Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.

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High dietary protein intake, reducing or eliciting insulin resistance?

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mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

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Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

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Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1

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Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

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Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways

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Skeletal muscle autophagy: a new metabolic regulator

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Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer

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The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

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Resveratrol prevents TNF-α-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes

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mTOR complex 2 in adipose tissue negatively controls whole-body growth

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mTOR signaling in tumorigenesis

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The central moTOR of metabolism

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TORC2 Structure and Function

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Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

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Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

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Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination

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Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

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Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice

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Rictor is a novel target of p70 S6 kinase-1

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Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

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Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy

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Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

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mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

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mTOR links oncogenic signaling to tumor cell metabolism

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The role of raptor in the mechanical load‐induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy

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Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis

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Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

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mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

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Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects

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mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR

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Feedback on Fat: p62-mTORC1-Autophagy Connections

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HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

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mTOR signaling for biological control and cancer

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Systems-Based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

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Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

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The Role of mTORC1 in Regulating Protein Synthesis and Skeletal Muscle Mass in Response to Various Mechanical Stimuli

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mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

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Role of mTORC1 in mechanically induced increases in translation and skeletal muscle mass

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Mtor is necessary for proper satellite cell activity and skeletal muscle regeneration

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mTORC1 is essential for leukemia propagation but not stem cell self-renewal

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Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

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Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1

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An emerging role for TOR signaling in mammalian tissue and stem cell physiology

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TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism

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Recent advances in the biology and therapy of muscle wasting

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Insulin Regulation of Proteostasis and Clinical Implications

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Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

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Autophagy, Stress, and Cancer Metabolism: What Doesn't Kill You Makes You StrongerPreprint

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Insulin Signaling in Type 2 Diabetes

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The Translation Regulatory Subunit eIF3f Controls the Kinase-Dependent mTOR Signaling Required for Muscle Differentiation and Hypertrophy in Mouse

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mTor Signaling in Skeletal Muscle During Sepsis and Inflammation: Where Does It All Go Wrong?

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Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

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Mammalian Target of Rapamycin (mTOR) Signaling Network in Skeletal Myogenesis

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Proteasome-dependent Activation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Is Essential for Autophagy Suppression and Muscle Remodeling Following Denervation

Quy, P. N., Kuma, A., Pierre, P., & Mizushima, N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.399949 · Cited by 120

mTOR inhibitors and diabetes

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Sestrins are evolutionarily conserved mediators of exercise benefits

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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

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mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis

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mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

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mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4

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Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease

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mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

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Molecular Mechanisms and Treatment Options for Muscle Wasting Diseases

Rüegg, M. A., & Glass, D. J. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100537 · Cited by 114

mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice

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Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals

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Understanding the Role of Exercise in Cancer Cachexia Therapy

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Coordinated maintenance of muscle cell size control by AMP‐activated protein kinase

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NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly

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Yin Yang 1 Deficiency in Skeletal Muscle Protects against Rapamycin-Induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling

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mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells

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Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway

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Antagonistic control of muscle cell size by AMPK and mTORC1

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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

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Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth

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Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle

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Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

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