The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells
Open accessAbstract
Summary Adipose tissue expansion involves the enlargement of existing adipocytes, the formation of new cells from committed preadipocytes, and the coordinated development of the tissue vascular network. Here we find that murine endothelial cells (EC) of classic white and brown fat depots share ultrastructural characteristics with pericytes, which are pluripotent and can potentially give rise to preadipocytes. Lineage tracing experiments using the VE-cadherin promoter reveal localization of reporter genes in EC, and also in preadipocytes and adipocytes of white and brown fat depots. Furthermore, capillary sprouts from human adipose tissue, which have predominantly EC characteristics, are found to express Zfp423, a recently identified marker of preadipocyte determination. In response to PPARγ activation, endothelial characteristics of sprouting cells are progressively lost, and cells form structurally and biochemically defined adipocytes. Together these data support an endothelial origin of murine and human adipocytes, suggesting a model for how adipogenesis and angiogenesis are coordinated during adipose tissue expansion.
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Cites
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · cited 1×
“A vascular origin for white and brown adipocytes may seem to be in contradiction with the work of Seale et al., in which a common origin of BAT and skeletal muscle cells (Seale et al., 2008) was proposed.”
ResultDevelopmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S. (2009) · The FASEB Journal · doi:10.1096/fj.09-133546 · Cited by 725
Self-citationRegulation of Adipose Cell Number in Man
Prins, J. B., & O'rahilly, S. (1997) · Clinical Science · doi:10.1042/cs0920003 · Cited by 406
Gealekman, O., Guseva, N., Hartigan, C., Apotheker, S., Gorgoglione, M., Gurav, K., Tran, K.-V., Straubhaar, J., Nicoloro, S., Czech, M. P., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.970145 · Cited by 346
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Cited by
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
Wang, Q. A., Tao, C., Gupta, R. K., & Scherer, P. E. (2013) · Nature Medicine · doi:10.1038/nm.3324 · Cited by 1,262
Adipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177
Evidence for two types of brown adipose tissue in humans
Lidell, M. E., Betz, M. J., Leinhard, O. D., Heglind, M., Elander, L., Slawik, M., Mussack, T., Nilsson, D., Romu, T., Nuutila, P., et al. (2013) · Nature Medicine · doi:10.1038/nm.3017 · Cited by 657
Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source
Chau, Y.-Y., Bandiera, R., Serrels, A., Martínez-Estrada, O. M., Qing, W., Lee, M., Slight, J., Thornburn, A., Berry, R., McHaffie, S., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2922 · Cited by 518
Metadata
- Authors
- Tran, K.-V., Gealekman, O., Frontini, A., Zingaretti, M. C., Morroni, M., Giordano, A., Smorlesi, A., Perugini, J., De Matteis, R., Sbarbati, A., Corvera, S., & Cinti, S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 15
- Issue
- 2
- Pages
- 222-229
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2063489655
- Cited by
- 382
- References
- 7
- FWCI
- 25.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tran, K.-V., Gealekman, O., Frontini, A., Zingaretti, M. C., Morroni, M., Giordano, A., Smorlesi, A., Perugini, J., De Matteis, R., Sbarbati, A., Corvera, S., & Cinti, S. (2012). The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells. Cell Metabolism. https://doi.org/10.1016/j.cmet.2012.01.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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