Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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TOR signaling in growth and metabolism

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.

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Metabolic Control by S6 Kinases Depends on Dietary Lipids

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Osteocalcin‐dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance

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eIF3f depletion impedes mouse embryonic development, reduces adult skeletal muscle mass and amplifies muscle loss during disuse

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A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity

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Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation

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Tissue-specific activation of insulin signaling as a potential target for obesity-related metabolic disorders

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Dual effects of obesity on satellite cells and muscle regeneration

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Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia

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The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility

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mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis

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The relation of mTOR with diabetic complications and insulin resistance in patients with type 2 diabetes mellitus

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Comparative Analyses of mTOR/Akt and Muscle Atrophy-Related Signaling in Aged Respiratory and Gastrocnemius Muscles

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Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy

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Ginsenoside Rg5 promotes muscle regeneration via p38MAPK and Akt/mTOR signaling

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Allele-Specific Down-Regulation of RPTOR Expression Induced by Retinoids Contributes to Climate Adaptations

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mTORC2 affects the maintenance of the muscle stem cell pool

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AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth

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mTOR signaling mediates ILC3-driven immunopathology

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Absence of γ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle

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Mammalian target of rapamycin pathway is up-regulated by both acute endurance exercise and chronic muscle contraction in rat skeletal muscle

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TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome

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Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats

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Protein Turnover in Skeletal Muscle: Looking at Molecular Regulation towards an Active Lifestyle

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Resistance Training Improves Hypertrophic and Mitochondrial Adaptation in Skeletal Muscle

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mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis

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mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior.

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Reciprocity Between Skeletal Muscle AMPK Deletion and Insulin Action in Diet-Induced Obese Mice

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Phosphoinositide Signalling Pathways in Metabolic Regulation

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Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins

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Enhanced Akt phosphorylation and myogenic differentiation in PI3K p110β-deficient myoblasts is mediated by PI3K p110α and mTORC2

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Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells

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Lost in translation: challenges of current pharmacotherapy for sarcopenia

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Interactions of the super complexes: When mTORC1 meets the proteasome

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Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice

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Mechanisms of Ovarian Cancer-Associated Cachexia

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Alpha‐Lipoic Acid Supplementation Reduces mTORC1 Signaling in Skeletal Muscle from High Fat Fed, Obese Zucker Rats

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Inducible deletion of raptor and mTOR from adult skeletal muscle impairs muscle contractility and relaxation

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Factors, mechanisms and improvement methods of muscle strength loss

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Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment

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Targeting the mTOR Pathway in Tumor Malignancy

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Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice

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Upstream Regulator Analysis of Wooden Breast Myopathy Proteomics in Commercial Broilers and Comparison to Feed Efficiency Proteomics in Pedigree Male Broilers

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Muscle Aging Heterogeneity: Genetic and Structural Basis of Sarcopenia Resistance

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Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis

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The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin

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Leucyl-tRNA synthetase is required for the myogenic differentiation of C2C12 myoblasts, but not for hypertrophy or metabolic alteration of myotubes

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Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation

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Self‐transducible LRS‐UNE‐L peptide enhances muscle regeneration

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Effects of Acute Muscle Contraction on the Key Molecules in Insulin and Akt Signaling in Skeletal Muscle in Health and in Insulin Resistant States

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Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice

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Prognostic and Predictive Role of Body Composition in Metastatic Neuroendocrine Tumor Patients Treated with Everolimus: A Real-World Data Analysis

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Genetic Variation in the Raptor Gene Is Associated With Overweight But Not Hypertension in American Men of Japanese Ancestry

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CCK-independent mTORC1 activation during dietary protein-induced exocrine pancreas growth

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Expert opinion on the metabolic complications of mTOR inhibitors

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The Mechanisms of Insulin Action

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mTORC1 activity is essential for erythropoiesis and B cell lineage commitment

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Effects of treadmill exercise on skeletal muscle mTOR signaling pathway in high-fat diet-induced obese mice

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Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network

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Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis

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Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation–contraction coupling supramolecular complex

López, R., Mosca, B., Treves, S., Maj, M., Bergamelli, L., Calderón, J. C., Bentzinger, C. F., Romanino, K., Hall, M. N., Rüegg, M. A., et al. (2014) · Biochemical Journal · doi:10.1042/bj20140935 · Cited by 12

Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts

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Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

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Exercise and Sestrin Mediate Speed and Lysosomal Activity in Drosophila by Partially Overlapping Mechanisms

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Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links

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Effect of Caloric Restriction on Aging: Fixing the Problems of Nutrient Sensing in Postmitotic Cells?

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Angiotensin Receptor Blockers Potentiate the Protective Effect of Branched‐Chain Amino Acids on Skeletal Muscle Atrophy in Cirrhotic Rats

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Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling

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Tissue-restricted inhibition of mTOR using chemical genetics

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mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia

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Regulatory-Associated Protein of mTOR-Mediated Signaling: A Nexus Between Tumorigenesis and Disease

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Reduced mTORC1-signaling in retinal progenitor cells leads to visual pathway dysfunction

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Analysis of the Molecular Signaling Signatures of Muscle Protein Wasting Between the Intercostal Muscles and the Gastrocnemius Muscles in db/db Mice

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Effect of resistance training on satellite cells in old mice – a transcriptome study

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Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy

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Elevated BCAA catabolism reverses the effect of branched-chain ketoacids on glucose transport in mTORC1-dependent manner in L6 myotubes

Mann, G., & Adegoke, O. A. J. (2024) · Journal of Nutritional Science · doi:10.1017/jns.2024.66 · Cited by 9

Exploring the Muscle Metabolomics in the Mouse Model of Sepsis-Induced Acquired Weakness

Jiang, Y., Wei, Q., Liu, W., Chen, Q., Chen, X., Yuan, Z., Luo, N., Chen, X., & Wang, C. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6908488 · Cited by 8

mTOR signalling controls the formation of smooth muscle cell-derived luminal myofibroblasts during vasculitis

Stock, A. T., Parsons, S. A., Hansen, J. A., D’Silva, D. B., Starkey, G., Fayed, A., Lim, X. Y., D’Costa, R., Gordon, C. L., & Wicks, I. P. (2024) · EMBO Reports · doi:10.1038/s44319-024-00251-1 · Cited by 8

The Target of Rapamycin: Structure and Functions

Wu, C., Chou, P., & Jacinto, E. (2012) · InTech eBooks · doi:10.5772/37927 · Cited by 8

Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice

Brooks, D. L. P., Garza, A., Katayama, I. A., Romero, J. R., Adler, G. K., Pojoga, L. H., & Williams, G. H. (2019) · Endocrinology · doi:10.1210/en.2018-00989 · Cited by 8

The past-tense debate

Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8

Activation of mTOR for the loss of skeletal muscle in a hindlimb-suspended rat model

Yoo, Y., Park, J. H., Seo, D.-H., Eom, S., Jung, Y., Kim, T., Han, T.-Y., & Kim, H. S. (2015) · International Journal of Precision Engineering and Manufacturing · doi:10.1007/s12541-015-0130-1 · Cited by 8

RNA signaling in skeletal muscle: the central role of microRNAs and exosomal microRNAs

Liu, S., & Dong, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1639123 · Cited by 10

Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1

Fallone, L., Pouxvielh, K., Arbez, L., Rousseaux, N., Picq, L., Drouillard, A., Mathieu, A., Nombel, A., Benezech, S., Bourdonnay, E., et al. (2025) · Science Signaling · doi:10.1126/scisignal.adq8778 · Cited by 8

Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 ( mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice

Tangseefa, P., Martin, S. K., Arthur, A., Panagopoulos, V., Page, A. J., Wittert, G., Proud, C. G., Fitter, S., & Zannettino, A. C. W. (2021) · JBMR Plus · doi:10.1002/jbm4.10486 · Cited by 6

A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

Tang, F., Zhang, P., Ye, P., Lazarski, C. A., Wu, Q., Bergin, I. L., Bender, T. P., Hall, M. N., Cui, Y., Zhang, L., et al. (2017) · eLife · doi:10.7554/elife.32497 · Cited by 7

Effects of Fish Meat-derived Peptide and Dipeptides on Dexamethasone-induced Fatigue in Mice

Iwasaki, Y., Sakai, H., Asami, M., Kitora, S., Naito, H., Kon, R., Ikarashi, N., & Kamei, J. (2019) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-7-12-2 · Cited by 7

Cross-talk between TRPC-1, mTOR, PGC-1α and PPARδ in the dystrophic muscle cells treated with tempol

da Rocha, G. L., Rupcic, I. F., Mizobuti, D. S., Hermes, T. D. A., Covatti, C., da Silva, H. N. M., Araújo, H. N., de Lourenço, C. C., Silveira, L. R., Pereira, E. C. L., et al. (2022) · Free Radical Research · doi:10.1080/10715762.2022.2074842 · Cited by 7

Muscle-specific regulation of the mTOR signaling pathway in MuSK antibody seropositive (MuSK+) experimental autoimmune Myasthenia gravis (EAMG)

Chauhan, M., Punga, T., & Punga, A. R. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.07.008 · Cited by 7

Negative regulation of initial steps in skeletal myogenesis by mTOR and other kinases

Wilson, R. A., Liu, J., Xu, L., Annis, J. E., Helmig, S. E., Moore, G., Timmerman, C., Grandori, C., Zheng, Y., & Skapek, S. X. (2016) · Scientific Reports · doi:10.1038/srep20376 · Cited by 7

Uncoupling TORC2 from AGC kinases inhibits tumour growth

Cameron, A. J. M., Veeriah, S., Marshall, J. J. T., Murray, E. R., Larijani, B., & Parker, P. J. (2017) · Oncotarget · doi:10.18632/oncotarget.20086 · Cited by 7

Depletion of the mRNA translation initiation inhibitor, programmed cell death protein 4 (PDCD4), impairs L6 myotube formation

Maeda, N., Abdullahi, A., Beatty, B., Dhanani, Z., & Adegoke, O. A. J. (2017) · Physiological Reports · doi:10.14814/phy2.13395 · Cited by 6

HK2 Mediated Glycolytic Metabolism in Mouse Photoreceptors Is Not Required to Cause Late Stage Age-Related Macular Degeneration-Like Pathologies

Cheng, S.-Y., Malachi, A., Cipi, J., Ma, S., Brush, R. S., Agbaga, M., & Punzo, C. (2021) · Biomolecules · doi:10.3390/biom11060871 · Cited by 7

Mtor-Fanconi Anemia DNA Damage Repair Pathway in Cancer

Guo, F. (2014) · Journal of Oncobiomarkers · doi:10.13188/2325-2340.1000008 · Cited by 6

The mTOR Pathway and Aging

Schreiber, K. H., O’Leary, M. N., & Kennedy, B. K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00002-2 · Cited by 7

Pathomorphologie der Schulterinstabilität

Wiedemann, E., Jäger, A., & Nebelung, W. (2008) · Der Orthopäde · doi:10.1007/s00132-008-1350-1 · Cited by 7

Insulin Resistance in Obesity

Qi, Y., Guo, X., & Guo, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_28 · Cited by 7

Starvation-induced metabolic rewiring affects mTORC1 composition in vivo

Kaade, E., Mausbach, S., Nina, E., Sylvester, M., Shakeri, F., Jachimowicz, R. D., Gieselmann, V., & Thelen, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-78873-7 · Cited by 8

mTORC2 regulates auditory hair cell structure and function

Cortada, M., Levano, S., Hall, M. N., & Bodmer, D. (2023) · iScience · doi:10.1016/j.isci.2023.107687 · Cited by 7

3‐Hydroxy‐3‐methylglutaryl‐CoA synthase 2 facilitates erectile dysfunction via inhibiting autophagy by enhancing the mammalian target of rapamycin pathway in type 1 diabetic mellitus rats

Dai, Z., Zeng, Y., Tan, X., Zhou, T., Li, X., & Deng, Q. (2024) · Andrology · doi:10.1111/andr.13600 · Cited by 6

mTORC2: A neglected player in aging regulation

Xu, W., Chen, H., & Xiao, H. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31363 · Cited by 7

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Risson, V., Mazelin, L., Roceri, M., Sanchez, H., Moncollin, V., Corneloup, C., Richard-Bulteau, H., Vignaud, A., Baas, D., Defour, A., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903131 · Cited by 381

The role of mTOR complex 1 in skeletal muscle

Romanino, K. (2012) · edoc (University of Basel) · doi:10.5451/unibas-006041355

Function of mTOR complex 1 and 2 in skeletal muscle

Bentzinger, C. F. (2009) · edoc (University of Basel) · doi:10.5451/unibas-004780718 · Cited by 1

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

Romanino, K., Mazelin, L., Albert, V., Conjard‐Duplany, A., Lin, S., Bentzinger, C. F., Handschin, C., Puigserver, P., Zorzato, F., Schaeffer, L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111448109 · Cited by 44

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy

Bentzinger, C. F., Lin, S., Romanino, K., Castets, P., Guridi, M., Summermatter, S., Handschin, C., Tintignac, L. A., Hall, M. N., & Rüegg, M. A. (2013) · Skeletal Muscle · doi:10.1186/2044-5040-3-6 · Cited by 153