Molecular control of vertebrate iron homeostasis by iron regulatory proteins
Open accessAbstract
Both deficiencies and excesses of iron represent major public health problems throughout the world. Understanding the cellular and organismal processes controlling iron homeostasis is critical for identifying iron-related diseases and in advancing the clinical treatments for such disorders of iron metabolism. Iron regulatory proteins (IRPs) 1 and 2 are key regulators of vertebrate iron metabolism. These RNA binding proteins post-transcriptionally control the stability or translation of mRNAs encoding proteins involved in iron homeostasis thereby controlling the uptake, utilization, storage or export of iron. Recent evidence provides insight into how IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system.
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Two cytosolic iron sensors, IRP1 and IRP2, regulate iron metabolism post-transcriptionally.
“Two cytosolic iron sensors, the iron regulatory proteins (IRPs) IRP1 and IRP2 (panel; appendix), regulate iron metabolism post-transcriptionally.12”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [12]
Cites
Textbook of Medical Physiology
Guyton, A. C., & Hall, J. E. (1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-64-6-1363_2 · Cited by 9,760 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166 · see citing works
Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736 · see citing works
Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
Makker, J. S., Hanif, A., Bajantri, B., & Chilimuri, S. S. (2015) · Case Reports in Gastroenterology · doi:10.1159/000373883 · Cited by 1,353 · see citing works
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275 · see citing works
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233 · see citing works
Haas, J. D., & Brownlie, T. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.2.676s · Cited by 1,186 · see citing works
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159 · see citing works
Iron Biology in Immune Function, Muscle Metabolism and Neuronal Functioning
Beard, J. L. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.568s · Cited by 1,136 · see citing works
An iron-regulated ferric reductase associated with the absorption of dietary iron
McKie, A. T., Barrow, D., Latunde-Dada, G. O., Rolfs, A., Sager, G., Mudaly, E., Mudaly, M., Richardson, C., Barlow, D., Bomford, A., et al. (2001) · Science · doi:10.1126/science.1057206 · Cited by 1,101 · see citing works
Vulpe, C. D., Kuo, Y.-M., Murphy, T. L., Cowley, L., Askwith, C., Libina, N., Gitschier, J., & Anderson, G. J. (1999) · Nature Genetics · doi:10.1038/5979 · Cited by 1,084 · see citing works
Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D., & Andrews, N. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1148 · Cited by 936 · see citing works
Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?
Gerlai, R. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)20020-7 · Cited by 881 · see citing works
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., & Vaulont, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072632499 · Cited by 880 · see citing works
Ohgami, R. S., Campagna, D. R., Greer, E. L., Antiochos, B., McDonald, A., Chen, J., Sharp, J. J., Fujiwara, Y., Barker, J. E., & Fleming, M. D. (2005) · Nature Genetics · doi:10.1038/ng1658 · Cited by 775 · see citing works
The quantitative assessment of body iron
Cook, J. D., Flowers, C. H., & Skikne, B. (2003) · Blood · doi:10.1182/blood-2002-10-3071 · Cited by 771 · see citing works
Identification of an Intestinal Heme Transporter
Shayeghi, M., Latunde-Dada, G. O., Oakhill, J. S., Laftah, A. H., Takeuchi, K., Halliday, N., Khan, Y., Warley, A., McCann, F. E., Hider, R. C., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.025 · Cited by 755 · see citing works
The Steap proteins are metalloreductases
Ohgami, R. S., Campagna, D. R., McDonald, A., & Fleming, M. D. (2006) · Blood · doi:10.1182/blood-2006-02-003681 · Cited by 744 · see citing works
Bush, A. (2000) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(99)00073-3 · Cited by 731 · see citing works
Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation
Casey, J. L., Hentze, M. W., Koeller, D. M., Caughman, S. W., Rouault, T. A., Klausner, R. D., & Harford, J. B. (1988) · Science · doi:10.1126/science.2452485 · Cited by 709 · see citing works
A permease-oxidase complex involved in high-affinity iron uptake in yeast.
Stearman, R., Yuan, D. S., Yamaguchi-Iwai, Y., Klausner, R. D., & Dancis, A. (1996) · Science · doi:10.1126/science.271.5255.1552 · Cited by 683 · see citing works
Leibold, E. A., & Munro, H. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2171 · Cited by 671 · see citing works
Self-citationI RON R EGULATORY P ROTEINS AND THE M OLECULAR C ONTROL OF M AMMALIAN I RON M ETABOLISM
Eisenstein, R. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.627 · Cited by 652 · see citing works
Self-citationMolecular Cloning of Transferrin Receptor 2
Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., & Koeffler, H. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20826 · Cited by 646 · see citing works
Textbook of medical physiology
Guyton, B. A. C. (1966) · American Heart Journal · doi:10.1016/0002-8703(66)90334-6 · Cited by 646 · see citing works
Aconitase as iron–sulfur protein, enzyme, and iron-regulatory protein
Beinert, H., Kennedy, M. C., & Stout, C. D. (1996) · Chemical Reviews · doi:10.1021/cr950040z · Cited by 606 · cited 1× · see citing works
“Aconitases are ancient enzymes that interconvert citrate to isocitrate through a stereospecific dehydration/rehydration mechanism requiring direct binding of substrate to the [4Fe–4S] cluster [96,97].”
BackgroundAconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.
Castro, L., Rodriguez, M., & Radi, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43894-x · Cited by 589 · see citing works
Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.
Hausladen, A., & Fridovich, I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43893-8 · Cited by 585 · see citing works
Transferrin receptor is necessary for development of erythrocytes and the nervous system
Levy, J. E., Jin, O., Fujiwara, Y., Kuo, F., & Andrews, N. (1999) · Nature Genetics · doi:10.1038/7727 · Cited by 574 · see citing works
Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Science · doi:10.1126/science.3685996 · Cited by 571 · see citing works
Müllner, E. W., & Kühn, L. C. (1988) · Cell · doi:10.1016/0092-8674(88)90098-0 · Cited by 554 · see citing works
Curtis, A. R. J., Fey, C., Morris, C. M., Bindoff, L. A., Ince, P. G., Chinnery, P. F., Coulthard, A., Jackson, M. J., Jackson, A. P., McHale, D. P., et al. (2001) · Nature Genetics · doi:10.1038/ng571 · Cited by 537 · see citing works
Iron Deficiency Alters Brain Development and Functioning
Beard, J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1468s · Cited by 534 · see citing works
LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics · doi:10.1038/84859 · Cited by 509 · see citing works
Iron Metabolism and the IRE/IRP Regulatory System: An Update
Pantopoulos, K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.001 · Cited by 505 · see citing works
Müllner, E. W., Neupert, B., & Kühn, L. C. (1989) · Cell · doi:10.1016/0092-8674(89)90851-9 · Cited by 497 · see citing works
Knutson, M. D., Oukka, M., Koss, L. M., Aydemir, F., & Wessling-Resnick, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409409102 · Cited by 479 · see citing works
Biochemical Basis for the Manifestations of Iron Deficiency
Dallman, P. R. (1986) · Annual Review of Nutrition · doi:10.1146/annurev.nu.06.070186.000305 · Cited by 447 · see citing works
Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Rouault, T. A., & Tong, W.-H. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1620 · Cited by 432 · see citing works
Hubert, N., & Hentze, M. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192423399 · Cited by 428 · see citing works
Gunshin, H., Fujiwara, Y., Custodio, A. O., DiRenzo, C., Robine, S., & Andrews, N. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24356 · Cited by 419 · see citing works
Drapier, J., & Hibbs, J. B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112642 · Cited by 415 · see citing works
Meyron‐Holtz, E. G., Ghosh, M. C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U. V., Land, W., Ollivierre‐Wilson, H., Grinberg, A., Love, P., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600041 · Cited by 408 · see citing works
Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.
Drapier, J. C., Hirling, H., Wietzerbin, J., Kaldy, P., & Kühn, L. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06038.x · Cited by 401 · see citing works
Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.
Weiss, G., Goossen, B., Doppler, W., Fuchs, D., Pantopoulos, K., Werner‐Felmayer, G., Wachter, H., & Hentze, M. W. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06039.x · Cited by 389 · see citing works
The Pathology of Hepatic Iron Overload: A Free Radical–Mediated Process?
Bacon, B. R., & Britton, R. S. (1990) · Hepatology · doi:10.1002/hep.1840110122 · Cited by 385 · see citing works
Puig, S., Askeland, E., & Thiele, D. J. (2005) · Cell · doi:10.1016/j.cell.2004.11.032 · Cited by 382 · see citing works
Pietrangelo, A. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2003.08.003 · Cited by 382 · see citing works
Jeong, S. Y., & David, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301988200 · Cited by 377 · see citing works
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.
The Tübingen 2000 Screen Consortium, Wingert, R. A., Galloway, J. L., Barut, B., Foott, H., Fraenkel, P., Axe, J. L., Weber, G. J., Dooley, K., Davidson, A. J., et al. (2005) · Nature · doi:10.1038/nature03887 · Cited by 370 · see citing works
Iron regulates ferritin mRNA translation through a segment of its 5′-untranslated region.
Aziz, N., & Munro, H. N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8478 · Cited by 368 · see citing works
Long-range disruption of gene expression by a selectable marker cassette
Pham, C. T. N., MacIvor, D. M., Hug, B. A., Heusel, J. W., & Ley, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13090 · Cited by 365 · see citing works
Cox, T. C., Bawden, M. J., Martin, A., & May, B. K. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07715.x · Cited by 360 · see citing works
Iron Metabolism in the Reticuloendothelial System
Knutson, M. D., & Wessling‐Resnick, M. (2003) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/713609210 · Cited by 360 · see citing works
Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA
Rouault, T. A., Hentze, M. W., Caughman, S. W., Harford, J. B., & Klausner, R. D. (1988) · Science · doi:10.1126/science.3413484 · Cited by 351 · see citing works
Kennedy, M. C., Mende‐Mueller, L., Blondin, G. A., & Beinert, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11730 · Cited by 341 · see citing works
Casey, J. L., Koeller, D. M., Ramin, V. C., Klausner, R. D., & Harford, J. B. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08544.x · Cited by 338 · see citing works
Iron–sulfur-protein biogenesis in eukaryotes
Lill, R., & Mühlenhoff, U. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.01.006 · Cited by 333 · see citing works
Aisen, P. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.007 · Cited by 329 · see citing works
Rapid responses to oxidative stress mediated by iron regulatory protein.
Pantopoulos, K., & Hentze, M. W. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07291.x · Cited by 328 · see citing works
Regulation of synthesis and turnover of ferritin in rat liver
Drysdale, J. W., & Munro, H. N. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99877-7 · Cited by 326 · see citing works
Neurodegeneration with brain iron accumulation
Hayflick, S. J., Kurian, M. A., & Hogarth, P. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63233-3.00019-1 · Cited by 323 · see citing works
RNA recognition by Tat-derived peptides: Interaction in the major groove?
Weeks, K. M., & Crothers, D. M. (1991) · Cell · doi:10.1016/0092-8674(81)90020-9 · Cited by 322 · see citing works
Haile, D. J., Rouault, T. A., Harford, J. B., Kennedy, M. C., Blondin, G. A., Beinert, H., & Klausner, R. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11735 · Cited by 321 · see citing works
Novel mechanism for translational control in regulation of ferritin synthesis by iron.
Zähringer, J., Baliga, B. S., & Munro, H. N. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.3.857 · Cited by 318 · see citing works
Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance
Chen, X. J., Wang, X., Kaufman, B. A., & Butow, R. A. (2005) · Science · doi:10.1126/science.1106391 · Cited by 315 · see citing works
Biological Mechanisms That Might Underlie Iron's Effects on Fetal Growth and Preterm Birth
Allen, L. H. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.581s · Cited by 308 · see citing works
Iron-dependent regulation of the divalent metal ion transporter
Gunshin, H., Allerson, C. R., Polycarpou-Schwarz, M., Rofts, A., Rogers, J. T., Kishi, F., Hentze, M. W., Rouault, T. A., Andrews, N. C., & Hediger, M. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03189-1 · Cited by 305 · see citing works
Muckenthaler, M., Gray, N. K., & Hentze, M. W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80282-8 · Cited by 297 · see citing works
Rouault, T. A., Stout, C. D., Kaptain, S., Harford, J. B., & Klausner, R. D. (1991) · Cell · doi:10.1016/0092-8674(91)90312-m · Cited by 296 · see citing works
Tong, W.-H., & Rouault, T. A. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.003 · Cited by 294 · see citing works
Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T., Minato, N., Klausner, R. D., Levine, R. L., & Rouault, T. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4924 · Cited by 293 · see citing works
Beaumont, C., Leneuve, P., Devaux, I., Scoazec, J.-Y., Berthier, M., Loiseau, M.-N., Grandchamp, B., & Bonneau, D. (1995) · Nature Genetics · doi:10.1038/ng1295-444 · Cited by 293 · see citing works
Theil, E. C. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132212 · Cited by 291 · see citing works
Heme binds to a short sequence that serves a regulatory function in diverse proteins.
Zhang, L., & Guarente, L. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07005.x · Cited by 290 · see citing works
Binder, R., Horowitz, J. A., Basilion, J. P., Koeller, D. M., Klausner, R. D., & Harford, J. B. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06466.x · Cited by 289 · see citing works
Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome
Guo, B., Phillips, J. D., Yu, Y., & Leibold, E. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21645 · Cited by 287 · see citing works
Self-citationIron trafficking in the mitochondrion: novel pathways revealed by disease
Napier, I. A., Ponka, P., & Richardson, D. R. (2004) · Blood · doi:10.1182/blood-2004-10-3856 · Cited by 287 · see citing works
Regulation by Heme of Mitochondrial Protein Transport Through a Conserved Amino Acid Motif
Lathrop, J. T., & Timko, M. P. (1993) · Science · doi:10.1126/science.8424176 · Cited by 282 · see citing works
Bekri, S., Kispál, G., Lange, H., Fitzsimons, E. J., Tolmie, J., Lill, R., & Bishop, D. F. (2000) · Blood · doi:10.1182/blood.v96.9.3256 · Cited by 281 · see citing works
Drapier, J., Pellat‐Deceunynck, C., & Henry, Y. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99204-5 · Cited by 279 · see citing works
Early Embryonic Lethality of H Ferritin Gene Deletion in Mice
Ferreira, C., Bucchini, D., Martin, M.-E., Levi, S., Arosio, P., Grandchamp, B., & Beaumont, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3021 · Cited by 275 · see citing works
Haile, D. J., Rouault, T. A., Tang, C., Chin, J., Harford, J. B., & Klausner, R. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7536 · Cited by 270 · see citing works
Kennedy, M. C., Antholine, W. E., & Beinert, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20340 · Cited by 259 · see citing works
Guo, B., Yu, Y., & Leibold, E. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51075-4 · Cited by 257 · see citing works
Self-citationMammalian Tissue Oxygen Levels Modulate Iron-Regulatory Protein Activities in Vivo
Meyron‐Holtz, E. G., Ghosh, M. C., & Rouault, T. A. (2004) · Science · doi:10.1126/science.1103786 · Cited by 246 · see citing works
Rutherford, J. C., Ojeda, L. D., Balk, J., Mühlenhoff, U., Lill, R., & Winge, D. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413731200 · Cited by 242 · see citing works
Nitric Oxide Sensitivity of the Aconitases
Gardner, P. R., Costantino, G., Szabó, C., & Salzman, A. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25071 · Cited by 237 · see citing works
Cooperman, S. S., Meyron-Holtz, E. G., Olivierre-Wilson, H., Ghosh, M. C., McConnell, J. P., & Rouault, T. A. (2005) · Blood · doi:10.1182/blood-2004-12-4703 · Cited by 235 · see citing works
Granick, S. (1946) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41274-9 · Cited by 232 · see citing works
Diferric transferrin regulates transferrin receptor 2 protein stability
Johnson, M. B., & Enns, C. A. (2004) · Blood · doi:10.1182/blood-2004-06-2477 · Cited by 230 · see citing works
Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron.
Owen, D., & Kühn, L. C. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02366.x · Cited by 223 · see citing works
Galy, B., Ferring–Appel, D., Miñana, B., Bell, O., Janser, H., Muckenthaler, M. U., Schümann, K., & Hentze, M. W. (2005) · Blood · doi:10.1182/blood-2005-04-1365 · Cited by 222 · see citing works
Pantopoulos, K., & Hentze, M. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1267 · Cited by 220 · see citing works
Samaniego, F., Chin, J., Iwaï, K., Rouault, T. A., & Klausner, R. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47367-x · Cited by 219 · see citing works
Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload
Mims, M. P., Guan, Y., Pospı́šilová, D., Priwitzerova, M., Indrák, K., Ponka, P., Divoký, V., & Prchal, J. T. (2005) · Blood · doi:10.1182/blood-2004-07-2966 · Cited by 219 · see citing works
Friedreich ataxia: the oxidative stress paradox
Seznec, H., Simon, D., Bouton, C., Reutenauer, L., Hertzog, A., Golik, P., Procaccio, V., Patel, M., Drapier, J.-C., Koenig, M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi042 · Cited by 219 · see citing works
Contrasting Sensitivities of Escherichia coli Aconitases A and B to Oxidation and Iron Depletion
Varghese, S., Tang, Y., & Imlay, J. A. (2002) · Journal of Bacteriology · doi:10.1128/jb.185.1.221-230.2003 · Cited by 215 · see citing works
Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2
Iwai, K., Klausner, R. D., & Rouault, T. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00219.x · Cited by 211 · see citing works
Iron Imports. II. Iron uptake at the apical membrane in the intestine
Mackenzie, B., & Garrick, M. D. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00363.2005 · Cited by 211 · see citing works
Kato, J., Fujikawa, K., Kanda, M., Fukuda, N., Sasaki, K., Takayama, T., Kobune, M., Takada, K., Takimoto, R., Hamada, H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/321261 · Cited by 211 · see citing works
Iron Metabolism: Iron Deficiency and Iron Overload
Andrews, N. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.75 · Cited by 211 · see citing works
White, K., & Munro, H. N. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68398-x · Cited by 208 · see citing works
Nitric Oxide Modulates the Activity of Tobacco Aconitase
Navarre, D. A., Wendehenne, D., Durner, J., Noad, R. J., & Klessig, D. F. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.2.573 · Cited by 208 · see citing works
Pondarré, C., Antiochos, B., Campagna, D. R., Clarke, S. L., Greer, E. L., Deck, K. M., McDonald, A. A., Han, A., Medlock, A. E., Kutok, J. L., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl012 · Cited by 208 · see citing works
Self-citationRegulation of transferrin receptor 2 protein levels by transferrin
Robb, A., & Wessling‐Resnick, M. (2004) · Blood · doi:10.1182/blood-2004-06-2481 · Cited by 204 · see citing works
Chen, O. S., Crisp, R. J., Valachovic, M., Bard, M., Winge, D. R., & Kaplan, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403209200 · Cited by 202 · see citing works
Li, J., Kogan, M., Knight, S. A. B., Pain, D., & Dancis, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33025 · Cited by 201 · see citing works
Melefors, Ö., Goossen, B., Johansson, H. E., Stripecke, R., Gray, N. K., & Hentze, M. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53414-1 · Cited by 200 · see citing works
Minotti, G., Ronchi, R., Salvatorelli, E., Menna, P., & Cairo, G. (2001) · PubMed · Cited by 199 · see citing works
Girelli, D., Corrocher, R., Bisceglia, L., Olivieri, O., De Franceschi, L., Zelante, L., & Gasparini, P. (1995) · Blood · doi:10.1182/blood.v86.11.4050.bloodjournal86114050 · Cited by 196 · see citing works
Pantopoulos, K., Weiss, G., & Hentze, M. W. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3781 · Cited by 195 · see citing works
Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
Camaschella, C. (2005) · Blood · doi:10.1182/blood-2005-05-1857 · Cited by 194 · see citing works
Addess, K. J., Basilion, J. P., Klausner, R. D., Rouault, T. A., & Pardi, A. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1377 · Cited by 194 · see citing works
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
Gunshin, H., Starr, C. N., DiRenzo, C., Fleming, M. D., Jin, J., Greer, E. L., Sellers, V. M., Galica, S. M., & Andrews, N. C. (2005) · Blood · doi:10.1182/blood-2005-02-0716 · Cited by 188 · see citing works
Gray, N. K., Pantopoulos, K., Dandekar, T., Ackrell, B. A. C., & Hentze, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4925 · Cited by 187 · see citing works
Gakh, O., Park, S., Liu, G., Macomber, L., Imlay, J. A., Ferreira, G. C., & Isaya, G. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi461 · Cited by 184 · see citing works
Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase
Hentze, M. W., & Argos, P. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.8.1739 · Cited by 182 · see citing works
Fleming, R. E., Holden, C. C., Tomatsu, S., Waheed, A., Brunt, E. M., Britton, R. S., Bacon, B. R., Roopenian, D. C., & Sly, W. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051630898 · Cited by 182 · see citing works
Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2
Yamanaka, K., Ishikawa, H., Megumi, Y., Tokunaga, F., Kanie, M., Rouault, T. A., Morishima, I., Minato, N., Ishimori, K., & Iwai, K. (2003) · Nature Cell Biology · doi:10.1038/ncb952 · Cited by 181 · see citing works
Cairo, G., Recalcati, S., Pietrangelo, A., & Minotti, G. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00825-0 · Cited by 176 · see citing works
Iron–sulfur protein maturation in human cells: evidence for a function of frataxin
Stehling, O., Elsässer, H.-P., Brückel, B., Mühlenhoff, U., & Lill, R. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh324 · Cited by 176 · see citing works
HIF hydroxylation and cellular oxygen sensing
Metzen, E., & Ratcliffe, P. J. (2004) · Biological Chemistry · doi:10.1515/bc.2004.016 · Cited by 171 · see citing works
Thompson, K., Menzies, S. L., Muckenthaler, M. U., Torti, F. M., Wood, T. L., Torti, S. V., Hentze, M. W., Beard, J., & Connor, J. R. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10463 · Cited by 168 · see citing works
RNA bulges and the helical periodicity of double-stranded RNA
Bhattacharyya, A., Murchie, A. I. H., & Lilley, D. M. J. (1990) · Nature · doi:10.1038/343484a0 · Cited by 165 · see citing works
Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice
Sirito, M., Lin, Q., Deng, J. M., Behringer, R. R., & Sawadogo, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3758 · Cited by 163 · see citing works
Pantopoulos, K., Mueller, S., Atzberger, A., Ansorge, W. J., Stremmel, W., & Hentze, M. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9802 · Cited by 163 · see citing works
Combinatorial mRNA Regulation: Iron Regulatory Proteins and Iso-iron-responsive Elements (Iso-IREs)
Theil, E. C., & Eisenstein, R. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000019200 · Cited by 162 · see citing works
Self-citationHan, D., Canali, R., Garcia, J., Aguilera, R., Gallaher, T. K., & Cadenas, E. (2005) · Biochemistry · doi:10.1021/bi0509393 · Cited by 161 · see citing works
Aceruloplasminemia: An Inherited Neurodegenerative Disease with Impairment of Iron Homeostasis
XU, X., PIN, S., GATHINJI, M., FUCHS, R., & HARRIS, Z. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.024 · Cited by 160 · see citing works
A novel eukaryotic factor for cytosolic Fe–S cluster assembly
Roy, A., Solodovnikova, N., Nicholson, T., Antholine, W. E., & Walden, W. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg455 · Cited by 160 · see citing works
Bacillus subtilis aconitase is an RNA-binding protein
Amaro, C. A., & Sonenshein, A. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10412 · Cited by 159 · see citing works
Unexpected role of ceruloplasmin in intestinal iron absorption
Cherukuri, S., Potla, R., Sarkar, J., Nurko, S., Harris, Z. L., & Fox, P. L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.003 · Cited by 158 · see citing works
Direct evidence for mRNA binding and post-transcriptional regulation by Escherichia coli aconitases
Tang, Y., & Guest, J. R. (1999) · Microbiology · doi:10.1099/00221287-145-11-3069 · Cited by 158 · see citing works
Cazzola, M., Bergamaschi, G., Tonon, L., Arbustini, E., Grasso, M., Vercesi, E., Barosi, G., Bianchi, P. E., Cairo, G., & Arosio, P. (1997) · Blood · doi:10.1182/blood.v90.2.814 · Cited by 156 · see citing works
Involvement of Heme Regulatory Motif in Heme-Mediated Ubiquitination and Degradation of IRP2
Ishikawa, H., Kato, M., Hori, H., Ishimori, K., Kirisako, T., Tokunaga, F., & Iwaï, K. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.05.027 · Cited by 155 · see citing works
Molecular and Cellular Iron Transport
(2002) · CRC Press eBooks · doi:10.1201/9780824744175.fmatt1 · Cited by 150 · see citing works
Loops and Bulge/Loops in Iron-responsive Element Isoforms Influence Iron Regulatory Protein Binding
Ke, Y., Wu, J., Leibold, E. A., Walden, W. E., & Theil, E. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23637 · Cited by 149 · see citing works
Self-citationHypoxia Post-translationally Activates Iron-regulatory Protein 2
Hanson, E. S., Foot, L. M., & Leibold, E. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.5047 · Cited by 146 · see citing works
Self-citationGoossen, B., & Hentze, M. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.1959-1966.1992 · Cited by 145 · see citing works
Crystal Structure of Human Iron Regulatory Protein 1 as Cytosolic Aconitase
Dupuy, J., Volbeda, A., Carpentier, P., Darnault, C., Moulis, J., & Fontecilla-Camps, J. C. (2006) · Structure · doi:10.1016/j.str.2005.09.009 · Cited by 145 · see citing works
Goossen, B., Caughman, S. W., Harford, J. B., Klausner, R. D., & Hentze, M. W. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07635.x · Cited by 144 · see citing works
The aconitase family: three structural variations on a common theme
Gruer, M. J., Artymiuk, P. J., & Guest, J. R. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10069-4 · Cited by 144 · see citing works
Iolascon, A., D’Apolito, M., Servedio, V., Cimmino, F., Piga, A. G., & Camaschella, C. (2005) · Blood · doi:10.1182/blood-2005-06-2477 · Cited by 143 · see citing works
Hemochromatosis: Genetics and Pathophysiology
Beutler, E. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.57.121304.131310 · Cited by 142 · see citing works
Kim, H.-Y., LaVaute, T., Iwai, K., Klausner, R. D., & Rouault, T. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.39.24226 · Cited by 141 · see citing works
Oxygen and Iron Regulation of Iron Regulatory Protein 2
Hanson, E. S., Rawlins, M. L., & Leibold, E. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302798200 · Cited by 140 · see citing works
Self-citationDifferences in the RNA binding sites of iron regulatory proteins and potential target diversity.
Butt, J., Kim, H. Y., Basilion, J. P., Cohen, S., Iwaï, K., Philpott, C. C., Altschul, S. F., Klausner, R. D., & Rouault, T. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4345 · Cited by 139 · see citing works
Minotti, G., Recalcati, S., Menna, P., Salvatorelli, E., Corna, G., & Cairo, G. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)78025-8 · Cited by 135 · see citing works
Iron Imports. I. Intestinal iron absorption and its regulation
Frazer, D. M., & Anderson, G. J. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00220.2005 · Cited by 135 · see citing works
Purification of a Specific Repressor of Ferritin mRNA Translation from Rabbit Liver
Walden, W. E., Patiño, M. M., & Gaffield, L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80066-7 · Cited by 134 · see citing works
Activation of iron regulatory protein-1 by oxidative stress in vitro
Pantopoulos, K., & Hentze, M. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10559 · Cited by 129 · see citing works
Characterization and Expression of Iron Regulatory Protein 2 (IRP2)
Guo, B., Brown, F. M., Phillips, J. D., Yu, Y., & Leibold, E. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16529 · Cited by 129 · see citing works
Self-citationMouse Phenome Research: Implications of Genetic Background
Yoshiki, A., & Moriwaki, K. (2006) · ILAR Journal · doi:10.1093/ilar.47.2.94 · Cited by 129 · see citing works
Cairo, G., Castrusini, E., Minotti, G., & Bernelli‐Zazzera, A. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.11.8836047 · Cited by 125 · see citing works
Kohler, S. A., Henderson, B. R., & Kühn, L. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30781 · Cited by 125 · see citing works
Phosphorylation and Activation of both Iron Regulatory Proteins 1 and 2 in HL-60 Cells
Schalinske, K. L., & Eisenstein, R. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.7168 · Cited by 125 · see citing works
Self-citationBrazzolotto, X., Gaillard, J., Pantopoulos, K., Hentze, M. W., & Moulis, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21625 · Cited by 123 · see citing works
Smith, S., Ghosh, M. C., Ollivierre, H., Tong, W. H., & Rouault, T. A. (2006) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.12.006 · Cited by 123 · see citing works
Iron-responsive element-binding protein. Phosphorylation by protein kinase C.
Eisenstein, R. S., Tuazon, P. T., Schalinske, K. L., Anderson, S. A., & Traugh, J. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74258-6 · Cited by 122 · see citing works
Self-citationAllerson, C. R., Cazzola, M., & Rouault, T. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26439 · Cited by 122 · see citing works
Regulation of Iron Regulatory Protein 1 during Hypoxia and Hypoxia/Reoxygenation
Hanson, E. S., & Leibold, E. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7588 · Cited by 122 · see citing works
Self-citationBasilion, J. P., Rouault, T. A., Massinople, C. M., Klausner, R. D., & Burgess, W. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.574 · Cited by 120 · see citing works
Wang, J., Chen, G., Muckenthaler, M. U., Galy, B., Hentze, M. W., & Pantopoulos, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.954-965.2004 · Cited by 116 · see citing works
Escherichia coli aconitases and oxidative stress: post-transcriptional regulation of sodA expression
Tang, Y., Quail, M. A., Artymiuk, P. J., Guest, J. R., & Green, J. D. (2002) · Microbiology · doi:10.1099/00221287-148-4-1027 · Cited by 115 · see citing works
Kinking of DNA and RNA by base bulges.
Lilley, D. M. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7140 · Cited by 113 · see citing works
Iron Regulatory Proteins 1 and 2 Bind Distinct Sets of RNA Target Sequences
Henderson, B. R., Menotti, E., & Kühn, L. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4900 · Cited by 112 · see citing works
Leibold, E. A., Laudano, A. P., & Yu, Y. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.7.1819 · Cited by 112 · see citing works
Self-citationDupic, F., Fruchon, S., Bensaid, M., Loréal, O., Brissot, P., Borot, N., Roth, M., & Coppin, H. (2002) · Gut · doi:10.1136/gut.51.5.648 · Cited by 112 · see citing works
Iron Regulation and the Cell Cycle
Sánchez, M., Galy, B., Dandekar, T., Bengert, P., Vainshtein, Y., Stolte, J., Muckenthaler, M. U., & Hentze, M. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603876200 · Cited by 112 · see citing works
Friedreich ataxia: a paradigm for mitochondrial diseases
Puccio, H. M., & Koenig, M. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00298-8 · Cited by 111 · see citing works
Rouault, T. A. (2001) · Nature Genetics · doi:10.1038/91036 · Cited by 110 · see citing works
Chen, O. S., Schalinske, K. L., & Eisenstein Richard, S. (1997) · Journal of Nutrition · doi:10.1093/jn/127.2.238 · Cited by 110 · see citing works
Tchernitchko, D., Bourgeois, M., Martin, M., & Beaumont, C. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630449 · Cited by 110 · see citing works
Bhasker, C. R., Burgiel, G., Neupert, B., Emery-Goodman, A., Kühn, L. C., & May, B. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31444-3 · Cited by 104 · see citing works
Modulation of Iron Regulatory Protein Functions
Bouton, C., Raveau, M., & Drapier, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.2300 · Cited by 104 · see citing works
Mütze, S., Hebling, U., Stremmel, W., Wang, J., Arnhold, J., Pantopoulos, K., & Mueller, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307159200 · Cited by 101 · see citing works
The impact of iron fortification on nutritional anaemia
LYNCH, S. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.09.003 · Cited by 100 · see citing works
Castro, L. A., Robalinho, R. L., Cayota, A., Meneghini, R., & Radi, R. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0898 · Cited by 98 · see citing works
Post-transcriptional Regulation of the Yeast High Affinity Iron Transport System
Felice, M. R., Domenico, I. D., Li, L., Ward, D. M., Bartók, B., Musci, G., & Kaplan, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414663200 · Cited by 98 · see citing works
Li, K., Tong, W.-H., Hughes, R. M., & Rouault, T. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600582200 · Cited by 97 · see citing works
Regulation of Iron Metabolism: Translational Effects Mediated by Iron, Heme, and Cytokines
Mascotti, D. P., Rup, D., & Thach, R. E. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.001323 · Cited by 97 · see citing works
Harrell, C. M., McKenzie, A. R., Patiño, M. M., Walden, W. E., & Theil, E. C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4166 · Cited by 96 · see citing works
Levi, S., Girelli, D., Perrone, F., Pasti, M., Beaumont, C., Corrocher, R., Albertini, A., & Arosio, P. (1998) · Blood · doi:10.1182/blood.v91.11.4180 · Cited by 96 · see citing works
Leibold, E. A., & Munro, H. N. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48241-5 · Cited by 95 · see citing works
Self-citationIron‐responsive degradation of iron‐regulatory protein 1 does not require the Fe–S cluster
Clarke, S. L., Vasanthakumar, A., Anderson, S. A., Pondarré, C., Koh, C. M., Deck, K. M., Pitula, J. S., Epstein, C. J., Fleming, M. D., & Eisenstein, R. S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600954 · Cited by 95 · see citing works
Self-citationBrain Iron Metabolism and Neurodegenerative Disorders
Sipe, J. C., Lee, P. L., & Beutler, E. (2002) · Developmental Neuroscience · doi:10.1159/000065701 · Cited by 94 · see citing works
Erlitzki, R., Long, J. C., & Theil, E. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207918200 · Cited by 94 · see citing works
Smith, S., Cooperman, S. S., LaVaute, T. M., Tresser, N. J., Ghosh, M. C., Meyron‐Holtz, E. G., Land, W., Ollivierre, H., Jortner, B. S., Switzer, R., et al. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.006 · Cited by 94 · see citing works
Reversing Productivity Losses from Iron Deficiency: The Economic Case
Hunt, J. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.4.794s · Cited by 93 · see citing works
Seiser, C., Teixeira, S. M. R., & Kühn, L. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38621-1 · Cited by 92 · see citing works
Casey, J. L., Jeso, B. D., Rao, K., Klausner, R. D., & Harford, J. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.6.1787 · Cited by 92 · see citing works
Schranzhofer, M., Schifrer, M., Cabrera, J. A., Kopp, S., Chiba, P., Beug, H., & Müllner, E. W. (2006) · Blood · doi:10.1182/blood-2005-05-1809 · Cited by 89 · see citing works
Post‐transcriptional expression of DMT1 in the heart of rat
Ke, Y., Chen, Y. Y., Chang, Y. Z., Duan, X. L., Ho, K. P., Jiang, D. H., Wang, K., & Qian, Z. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10284 · Cited by 89 · see citing works
Book Review: Iron and Parkinson’s Disease
Wolozin, B. L., & Golts, N. (2002) · The Neuroscientist · doi:10.1177/107385840200800107 · Cited by 89 · see citing works
Effects of iron regulatory protein regulation on iron homeostasis during hypoxia
Schneider, B. D., & Leibold, E. A. (2003) · Blood · doi:10.1182/blood-2003-02-0433 · Cited by 88 · see citing works
Self-citationCytosolic Aconitase and Ferritin Are Regulated by Iron inCaenorhabditis elegans
Gourley, B. L., Parker, S. B., Jones, B. J., Zumbrennen‐Bullough, K. B., & Leibold, E. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210333200 · Cited by 88 · see citing works
Self-citationREVIEW ARTICLE Neurodegeneration with brain iron accumulation
Gregory, A., & Hayflick, S. J. (2006) · Folia Neuropathologica · Cited by 88 · see citing works
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The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
Function and biogenesis of iron-sulphur proteins
Lill, R. (2009) · Nature · doi:10.1038/nature08301 · Cited by 1,167 · see citing works
Regulation of cellular iron metabolism
Wang, J., & Pantopoulos, K. (2011) · Biochemical Journal · doi:10.1042/bj20101825 · Cited by 986 · see citing works
Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701 · see citing works
Maturation of Iron-Sulfur Proteins in Eukaryotes: Mechanisms, Connected Processes, and Diseases
Lill, R., & Mühlenhoff, U. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.052705.162653 · Cited by 595 · see citing works
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Regulation of iron transport and the role of transferrin
Gkouvatsos, K., Papanikolaou, G., & Pantopoulos, K. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.10.013 · Cited by 518 · see citing works
The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism
Lill, R., Hoffmann, B., Molik, S., Pierik, A. J., Rietzschel, N., Stehling, O., Uzarska, M. A., Webert, H., Wilbrecht, C., & Mühlenhoff, U. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.009 · Cited by 501 · see citing works
Mammalian iron metabolism and its control by iron regulatory proteins
Anderson, C. P., Shen, M., Eisenstein, R. S., & Leibold, E. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.010 · Cited by 493 · see citing works
Self-citationDifferential regulation of iron homeostasis during human macrophage polarized activation
Recalcati, S., Locati, M., Marini, A., Santambrogio, P., Zaninotto, F., De Pizzol, M., Zammataro, L., Girelli, D., & Cairo, G. (2010) · European Journal of Immunology · doi:10.1002/eji.200939889 · Cited by 438 · see citing works
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis
Salahudeen, A. A., Thompson, J. W., Ruiz, J. C., Ma, H.-W., Kinch, L. N., Li, Q., Grishin, N. V., & Bruick, R. K. (2009) · Science · doi:10.1126/science.1176326 · Cited by 432 · see citing works
Control of iron homeostasis by an iron-regulated ubiquitin ligase
Vashisht, A. A., Zumbrennen, K. B., Huang, X., Powers, D. N., Durazo, A., Sun, D., Bhaskaran, N., Persson, A., Uhlen, M., Sangfelt, O., et al. (2009) · Science · doi:10.1126/science.1176333 · Cited by 429 · see citing works
Self-citationSheftel, A. D., Stehling, O., Pierik, A. J., Elsässer, H.-P., Mühlenhoff, U., Webert, H., Hobler, A., Hannemann, F., Bernhardt, R., & Lill, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004250107 · Cited by 406 · see citing works
Iron–sulfur cluster biogenesis and human disease
Rouault, T. A., & Tong, W. H. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.05.008 · Cited by 387 · see citing works
Alessio, E. (2016) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.201600986 · Cited by 394 · see citing works
Gut Microbiota and Iron: The Crucial Actors in Health and Disease
Yilmaz, B., & Li, H. (2018) · Pharmaceuticals · doi:10.3390/ph11040098 · Cited by 317 · see citing works
Cellular Iron Metabolism and Regulation
Gao, G., Li, J., Zhang, Y., & Chang, Y.-Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9589-5_2 · Cited by 322 · see citing works
The physiological functions of iron regulatory proteins in iron homeostasis - an update
Zhang, D., Ghosh, M. C., & Rouault, T. A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00124 · Cited by 310 · see citing works
An overview of molecular basis of iron metabolism regulation and the associated pathologies
Silva, B., & Faustino, P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.011 · Cited by 300 · see citing works
Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency
Sanchez, M., Galy, B., Muckenthaler, M. U., & Hentze, M. W. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1222 · Cited by 294 · see citing works
Zhang, D.-L., Hughes, R. M., Ollivierre-Wilson, H., Ghosh, M. C., & Rouault, T. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.006 · Cited by 281 · see citing works
Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals
Moulis, J. (2010) · BioMetals · doi:10.1007/s10534-010-9336-y · Cited by 274 · see citing works
Jiao, Y., Wilkinson, J., Di, X., Wang, W., Hatcher, H., Kock, N. D., D'Agostino, R., Knovich, M. A., Torti, F. M., & Torti, S. V. (2009) · Blood · doi:10.1182/blood-2008-05-155952 · Cited by 266 · see citing works
Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells
Asano, T., Komatsu, M., Yamaguchi-Iwai, Y., Ishikawa, F., Mizushima, N., & Iwai, K. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01437-10 · Cited by 265 · see citing works
Living with Iron (and Oxygen): Questions and Answers about Iron Homeostasis
Theil, E. C., & Goss, D. J. (2009) · Chemical Reviews · doi:10.1021/cr900052g · Cited by 265 · see citing works
Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents
Richardson, D. R., Kalinowski, D. S., Lau, S. L., Jansson, P. J., & Lovejoy, D. B. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.04.003 · Cited by 260 · see citing works
Oxidative Stress and the Homeodynamics of Iron Metabolism
Bresgen, N., & Eckl, P. (2015) · Biomolecules · doi:10.3390/biom5020808 · Cited by 247 · see citing works
Ye, H., Jeong, S. Y., Ghosh, M. C., Kovtunovych, G., Silvestri, L., Ortillo, D., Uchida, N., Tisdale, J. F., Camaschella, C., & Rouault, T. A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40372 · Cited by 239 · see citing works
Human Iron−Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease
Ye, H., & Rouault, T. A. (2010) · Biochemistry · doi:10.1021/bi1004798 · Cited by 247 · see citing works
Lawen, A., & Lane, D. J. R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4271 · Cited by 217 · see citing works
Sheftel, A. D., Wilbrecht, C., Stehling, O., Niggemeyer, B., Elsässer, H., Mühlenhoff, U., & Lill, R. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0772 · Cited by 213 · see citing works
Iron–sulfur proteins in health and disease
Sheftel, A. D., Stehling, O., & Lill, R. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.12.006 · Cited by 203 · see citing works
Galy, B., Ferring-Appel, D., Kaden, S., Gröne, H.-J., & Hentze, M. W. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.006 · Cited by 195 · see citing works
Hypoxia-inducible factors link iron homeostasis and erythropoiesis
Shah, Y. M., & Xie, L. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.12.031 · Cited by 187 · see citing works
Cho, H.-H., Cahill, C. M., Vanderburg, C. R., Scherzer, C. R., Wang, B., Huang, X., & Rogers, J. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149161 · Cited by 188 · see citing works
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster
Wang, H., Shi, H., Rajan, M., Canarie, E. R., Hong, S., Simoneschi, D., Pagano, M., Bush, M. F., Stoll, S., Leibold, E. A., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.02.011 · Cited by 185 · see citing works
Self-citationIron toxicity in neurodegeneration
Núñez, M. T., Urrutia, P. J., Mena, N. P., Aguirre, P., Tapia, V., & Salazar, J. (2012) · BioMetals · doi:10.1007/s10534-012-9523-0 · Cited by 181 · see citing works
Breuer, W., Shvartsman, M., & Cabantchik, Z. I. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.010 · Cited by 175 · see citing works
Mechanisms of iron–sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes
Lill, R., Dutkiewicz, R., Elsässer, H., Hausmann, A., Netz, D. J. A., Pierik, A. J., Stehling, O., Urzica, E. I., & Mühlenhoff, U. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.011 · Cited by 170 · see citing works
Ashraf, A., Clark, M., & So, P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00065 · Cited by 158 · see citing works
Ng, S., Norwitz, S. G., & Norwitz, E. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133283 · Cited by 162 · see citing works
Shi, Y., Ghosh, M. C., Tong, W.-H., & Rouault, T. A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp239 · Cited by 155 · see citing works
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity
Song, J., Liu, T., Yin, Y., Zhao, W., Lin, Z., Yin, Y., Lü, D., & You, F. (2021) · EMBO Reports · doi:10.15252/embr.202051162 · Cited by 156 · see citing works
Iron levels in polarized macrophages: regulation of immunity and autoimmunity
Recalcati, S., Locati, M., Gammella, E., Invernizzi, P., & Cairo, G. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.03.003 · Cited by 150 · see citing works
Iron homeostasis and organismal aging
Zeidan, R. S., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101510 · Cited by 150 · see citing works
Iron regulatory proteins secure mitochondrial iron sufficiency and function
Galy, B., Ferring-Appel, D., Sauer, S. W., Kaden, S., Lyoumi, S., Puy, H., Kölker, S., Gröne, H.-J., & Hentze, M. W. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.06.007 · Cited by 147 · see citing works
Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia
Li, K., Besse, E. K., Ha, D., Kovtunovych, G., & Rouault, T. A. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn127 · Cited by 141 · see citing works
The functional duality of iron regulatory protein 1
Volz, K. W. (2008) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2007.12.010 · Cited by 138 · see citing works
Bertrand, R. L. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.02.017 · Cited by 130 · see citing works
Iron Reduces M1 Macrophage Polarization in RAW264.7 Macrophages Associated with Inhibition of STAT1
Gan, Z.-S., Wang, Q., Li, J., Wang, X., Wang, Y., & Du, H. (2017) · Mediators of Inflammation · doi:10.1155/2017/8570818 · Cited by 127 · see citing works
Iron-regulatory proteins: molecular biology and pathophysiological implications
Cairo, G., & Recalcati, S. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399407000531 · Cited by 124 · see citing works
Iron-Based Redox Switches in Biology
Outten, F. W., & Theil, E. C. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2296 · Cited by 123 · see citing works
Iron-Responsive miR-485-3p Regulates Cellular Iron Homeostasis by Targeting Ferroportin
Sangokoya, C., Doss, J. F., & Chi, J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003408 · Cited by 122 · see citing works
Adaptation of iron requirement to hypoxic conditions at high altitude
Gassmann, M., & Muckenthaler, M. U. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00248.2015 · Cited by 123 · see citing works
Iron Regulatory Proteins: From Molecular Mechanisms to Drug Development
Recalcati, S., Minotti, G., & Cairo, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2983 · Cited by 127 · see citing works
The REM phase of gene regulation
Hentze, M. W., & Preiss, T. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.009 · Cited by 115 · see citing works
High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats
Meli, R., Raso, G. M., Irace, C., Simeoli, R., Pascale, A. D., Paciello, O., Pagano, T. B., Calignano, A., Colonna, A., & Santamaria, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066570 · Cited by 112 · see citing works
Iron homeostasis in breast cancer
Marques, O., da Silva, B. M., Porto, G., & Lopes, C. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.01.029 · Cited by 115 · see citing works
Jiang, D., Li, X., Williams, R. S., Patel, S., Men, L., Wang, Y., & Zhou, F. (2009) · Biochemistry · doi:10.1021/bi900907a · Cited by 109 · see citing works
T‐type calcium channel blockade improves survival and cardiovascular function in thalassemic mice
Kumfu, S., Chattipakorn, S. C., Chinda, K., Fucharoen, S., & Chattipakorn, N. (2012) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2012.01779.x · Cited by 108 · see citing works
Human Nbp35 Is Essential for both Cytosolic Iron-Sulfur Protein Assembly and Iron Homeostasis
Stehling, O., Netz, D. J. A., Niggemeyer, B., Rösser, R., Eisenstein, R. S., Puccio, H. M., Pierik, A. J., & Lill, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00545-08 · Cited by 107 · see citing works
Self-citationThe family of iron responsive RNA structures regulated by changes in cellular iron and oxygen
Leipuvienė, R., & Theil, E. C. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7198-4 · Cited by 104 · see citing works
Regulation of iron pathways in response to hypoxia
Chepelev, N. L., & Willmore, W. G. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.023 · Cited by 102 · see citing works
Iron–Sulfur Clusters: Biogenesis, Molecular Mechanisms, and Their Functional Significance
Xu, X. M., & Møller, S. G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3259 · Cited by 102 · see citing works
Ferritin L and H Subunits Are Differentially Regulated on a Post-transcriptional Level
Sammarco, M. C., Ditch, S., Banerjee, A., & Grabczyk, E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703456200 · Cited by 102 · see citing works
Molecular and cellular bases of iron metabolism in humans
Васильевич, М. И., Suhodolo, I. V., Prokopieva, V. D., & Klimenteva, T. K. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916060018 · Cited by 103 · see citing works
The many faces of the octahedral ferritin protein
Watt, R. K. (2011) · BioMetals · doi:10.1007/s10534-011-9415-8 · Cited by 97 · see citing works
H+-Coupled Divalent Metal-Ion Transporter-1
Shawki, A., Knight, P. B., Maliken, B. D., Niespodzany, E. J., & Mackenzie, B. (2012) · Current topics in membranes · doi:10.1016/b978-0-12-394316-3.00005-3 · Cited by 94 · see citing works
Iron metabolism in trypanosomatids, and its crucial role in infection
Taylor, M. C., & Kelly, J. M. (2010) · Parasitology · doi:10.1017/s0031182009991880 · Cited by 95 · see citing works
Calcium, iron and neuronal function
Hidalgo, C., & Núñez, M. T. (2007) · IUBMB Life · doi:10.1080/15216540701222906 · Cited by 95 · see citing works
Role of iron in brain development, aging, and neurodegenerative diseases
Gao, Q., Zhou, Y., Chen, Y., Hu, W., Jin, W., Zhou, C., Yuan, H., Li, J., Lin, Z., & Lin, W. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2472871 · Cited by 103 · see citing works
Ghosh, M. C., Tong, W.-H., Zhang, D., Ollivierre, H., Singh, A., Krishna, M. C., Mitchell, J. B., & Rouault, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805361105 · Cited by 93 · see citing works
A general map of iron metabolism and tissue-specific subnetworks
Hower, V., Mendes, P., Torti, F. M., Laubenbacher, R., Akman, S. A., Shulaev, V., & Torti, S. V. (2009) · Molecular BioSystems · doi:10.1039/b816714c · Cited by 97 · see citing works
Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest
Zhang, F., Wang, W., Tsuji, Y., Torti, S. V., & Torti, F. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806432200 · Cited by 90 · see citing works
Prasanthi, J. R. P., Larson, T., Schommer, J., & Ghribi, O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026420 · Cited by 80 · see citing works
RetractedNitric Oxide, Iron and Neurodegeneration
Liu, C., Liang, M. C., & Soong, T. W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00114 · Cited by 79 · see citing works
Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma
Yao, F., Cui, X., Zhang, Y., Bei, Z., Wang, H., Zhao, D., Wang, H., & Yang, Y. (2021) · Oncology Letters · doi:10.3892/ol.2021.12918 · Cited by 79 · see citing works
Eukaryotic RNA 5′-End NAD + Capping and DeNADding
Kiledjian, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.005 · Cited by 75 · see citing works
Ferroptosis: an important player in the inflammatory response in diabetic nephropathy
Li, J., Li, L., Zhang, Z., Chen, P., Shu, H., Yang, C., Chu, Y., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294317 · Cited by 82 · see citing works
Franceschi, L. D., Bertoldi, M., Falco, L. D., Franco, S. S., Ronzoni, L., Turrini, F., Colancecco, A., Camaschella, C., Cappellini, M. D., & Iolascon, A. (2011) · Haematologica · doi:10.3324/haematol.2011.043612 · Cited by 77 · see citing works
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias
Magaki, S., Raghavan, R., Mueller, C., Oberg, K. C., Vinters, H. V., & Kirsch, W. M. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.077 · Cited by 77 · see citing works
Romney, S. J., Newman, B. S., Thacker, C. M., & Leibold, E. A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002394 · Cited by 74 · see citing works
Self-citationFrancischini, C. W., & Quaggio, R. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07230.x · Cited by 72 · see citing works
Ma, J., Haldar, S., Khan, M. A., Sharma, S. D., Merrick, W. C., Theil, E. C., & Goss, D. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120045109 · Cited by 72 · see citing works
Goforth, J. B., Anderson, S. A., Nizzi, C. P., & Eisenstein, R. S. (2010) · RNA · doi:10.1261/rna.1857210 · Cited by 71 · see citing works
Self-citationMaffettone, C., Chen, G., Drozdov, I. A., Ouzounis, C. A., & Pantopoulos, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010163 · Cited by 68 · see citing works
Prasanthi, J. R. P., Schrag, M., Dasari, B., Marwarha, G., Dickson, A., Kirsch, W. M., & Ghribi, O. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111346 · Cited by 68 · see citing works
Influence of microRNA on the Maintenance of Human Iron Metabolism
Davis, M. R., & Clarke, S. L. (2013) · Nutrients · doi:10.3390/nu5072611 · Cited by 62 · see citing works
Trading translation with RNA-binding proteins
Abaza, I., & Gebauer, F. (2008) · RNA · doi:10.1261/rna.848208 · Cited by 62 · see citing works
Iron–sulfur clusters as inhibitors and catalysts of viral replication
Ebrahimi, K. H., Ciofi‐Baffoni, S., Hagedoorn, P., Nicolet, Y., Brun, N. E. L., Hagen, W. R., & Armstrong, F. A. (2022) · Nature Chemistry · doi:10.1038/s41557-021-00882-0 · Cited by 61 · see citing works
Cellular sensing and transport of metal ions: implications in micronutrient homeostasis
Bird, A. J. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.002 · Cited by 58 · see citing works
Ferroptosis Is Regulated by Mitochondria in Neurodegenerative Diseases
Zhou, J.-P., Jin, Y., Lei, Y.-H., Liu, T., Wan, Z., Meng, H., & Wang, H. (2020) · Neurodegenerative Diseases · doi:10.1159/000510083 · Cited by 57 · see citing works
Scheers, N. (2013) · Nutrients · doi:10.3390/nu5030957 · Cited by 57 · see citing works
Seco-Cervera, M., González-Cabo, P., Pallardó, F., Romá-Mateo, C., & García-Giménez, J. (2020) · Antioxidants · doi:10.3390/antiox9121257 · Cited by 52 · see citing works
An Iron Responsive Element-like Stem-Loop Regulates α-Hemoglobin-stabilizing Protein mRNA
dos Santos, C. O., Doré, L. C., Valentine, E. R., Shelat, S. G., Hardison, R. C., Ghosh, M. C., Wang, W., Eisenstein, R. S., Costa, F. F., & Weiss, M. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802421200 · Cited by 54 · see citing works
Self-citationFerring–Appel, D., Hentze, M. W., & Galy, B. (2008) · Blood · doi:10.1182/blood-2008-05-155093 · Cited by 53 · see citing works
Gaster, M., Nehlin, J. O., & Minet, A. D. (2012) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2012.656653 · Cited by 53 · see citing works
Mineral nutrient interaction: Improving bioavailability of calcium and iron
Skibsted, L. H. (2016) · Food Science and Biotechnology · doi:10.1007/s10068-016-0196-2 · Cited by 52 · see citing works
Lee, Y.-K., Ho, P. W., Schick, R., Lau, Y., Lai, W., Zhou, T., Li, Y., Ng, K., Ho, S. L., Esteban, M. A., et al. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1414-x · Cited by 54 · see citing works
Kojouri, G., Jahanabadi, S., Shakibaie, M., Ahadi, A. M., & Shahverdi, A. R. (2011) · Research in Veterinary Science · doi:10.1016/j.rvsc.2011.07.029 · Cited by 51 · see citing works
- Authors
- Wallander, M. L., Leibold, E. A., & Eisenstein, R. S.
- Affiliations
- University of Utah (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Eisenstein, Richard S.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 1763
- Issue
- 7
- Pages
- 668-689
- ISSN
- 0167-4889 (ISSN-L)
- PMC
- PMC2291536
- OpenAlex
- W2121798267
- Cited by
- 287
- References
- 307
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 13 · 2019: 6 · 2018: 11 · 2017: 6 · 2016: 12 · 2015: 11 · 2014: 19 · 2013: 18 · 2012: 22
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (GM 45201, R01GM045201)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 66600, R56DK066600, DK47219, R01DK066600)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron homeostasis, iron regulatory proteins, iron regulatory protein 1, IRP2, RNA-binding proteins, post-transcriptional regulation, mRNA stability, translational regulation, iron metabolism disorders, iron deficiency, iron overload
- MeSH terms
- Animals, Homeostasis, Iron, Vertebrates, Iron-Regulatory Proteins
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