The DOI matches its Crossref record; 54 of the 57 references it cites were found in a registry or an index.
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Open accessAbstract
Skeletal muscles adapt to increasing workload by augmenting their fiber size, through mechanisms that are poorly understood. This study identifies the cytokine interleukin-6 (IL-6) as an essential regulator of satellite cell (muscle stem cell)-mediated hypertrophic muscle growth. IL-6 is locally and transiently produced by growing myofibers and associated satellite cells, and genetic loss of IL-6 blunted muscle hypertrophy in vivo. IL-6 deficiency abrogated satellite cell proliferation and myonuclear accretion in the preexisting myofiber by impairing STAT3 activation and expression of its target gene cyclin D1. The growth defect was indeed muscle cell intrinsic, since IL-6 loss also affected satellite cell behavior in vitro, in a STAT3-dependent manner. Myotube-produced IL-6 further stimulated cell proliferation in a paracrine fashion. These findings unveil a role for IL-6 in hypertrophic muscle growth and provide mechanistic evidence for the contribution of satellite cells to this process.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For instance, the pro-inflammatory cytokine IL-6 mediates lipid oxidation [7], induces the production of anti-inflammatory interleukins during exercise (e.g. IL-10 and IL-1ra) [8] and stimulates muscle growth [9].”
In the citing paper
“In vitro, IL-6 bears anabolic effects by regulating satellite cells’ function and enhancing glucose metabolism; furthermore, a loss of IL-6 signaling in myoblasts results in a reduced proliferation and migration [49,50].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [50]
In the citing paper
“Elimination of these cytokines in vivo has been shown to diminish muscle repair [118].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [118]
In the citing paper
“Briefly, a number of studies have shown that the chemokines and cytokines (TNF-α, IL-1β, IL-6) produced by initially infiltrating M1 macrophages are chemoattractant and mitogenic for muscle progenitor cells, including Pax7+ satellite cells [115–119].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [118]
In the citing paper
“Although the myokine IL-6 is mostly recognized for its regulatory effects in lipid and glucose metabolism, IL-6 also plays important roles in myogenesis.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [49]
In the citing paper
“Genetic loss of IL-6 impaired muscle hypertrophy in vivo, whereas myotube-produced IL-6 stimulated muscle cell proliferation in a paracrine fashion (49).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [49]
In the citing paper
“Although being considered pro-inflammatory, TNF-α and IL-6 also appear to play important role in the early stages of muscle regeneration following injury by enhancing myoblast proliferation and inhibiting differentiation [73,74,75].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [73]
In the citing paper
“This inhibition involves the down regulation of the MRFs, MyoD and Myogenin [73,74,75], with TNF-α receptor double knock out mice [74] and with IL-6 non-specific knock out mice [73] shown to present impaired myogenic differentiation and hypertrophy when compared to wild type mice during functional overloading.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [73]
Citations
Cites
1 retracted
Immunohistochemical detection of interleukin‐6 in human skeletal muscle fibers following exercise
Penkowa, M., Keller, C., Keller, P., Jauffred, S., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0311fje · Cited by 157
RetractedBodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · cited 1×
“…3 C57BL/6 background (WT) and generated by heterozygous mating of mice carrying a targeted disruption in which the second exon in the IL-6 gene was replaced by a neo r cassette (Kopf et al., 1994), were generously provided by A. Bernad (Centro Nacional de Investiga-ciones Cardiovasculares, Madrid).”
MethodNF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
D, D. C. G., Albanese, C., Reuther, J. Y., Pestell, R. G., & Baldwin, A. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5785 · Cited by 1,304
Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD
Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., & Lassar, A. B. (1995) · Science · doi:10.1126/science.7863327 · Cited by 1,139
Skeletal muscle hypertrophy and atrophy signaling pathways
Glass, D. J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.018 · Cited by 1,106
INTERLEUKIN-6: From Basic Science to Medicine—40 Years in Immunology
Kishimoto, T. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115806 · Cited by 1,040
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
Glass, D. J. (2003) · Nature Cell Biology · doi:10.1038/ncb0203-87 · Cited by 694
IL-6 signal transduction and its physiological roles: the signal orchestration model
Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673
IL-6-induced skeletal muscle atrophy
Haddad, F., Zaldivar, F., Cooper, D. M., & Adams, G. R. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01026.2004 · Cited by 612
Flagged first, then by citations
3 of the 57 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–400 of 868
Regulation of Skeletal Muscle DRP-1 and FIS-1 Protein Expression by IL-6 Signaling
Fix, D. K., VanderVeen, B. N., Counts, B. R., & Carson, J. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8908457 · Cited by 39
“STAT3 is a widely investigated downstream e ff ector of IL-6 in skeletal muscle [10, 14, 30 – 34], and chronic STAT3 activation can drive muscle atrophy through accelerated protein degradation [3, 4, 33, 35].”
Inflammatory response during slow‐ and fast‐twitch muscle regeneration
Zimowska, M., Kasprzycka, P., Bocian, K., Delaney, K., Jung, P., Kuchcinska, K., Kaczmarska, K., Gladysz, D., Stremińska, W., & Ciemerych, M. (2017) · Muscle and Nerve · doi:10.1002/mus.25246 · Cited by 32
Schweer, W., Schwartz, K., Patience, J. F., Karriker, L. A., Sparks, C., Weaver, M., Fitzsimmons, M., Burkey, T. E., & Gabler, N. K. (2017) · Translational Animal Science · doi:10.2527/tas2017.0054 · Cited by 37
“Increased concentrations of IL-6 have been reported in contracting muscle fibers (Febbraio et al., 2004) which can lead to increased muscle mass by satellite cell activation (Serrano et al., 2008).”
BackgroundRole of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic Progenitors
Collao, N., Farup, J., & Lisio, M. D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00009 · Cited by 39
Skeletal muscle redox signaling in rheumatoid arthritis
Steinz, M. M., Alves, E. S., & Lanner, J. T. (2020) · Clinical Science · doi:10.1042/cs20190728 · Cited by 39
Therapeutic aspects of cell signaling and communication in Duchenne muscular dystrophy
Starosta, A., & Konieczny, P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03821-x · Cited by 41
“IL-6 is a pro-osteoclastogenic and pro-myogenic cytokine released by tissues with essential functions in bone homeostasis [93] and myogenesis [99].”
BackgroundMyofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche
Haroon, M. F., Klein‐Nulend, J., Bakker, A. D., Jin, J., Seddiqi, H., Offringa, C., de Wit, G. M. J., Grand, F. L., Giordani, L., Liu, K. J., et al. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.05.021 · Cited by 35
“IL-6 is essential for muscle regeneration and MuSC proliferation (40).”
BackgroundGros, M., Nunes, A. M., Daoudlarian, D., Pini, J., Martinuzzi, E., Barbosa, S., Ramirez, M., Puma, A. R., Villa, L., Cavalli, M., et al. (2021) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-210711 · Cited by 37
“Conversely, experimental evidence implicated IL-6 in promoting satellite cell proliferation during hypertrophic muscle growth [27].”
BackgroundPerfusable Biohybrid Designs for Bioprinted Skeletal Muscle Tissue
Filippi, M., Yaşa, Ö., Giachino, J., Graf, R., Balciunaite, A., Stefani, L., & Katzschmann, R. K. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300151 · Cited by 34
Early inflammatory and myogenic responses to resistance exercise in the elderly
Mathers, J. L., Farnfield, M. M., GARNHAM, A. P., Caldow, M. K., Cameron‐Smith, D., & Peake, J. M. (2012) · Muscle & Nerve · doi:10.1002/mus.23317 · Cited by 39
“IL-6 regulates myoblast differentiation and proliferation in vitro(14,15) most likely by activating signal transducer and activator of transcription (STAT) 3.(38) MCP-1 and its receptor also play a key role in muscle regeneration fol-”
BackgroundZanchi, N. E., Lira, F. S., Filho, M. A. D. S., Neto, J. C. R., Carvalho, C. R. D. O., Seelaender, M. C. L., dos Santos, R. V. T., & Lancha, A. H. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1456-0 · Cited by 37
“Interestingly, it has been demonstrated that overloaded plantaris muscle also shows a time-dependent regulation related to IL-6 production in skeletal muscle ( Serrano et al. 2008 ).”
BackgroundEnergy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review
Barros, D. G. M., Marques, E. A., Magalhães, J., & Carvalho, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101780 · Cited by 41
“Although IL-6 secreted from skeletal muscle promotes hypertrophy via satellite cell proliferation and differentiation (Serrano et al., 2008), this cytokine is generally investigated regarding its relationship with low-grade inflammation and its detrimental impact on muscle mass and functionality in older adults.”
Isanejad, A., صراف, ز. ح., Mahdavi, M., Gharakhanlou, R., Shamsi, M. M., & Paulsen, G. (2015) · Cytokine · doi:10.1016/j.cyto.2015.03.013 · Cited by 36
“Elevated muscular levels of IL-6 may be due to regeneration after injury [37,38], apparently by regulating both proliferation and differentiation of myoblasts [39].”
BackgroundSkeletal muscle satellite cell activation following cutaneous burn in rats
Wu, X., Walters, J., & Rathbone, C. R. (2012) · Burns · doi:10.1016/j.burns.2012.10.016 · Cited by 36
“[22] Serrano AL, Baeza-Raja B, Perdiguero E, Jardı́ M, MuñozCánoves P.”
Lamin-Related Congenital Muscular Dystrophy Alters Mechanical Signaling and Skeletal Muscle Growth
Owens, D. J., Messéant, J., Moog, S., Viggars, M. R., Ferry, A., Mamchaoui, K., Lacène, E., Romero, N. B., Brull, A., Bonne, G., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010306 · Cited by 36
“Functional overload (FO) of plantaris (PLN) muscles of WT (n = 10 WT C57Bl/6_129/6J and n = 6 WT 129S2/SvPasCrl) and mutant (n = 7 Lmna+/∆K32 and n = 7 in LmnaH222P/H222P) mice was induced through the tenotomy of soleus and gastrocnemius muscles, in both legs [65].”
MethodMechanisms governing the health and performance benefits of exercise
Bishop‐Bailey, D. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12399 · Cited by 40
“, 2005), but also appears to be an important regulator of satellite cell mediated muscle hypertrophy (Serrano et al., 2008).”
BackgroundLu, Z., Wang, Z., Zhang, X., & Ning, K. (2024) · Biomolecules · doi:10.3390/biom14101205 · Cited by 47
“…interactions between it and immune cells in muscle tissue have been suggested as determinants in the regulation of muscle injury and inflammation [136,137], and it is responsible for inducing regeneration-promoting pathways and anti-inflammatory processes in skeletal muscle [94,138,139].”
BackgroundRandolph, M. E., Phillips, B. L., Choo, H. J., Vest, K. E., Vera, Y., & Pavlath, G. K. (2015) · Stem Cells · doi:10.1002/stem.2098 · Cited by 36
Nunes, A. M., Wuebbles, R. D., Sarathy, A., Fontelonga, T. M., Deries, M., Burkin, D. J., & Þorsteinsdóttir, S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx083 · Cited by 35
Isesele, P., & Mazurak, V. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.682091 · Cited by 38
Lecompte, S., Abou-Samra, M., Boursereau, R., Noel, L., & Brichard, S. M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2465-5 · Cited by 34
“In line with the anti-inflammatory properties of IL-6, which were also evidenced after muscle exercise [5], this myokine has further been reported to play a beneficial role in muscle regeneration by promoting myoblast differentiation [42].”
BackgroundIL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse
Kostek, M., Nagaraju, K., Pistilli, E., Sali, A., Lai, S.-H., Gordon, B. S., & Chen, Y.-W. (2012) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-13-106 · Cited by 36
“remodeling [38,39].”
Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention
Lightfoot, A. P., McCormick, R., Nye, G. A., & McArdle, A. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.05.005 · Cited by 34
Roles of IL-1α/β in regeneration of cardiotoxin-injured muscle and satellite cell function.
Chaweewannakorn, C., Tsuchiya, M., Koide, M., Hatakeyama, H., Tanaka, Y., Yoshida, S., Sugawara, S., Hagiwara, Y., Sasaki, K., & Kanzaki, M. (2018) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00310.2017 · Cited by 30
“1 and 2, IL-1 molecules appear to be involved in the initial inflammatory responses including local productions of IL-6 and CXCL1, which are highly likely to contribute to triggering the stimulation of satellite cells to undergo proliferation and migration within the regenerating muscle tissues (13, 27, 33, 35).”
BackgroundSasaki, T., Akiyama, M., Kaneko, Y., & Takeuchi, T. (2021) · Rheumatology · doi:10.1093/rheumatology/keab634 · Cited by 24
Lin, B., Bai, L., Wang, S., & Hong, L. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s321229 · Cited by 34
“It is an important muscle cell molecule released during skeletal muscle movement, promoting muscle fiber metabolism and regeneration.(28) However, when IL-6 activates cells with a trans-signaling pathway, it has a pro-inflammatory effect,(29) which is also involved in the induction of chronic inflammation in patients…”
Négroni, E., Kondili, M., Muraine, L., Bensalah, M., Butler-Browne, G. S., Mouly, V., Bigot, A., & Trollet, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.952041 · Cited by 42
“, 2013), Il6 (Serrano et al., 2008), Cxcl5 and Cxcl1, known to attract monocytes and neutrophils (Soliman et al.”
BackgroundInfluentialMEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM: Stem cell niche and postnatal muscle growth1,2
Bi, P., & Kuang, S. (2011) · Journal of Animal Science · doi:10.2527/jas.2011-4594 · Cited by 34
“…demonstrated that some cytokines released by adipogenic cells can positively regulate myogenic cell proliferation and differentiation (Li, 2003; Serrano et al., 2008; Acharyya et al., 2010; Joe et al., 2010; Palacios et al., 2010; Toth et al., 2011), our results demonstrated for the first time…”
ResultGlund, S., Treebak, J. T., Long, Y. C., Barrès, R., Viollet, B., Wojtaszewski, J. F. P., & Zierath, J. R. (2008) · Endocrinology · doi:10.1210/en.2008-1204 · Cited by 35
Hansen, M. J., Chen, H., Jones, J. E. C., Langenbach, S. Y., Vlahos, R., Gualano, R. C., Morris, M. J., & Anderson, G. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080471 · Cited by 34
“Local IL-6 expression has pro- and anti-inflammatory effects and has been implicated in satellite cell mediated skeletal muscle hypertrophy [49].”
BackgroundThe Regenerative Activity of Interleukin-6
Galun, E., & Rose-John, S. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-308-4_4 · Cited by 34
Fujita, R., Kawano, F., Ohira, T., Nakai, N., Shibaguchi, T., Nishimoto, N., & Ohira, Y. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.014 · Cited by 34
Effect of ionizing radiation on human skeletal muscle precursor cells
Jurdana, M., Čemažar, M., Pegan, K., & Marš, T. (2013) · Radiology and Oncology · doi:10.2478/raon-2013-0058 · Cited by 33
Biomimetic sponges for regeneration of skeletal muscle following trauma.
Haas, G., Dunn, A., Marcinczyk, M., Talović, M., Schwartz, M. A., Scheidt, R., Patel, A., Hixon, K., Elmashhady, H., McBride-Gagyi, S., et al. (2018) · Journal of Biomedical Materials Research. Part A · doi:10.1002/jbm.a.36535 · Cited by 28
Martin, K. S., Kegelman, C. D., Virgilio, K. M., Passipieri, J. A., Christ, G., Blemker, S., & Peirce, S. (2017) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1707-2 · Cited by 23
Attia, M., Maurer, M., Robinet, M., Grand, F. L., Fadel, É., Panse, R. L., Butler-Browne, G. S., & Berrih‐Aknin, S. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1754-2 · Cited by 33
“IL-6 is known to stimulate SC proliferation and differentiation [66].”
BackgroundHo, T., Tsai, S. H., Yeh, S., Chen, S., Tung, K., Chien, H.-Y., Lu, Y., Huang, C., & Tsao, Y. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1110-z · Cited by 32
Pirkmajer, S., Bezjak, K., Matkovič, U., Dolinar, K., Jiang, L. Q., Miš, K., Gros, K., Милованова, К. Г., Pirkmajer, K. P., Marš, T., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.566584 · Cited by 33
Fukada, S., & Ito, N. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112907 · Cited by 32
Olmedillas, H., Sanchis‐Moysi, J., Fuentes, T., Guadalupe‐Grau, A., Ponce‐González, J. G., Morales‐Álamo, D., Santana, A., Dorado, C., Calbet, J. A. L., & Guerra, B. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1281-5 · Cited by 32
“Serrano et al. (2008) have shown that interleukin-6 (IL-6) is necessary for satellite cell-mediated muscle hypertrophy by a Tyr705-STAT3-dependent mechanism.”
BackgroundChodkowska, K. A., Abramowicz-Pindor, P. A., Tuśnio, A., Gawin, K., Taciak, M., & Barszcz, M. (2022) · Animals · doi:10.3390/ani12192625 · Cited by 31
“It has previously been described as the cytokine responsible for satellite cell proliferation in vitro [56].”
BackgroundInfluentialGuo, Q., Luo, Q., & Song, G. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13440 · Cited by 35
“47,71 Loss of IL-6 attenuates muscle hypertrophy induced by overload, 46 and a recent theory suggested that IL-6 acts as an energy al-locator in muscle by regulating lipolysis, muscular energy uptake, and immune function.”
BackgroundOrsatti, F. L., Nahás, E. A. P., Orsatti, C. L., de Oliveira, E. P., Nahás-Neto, J., da Mota, G. R., & Burini, R. C. (2011) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318239f837 · Cited by 30
“In contrast to the findings of the studies described above, IL-6 has the potential to stimulate myoblast or satellite cell proliferation, both of which characterize hypertrophy (34).”
ResultWu, D., Gao, X., Shi, Y., Wang, H., Wang, W., Li, Y., & Zheng, Z. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192013616 · Cited by 32
Src mediates the mechanical activation of myogenesis by activating TNFα-converting enzyme
Niu, A., Wen, Y., Liu, H., Zhan, M., Jin, B., & Li, Y.-P. (2013) · Journal of Cell Science · doi:10.1242/jcs.125328 · Cited by 31
“, 1994) and differentiation (Liu et al., 2010; Serrano et al., 2008).”
MethodPerdiguero, E., Kharraz, Y., Serrano, A. L., & Muñoz-Cánoves, P. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19374 · Cited by 30
Self-citationAdvances in the research on myokine-driven regulation of bone metabolism
Shao, M., Wang, Q., Lv, Q., Zhang, Y., Gao, G., & Lu, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22547 · Cited by 35
“IL-6 is essential for muscle stem cell-mediated hypertrophy, while IL-6 deficiency decreases muscle hypertrophy by suppressing muscle stem cell proliferation and fusion with previously existing myofibers [68].”
BackgroundImpact of SOCS3 overexpression on human skeletal muscle development in vitro
Caldow, M. K., Steinberg, G. R., & Cameron‐Smith, D. (2011) · Cytokine · doi:10.1016/j.cyto.2011.03.012 · Cited by 29
Péladeau, C. L., Ahmed, A., Amirouche, A., Parks, T. E. C., Bronicki, L., Ljubicic, V., Renaud, J., & Jasmin, B. J. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv444 · Cited by 29
“However, if toll-like receptors (TLR) are activated by heparin as suggested previously (78), it may be that activation of these receptors by heparin induces IL-6 production (85) which could promote muscle fiber hypertrophy (86,87).”
BackgroundNarsale, A. A., Puppa, M., Hardee, J. P., VanderVeen, B. N., Enos, R. T., Murphy, E. A., & Carson, J. A. (2016) · Oncotarget · doi:10.18632/oncotarget.10699 · Cited by 33
COUP-TFII regulates satellite cell function and muscular dystrophy
Xie, X., Tsai, S. Y., & Tsai, M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87414 · Cited by 29
“Among those suppressed cell-cycle regulators, Ccnd1, a key player of cell-cycle progression (33), and Myf5 were upregulated in the COUP-TFII–silencing cells (Figure 4D and Supplemental Figure 6D).”
BackgroundRole of gp130 in basal and exercise-trained skeletal muscle mitochondrial quality control
Fix, D. K., Hardee, J. P., Gao, S., VanderVeen, B. N., Velázquez, K. T., & Carson, J. A. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01063.2017 · Cited by 31
“The interleukin-6 (IL-6) cytokine family has been widely investigated for its role in the regulation of muscle remodeling, growth, and metabolism (54, 63, 67).”
BackgroundFirearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
Moriscot, A. S., Miyabara, E. H., Langeani, B., Belli, A., Egginton, S., & Bowen, T. S. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00127-1 · Cited by 36
RNAi Screen Reveals Potentially Novel Roles of Cytokines in Myoblast Differentiation
Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D., & Chen, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068068 · Cited by 32
“Interleukin-6 (IL-6) is also expressed in muscle [14,15], and it promotes myogenic differentiation [14,16] as well as satellite cell proliferation during muscle growth [15].”
BackgroundTime Course Change in Muscle Swelling: High-Intensity vs. Blood Flow Restriction Exercise
Freitas, E. D. S., Poole, C., Miller, R., Heishman, A. D., Kaur, J., Bemben, D. A., & Bemben, M. G. (2017) · International Journal of Sports Medicine · doi:10.1055/s-0043-118342 · Cited by 30
“Although hormonal responses seem to play an important role in muscle growth, alternative mechanisms have also been postulated to provide a significant contribution to the physiological adaptations of skeletal muscle in response to high intensity resistance exercise [35].”
BackgroundBritto, F. A., Gnimassou, O., Groote, E. D., Balan, E., Warnier, G., Everard, A., Cani, P. D., & Deldicque, L. (2019) · The FASEB Journal · doi:10.1096/fj.201902244r · Cited by 30
Scully, D., Sfyri, P., Verpoorten, S., Papadopoulos, P., Muñoz‐Turrillas, M. C., Mitchell, R., Aburima, A. A., Patel, K., Gutiérrez, L., Naseem, K. M., et al. (2018) · Acta Physiologica · doi:10.1111/apha.13207 · Cited by 31
“Moreover, SCF increases skeletal muscle stem cell number, IL‐6 regulates myoblast proliferation and migration, while TNF‐α inhibits myogenic differentiation in C2C12 cells through NF‐κΒ and promotes myotube atrophy.(56,64) Conversely, IGFBP‐1, Angiopoietin‐ 2and uPA have been shown to promote myogenic differentiation.”
BackgroundRhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth
Noviello, C., Kobon, K., Delivry, L., Guilbert, T., Britto, F. A., Julienne, F., Maire, P., Randrianarison-Huetz, V., & Sotiropoulos, A. (2021) · iScience · doi:10.1016/j.isci.2021.103616 · Cited by 29
“It was already proved that after increased load, myofibers secretemyokines like IL-4 and IL-6 that are able to influence SC proliferation and fusion (Guerci et al., 2012; Serrano et al., 2008; Horsley et al., 2003), and it has been recently shown that SC-derived extracellular vesiclemay participate in the creation of…”
BackgroundAmphiregulin mediates non-cell-autonomous effect of senescence on reprogramming
von Joest, M., Chen, C., Douché, T., Chantrel, J., Chiche, A., Gianetto, Q. G., Matondo, M., & Li, H. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111074 · Cited by 31
Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner
Ferrer, B., Navia, B., Giralt, M., Comes, G., Carrasco, J., Molinero, A., Quintana, A., Señarís, R. M., & Hidalgo, J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.001 · Cited by 32
“, 2003) as well as controlling muscle mass (Serrano et al., 2008).”
Muscle satellite cells are activated after exercise to exhaustion in T horoughbred horses
Kawai, M., Aida, H., Hiraga, A., & Miyata, H. (2012) · Equine Veterinary Journal · doi:10.1111/evj.12010 · Cited by 30
“This anti-Pax7 is well knownas themostpopularantibody for identificationof satellitecells in musclesof several species [1,5,6,10,11,17].”
BackgroundResultInfluentialDavies, O. G., Liu, Y., Player, D. J., Martin, N. R. W., Grover, L. M., & Lewis, M. P. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00194 · Cited by 29
“IL-6 is released from skeletal muscle following contraction (e.g., exercise), and its autocrine effects on skeletal muscle tissue are equivocal, having been shown to be important for satellite cell mediated muscle growth (Serrano et al., 2008) and implicated in muscle atrophy (Haddad et al., 2005).”
BackgroundLira, F. S., de Freitas, M. C., Gerosa-Neto, J., Cholewa, J. M., & Rossi, F. E. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002653 · Cited by 29
“, MyoD) (2,36), and activating muscle satellite cells (32), and therefore may play a role in the hypertrophic process (23).”
BackgroundSculpting Chromatin Beyond the Double Helix
Sartorelli, V., & Juan, A. H. (2011) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385940-2.00003-6 · Cited by 28
Rovira, M., Arrey, G., & Planas, J. V. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01063 · Cited by 29
“Functionally, IL6 is known to participate in the regulation of myogenesis and muscle growth in mammals through the regulation of satellite cell proliferation and myonuclear accretion (Serrano et al., 2008) and its circulating or expression levels in muscle are related with training adaptation in humans (Fischer, 2006).”
BackgroundKuo, Y.-K., Lin, Y., Lee, C., Chen, C., Tani, J., Huang, T., Chang, H. C., & Wu, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21083010 · Cited by 31
Mageriu, V., Manole, E., Bastian, A. E., & Stăniceanu, F. (2020) · Journal of Immunology Research · doi:10.1155/2020/9079083 · Cited by 28
“Serrano et al. in an in vitro study on mice lacking IL-6 gene in skeletal muscle [35] have shown that this myokine is an important regulator of muscular hypertrophy mediated by the satellite cells in normal muscle.”
Hillege, M. M., Shi, A., Galli, R., Wu, G., Bertolino, P., Hoogaars, W. M. H., & Jaspers, R. T. (2022) · eLife · doi:10.7554/elife.77610 · Cited by 28
Roy, A., & Kumar, A. (2022) · Nature Communications · doi:10.1038/s41467-022-29752-0 · Cited by 29
Eynon, N., Ruiz, J. R., Meckel, Y., Santiago, C., Fiuza‐Luces, C., Gómez‐Gallego, F., de Oliveira, J. J. F., & Lucía, A. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2010.055442 · Cited by 30
“Interleukin-6 (IL-6) is not only involved in immune function (Amir et al. , 2007), but also in muscle repair and hypertrophy following exercise-induced damage (Cantini et al. , 1995; Helge et al. , 2003; Weigert et al. , 2007; McKay et al. , 2008; Serrano et al. , 2008).”
InfluentialOchi, E., Nakazato, K., & Ishii, N. (2011) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181f1592e · Cited by 28
“More recently, IL-6 knockout mice showed a depressed muscular growth, suggesting that IL-6 is an important factor for muscular hypertrophy (35).”
BackgroundDrummond, M. J., Marcus, R. L., & LaStayo, P. C. (2012) · Journal of Aging Research · doi:10.1155/2012/486930 · Cited by 28
“Certainly inflammation is both a normal and necessary response for muscle remodeling [63] and the hypertrophy process [64].”
BackgroundHenriksen, T. I., Davidsen, P. K., Pedersen, M., Schultz, H. S., Hansen, N. S., Larsen, T. J., Vaag, A. A., Pedersen, B. K., Nielsen, S. J., & Schéele, C. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.006 · Cited by 29
“Muscle stem cells contribute to muscle hypertrophy [12] and, although debated, could thus have a role in replacing old and damaged muscle cells in a continuous manner [13].”
BackgroundFernández, T., Briceño, F. A. C., Espinosa‐Ramírez, M., García-Valdés, P., López‐Fuenzalida, A., Riquelme, A. J., Arab, J. P., Cabrera, D., Arrese, M. A., & Francisco Barrera, M. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1810563 · Cited by 28
Mitochondrial Functionality in Inflammatory Pathology-Modulatory Role of Physical Activity
Casuso, R. A., & Huertas, J. R. (2021) · Life · doi:10.3390/life11010061 · Cited by 28
“Studies in mice showed that genetic loss of IL-6 impair skeletal muscle hypertrophy [37].”
BackgroundKoya, T., Nishizawa, S., Ohno, Y., Goto, A., Ikuta, A., Suzuki, M., Ohira, T., Egawa, T., Nakai, A., Sugiura, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077788 · Cited by 28
“Although it has been suggested that IL-6 plays a significant role in muscle satellite cell-mediated skeletal muscle hypertrophy [54,55], the role(s) of the prolonged up-regulation of IL-6 and ATF3 in overloading-associated skeletal muscle hypertrophy remains unclear.”
BackgroundEffect of Physical Training on Exercise-Induced Inflammation and Performance in Mice
de Barcellos, L. A. M., Gonçalves, W. A., de Oliveira, M. P. E., Guimarães, J. B., Queiroz‐Junior, C. M., de Resende, C. B., Russo, R. C., Coimbra, C. C., Silva, A. N., Teixeira, M. M., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.625680 · Cited by 31
Champ, C. E., Carpenter, D. J., Diaz, A. K., Rosenberg, J., Ackerson, B. G., & Hyde, P. N. (2022) · Sports Medicine · doi:10.1007/s40279-022-01759-z · Cited by 29
Ahn, N., & Kim, K. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082685 · Cited by 29
“Moreover, IL-6 has important effects on hypertrophic muscle growth and myogenesis in mice [15].”
BackgroundRossi, F. E., Gerosa-Neto, J., Zanchi, N. E., Cholewa, J. M., & Lira, F. S. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001189 · Cited by 27
“, MyoD) to initiate the processes of recovery (5,16,19) and hypertrophy by activating muscle satellite cells (15).”
BackgroundWang, B. Y., Chen, Y., Hsiao, A. W., Chen, W., Lee, C., & Lee, O. K. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13228 · Cited by 26
The Role of Supporting Cell Populations in Satellite Cell Mediated Muscle Repair
Johnson, A. L., Kamal, M. J., & Parise, G. (2023) · Cells · doi:10.3390/cells12151968 · Cited by 30
“Several of these cytokines, including IL-13 and IL-4, have been linked to myotube fusion; studies have reported that myofibres lacking IL-4 or IL-4a receptors were smaller and contained fewer myonuclei [46,84,98].”
BackgroundWright, C., Allsopp, G., Addinsall, A., McRae, N. L., Andrikopoulos, S., & Stupka, N. (2017) · Mediators of Inflammation · doi:10.1155/2017/7043429 · Cited by 31
“The release of cytokines, such as interleukin 6 (IL-6) [2] and tumour necrosis factor alpha (TNFα) [3], stimulates satellite cell activation and commitment to myogenesis.”
BackgroundGenes and power athlete status
Maciejewska, A., Sawczuk, M., Cięszczyk, P., & Ahmetov, I. I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816193-7.00003-8 · Cited by 26
Fighting obesity: When muscle meets fat
Yang, X., Bi, P., & Kuang, S. (2014) · Adipocyte · doi:10.4161/21623945.2014.964075 · Cited by 25
Hayakawa, N., Fukumura, J., Yasuno, H., Fujimoto-Ouchi, K., & Kitamura, H. (2015) · Biomedical Research · doi:10.2220/biomedres.36.71 · Cited by 25
“These IL-6 functions have been shown by knockout experiments using mice and examinations of C2C12 cells in which IL-6 is overexpressed (40).”
BackgroundGerosa-Neto, J., Rossi, F. E., Campos, E. Z., Antunes, B. M., Cholewa, J. M., & Lira, F. S. (2016) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001413 · Cited by 25
Kasprzycka, P., Archacka, K., Kowalski, K., Mierzejewski, B., Zimowska, M., Grabowska, I., Piotrowski, M., Rafałko, M., Ryżko, A., Irhashava, A., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1444-1 · Cited by 26
“cates the role of this cytokine in satellite cell-mediated hypertrophy [36].”
BackgroundGinkgolide B increases healthspan and lifespan of female mice
Lee, C., Wang, B. Y., Wong, S. H., Chen, Y., Cao, Q., Hsiao, A. W., Fung, S.-H., Chen, Y.-F., Wu, H.-H., Cheng, P.-Y., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00802-0 · Cited by 26
Bohaud, C., Johansen, M. D., Jørgensen, C., Kremer, L., Ipseiz, N., & Djouad, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.707856 · Cited by 25
Decline of regenerative potential of old muscle stem cells: contribution to muscle aging
Sahinyan, K., Lazure, F., Blackburn, D. M., & Soleimani, V. D. (2022) · FEBS Journal · doi:10.1111/febs.16352 · Cited by 25
Mitochondrial transplantation as a possible therapeutic option for sarcopenia
Türkel, İ., Özerkliğ, B., Yılmaz, M., Ülger, Ö., Kubat, G. B., & Tuncer, M. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02326-3 · Cited by 25
Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2
García‐Guerra, L., Vila‐Bedmar, R., Carrasco‐Rando, M., Cruces‐Sande, M., Martín, M., Ruiz‐Gómez, A., Ruiz‐Gómez, M., Lorenzo, M., Fernández‐Veledo, S., Mayor, F., et al. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju025 · Cited by 24
“On the other hand, skeletal muscle hypertrophy, the increase in muscle mass that occurs as a result of an increase in load, is characterized by increased fiber size and protein synthesis (Serrano et al., 2008).”
BackgroundEarly Exercise Rehabilitation of Muscle Weakness in Acute Respiratory Failure Patients
Berry, M. J., & Morris, P. E. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182a4e67c · Cited by 24
“Although the cytokine storm seen in critically ill patients is overall myopathic, there are data to suggest that increases in cytokines can be beneficial because they play a role in protein synthesis (46) and pain management (31).”
BackgroundNuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model
Fongy, A., Falcone, S., Lainé, J., Prudhon, B., Martins-Bach, A. B., & Bitoun, M. (2019) · Scientific Reports · doi:10.1038/s41598-018-38184-0 · Cited by 27
Gallardo, F. S., Córdova-Casanova, A., & Brandan, E. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-021-00610-w · Cited by 27
“Indeed, IL-6 functions as a pro-myogenic factor that regulates the proliferation of SCs and myoblasts (Okazaki et al. 1996; Serrano et al. 2008; Al-Shanti et al. 2008).”
BackgroundLegaard, G. E., & Pedersen, B. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814593-7.00013-x · Cited by 24
Krzysik-Walker, S. M., Hadley, J. A., Pesall, J. E., McFarland, D. C., VASILATOS-YOUNKEN, R., & Ramachandran, R. (2011) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2011.04.007 · Cited by 23
- Invited Review - Physiological Roles of Adipokines, Hepatokines, and Myokines in Ruminants
Roh, S., Suzuki, Y., Gotoh, T., Tatsumi, R., & Katoh, K. (2015) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.16.0001r · Cited by 24
“IL-6 was also observed in growing murine myofibers and satellite cells (Serrano et al., 2008).”
BackgroundLevitt, D. E., Luk, H., Duplanty, A. A., McFarlin, B. K., Hill, D. W., & Vingren, J. L. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3606-0 · Cited by 23
Metadata
- Authors
- Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 7
- Issue
- 1
- Pages
- 33-44
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1997149085
- Cited by
- 873
- References
- 57
- Citations by year
- 2026: 43 · 2025: 56 · 2024: 42 · 2023: 55 · 2022: 71 · 2021: 73 · 2020: 48 · 2019: 55 · 2018: 50 · 2017: 54 · 2016: 45 · 2015: 69 · 2014: 42 · 2013: 48 · 2012: 51
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2024 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association Française contre les Myopathies (Marató-TV3)
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Muscular Dystrophy Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- interleukin-6, satellite cells, skeletal muscle hypertrophy, muscle stem cells, STAT3 signaling, cyclin D1, myonuclear accretion, satellite cell proliferation, paracrine signaling, myofiber growth, cytokine deficiency
- MeSH terms
- Animals, Cell Line, Cell Movement, Enzyme-Linked Immunosorbent Assay, Hypertrophy, Immunohistochemistry, Muscular Diseases, Blotting, Western, Interleukin-6, Mice, Knockout, Muscle, Skeletal, Muscle Fibers, Skeletal, Cyclin D1, Reverse Transcriptase Polymerase Chain Reaction, Myoblasts, Satellite Cells, Skeletal Muscle, Cell Proliferation, STAT3 Transcription Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
