The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

Circadian Control of the NAD + Salvage Pathway by CLOCK-SIRT1

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The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

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The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

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Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

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Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

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SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

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PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

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Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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NAD+ metabolism and its roles in cellular processes during ageing

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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

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CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

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The role of oxidative stress during inflammatory processes

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NAD+ homeostasis in health and disease

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Poly(ADP-ribose) polymerase inhibition: past, present and future

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Understanding and overcoming resistance to PARP inhibitors in cancer therapy

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The evolving metabolic landscape of chromatin biology and epigenetics

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Regulation of chromatin and gene expression by metabolic enzymes and metabolites

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Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

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PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer

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Poly (ADP-Ribose) Polymerase Inhibitors: Recent Advances and Future Development

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Molecular mechanisms of aging and anti-aging strategies

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Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

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Sirtuins: guardians of mammalian healthspan

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SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

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PARP-1 and gene regulation: Progress and puzzles

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Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

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Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

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NAD+ homeostasis in human health and disease

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PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

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Modulating NAD+ metabolism, from bench to bedside

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Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue

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Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration

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Cytotoxicity and genotoxicity of nano - and microparticulate copper oxide: role of solubility and intracellular bioavailability

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Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease

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PARPs and ADP-Ribosylation: 50 Years … and Counting

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Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

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Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

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Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life

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PARPs in lipid metabolism and related diseases

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The role of PARP1 in neurodegenerative diseases and aging

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Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

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Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer

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RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination

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Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism

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A new wave of innovations within the DNA damage response

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Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

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Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents - A recent update

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Non‐coding RNAs: the dark side of nuclear–mitochondrial communication

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PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling

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SIRT1 metabolic actions: Integrating recent advances from mouse models

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Poly(ADP-ribose) polymerases as modulators of mitochondrial activity

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Predictive biomarkers for cancer therapy with PARP inhibitors

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The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells

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Poly(ADP-ribose): A signaling molecule in different paradigms of cell death

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ADP-ribosylation signalling and human disease

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Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health

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Role of poly(ADP‐ribose) polymerases in the regulation of inflammatory processes

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Poly(ADP‐ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications

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Accurate Measurement of Nicotinamide Adenine Dinucleotide (NAD+) with High-Performance Liquid Chromatography

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Enhancing NAD+ salvage pathway reverts the toxicity of primary astrocytes expressing amyotrophic lateral sclerosis-linked mutant superoxide dismutase 1 (SOD1)

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Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

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Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotypePreprint

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Puerarin protects against high‐fat high‐sucrose diet‐induced non‐alcoholic fatty liver disease by modulating PARP‐1/PI3K/AKT signaling pathway and facilitating mitochondrial homeostasis

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The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolismPreprint

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Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice

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Nicotinamide adenine dinucleotide: Biosynthesis, consumption and therapeutic role in cardiac diseases

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Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality

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PARP inhibitors: polypharmacology versus selective inhibition

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Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation

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Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration

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Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage

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Inborn disorders of the malate aspartate shuttle

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Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition

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NAD+ Homeostasis and NAD+-Consuming Enzymes: Implications for Vascular Health

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Deficiency of Parkinson’s disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation

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MicroRNA-379-5p is associated with biochemical premature ovarian insufficiency through PARP1 and XRCC6

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PARPs in genome stability and signal transduction: implications for cancer therapy

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Radioresistance of Brain Tumors

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In-silico Design, ADMET Screening, MM-GBSA Binding Free Energy of Some Novel Isoxazole Substituted 9-Anilinoacridines as HER2 Inhibitors Targeting Breast Cancer

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Bi-allelic ADPRHL2 Mutations Cause Neurodegeneration with Developmental Delay, Ataxia, and Axonal Neuropathy

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Bioenergetic Impairment in Animal and Cellular Models of Alzheimer’s Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions

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SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation

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TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors

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Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity

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Detection of cerebral NAD+ by in vivo1H NMR spectroscopy

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NAD+ and NAFLD – caution, causality and careful optimism

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Liquid-liquid phase separation in DNA double-strand breaks repair

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Impact of NAD+ metabolism on ovarian aging

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Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy

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