Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.

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Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

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AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology

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Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

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Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis

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Mammalian TOR signaling to the AGC kinases

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mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation

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Skeletal muscle mTORC1 regulates neuromuscular junction stability

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mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease

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The Effects of Testosterone Deprivation and Supplementation on Proteasomal and Autophagy Activity in the Skeletal Muscle of the Male Mouse: Differential Effects on High-Androgen Responder and Low-Androgen Responder Muscle Groups

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mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer

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mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

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Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

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In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons

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Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

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High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway

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Is REDD1 a metabolic double agent? Lessons from physiology and pathology

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mTOR-Dependent Regulation of PHLPP Expression Controls the Rapamycin Sensitivity in Cancer Cells

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Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex

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IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism

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Lkb1 Is Indispensable for Skeletal Muscle Development, Regeneration, and Satellite Cell Homeostasis

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High mitochondria content is associated with prostate cancer disease progression

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The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy

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mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress

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Rapamycin‐insensitive mechanistic target of rapamycin regulates basal and resistance exercise‐induced muscle protein synthesis

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Hypothalamic mTORC2 is essential for metabolic health and longevity

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mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?

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ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

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mTOR controls embryonic and adult myogenesis via mTORC1

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Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia

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Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation

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Age-Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia

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Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice

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Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy

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Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells

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mTORC1 signaling in energy balance and metabolic disease

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Leucine induces myofibrillar protein accretion in cultured skeletal muscle through m TOR dependent and ‐independent control of myosin heavy chain m RNA levels

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The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond

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Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis

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The role of mTORC1 in the regulation of skeletal muscle mass

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mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

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The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity

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The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4 + T Cell Subsets

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mTOR in health and in sickness

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A role for Raptor phosphorylation in the mechanical activation of mTOR signaling

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mTORC2 critically regulates renal potassium handling

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Changes in muscle mass with mechanical load: possible cellular mechanismsThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

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Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

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Dehydroepiandrosterone-induced activation of mTORC1 and inhibition of autophagy contribute to skeletal muscle insulin resistance in a mouse model of polycystic ovary syndrome

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Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR)

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mTORC1 Signaling in Oocytes Is Dispensable for the Survival of Primordial Follicles and for Female Fertility

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The Type 1 Insulin-Like Growth Factor Receptor (IGF-IR) Pathway Is Mandatory for the Follistatin-Induced Skeletal Muscle Hypertrophy

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Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis

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Sarcopenia in the aging high-fat fed rat: a pilot study for modeling sarcopenic obesity in rodents

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Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology

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Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

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Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine

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Proteomics of Breast Muscle Tissue Associated with the Phenotypic Expression of Feed Efficiency within a Pedigree Male Broiler Line: I. Highlight on Mitochondria

Kong, B. C., Lassiter, K., Piekarski, A., Dridi, S., Reverter, A., Hudson, N. J., & Bottje, W. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155679 · Cited by 61

mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons

Lee, H.-K., Kwon, B., Lemere, C. A., de la Monte, S., Itamura, K., Ha, A. Y., & Querfurth, H. W. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161029 · Cited by 57

Modulation of asymmetric cell division as a mechanism to boost CD8 + T cell memory

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The role of mitochondria in mTOR‐regulated longevity

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mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis

Mazelin, L., Panthu, B., Nicot, A.-S., Belotti, E., Tintignac, L. A. J., Teixeira, G., Zhang, Q., Risson, V., Baas, D., Delaune, E. A., et al. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.04.011 · Cited by 56

Resistance Exercise-Induced Hypertrophy: A Potential Role for Rapamycin-Insensitive mTOR

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Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle

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Leucine limitation regulates myf5 and myoD expression and inhibits myoblast differentiation

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Immune Regulation by Rapamycin: Moving Beyond T Cells

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Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing

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Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia

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Hot topics in aging research: protein translation, 2009

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Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

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Proteome-wide Adaptations of Mouse Skeletal Muscles during a Full Month in Space

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Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

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Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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Linking Cancer Cachexia‐Induced Anabolic Resistance to Skeletal Muscle Oxidative Metabolism

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Skeletal Muscle Response to Deflazacort, Dexamethasone and Methylprednisolone

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Sepsis-Induced Alterations in Protein-Protein Interactions Within mTOR Complex 1 and the Modulating Effect of Leucine on Muscle Protein Synthesis

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Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise

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Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila

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mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability

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Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signaling Network

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Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells

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Insulin resistance syndrome blunts the mitochondrial anabolic response following resistance exercise

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Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control

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Monotropein Improves Dexamethasone-Induced Muscle Atrophy via the AKT/mTOR/FOXO3a Signaling Pathways

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Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass

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Glutamine at focus: versatile roles in cancer

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Gene expression profiling of laser microdissected airway smooth muscle tissue in asthma and atopy

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Translocation and protein complex co-localization of mTOR is associated with postprandial myofibrillar protein synthesis at rest and after endurance exercise

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Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction

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Targeting TOR dependence in cancer

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Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

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Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of rapamycin complex 1 pathway

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p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells

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Target of rapamycin‐signaling modulates starch accumulation via glycogenin phosphorylation status in the unicellular red alga Cyanidioschyzon merolae

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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

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The role of mTOR complex 1 in skeletal muscle

Romanino, K. (2012) · edoc (University of Basel) · doi:10.5451/unibas-006041355

Function of mTOR complex 1 and 2 in skeletal muscle

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Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy

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