H., Li, G., Du, H., Nie, Q., & Zhang, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137087 · Cited by 71
“Cytokines such as IL-6 are key regulators of cell growth, proliferation, differentiation and apoptosis [16].”
BackgroundArchacka, K., Grabowska, I., Mierzejewski, B., Graffstein, J., Górzyńska, A., Krawczyk, M., Różycka, A. M., Kalaszczyńska, I., Muras, G., Stremińska, W., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02530-3 · Cited by 68
Brown, A. E., Jones, D. E., Walker, M., & Newton, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122982 · Cited by 64
Madaro, L., & Bouché, M. (2014) · BioMed Research International · doi:10.1155/2014/438675 · Cited by 66
“From Innate to Adaptive Immune Response in”
Metadata
- Authors
- Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 7
- Issue
- 1
- Pages
- 33-44
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1997149085
- Cited by
- 873
- References
- 57
- Citations by year
- 2026: 43 · 2025: 56 · 2024: 42 · 2023: 55 · 2022: 71 · 2021: 73 · 2020: 48 · 2019: 55 · 2018: 50 · 2017: 54 · 2016: 45 · 2015: 69 · 2014: 42 · 2013: 48 · 2012: 51
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2024 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association Française contre les Myopathies (Marató-TV3)
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Muscular Dystrophy Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- interleukin-6, satellite cells, skeletal muscle hypertrophy, muscle stem cells, STAT3 signaling, cyclin D1, myonuclear accretion, satellite cell proliferation, paracrine signaling, myofiber growth, cytokine deficiency
- MeSH terms
- Animals, Cell Line, Cell Movement, Enzyme-Linked Immunosorbent Assay, Hypertrophy, Immunohistochemistry, Muscular Diseases, Blotting, Western, Interleukin-6, Mice, Knockout, Muscle, Skeletal, Muscle Fibers, Skeletal, Cyclin D1, Reverse Transcriptase Polymerase Chain Reaction, Myoblasts, Satellite Cells, Skeletal Muscle, Cell Proliferation, STAT3 Transcription Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
