Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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The response to DNA damage during differentiation: Pathways and consequences

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Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis

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Reversal of Muscle Atrophy by Zhimu-Huangbai Herb-Pair via Akt/mTOR/FoxO3 Signal Pathway in Streptozotocin-Induced Diabetic Mice

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Cholecystokinin (CCK) Regulation of Pancreatic Acinar Cells: Physiological Actions and Signal Transduction Mechanisms

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Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

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Differential control of muscle mass in type 1 and type 2 diabetes mellitus

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Multifaceted Role of Insulin-Like Growth Factors and Mammalian Target of Rapamycin in Skeletal Muscle

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mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function

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Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s Disease

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ENDOTOXIN AND INTERFERON-γ INHIBIT TRANSLATION IN SKELETAL MUSCLE CELLS BY STIMULATING NITRIC OXIDE SYNTHASE ACTIVITY

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Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle

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The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases

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Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss

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Autophagy modulates amino acid signaling network in myotubes: differential effects on mTORC1 pathway and the integrated stress response

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Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function

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AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle

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The role of mTOR in lipid homeostasis and diabetes progression

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Regulation of REDD1 by insulin‐like growth factor‐I in skeletal muscle and myotubes

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Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells

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Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase

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m TORC 1 and m TORC 2 have largely distinct functions in Purkinje cells

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Myotubularin Regulates Akt-dependent Survival Signaling via Phosphatidylinositol 3-Phosphate

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Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

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AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model

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Contractile activity-induced mitochondrial biogenesis and mTORC1

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Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibition

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Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism

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lncRNA-Encoded Polypeptide SPAR(s) with mTORC1 to Regulate Skeletal Muscle Regeneration

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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

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Raptor and Rheb Negatively Regulate Skeletal Myogenesis through Suppression of Insulin Receptor Substrate 1 (IRS1)

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Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations

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Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling

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Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls

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The regulation of rapamycin on nutrient metabolism in Nile tilapia fed with high-energy diet

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The Roles of Post-Translational Modifications on mTOR Signaling

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Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training

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Phosphoinositide-Dependent Kinase 1 and mTORC2 Synergistically Maintain Postnatal Heart Growth and Heart Function in Mice

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Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program

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mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice

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Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival

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Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice

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REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization

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Cortisone and dexamethasone inhibit myogenesis by modulating the AKT/mTOR signaling pathway in C2C12

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Interactions between Growth of Muscle and Stature: Mechanisms Involved and Their Nutritional Sensitivity to Dietary Protein: The Protein-Stat Revisited

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Inducible raptor and rictor Knockout Mouse Embryonic Fibroblasts

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Oxytocin modulates mTORC1 pathway in the gut

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Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS

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Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling

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Metabolic Regulation, Mitochondria and the Life-Prolonging Effect of Rapamycin: A Mini-Review

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mTOR and Tumor Cachexia

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Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation

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Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways

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Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

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Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy

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Prediction of Everolimus Toxicity and Prognostic Value of Skeletal Muscle Index in Patients With Metastatic Renal Cell Carcinoma

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H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles

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Circadian rhythm of intracellular protein synthesis signaling in rat cardiac and skeletal muscles

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Impact of angiotensin II on skeletal muscle metabolism and function in mice: Contribution of IGF-1, Sirtuin-1 and PGC-1α

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Rapamycin and mTORC2 inhibition synergistically reduce contraction‐stimulated muscle protein synthesis

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Complement C1q binding protein regulates T cells’ mitochondrial fitness to affect their survival, proliferation, and anti–tumor immune function

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Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation

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Acute oral administration of L-leucine upregulates slow-fiber– and mitochondria-related genes in skeletal muscle of rats

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Emerging role of MyomiRs as biomarkers and therapeutic targets in skeletal muscle diseases

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Molecular mechanisms of post‐burn muscle wasting and the therapeutic potential of physical exercise

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mTOR signalling: jack-of-all-trades

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Heat Treatment Inhibits Skeletal Muscle Atrophy of Glucocorticoid-Induced Myopathy in Rats

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The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt

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Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

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Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand

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Dissecting the biology of mTORC1 beyond rapamycin

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Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

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Chronic rapamycin treatment on the nutrient utilization and metabolism of juvenile turbot (Psetta maxima)

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Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9

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Integrative effects of resistance training and endurance training on mitochondrial remodeling in skeletal muscle

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m TORC 2 controls Th9 polarization and allergic airway inflammation

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Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration

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Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy

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mTORC1 mediates fiber type-specific regulation of protein synthesis and muscle size during denervation

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Targeting mTOR Signaling in Type 2 Diabetes Mellitus and Diabetes Complications

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Mitochondria in response to nutrients and nutrient-sensitive pathways

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Downregulation of GATA6 in mTOR-inhibited human aortic endothelial cells: effects on TNF-α-induced VCAM-1 expression and monocytic cell adhesion

Fan, X., Chen, X., Feng, Q., Peng, K., Wu, Q., Passerini, A. G., Simon, S. I., & Sun, C. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00411.2018 · Cited by 27

mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation

Pollard, H. J., Willett, M., & Morley, S. (2014) · Cell Cycle · doi:10.4161/15384101.2014.941747 · Cited by 26

Targeted suppression of mTORC2 reduces seizures across models of epilepsy

Okoh, J. T., Mays, J., Bacq, A., Osés-Prieto, J. A., Tyanova, S., Chen, C.-J., Imanbeyev, K., Doladilhe, M., Zhou, H., Jafar‐Nejad, P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42922-y · Cited by 26

Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult

Aimi, F., Georgiopoulou, S., Kalus, I., Lehner, F., Hegglin, A., Limani, P., de Lima, V. G., Rüegg, M. A., Hall, M. N., Lindenblatt, N., et al. (2015) · Scientific Reports · doi:10.1038/srep17705 · Cited by 26

Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance

Ruiz, A., Dror, E., Handschin, C., Furrer, R., Pérez‐Schindler, J., Bachmann, C., Treves, S., & Zorzato, F. (2018) · Scientific Reports · doi:10.1038/s41598-017-18844-3 · Cited by 26

Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice

Babaev, V. R., Huang, J., Ding, L., Zhang, Y., May, J. M., & Linton, M. F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00215 · Cited by 27

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03491-1 · Cited by 27

Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity

Nguyen, H. T., Wiederkehr, A., Wollheim, C. B., & Park, K. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01161-x · Cited by 24

Role of the mTORC1 Complex in Satellite Cell Activation by RNA-Induced Mitochondrial Restoration: Dual Control of Cyclin D1 through MicroRNAs

Jash, S., Dhar, G., Ghosh, U., & Adhya, S. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00742-14 · Cited by 25

Control of DNA integrity in skeletal muscle under physiological and pathological conditions

Saada, Y. B., Zakharova, V., Chernyak, B. V., Dib, C., Carnac, G., Dokudovskaya, S., & Vassetzky, Y. S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2530-0 · Cited by 25

Unraveling the multifaceted nature of the nuclear function of mTOR

Torres, A. S., & Holz, M. K. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118907 · Cited by 23

Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response

Camacho‐Morales, A., Rodriguez-Cuenca, S., Blount, M., Prieur, X., Barbarroja, N., Fuller, M., Hardingham, G. E., & Vidal‐Puig, A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.06.031 · Cited by 25

Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria

Rangel, É. B., Gomes, S. A., Kanashiro‐Takeuchi, R. M., Saltzman, R., Wei, C., Ruiz, P., Reiser, J., & Hare, J. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-33082-x · Cited by 25

Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes

Liang, H., Nie, J., Skike, C. E. V., Valentine, J. M., & Orr, M. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_10 · Cited by 24

The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?

Castets, P., Ham, D. J., & Rüegg, M. A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00162 · Cited by 29

Mammalian Target of Rapamycin Complex 2 Modulates αβTCR Processing and Surface Expression during Thymocyte Development

Chou, P., Oh, W. J., Wu, C., Moloughney, J. G., Rüegg, M. A., Hall, M. N., Jacinto, E., & Werlen, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303162 · Cited by 23

Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors

Carr, T. D., Feehan, R. P., Hall, M. N., Rüegg, M. A., & Shantz, L. M. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv012 · Cited by 25

The subunit assembly state of the Mediator complex is nutrient-regulated and is dysregulated in a genetic model of insulin resistance and obesity

Youn, D. Y., Xiaoli, A. M., Kwon, H., Yang, F., & Pessin, J. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007850 · Cited by 23

The role of TORC1 in muscle development in Drosophila

Hatfield, I., Harvey, I. C., Yates, E. R., Redd, J. R., Reiter, L. T., & Bridges, D. (2015) · Scientific Reports · doi:10.1038/srep09676 · Cited by 23

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Risson, V., Mazelin, L., Roceri, M., Sanchez, H., Moncollin, V., Corneloup, C., Richard-Bulteau, H., Vignaud, A., Baas, D., Defour, A., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903131 · Cited by 381

The role of mTOR complex 1 in skeletal muscle

Romanino, K. (2012) · edoc (University of Basel) · doi:10.5451/unibas-006041355

Function of mTOR complex 1 and 2 in skeletal muscle

Bentzinger, C. F. (2009) · edoc (University of Basel) · doi:10.5451/unibas-004780718 · Cited by 1

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

Romanino, K., Mazelin, L., Albert, V., Conjard‐Duplany, A., Lin, S., Bentzinger, C. F., Handschin, C., Puigserver, P., Zorzato, F., Schaeffer, L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111448109 · Cited by 44

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy

Bentzinger, C. F., Lin, S., Romanino, K., Castets, P., Guridi, M., Summermatter, S., Handschin, C., Tintignac, L. A., Hall, M. N., & Rüegg, M. A. (2013) · Skeletal Muscle · doi:10.1186/2044-5040-3-6 · Cited by 153