Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function

Regulation of Iron Metabolism by Hepcidin

Nemeth, E., & Ganz, T. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111303 · Cited by 756 · cited 1×

Porphyrias

Puy, H., Gouya, L., & Deybach, J. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61925-5 · Cited by 727

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701

Mitoferrin is essential for erythroid iron assimilation

Shaw, G. C., Cope, J. J., Li, L., Corson, K., Hersey, C., Ackermann, G. E., Gwynn, B., Lambert, A. J., Wingert, R. A., Traver, D., et al. (2006) · Nature · doi:10.1038/nature04512 · Cited by 624

Forging a field: the golden age of iron biology.

Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623

Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells

Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., & Cousins, R. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606424103 · Cited by 577

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics · doi:10.1038/84859 · Cited by 509

Biosynthesis of heme in mammals

Ajioka, R. S., Phillips, J. D., & Kushner, J. P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.005 · Cited by 493

Biochemical Basis for the Manifestations of Iron Deficiency

Dallman, P. R. (1986) · Annual Review of Nutrition · doi:10.1146/annurev.nu.06.070186.000305 · Cited by 447

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

Mantena, S. K., King, A. L., Andringa, K. K., Eccleston, H. B., & Bailey, S. M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.029 · Cited by 429

Vagaries of conditional gene targeting

Schmidt‐Supprian, M., & Rajewsky, K. (2007) · Nature Immunology · doi:10.1038/ni0707-665 · Cited by 422

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.

Meyron‐Holtz, E. G., Ghosh, M. C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U. V., Land, W., Ollivierre‐Wilson, H., Grinberg, A., Love, P., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600041 · Cited by 408

Iron–sulfur cluster biogenesis and human disease

Rouault, T. A., & Tong, W. H. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.05.008 · Cited by 391

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

Paradkar, P. N., Zumbrennen, K. B., Paw, B. H., Ward, D. M., & Kaplan, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01685-08 · Cited by 362

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis

Tong, W.-H., & Rouault, T. A. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.003 · Cited by 294

Molecular control of vertebrate iron homeostasis by iron regulatory proteins

Wallander, M. L., Leibold, E. A., & Eisenstein, R. S. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.004 · Cited by 287

Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia

Guernsey, D. L., Jiang, H., Campagna, D. R., Evans, S. C., Ferguson, M., Kellogg, M. D., Lachance, M., Matsuoka, M., Nightingale, M., Rideout, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.359 · Cited by 244 · cited 1×

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Galy, B., Ferring–Appel, D., Miñana, B., Bell, O., Janser, H., Muckenthaler, M. U., Schümann, K., & Hentze, M. W. (2005) · Blood · doi:10.1182/blood-2005-04-1365 · Cited by 224

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

Huang, M. L.-H., Becker, E. M., Whitnall, M., Rahmanto, Y. S., Ponka, P., & Richardson, D. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906784106 · Cited by 212

The role of iron in mitochondrial function

Levi, S., & Rovida, E. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.008 · Cited by 202

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum

Galy, B., Ferring-Appel, D., Kaden, S., Gröne, H.-J., & Hentze, M. W. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.006 · Cited by 195

Liver iron transport

Graham, R. M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4725 · Cited by 184

Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression

Delaby, C., Pilard, N., Puy, H., & Canonne-Hergaux, F. (2008) · Biochemical Journal · doi:10.1042/bj20071474 · Cited by 144

Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development

Smith, S., Ghosh, M. C., Ollivierre, H., Tong, W. H., & Rouault, T. A. (2006) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.12.006 · Cited by 123

Bioenergetics in Glutaryl-Coenzyme A Dehydrogenase Deficiency

Sauer, S., Okun, J., Schwab, M., Crnic, L. R., Hoffmann, G., Goodman, S., Koeller, D., & Kolker, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502845200 · Cited by 120

Enlargement of Mitochondrial Compartment in Iron and Copper Deficiency

Dallman, P. R., & Goodman, J. R. (1970) · Blood · doi:10.1182/blood.v35.4.496.496 · Cited by 119

The Role of Heme and Iron-Sulfur Clusters in Mitochondrial Biogenesis, Maintenance, and Decay with Age

Atamna, H., Walter, P. B., & Ames, B. N. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2671 · Cited by 118

Dietary Iron Intake Modulates the Activity of Iron Regulatory Proteins and the Abundance of Ferritin and Mitochondrial Aconitase in Rat Liver , ,

Chen, O. S., Schalinske, K. L., & Eisenstein Richard, S. (1997) · Journal of Nutrition · doi:10.1093/jn/127.2.238 · Cited by 110

Molybdenum cofactor-deficient mice resemble the phenotype of human patients

Lee, H. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.26.3309 · Cited by 70

Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice

Lyoumi, S., Abitbol, M., Andrieu, V., Hénin, D., Robert, E., Schmitt, C., Gouya, L., de Verneuil, H., Deybach, J., Montagutelli, X., et al. (2006) · Blood · doi:10.1182/blood-2006-04-014142 · Cited by 63

Generation of conditional alleles of the murine iron regulatory protein (IRP)‐1 and ‐2 genes

Galy, B., Ferring–Appel, D., & Hentze, M. W. (2005) · genesis · doi:10.1002/gene.20169 · Cited by 54

The power plant of the cell is also a smithy: The emerging role of mitochondria in cellular iron homeostasis

Sheftel, A. D., & Lill, R. (2008) · Annals of Medicine · doi:10.1080/07853890802322229 · Cited by 49

Gender Disparity of Hepatic Lipid Homoeostasis Regulated by the Circadian Clock

Yang, X., Zhang, Y.-K. J., Esterly, N., Klaassen, C. D., & Wan, Y.-J. Y. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp018 · Cited by 38

Getting around lethality with inducible Cre-mediated excision

Garcia, E. L., & Mills, A. A. (2002) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(02)00019-8 · Cited by 37

Hepatic Gene Expression in Protoporphyic Fech Mice Is Associated with Cholestatic Injury but Not a Marked Depletion of the Heme Regulatory Pool

Davies, R., Schuurman, A., Barker, C. R., Clothier, B., Chernova, T., Higginson, F. M., Judah, D. J., Dinsdale, D. D., Edwards, R., Greaves, P., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62325-5 · Cited by 35

Dietary iron deficiency in the rat. I. Abnormalities in energy metabolism of the hepatic tissue

Masini, A., Salvioli, G., Cremonesi, P., Botti, B., Gallesi, D., & Ceccarelli, D. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(94)90020-5 · Cited by 24

Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre)

Holzenberger, M., Zaoui, R., Leneuve, P., Hamard, G., & Bouc, Y. L. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2 · Cited by 23

Melatonin and Environmental Lighting Regulate ALA‐S Gene Expression and So Porphyrin Biosynthesis in the Rat Harderian Gland

Lyoumi, S., Schmitt, C., Touitou, Y., Puy, H., & Djeridane, Y. (2008) · Chronobiology International · doi:10.1080/07420520802548242 · Cited by 12

Subcellular Distribution of Hepatic Copper, Zinc and Iron and Serum Ceruloplasmin in Rats Intoxicated by Oral Pyrrolizidine (Senecio) Alkaloids

Swick, R. A., Cheeke, P. R., & Buhler, D. R. (1982) · Journal of Animal Science · doi:10.2527/jas1982.5561425x · Cited by 5

Two to tango: Regulation of Mammalian iron metabolism

Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120

Regulation of cellular iron metabolism

Wang, J., & Pantopoulos, K. (2011) · Biochemical Journal · doi:10.1042/bj20101825 · Cited by 986

Mechanisms controlling cellular and systemic iron homeostasis

Galy, B., Conrad, M., & Muckenthaler, M. U. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00648-1 · Cited by 843

Mechanisms of mammalian iron homeostasis

Pantopoulos, K., Porwal, S. K., Tartakoff, A., & Devireddy, L. (2012) · Biochemistry · doi:10.1021/bi300752r · Cited by 598

Regulation of iron transport and the role of transferrin

Gkouvatsos, K., Papanikolaou, G., & Pantopoulos, K. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.10.013 · Cited by 518

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts

Li, H., Zhao, H., Hao, S., Shang, L., Wu, J., Song, C., Meyron‐Holtz, E. G., Qiao, T., & Li, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-23175-y · Cited by 45

The IRP/IRE system in vivo: insights from mouse models

Wilkinson, N., & Pantopoulos, K. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00176 · Cited by 366

Iron Regulatory Protein 1 Sustains Mitochondrial Iron Loading and Function in Frataxin Deficiency

Martelli, A., Schmucker, S., Reutenauer, L., Mathieu, J. R. R., Peyssonnaux, C., Karim, Z., Puy, H., Galy, B., Hentze, M. W., & Puccio, H. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.010 · Cited by 82

Methods for Studying Iron Regulatory Protein 1: An Important Protein in Human Iron Metabolism

Holmes‐Hampton, G. P., Ghosh, M. C., & Rouault, T. A. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.09.006 · Cited by 13

Reviewed by:

Wilkinson, N., Pantopoulos, K., Sanchez, M., Carreras, J., Pantopoulos, K., & Davis, L. (2014)