Cited by 287Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

Molecular control of vertebrate iron homeostasis by iron regulatory proteins

Open access
Wallander, Michelle L., Leibold, Elizabeth A., Eisenstein, Richard S.·2006·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Abstract

Both deficiencies and excesses of iron represent major public health problems throughout the world. Understanding the cellular and organismal processes controlling iron homeostasis is critical for identifying iron-related diseases and in advancing the clinical treatments for such disorders of iron metabolism. Iron regulatory proteins (IRPs) 1 and 2 are key regulators of vertebrate iron metabolism. These RNA binding proteins post-transcriptionally control the stability or translation of mRNAs encoding proteins involved in iron homeostasis thereby controlling the uptake, utilization, storage or export of iron. Recent evidence provides insight into how IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system.

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Crossref · 10.1016/j.bbamcr.2006.05.004

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304 of 304 references verified0 citation errors · 0 not checkable

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  • Two cytosolic iron sensors, IRP1 and IRP2, regulate iron metabolism post-transcriptionally.

    “Two cytosolic iron sensors, the iron regulatory proteins (IRPs) IRP1 and IRP2 (panel; appendix), regulate iron metabolism post-transcriptionally.12”

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Authors
Wallander, M. L., Leibold, E. A., & Eisenstein, R. S.
Affiliations
  • University of Utah (US)
  • University of Wisconsin–Madison (US)
Corresponding author
Eisenstein, Richard S.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher
Elsevier BV
Published
2006-07
Volume
1763
Issue
7
Pages
668-689
ISSN
0167-4889 (ISSN-L)
OpenAlex
W2121798267
Cited by
287
References
307
Citations by year
2026: 4 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 13 · 2019: 6 · 2018: 11 · 2017: 6 · 2016: 12 · 2015: 11 · 2014: 19 · 2013: 18 · 2012: 22
FWCI
2.94
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (GM 45201, R01GM045201)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 66600, R56DK066600, DK47219, R01DK066600)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
iron homeostasis, iron regulatory proteins, iron regulatory protein 1, IRP2, RNA-binding proteins, post-transcriptional regulation, mRNA stability, translational regulation, iron metabolism disorders, iron deficiency, iron overload
MeSH terms
Animals, Homeostasis, Iron, Vertebrates, Iron-Regulatory Proteins

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